Analysis of V(h) genes rearranged by individual B cells in dermal infiltrates of patients with mycosis fungoides

Clinical and Experimental Immunology

Volumn 110, Issue 3, 1997, Pages 464-471

  Forste N ^a   Gellrich, S ^a   Golembowski, S ^a   Rutz, S ^a   Audring, H ^a   Sterry, W ^a   Jahn, Sigbert ^a,b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

B cells; Cutaneous lymphomas; Immunoglobulin genes

Indexed keywords

ARTICLE; B LYMPHOCYTE; CELL INFILTRATION; GENE REARRANGEMENT; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MYCOSIS FUNGOIDES; PRIORITY JOURNAL; SKIN LYMPHOMA;

EID: 0030734365     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1997.4401457.x     Document Type: Article

References (55)

1. Sterry W. Mycosis fungoides. In: Berry CL, ed. Current topics in pathology. Berlin: Springer Verlag, 1985:167.
2. Diamandidou E, Cohen PR, Kurzrock R. Mycosis fungoides and Sezary syndrome. Blood 1996; 88:2385-409.
3. Boehncke WH, Schulte-Rebbelmund H, Sterry W. Plasma cells in the dermal infiltrate of mycosis fungoidcs are of polyclonal origin. Acta Dermatol Venerol (Stockh) 1989; 69:166-9.
4. van der Putte SC, Toonstra J, van Wichen DF. B cells and plasma cells in mycosis fungoides. A study including cases with B cell follicle formation or a monotypical plasma cell component. Am J Dermathopathol 1989; 11:509-16.
5. Asadullah K, Döcke WD, Haeußler A, Sterry W, Volk HD. Progression of mycosis fungoides is associated with increasing cutaneous expression of interleukin 10 (IL-10) mRNA. J Invest Dermatol 1996; 107:833-7.
6. Mayer L, Posnett DN, Kunkel HG. Human malignant T cells capable of inducing an immunoglobulin class switch. J Exp Med 1985; 161:134- 44.
7. Bazex A, Parant M, Bazex J. Mycosis fungoide. Protéine monoclonale IgM. Bull Soc Fr Derm Syph 1975; 82:149.
8. Gianadda B, Robart S, Brutzkus A, Perrot H. Mycosis fungoide et dysglobulinémie monoclonale. Annul Derm Vener 1980; 107:71-74.
9. Ruffieux C, Stalder M, Tran-Thang C. Mycosis fungoide et gammopathie monoclonale. Dermatological 1984; 168:170-4.
10. Bryant E, Ronan SG, Iosifides IA. Plasma cell myeloma in a patient with cutaneous T-cell lymphoma. Cancer 1982; 50:2122-5.
11. Geerts ML, Hamers J, Schwarze E-W, Kint A, Roels H, Lennert K. Mycosis fungoides and lymphoplasmacytoid immunocytoma in the same patient. Cancer 1984; 54:2294-9.
12. Kurosawa Y, Tonegawa S. Organization, structure and assembly of immunoglobulin heavy chain diversity DNA segments. J Exp Med 1982; 155:201-18.
13. Desiderio SV, Yancopoulos GD, Paskind M, Thomas E, Boss MA, Landau N, Alt FW, Baltimore D. Insertion of N regions into heavy chain genes is correlated with expression of terminal desoxytransferase in B cells. Nature 1984; 311:752-5.
14. Alt FW, Blackwell TK, Yancopoulos GD. Development of the primary antibody repertoire. Science 1984; 238:1079-87.
15. Berek C, Milstein C. The dynamic nature of the antibody repertoire. Immunol Rev 1988; 105:5-26.
16. Nickerson J, Berman J, Glickman E, Chess T, Alt FW. Early human IgH gene assembly in Epstein-Barr virus transformed fetal B cell lines. J Exp Med 1989; 169:1391-403.
17. L gene expression in polyreactive antibody-producing human hybridomas from the fetal B cell repertoire. Exp Clin Immunogenet 1994; 11:1-16.
18. Pascual V, Verkryse L, Casey ML, Capra JD. Analysis of IgH-chain gene segment utilization in human fetal liver. Revisiting the 'proximal utilization hypothesis'. J Immunol 1993; 151:4164-72.
19. Brezinschek HP, Brezinschek RI, Lipsky PE. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J Immunol 1995; 155:190-202.
20. Pascual V, Liu YJ, Magalski A, de Bouteiller O, Banchereau J, Capra JD. Analysis of somatic mutation in live B cell subsets of human tonsil. J Exp Med 1994; 180:329-39.
21. Kelsoe G. In situ studies of the germinal center reaction. Adv Immunol 1995; 60:267-88.
22. H genes expressed in peripheral blood IgE producing B cells from patients with atopic dermatitis. Clin Exp Immunol 1997; 107:528-35.
23. Adderson EE, Shackelford PG, Quinn A, Carroll LW. Restricted IgH chain V-gene usage in the human antibody response to Haemophilus influenzae type b capsular polysaccharide. J Immunol 1991; 147:1667- 74.
24. Zouali M. Development of human antibody variable genes in systemic autoimmunity. Immunol Rev 1992; 128:73-49.
25. Logtenberg T, Schutte MEM, Ebeling SB, Gmelig-Meyling FHJ, van Es JH. Molecular approaches to the study of human B cell and (auto) antibody repertoire generation and selection. Immunol Rev 1992; 128: 23-47.
26. Küppers R, Hansmann M-L, Rajewsky K. Micromanipulation and PCR analysis of single cells from tissue sections. In: Weir DM, Blackwell C, Herzenberg LA, Herzenberg LA, eds. Handbook of Experimental immunology, 5th edn. Cambridge, MA: Blackwell Scientific Publications 1995.
27. Küppers R, Zhao M, Hansman ML, Rajewsky K, Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J 1993; 12: 4955-67.
28. H segments with different hypervariable loops. J Mol Biol 1992; 227: 776-98.
29. Brezinschek HP, Brezinschek RI, Lipsky P. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J Immunol 1995; 155:190-202.
30. Matsuda E, Shin EK, Nagaoka H et al. Structure and physical map of 64 variable segments in the 3′ 0.8-megabase region of the human immunoglobulin heavy-chain locus. Nature Genetics 1993; 3:88-94.
31. Winkler TH, Fehr H, Kalden JR. Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas. Eur J Immunol 1992; 22:1719-28.
32. H gene families display remarkably little polymorphism. EMBO J 1989; 8:3741-8.
33. H locus completed by analysis of the telomeric region of chromosome 14q. Nature Genetics 1994; 7:162-8.
34. Shin EK, Matsuda F, Nagaoka H, Fukita Y, Imai T, Yokoyama K, Soeda E, Honjo T. Physical map of the 3 region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotype. EMBO J 1991; 10:3641-5.
35. H locus. J Immunol 1992; 149:492-7.
36. H locus. EMBO J 1988; 7:2003-10.
37. Ichihara Y, Matsuoka H, Kurosawa Y. Organisation of human immunogloblin heavy chain diversity gene loci. EMBO J 1988; 7:4141-50.
38. 5 cluster within the locus and interchromosomal translocation of variable region segments. EMBO J 1990; 9:2501-6.
39. Siebenlist U, Ravetch JV, Korsmeyer S, Waldmann T, Leder P. Human immunoglobulin D segments encoded in tandem multigenic families. Nature 1981; 294:631-5.
40. Ravetch JV, Siebenlist U, Korsmeyer S, Waldmann T, Leder P. Structure of the human immunoglobulin μ locus: characterisation of embryonic and rearranged J and D genes. Cell 1981; 27:583-91.
41. Kabat EA, Wu TT, Perry HM, Gottesman KS, Foeller C. Sequences of proteins of immunological interest. Washington, DC: US Department of Health and Human Services, 1991.
42. Kocks C, Rajewsky K. Stable expression and somatic hypermutation of antibody V regions in B-cell developmental pathways. Ann Rev Immunol 1989; 7:537-59.
43. Huang C, Stollar BD. Construction of representative immunoglobulin variable region cDNA from libraries from human peripheral blood lymphocytes without in vitro stimulation. J Immunol Methods 1991; 141:227-36.
44. K repertoire revealed by in situ hybridization. Mol Immunol 1990; 27:935-40.
45. Pascual V, Randen I, Thompson K, Sioud M, Forre O, Natvig J, Capra JD. The complete nucleotide sequence of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from synovial tissue of patients with rheumatoid arthritis: further evidence that some antibodies are unmutated copies of germline genes. J Clin Invest 1990; 86:1320-8.
46. Stewart AK, Huang C, Long AA, Stollar BD, Schwartz RS. VH-gene representation in autoantibodies reflects the normal human B-cell repertoire. Immunol Rev 1992; 128:101-22.
47. Huang C, Stewart AK, Schwartz AS, Stollar BD. Immunoglobulin heavy chain gene expression in peripheral blood lymphocytes. J Clin Invest 1992; 89:1331-43.
48. Raaphorst FM, Timmers E, Kenter MJH, van Toi MJD, Vossen JM, Schuurman RKB. Restricted utilization of germ-line VH3 genes and short diverse third complementarity-determining regions (CDR3) in human fetal B lymphocyte immunoglobulin heavy chain rearrangements. Eur J Immunol 1992; 22:247-51.
49. van Dijk KW, Sasso EH, Milner ECB. Polymorphism of the human Ig VH4 gene family. J Immunol 1991; 146:3646-51.
50. van Es JH, Heutink M, Aanstoot H, Logtenberg T. Sequence analysis of members of the human Ig VH4 gene family derived from a single VH locus. J Immunol 1992; 149:492-7.
51. Pascual V, Capra JD, VH4-21, a human VH gene segment over- represented in the autoimmune repertoire. Arthritis Rheum 1992; 35: 11-18.
52. Dellabona P, Peccoud J, Kappler J, Marrack P, Benoist C, Mathis D. Superantigens interact with MHC class II molecules outside of the antigen groove. Cell 1990; 62:1115-21.
53. Pacual V, Victor K, Lelsz D et al. Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. J Immunol 1991; 146:4385-91.
54. L, genes display a high inherent susceptibility to amino acid replacement. Ann N Y Acad Sci 1995; 764:170-9.
55. Allen D, Simon T, Sablitzky F, Rajewsky K, Cumano A. Antibody engineering for the analysis of affinity maturation of an anti-hapten response. EMBO J 1988; 7:1995-2001.