Novel derivatives of speudomonic acid

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 21, 1997, Pages 2805-2808

  Carcanague, Daniel R ^a  

^a CUBIST PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; PSEUDOMONIC ACID; PSEUDOMONIC ACID DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030733620     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10088-9     Document Type: Article

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23. +): 660.2149, found: 660.2132.
24. The amine 2 was generated and used immediately; however, no decomposition was observed after several weeks at room temperature in chloroform solution.
25. The compound mixtures were subjected to NMR, HPLC and mass spectroscopic analyses to determine their compositions. Most of the desired components were shown to be present in addition to smaller numbers of unidentified materials.
26. Samples were assayed for inhibition of E. Coli isoleucyl tRNA synthetase as described in ref 6. Bacterial growth inhibition assays were performed using standard broth dilution techniques.