Sequential development of intraepithelial γδ and αβ T lymphocytes expressing CD8αβ in neonatal rat intestine: Requirement for the thymus

Immunology

Volumn 92, Issue 4, 1997, Pages 447-456

  Helgeland, L ^a,c   Brandtzaeg, P ^a   Rolstad, B ^b   Vaage, J T ^b  

^a Institute of Pathology   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; INTESTINE EPITHELIUM CELL; JEJUNUM MUCOSA; NEWBORN; NONHUMAN; NUDE MOUSE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; T LYMPHOCYTE; THYMUS;

EID: 0030734755     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1997.00379.x     Document Type: Article

References (47)

1. + and are thymus-dependent. Eur J Immunol 20, 1193.
2. +/CD2 cells and high expression of the RT6 alloantigen. Eur J Immunol 21, 753.
3. VINEY J.L., MACDONALD T.T. & KILSHAW P.J. (1989) T-cell receptor expression in intestinal intra-epithelial lymphocyte subpopulations of normal and athymic mice. Immunology 66, 583.
4. MOSLEY R.L., STYRE D. & KLEIN J.R. (1990) Differentiation and functional maturation of bone marrow-derived intestinal epithelial T cells expressing membrane T cell receptor in athymic radiation chimeras. J Immunol 145, 1369.
5. POUSSIER P. & JULIUS M. (1994) Thymus independent T cell development and selection in the intestinal epithelium. Annu Rev Immunol 12, 521.
6. REGNAULT A., CUMANO A., VASSALLI P., GUY-GRAND D. & KOURILSKY P. (1994) Oligoclonal repertoire of the CD8αα and the CD8αβ TCR-α/β murine intestinal intraepithelial T lymphocytes: evidence for the random emergence of T cells. J Exp Med 180, 1345.
7. +αα intestinal intraepithelial lymphocytes early in ontogeny. Eur J Immunol 24, 1785.
8. LEFRANCOIS L. & OLSON S. (1994) A novel pathway of thymus-directed T lymphocyte maturation. J Immunol 153, 987.
9. DUNON D., COOPER M.D. & IMHOF B.A. (1993) Thymic origin of embryonic intestinal γ/δ T cells. J Exp Med 177, 257.
10. β1 repertoire selection. EMBO J 13, 808.
11. HÜNIG T., WALLNY H.-J., HARTLEY J.K., LAWETZKY A. & TIEFENTHALER G. (1989) A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. J Exp Med 169, 73.
12. TORRES-NAGEL N., KRAUS E., BROWN M.H. et al. (1992) Differential thymus dependence of rat CD8 isoform expression. Eur J Immunol 22, 2841.
13. NICOLLS M. R., AVERSA G.G., PEARCE N.W. et al. (1993) Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody. Transplantation 55, 459.
14. KÜHNLEIN P., PARK J.-H., HERRMANN T., ELBE A. & HÜNIG T. (1994) Identification and characterization of rat γ/δ T lymphocytes in peripheral lymphoid organs, small intestine, and skin with a monoclonal antibody to a constant determinant of the γ/δ T cell receptor. J Immunol 153, 979.
15. HELGELAND L., VAAGE J.T., ROLSTAD B., MIDTVEDT T. & BRANDTZAEG P. (1996) Microbial colonization influences composition and T cell receptor Vβ repertoire of intraepithelial lymphocytes in rat intestine. Immunology 89, 494.
16. + intestinal intraepithelial lymphocytes in rats. Eur J Immunol 22, 159.
17. HÜNIG T. (1983) T-cell function and specificity in athymic mice. Immunol Today 4, 84.
18. BELL E.B., SPARSHOTT S.M., DRAYSON M.T. & FORD W.L. (1987) The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells. J Immunol 139, 1379.
19. SARAWAR S.R. & BELL E.B. (1991) T-cell receptor-bearing cells from athymic nude rats respond to alloantigen in vitro but are defective in vivo. Immunology 73, 334.
20. SCHWINZER R., HEDRICH H.-J. & WONIGEIT K. (1989) T cell differentiation in athymic nude rats (rnu/rnu): demonstration of a distorted T cell subset structure by flow cytometry analysis. Eur J Immunol 19, 1841.
21. LAWETZKY A., TIEFENTHALER G., KUBO R. & HÜNIG T. (1990) Identification and characterization of rat T cell subpopulations expressing T cell receptors α/β and γ/δ. Eur J Immunol 20, 343.
22. COLTEY M., BUCY R.P., CHEN C.H. et al. (1989) Analysis of the first two waves of thymus homing stem cells and their T cell progeny in chick-quail chimeras. J Exp Med 170, 543.
23. ITOHARA S., NAKANISHI N., KANAGAWA O., KUBO R. & TONEGAWA S. (1989) Monoclonal antibodies specific to native murine T-cell receptor γδ: analysis of γδ T cells during thymic ontogeny and in peripheral lymphoid organs. Proc Natl Acad Sci USA 86, 5094.
24. KÜHNLEIN P., VICENTE A., VARAS A., HÜNIG T. & ZAPATA A. (1995) γ/δ Tcells in fetal, neonatal, and adult rat lymphoid organs. Dev Immunol 4, 181.
25. LAWETZKY A., KUBBIES M. & HÜNIG T. (1991) Rat 'first-wave' thymocytes: cycling lymphoblasts that are sensitive to activation-induced cell death but rescued by interleukin 2. Eur J Immunol 21, 2599.
26. FERGUSON A. & PARROTT D.M.V. (1972) The effect of antigen deprivation on thymus-dependent and thymus-independent lymphocytes in the small intestine of the mouse. Clin Exp Immunol 12, 477.
27. + intestinal intraepithelial lymphocytes (IEL) and the extrathymic development of IEL. Eur J Immunol 24, 1080.
28. CUMMINS A.G., STEELE T.W., LABROOY J.T. & SHEARMAN D.J.C. (1988) Maturation of the rat small intestine at weaning: changes in epithelial cell kinetics, bacterial flora, and mucosal immune activity. Gut 29, 1672.
29. THOMPSON F.M., MAYRHOFER G. & CUMMINS A.G. (1996) Dependence of epithelial growth of the small intestine on T-cell activation during weaning in the rat. Gastroenterology 111, 37.
30. + lympho-hemopoietic progenitors develop. J Exp Med 184, 1449.
31. SAVAGE D.C. (1977) Microbial ecology of the gastrointestinal tract. Annu Rev Microbiol 31, 107.
32. OHTEKI T. & MACDONALD H.R. (1993) Expression of the CD28 costimulatory molecule on subsets of murine intestinal intraepithelial lymphocytes correlates with lineage and responsiveness. Eur J Immunol 23, 1251.
33. SIEBRECHT M.S., HSIA E., SPYCHALSKI C. & NAGLER-ANDERSON C. (1993) Stimulation of murine intestinal intraepithelial lymphocytes by the bacterial superantigen staphylococcal enterotoxin B. Int Immunol 5, 717.
34. CUFF C.F., CEBRA C.K., RUBIN D.H. & CEBRA J.J. (1993) Developmental relationship between cytotoxic α/β T cell receptor-positive intraepithelial lymphocytes and Peyer's patch lymphocytes. Eur J Immunol 23, 1333.
35. + gut intraepithelial lymphocytes, lytic for parasite-infected enterocytes. J Immunol 153, 4596.
36. LEFRANCOIS L. & PUDDINGTON L. (1995) Extralhymic intestinal T-cell development: virtual reality? Immunol Today 16, 16.
37. YANG C.P. & BELL E.B. (1994) Thymic education curtailed: defective immune responses in nude rats reconstituted with immature thymocyte subsets. Int Immunol 6, 569.
38. KLEIN J.R. (1996) Whence the intestinal intraepithelial lymphocyte? J Exp Med 184, 1203.
39. MACKALL C.L., HAKIM F.T. & GRESS R.E. (1997) T-cell regeneration: all repertoires are not created equal. Immunol Today 18, 245.
40. BANDEIRA A., MOTA-SANTOS T., ITOHARA S. et al. (1990) Localization of γ/δ T cells to the intestinal epithelium is independent of normal microbial colonization. J Exp Med 172, 239.
41. + fetal murine thymocytes home to the skin and give rise to proliferating dendritic epidermal T cells. J Immunol 146, 2536.
42. WANG J. & KLEIN J.R. (1994) Thymus-neuroendocrine interactions in extrathymic T cell development. Science 265, 1860.
43. HAYES S.M., SIRR A., JACOB S., SIM G.-K. & AUGUSTIN A. (1996) Role of IL-7 in the shaping of the pulmonary γδ T cell repertoire. J Immunol 156, 2723.
44. FULLER B. & LEFRANCOIS L. (1995) Requirement for extrathymic class I histocompatibility antigens for positive selection of thymus-derived T lymphocytes. J Immunol 155, 2808.
45. 2-microglobulin-and/or TAP1-deficient mice. J Immunol 156, 2710.
46. + intraepithelial lymphocytes in the murine small intestine. Immunology 86, 212.
47. a mice. J Exp Med 169, 2149.