Cloning of two alternatively spliced 21-hydroxylase CDNAs from rat adrenal

Journal of Steroid Biochemistry and Molecular Biology

Volumn 62, Issue 4, 1997, Pages 277-286

  Zhou, Ming Yi ^a   Del Carmen Vila, Maria ^b   Gomez Sanchez, Elise P ^a,c,d   Gomez Sanchez, Celso E ^a,c  

^a University of Missouri   (United States)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c UNIVERSITY OF MISSOURI   (United States)

^d UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOCHROME P450; STEROID 21 MONOOXYGENASE;

ADRENAL GLAND; ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTICLE; BRAIN; BRAIN STEM; CEREBELLUM; CHO CELL; CONTROLLED STUDY; ENZYME ACTIVITY; GENE CONSTRUCT; GENE EXPRESSION; HEART; HISTOCHEMISTRY; HYPOTHALAMUS; KIDNEY; LIVER; MOLECULAR CLONING; MUTANT; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SOUTHERN BLOTTING;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; COS CELLS; DNA, COMPLEMENTARY; MOLECULAR SEQUENCE DATA; RATS; RATS, SPRAGUE-DAWLEY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID; STEROID 21-HYDROXYLASE; STEROIDS; ZONA GLOMERULOSA;

ANIMALIA;

EID: 0030735947     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(97)00040-X     Document Type: Article

References (20)

1. Nebert D. W., Nelson D. R., Coon M. J., Estabrook R. W., Feyereisen R., Fujii-Kuriyama Y., Gonzalez F. J., Guengerich F. P., Gunsalus I. C., Johnson E. F., Loper J. C., Sato R., Waterman M. R. and Waxman D. J., The P450 superfamily: update of new sequences, gene mapping, and recommended nomenclature. DNA Cell Biol. 10 (1991) 1-14.
2. White P. C., New M. I. and Dupont B., Structure of human steroid 21-hydroxylase genes. Proc. Natl. Acad, Sci. U.S.A. 83 (1986) 5111-5115.
3. White P. C., Grossberger D., Onufer B. J., Chaplin D. D., New M. I., Dupont B. and Strominger J. L., Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man. Proc. Natl. Acad. Sci. U.S.A. 82 (1985) 1089-1093.
4. Bristow J., Gitelman S. E., Tee M. K., Staels B. and Miller W. L., Abundant adrenal-specific transcription of the human P450c21A "pseudogene". J. Biol. Chem. 268 (1993) 12919-12924.
5. Chaplin D. D., Galbraith L. J., Seidman J. G., White P. C. Parker K. L., Nucleotide sequence analysis of murine 21-hydroxylase genes: mutations affecting gene expression. Proc. Natl. Acad. Sci. U.S.A. 83 (1986) 9601-9605.
6. John M. E., Okamura T., Dee A., Adler B., John M. C., White P. C., Simpson E. R. and Waterman M. R., Bovine Steroid 21-hydroxylase: regulation of biosynthesis. Biochemistry 25 (1986) 2846-2853.
7. Miller W. L. and Morel Y., The molecular genetics of 21-hydroxylase deficiency. Annu. Rev. Genet. 23 (1989) 371-393.
8. White P. C., Vitek A., Dupont B. and New M. I., Characterization of frequent deletions causing steroid 21-hydroxylase deficiency. Proc. Natl. Acad. Sci. U.S.A. 85 (1988) 4436-4440.
9. Casey M. L. and MacDonald P. C., Extraadrenal formation of a mineralocorticosteroid: deoxycorticosterone and deoxycorticosterone sulfate biosynthesis and metabolism. Endocr. Rev. 3 (1982) 396-403.
10. Pendurthi U. R., Lamb J. G., Nguyen N., Johnson E. F. and Tukey R. H., Characterization of the CYP2C5 gene in 21L II/J rabbits. Allelic variation affects the expression of P450IIC5. J. Biol. Chem. 265 (1990) 14662-14668.
11. s21 (steroid 21-hydroxylases) of liver and adrenocortical microsomes. FEBS Lett. 167 (1984) 131-136.
12. Mellon S. H. and Miller W. L., Extraadrenal steroid 21-hydroxylation is not mediated by P450c21. J. Clin. Invest. 84 (1989) 1497-1502.
13. 21-linked monooxygenase system in adult rat brain. J. Steroid Biochem, Mol. Biol. 44 (1993) 163-169.
14. Zhou M. and Gomez-Sanchez C. E., Cloning and expression of a rat cytochrome P-450 11β-hydroxylase/aldosterone synthase (CYP11B2) cDNA variant (correction BBRC 196:1018, 1993). Biochem. Biophys. Res. Commun. 194 (1993) 112-117.
15. Zhou M., Clark S. E. and Gomez-Sanchez C. E., A universal cloning method by TA strategy. BioTechniques 19 (1995) 34-35.
16. Kozac M., The scanning model for translation: an update. J. Cell. Biol. 108 (1989) 229-241.
17. Parker K. L., Schimmer B. P., Chaplin D. D. and Seidman J. G., Characterization of a regulatory region of the steroid 21-hydroxylase gene. J. Biol. Chem. 261 (1986) 15353-15355.
18. Kominami S., Tagashira H., Ohta Y., Yamada M., Kawato S. Takemori S., Membrane topology of bovine adrenocortical cytochrome P-450c21: structural studies by trypsin digestion in vesicle membranes. Biochemistry 32 (1993) 12935-12940.
19. Hatakeyama H., Miyamori I., Fujita T., Takeda Y., Takeda R. Yamamoto H., Vascular aldosterone. Biosynthesis and a link to a angiotensin II-induced hypertrophy of vascular smooth muscle cells. J. Biol. Chem. 269 (1994) 24316-24320.
20. Koenig H. L., Schumacher M., Ferzaz B., Do Thi A. N., Ressouches A., Guennoun R., Jung-Testas I., Robel P., Akwa Y. and Baulieu E. E., Progesterone synthesis and myelin formation by Schwann cells. Science 268 (1995) 1500-1503.