Toward a transition state analog inhibitor of N-acetylglucosaminyl transferase V

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 21, 1997, Pages 2809-2812

  Kaneko, Mitsuaki ^a   Kanie, Osamu ^a   Kajimoto, Tetsuya ^a   Wong, Chi Huey ^a,b  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; GLYCOPROTEIN; N ACETYLGLUCOSAMINYLTRANSFERASE; TRISACCHARIDE;

ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITOR COMPLEX; ENZYME MECHANISM; ENZYME SPECIFICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

EID: 0030733621     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10087-7     Document Type: Article

References (11)

1. (a) Arango, J.; Pierce M. J. Cell. Biochem. 1988, 37, 225.
2. (b) Yamashita, K.; Tachibana, Y.; Ohkura, T.; Kobata, A. J. Biol. Chem. 1985, 260, 3963.
3. Dennis, J. W.; Laferte, S.; Waghorne, C.; Breitman, M. C; Kerbel, R. S. Science 1987, 236, 580.
4. (a) Palcic, M. M.; Rapka, J.; Kaur, K. J.; Shoreibah, M.; Hindsgaul O.; Pierce, M. J. Biol. Chem., 1990, 265, 6759.
5. (b) Khan, S. H.; Crawley, S. C.; Kanie, O.; Hindsgaul O. J. Biol. Chem. 1993, 268, 2468.
6. Takaoka, Y.; Kajimoto, T.; Wong C.-H. J. Org. Chem. 1993, 58, 4809.
7. Wang, R.; Steensma, D. H.; Takaoka, Y.; Yun, J. W.; Kajimoto, T.; Wong, C.-H. Bioorg. Med. Chem. 1997, 5, 661.
8. Qiao, L.; Murray. B W.; Shimazaki, M.; Schultz, J.; Wong, C.-H. J. Am. Chem. Soc. 1996, 118, 7653.
9. Sondheimer, S. J,; Eby, R.; Schuerch, C. Carbohydr. Res. 1978, 60, 187.
10. 3), 2.86-2.98 (m, 3H, H-6′ and H-7), 2.56 (m, 1H, H-2′), 2.42 (m, 1H, H-6′), 1.68 (s, 3H, NHAc), and 1.32-1.63 (m, 6H, H-3′, H-4′, and H-5′).
11. Ohtani, I.; Kusumi, T.; Kashman, Y.; Kakisawa, H. J. Am. Chem. Soc. 1991, 113, 4092.