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Volumn 41, Issue 12, 1997, Pages 2680-2685

Lobucavir is phosphorylated in human cytomegalovirus-infected and - uninfected cells and inhibits the viral DNA polymerase

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; GANCICLOVIR; LOBUCAVIR;

EID: 0030734329     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.41.12.2680     Document Type: Article
Times cited : (47)

References (58)
  • 1
    • 0029864630 scopus 로고    scopus 로고
    • Cytomegalovirus: Genetics of drug resistance
    • Biron, K. K. 1996. Cytomegalovirus: genetics of drug resistance. Adv. Exp. Med. Biol. 394:135-143.
    • (1996) Adv. Exp. Med. Biol. , vol.394 , pp. 135-143
    • Biron, K.K.1
  • 2
    • 2742573036 scopus 로고
    • A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl) ethoxy] methyl) guanine (BW B759U) induces reduced levels of BW B759U triphosphate
    • Biron, K. K., J. A. Fyfe, S. C. Stanat, L. K. Leslie, J. B. Sorrell, C. U. Lambe, and D. M. Coen. 1986. A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl) ethoxy] methyl) guanine (BW B759U) induces reduced levels of BW B759U triphosphate. Proc. Natl. Acad. Sci. USA 83:8769-8773.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 8769-8773
    • Biron, K.K.1    Fyfe, J.A.2    Stanat, S.C.3    Leslie, L.K.4    Sorrell, J.B.5    Lambe, C.U.6    Coen, D.M.7
  • 3
    • 0021807545 scopus 로고
    • Metabolic activation of the nucleoside analog 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus
    • Biron, K. K., S. C. Stanat, J. B. Sorrell, J. A. Fyfe, P. M. Keller, C. U. Lambe, and D. J. Nelson. 1985. Metabolic activation of the nucleoside analog 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus. Proc. Natl. Acad. Sci. USA 82:2473-2477.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 2473-2477
    • Biron, K.K.1    Stanat, S.C.2    Sorrell, J.B.3    Fyfe, J.A.4    Keller, P.M.5    Lambe, C.U.6    Nelson, D.J.7
  • 6
    • 0024599231 scopus 로고
    • Alpha-, beta- and gammaherpesviruses encode a putative phosphotransferase
    • Chee, M. S., G. L. Lawrence, and B. G. Barrell. 1989. Alpha-, beta- and gammaherpesviruses encode a putative phosphotransferase. J. Gen. Virol. 70:1151-1160.
    • (1989) J. Gen. Virol. , vol.70 , pp. 1151-1160
    • Chee, M.S.1    Lawrence, G.L.2    Barrell, B.G.3
  • 7
    • 0028940302 scopus 로고
    • Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance
    • Chou, S., A. Erice, M. C. Jordan, G. M. Vercellotti, K. R. Michels, C. L. Talarico, S. C. Stanat, and K. K. Biron. 1995. Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance. J. Infect. Dis. 171:576-583.
    • (1995) J. Infect. Dis. , vol.171 , pp. 576-583
    • Chou, S.1    Erice, A.2    Jordan, M.C.3    Vercellotti, G.M.4    Michels, K.R.5    Talarico, C.L.6    Stanat, S.C.7    Biron, K.K.8
  • 8
    • 0025817825 scopus 로고
    • Cyclobutyl compounds as antiviral agents
    • Clement, J. J., and E. R. Kern. 1991. Cyclobutyl compounds as antiviral agents. Transplant. Proc. 23(Suppl. 3):159-161.
    • (1991) Transplant. Proc. , vol.23 , Issue.3 SUPPL. , pp. 159-161
    • Clement, J.J.1    Kern, E.R.2
  • 9
    • 0030570951 scopus 로고    scopus 로고
    • Drug therapy: Ganciclovir
    • Crumpacker, C. S. 1996. Drug therapy: ganciclovir. N. Engl. J. Med. 335:721-729.
    • (1996) N. Engl. J. Med. , vol.335 , pp. 721-729
    • Crumpacker, C.S.1
  • 10
    • 0024541984 scopus 로고
    • Regulated expression of the human cytomegalovirus pp65 gene: Octamer sequence in the promoter is required for activation by viral gene products
    • Depto, A. S., and R. M. Stenberg. 1989. Regulated expression of the human cytomegalovirus pp65 gene: octamer sequence in the promoter is required for activation by viral gene products. J. Virol. 63:1232-1238.
    • (1989) J. Virol. , vol.63 , pp. 1232-1238
    • Depto, A.S.1    Stenberg, R.M.2
  • 12
    • 0024574822 scopus 로고
    • Progressive disease due to ganciclovir-resistant cytomegalovirus in immunocompromised patients
    • Erice, A., S. Chou, K. K. Biron, S. C. Stanat, H. H. Balfour, and M. C. Jordan. 1989. Progressive disease due to ganciclovir-resistant cytomegalovirus in immunocompromised patients. N. Engl. J. Med. 320:289-293.
    • (1989) N. Engl. J. Med. , vol.320 , pp. 289-293
    • Erice, A.1    Chou, S.2    Biron, K.K.3    Stanat, S.C.4    Balfour, H.H.5    Jordan, M.C.6
  • 14
    • 0021814455 scopus 로고
    • Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegaloviruses
    • Freitas, V. R., D. F. Smee, M. Chernow, R. Boehme, and T. R. Matthews. 1985. Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegaloviruses. Antimicrob. Agents Chemother. 28:240-245.
    • (1985) Antimicrob. Agents Chemother. , vol.28 , pp. 240-245
    • Freitas, V.R.1    Smee, D.F.2    Chernow, M.3    Boehme, R.4    Matthews, T.R.5
  • 15
    • 0020066676 scopus 로고
    • Differential phosphorylation of (E)-5-(2-bromovinyl)-2′-deoxyuridine monophosphate by thymidine kinases from herpes simplex viruses types 1 and 2 and varicella zoster virus
    • Fyfe, J. A. 1982. Differential phosphorylation of (E)-5-(2-bromovinyl)-2′-deoxyuridine monophosphate by thymidine kinases from herpes simplex viruses types 1 and 2 and varicella zoster virus. Mol. Pharmacol. 21:432-437.
    • (1982) Mol. Pharmacol. , vol.21 , pp. 432-437
    • Fyfe, J.A.1
  • 16
    • 0343417102 scopus 로고    scopus 로고
    • Unpublished data
    • Hamatake, R. K. Unpublished data.
    • Hamatake, R.K.1
  • 17
    • 0025156999 scopus 로고
    • Cyclobut-A and cyclobut-G, carbocyclic oxetanocin analogs that inhibit the replication of human immunodeficiency virus in T cells and monocytes and macrophages in vitro
    • Hayashi, S., D. W. Norbeck, W. Rosenbrook, R. L. Fine, M. Matsukura, J. J. Plattner, S. Broder, and H. Mitsuya. 1990. Cyclobut-A and cyclobut-G, carbocyclic oxetanocin analogs that inhibit the replication of human immunodeficiency virus in T cells and monocytes and macrophages in vitro. Antimicrob. Agents Chemother. 34:287-294.
    • (1990) Antimicrob. Agents Chemother. , vol.34 , pp. 287-294
    • Hayashi, S.1    Norbeck, D.W.2    Rosenbrook, W.3    Fine, R.L.4    Matsukura, M.5    Plattner, J.J.6    Broder, S.7    Mitsuya, H.8
  • 18
    • 0031060542 scopus 로고    scopus 로고
    • The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines
    • He, Z., Y. S. He, Y. Kim, L. Chu, C. Ohmstede, K. K. Biron, and D. M. Coen. 1997. The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines. J. Virol. 71:405-411.
    • (1997) J. Virol. , vol.71 , pp. 405-411
    • He, Z.1    He, Y.S.2    Kim, Y.3    Chu, L.4    Ohmstede, C.5    Biron, K.K.6    Coen, D.M.7
  • 19
    • 0025942865 scopus 로고
    • Effects of purine nucleoside analogues with a cyclobutane ring and erythromycin a oxime derivatives on duck hepatitis B virus replication in vivo and in cell culture and HIV-1 in cell culture
    • Hung, L.-F., A. E. Brumbaugh, G. Bhatia, P. L. Marion, P. P. Hung, D. W. Norbeck, J. J. Plattner, and W. S. Robinson. 1991. Effects of purine nucleoside analogues with a cyclobutane ring and erythromycin A oxime derivatives on duck hepatitis B virus replication in vivo and in cell culture and HIV-1 in cell culture. J. Med. Virol. 35:180-186.
    • (1991) J. Med. Virol. , vol.35 , pp. 180-186
    • Hung, L.-F.1    Brumbaugh, A.E.2    Bhatia, G.3    Marion, P.L.4    Hung, P.P.5    Norbeck, D.W.6    Plattner, J.J.7    Robinson, W.S.8
  • 21
    • 0026637255 scopus 로고
    • Inhibitory effects of triphosphate derivatives of oxetanocin G and related compounds on eukaryotic and viral DNA polymerases and human immunodeficiency virus reverse transcriptases
    • Izuta, S., N. Shimada, M. Kitagawa, M. Suzuki, K. Kojima, and S. Yoshida. 1992. Inhibitory effects of triphosphate derivatives of oxetanocin G and related compounds on eukaryotic and viral DNA polymerases and human immunodeficiency virus reverse transcriptases. J. Biochem. 112:81-87.
    • (1992) J. Biochem. , vol.112 , pp. 81-87
    • Izuta, S.1    Shimada, N.2    Kitagawa, M.3    Suzuki, M.4    Kojima, K.5    Yoshida, S.6
  • 22
    • 0025641544 scopus 로고
    • Efficiency of phosphorylation of the Cyclobut-G (A-69992) enantiomers by HSV-1 thymidine kinase does not correlate with their antiherpesvirus activity
    • Kohlbrenner, W. E., C. D. Carter, S. W. Fesik, D. W. Norbeck, and J. Erikson. 1990. Efficiency of phosphorylation of the Cyclobut-G (A-69992) enantiomers by HSV-1 thymidine kinase does not correlate with their antiherpesvirus activity. Biochem. Pharmacol. 40:R5-R10.
    • (1990) Biochem. Pharmacol. , vol.40
    • Kohlbrenner, W.E.1    Carter, C.D.2    Fesik, S.W.3    Norbeck, D.W.4    Erikson, J.5
  • 24
    • 0029928614 scopus 로고    scopus 로고
    • Analysis of phosphorylation pathways of antiherpesvirus nucleosides by varicella-zoster virus-specific enzymes
    • Koyano, S., T. Suzutani, I. Yoshida, and M. Azuma. 1996. Analysis of phosphorylation pathways of antiherpesvirus nucleosides by varicella-zoster virus-specific enzymes. Antimicrob. Agents Chemother. 40:920-923.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 920-923
    • Koyano, S.1    Suzutani, T.2    Yoshida, I.3    Azuma, M.4
  • 25
    • 0026664424 scopus 로고
    • Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir
    • Littler, E., A. D. Stuart, and M. S. Chee. 1992. Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir. Nature 358:160-162.
    • (1992) Nature , vol.358 , pp. 160-162
    • Littler, E.1    Stuart, A.D.2    Chee, M.S.3
  • 26
    • 0028271126 scopus 로고
    • Mutation in the UL97 open reading frame of human cytomegalovirus strains resistant to ganciclovir
    • Lurain, N. S., L. E. Spafford, and K. D. Thompson. 1994. Mutation in the UL97 open reading frame of human cytomegalovirus strains resistant to ganciclovir. J. Virol. 68:4427-4431.
    • (1994) J. Virol. , vol.68 , pp. 4427-4431
    • Lurain, N.S.1    Spafford, L.E.2    Thompson, K.D.3
  • 27
    • 0026476302 scopus 로고
    • Point mutations in the DNA polymerase gene of human cytomegalovirus that result in resistance to antiviral agents
    • Lurain, N. S., K. D. Thompson, E. W. Holmes, and G. S. Read. 1992. Point mutations in the DNA polymerase gene of human cytomegalovirus that result in resistance to antiviral agents. J. Virol. 66:7146-7152.
    • (1992) J. Virol. , vol.66 , pp. 7146-7152
    • Lurain, N.S.1    Thompson, K.D.2    Holmes, E.W.3    Read, G.S.4
  • 28
    • 0020573744 scopus 로고
    • Effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on human cytomegalovirus replication in vitro
    • Mar, E. C., Y. C. Cheng, and E.-S. Huang. 1983. Effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on human cytomegalovirus replication in vitro. Antimicrob. Agents Chemother. 24:518-521.
    • (1983) Antimicrob. Agents Chemother. , vol.24 , pp. 518-521
    • Mar, E.C.1    Cheng, Y.C.2    Huang, E.-S.3
  • 29
    • 0021968648 scopus 로고
    • Inhibition of cellular DNA polymerase alpha and human cytomegalovirus-induced DNA polymerase by the triphosphates of 9-(2-hydroxyethoxymethyl)guanine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine
    • Mar, E.-C., J.-F. Chiou, Y.-C. Cheng, and E.-S. Huang. 1985. Inhibition of cellular DNA polymerase alpha and human cytomegalovirus-induced DNA polymerase by the triphosphates of 9-(2-hydroxyethoxymethyl)guanine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine. J. Virol. 53:776-780.
    • (1985) J. Virol. , vol.53 , pp. 776-780
    • Mar, E.-C.1    Chiou, J.-F.2    Cheng, Y.-C.3    Huang, E.-S.4
  • 30
    • 0020636893 scopus 로고
    • 9-[1,3-dihydroxy-2-propoxymethyl]guanine: A new potent and selective antiherpes agent
    • Martin, J. C., C. A. Dvorak, D. F. Smee, T. R. Matthews, and J. P. H. Verheyden. 1983. 9-[1,3-dihydroxy-2-propoxy)methyl]guanine: a new potent and selective antiherpes agent. J. Med. Chem. 26:759-761.
    • (1983) J. Med. Chem. , vol.26 , pp. 759-761
    • Martin, J.C.1    Dvorak, C.A.2    Smee, D.F.3    Matthews, T.R.4    Verheyden, J.P.H.5
  • 31
    • 0024534192 scopus 로고
    • Analysis of a region of the human cytomegalovirus (AD169) genome coding for a 25-kilodalton virion protein
    • Martinez, J., R. S. Lahijani, and S. C. St. Jeor. 1989. Analysis of a region of the human cytomegalovirus (AD169) genome coding for a 25-kilodalton virion protein. J. Virol. 63:233-241.
    • (1989) J. Virol. , vol.63 , pp. 233-241
    • Martinez, J.1    Lahijani, R.S.2    St Jeor, S.C.3
  • 33
    • 0027308966 scopus 로고
    • Synthesis and antiviral activities of carbocyclic oxetanocin analogues (c-oxt-A, c-oxt-G) and related compounds
    • Tokyo
    • Maruyama, T., Y. Hanai, Y. Sato, R. Snoeck, G. Andrei, M. Hosoya, J. Balzarini, and E. De Clercq. 1993. Synthesis and antiviral activities of carbocyclic oxetanocin analogues (c-oxt-A, c-oxt-G) and related compounds. Chem. Pharm. Bull. (Tokyo) 41:516-521.
    • (1993) Chem. Pharm. Bull. , vol.41 , pp. 516-521
    • Maruyama, T.1    Hanai, Y.2    Sato, Y.3    Snoeck, R.4    Andrei, G.5    Hosoya, M.6    Balzarini, J.7    De Clercq, E.8
  • 34
    • 0028051525 scopus 로고
    • Human cytomegalovirus UL97 kinase confers ganciclovir susceptibility to recombinant vaccinia virus
    • Metzger, C., D. Michel, K. Schneider, A. Luske, H. J. Schlicht, and T. Mertens. 1994. Human cytomegalovirus UL97 kinase confers ganciclovir susceptibility to recombinant vaccinia virus. J. Virol. 68:8423-8427.
    • (1994) J. Virol. , vol.68 , pp. 8423-8427
    • Metzger, C.1    Michel, D.2    Schneider, K.3    Luske, A.4    Schlicht, H.J.5    Mertens, T.6
  • 35
    • 0029841220 scopus 로고    scopus 로고
    • The UL97 gene product of human cytomegalovirus is an early-late protein with a nuclear localization but is not a nucleoside kinase
    • Michel, D., I. Pavic, A. Zimmermann, E. Haupt, K. Wunderlich, M. Heuschmid, and T. Mertens. 1996. The UL97 gene product of human cytomegalovirus is an early-late protein with a nuclear localization but is not a nucleoside kinase. J. Virol. 70:6340-6346.
    • (1996) J. Virol. , vol.70 , pp. 6340-6346
    • Michel, D.1    Pavic, I.2    Zimmermann, A.3    Haupt, E.4    Wunderlich, K.5    Heuschmid, M.6    Mertens, T.7
  • 38
    • 0025201144 scopus 로고
    • A simple and fast method to extract RNA from tissue culture cells
    • Peppel, K., and C. Baglioni. 1990. A simple and fast method to extract RNA from tissue culture cells. BioTechniques 9:710-713.
    • (1990) BioTechniques , vol.9 , pp. 710-713
    • Peppel, K.1    Baglioni, C.2
  • 39
    • 0022367169 scopus 로고
    • Viral polypeptides detected by a complement-dependent neutralizing murine monoclonal antibody to human cytomegalovirus
    • Rasmussen L., J. Mullenax, R. Nelson, and T. C. Merigan. 1985. Viral polypeptides detected by a complement-dependent neutralizing murine monoclonal antibody to human cytomegalovirus. J. Virol. 55:274-280.
    • (1985) J. Virol. , vol.55 , pp. 274-280
    • Rasmussen, L.1    Mullenax, J.2    Nelson, R.3    Merigan, T.C.4
  • 40
    • 0029981145 scopus 로고    scopus 로고
    • Analysis of the complete DNA sequence of murine cytomegalovirus
    • Rawlinson, W. D., H. E. Farrell, and B. G. Barrell. 1996. Analysis of the complete DNA sequence of murine cytomegalovirus. J. Virol. 70:8833-8849.
    • (1996) J. Virol. , vol.70 , pp. 8833-8849
    • Rawlinson, W.D.1    Farrell, H.E.2    Barrell, B.G.3
  • 41
    • 0025155080 scopus 로고
    • Transcriptional analysis of the eight-kilobase mRNA encoding the major capsid protein of human cytomegalovirus
    • Rudolph, S.-A., T. Stamminger, and G. Jahn. 1990. Transcriptional analysis of the eight-kilobase mRNA encoding the major capsid protein of human cytomegalovirus. J. Virol 64:5167-5172.
    • (1990) J. Virol , vol.64 , pp. 5167-5172
    • Rudolph, S.-A.1    Stamminger, T.2    Jahn, G.3
  • 43
  • 44
    • 0028809242 scopus 로고
    • Antiviral activities of nucleosides and nucleotides against wild-type and drug-resistant strains of murine cytomegalovirus
    • Smee, D. F., B. B. Barnett, R. W. Sidwell, E. J. Reist, and A. Holy. 1995. Antiviral activities of nucleosides and nucleotides against wild-type and drug-resistant strains of murine cytomegalovirus. Antivir. Res. 26:1-9.
    • (1995) Antivir. Res. , vol.26 , pp. 1-9
    • Smee, D.F.1    Barnett, B.B.2    Sidwell, R.W.3    Reist, E.J.4    Holy, A.5
  • 45
    • 0024599635 scopus 로고
    • Identification of new protein kinase-related genes in three herpesviruses, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus
    • Smith, R. F., and T. F. Smith. 1989. Identification of new protein kinase-related genes in three herpesviruses, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus. J. Virol. 63:450-455.
    • (1989) J. Virol. , vol.63 , pp. 450-455
    • Smith, R.F.1    Smith, T.F.2
  • 47
    • 0024391857 scopus 로고
    • Regulated expression of early and late RNAs and proteins from the human cytomegalovirus immediate early gene region
    • Stenberg, R. M., A. S. Depto, J. Fortney, and J. A. Nelson. 1989. Regulated expression of early and late RNAs and proteins from the human cytomegalovirus immediate early gene region. J. Virol. 63:2699-2708.
    • (1989) J. Virol. , vol.63 , pp. 2699-2708
    • Stenberg, R.M.1    Depto, A.S.2    Fortney, J.3    Nelson, J.A.4
  • 48
    • 0026720227 scopus 로고
    • A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells
    • Sullivan, V., C. L. Talarico, S. C. Stanat, M. Davis, D. M. Coen, and K. K. Biron. 1992. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature 358:162-164.
    • (1992) Nature , vol.358 , pp. 162-164
    • Sullivan, V.1    Talarico, C.L.2    Stanat, S.C.3    Davis, M.4    Coen, D.M.5    Biron, K.K.6
  • 49
    • 0027473447 scopus 로고
    • A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives
    • Sullivan, V., K. K. Biron, C. Talarico, S. C. Stanat, M. Davis, L. M. Pozzi, and D. M. Coen. 1993. A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives. Antimicrob. Agents Chemother. 37:19-25.
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 19-25
    • Sullivan, V.1    Biron, K.K.2    Talarico, C.3    Stanat, S.C.4    Davis, M.5    Pozzi, L.M.6    Coen, D.M.7
  • 50
    • 0025889789 scopus 로고
    • Human cytomegalovirus immediate-early RNA: Temporally regulated expression of nuclear, cytoplasmic, and polysome-associated transcripts during infection
    • Tenney, D. J., and A. M. Colberg-Poley. 1991. Human cytomegalovirus immediate-early RNA: temporally regulated expression of nuclear, cytoplasmic, and polysome-associated transcripts during infection. J. Virol. 65:6724-6734.
    • (1991) J. Virol. , vol.65 , pp. 6724-6734
    • Tenney, D.J.1    Colberg-Poley, A.M.2
  • 51
    • 0025909411 scopus 로고
    • Expression of the human cytomegalovirus UL36-38 immediate early region during permissive infection
    • Tenney, D. J., and A. M. Colberg-Poley. 1991. Expression of the human cytomegalovirus UL36-38 immediate early region during permissive infection. Virology 182:199-210.
    • (1991) Virology , vol.182 , pp. 199-210
    • Tenney, D.J.1    Colberg-Poley, A.M.2
  • 52
    • 0027404188 scopus 로고
    • Mutations in the C terminus of herpes simplex virus type 1 DNA polymerase can affect binding and stimulation by its accessory protein UL42 without affecting basal polymerase activity
    • Tenney, D. J., P. A. Micheletti, J. T. Stevens, R. K. Hamatake, J. T. Matthews, A. R. Sanchez, W. W. Hurlburt, M. Bifano, and M. G. Cordingley. 1993. Mutations in the C terminus of herpes simplex virus type 1 DNA polymerase can affect binding and stimulation by its accessory protein UL42 without affecting basal polymerase activity. J. Virol. 67:543-547.
    • (1993) J. Virol. , vol.67 , pp. 543-547
    • Tenney, D.J.1    Micheletti, P.A.2    Stevens, J.T.3    Hamatake, R.K.4    Matthews, J.T.5    Sanchez, A.R.6    Hurlburt, W.W.7    Bifano, M.8    Cordingley, M.G.9
  • 53
    • 0026001583 scopus 로고
    • Inhibition of herpes simplex virus type 1 DNA polymerase by [1R(1α,2β,3α)]-9-[2,3-Bis(hydroxymethyl) cyclobutyl]guanine
    • Terry, B. J., C. W. Cianci, and M. E. Hagen. 1991. Inhibition of herpes simplex virus type 1 DNA polymerase by [1R(1α,2β,3α)]-9-[2,3-Bis(hydroxymethyl) cyclobutyl]guanine. Mol. Pharmacol. 40:591-596.
    • (1991) Mol. Pharmacol. , vol.40 , pp. 591-596
    • Terry, B.J.1    Cianci, C.W.2    Hagen, M.E.3
  • 55
    • 0343853003 scopus 로고
    • (R)-BHCA, (SQ-34,990): A dihydroxymethylcyclobutyl deoxyadenosine analog active against ganciclovir-resistant HCMV
    • M. P. Landini (ed.), Excerpta medica international congress series. Elsevier Science Publishers, Amsterdam, The Netherlands
    • Yamanaka, G., A. V. Tuomari, M. Cristodoulides, and A. K. Field. 1991. (R)-BHCA, (SQ-34,990): a dihydroxymethylcyclobutyl deoxyadenosine analog active against ganciclovir-resistant HCMV, p. 341-344. In M. P. Landini (ed.), Excerpta medica international congress series, Third International Cytomegalovirus Workshop. Elsevier Science Publishers, Amsterdam, The Netherlands.
    • (1991) Third International Cytomegalovirus Workshop , pp. 341-344
    • Yamanaka, G.1    Tuomari, A.V.2    Cristodoulides, M.3    Field, A.K.4
  • 56
    • 0026059091 scopus 로고
    • Selective activity and cellular pharmacology of (1R-1α,2β,3α)-9-[2,3-bis(hydroxymethyl)cyclobutyl] guanine in herpesvirus infected cells
    • Yamanaka, G., A. V. Tuomari, M. Hagen, B. McGeever-Rubin, B. J. Terry, M. Haffey, G. S. Bisacchi, and A. K. Field. 1991. Selective activity and cellular pharmacology of (1R-1α,2β,3α)-9-[2,3-bis(hydroxymethyl)cyclobutyl] guanine in herpesvirus infected cells. Mol. Pharmacol. 40:446-453.
    • (1991) Mol. Pharmacol. , vol.40 , pp. 446-453
    • Yamanaka, G.1    Tuomari, A.V.2    Hagen, M.3    McGeever-Rubin, B.4    Terry, B.J.5    Haffey, M.6    Bisacchi, G.S.7    Field, A.K.8
  • 57
    • 0343417101 scopus 로고    scopus 로고
    • Unpublished observations
    • Yamanaka, G. Unpublished observations.
    • Yamanaka, G.1
  • 58
    • 0029864703 scopus 로고    scopus 로고
    • Efficacy of BMS-180194 against experimental cytomegalovirus infections in immunocompromised mice
    • Yang, H., R. L. Drain, C. A. Franco, and J. M. Clark. 1996. Efficacy of BMS-180194 against experimental cytomegalovirus infections in immunocompromised mice. Antivir. Res. 29:233-241.
    • (1996) Antivir. Res. , vol.29 , pp. 233-241
    • Yang, H.1    Drain, R.L.2    Franco, C.A.3    Clark, J.M.4


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