Presence of Epstein-Barr virus latency type III at the single cell level in post-transplantation lymphoproliferative disorders and AIDS related lymphomas

Journal of Clinical Pathology

Volumn 50, Issue 11, 1997, Pages 911-918

  Brink, Antoinette A T P ^a   Dukers, Danny F ^a   Van Den Brule, Adriaan J C ^a   Oudejans, Joost J ^a   Middeldorp, Jaap M ^b   Meijer, Chris J L M ^a   Jiwa, Mehdi ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Organon Teknika   (Netherlands)

Author keywords

AIDS; Epstein Barr virus; Immunocompromised host; Immunohistochemistry; Lymphoma

Indexed keywords

CELL NUCLEUS ANTIGEN; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; VIRUS ANTIGEN; VIRUS PROTEIN; VIRUS RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EPSTEIN BARR VIRUS; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFECTIOUS MONONUCLEOSIS; KIDNEY TRANSPLANTATION; LYMPHOMA; LYMPHOPROLIFERATIVE DISEASE; PRIORITY JOURNAL; TUMOR CELL LINE; VIRUS GENE; VIRUS LATENCY;

EID: 0030733535     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.50.11.911     Document Type: Article

References (29)

1. Henle G, Henle W. The virus as the etiologic agent of infectious mononucleosis. In: Epstein MA, Achong BG, eds. Epstein-Barr virus. Berlin: Springer-Verlag, 1979:297-320.
2. de-The G. Role of Epstein-Barr virus in human diseuses: Infectious mononucleosis, Burkitt's lymphoma and nasopharyngeal carcinoma. In: Klein G, ed. Viral oncology. New York: Raven Press, 1980:769-97.
3. Liebowitz D, Kieff E. Epstein-Barr virus. In: Roizman B, Whitley RJ, Lopez C, eds. The human herpesviruses. New York: Raven Press, 1993:107-30.
4. Jones JF, Shurin S, Abramowsky C, Tubbs RR, Sciotto CG, Wahl R, et al. T-cell lymphomas containing Epstein-Barr viral DNA m patients with chronic Epstein-Barr virus infections. N Engl J Med 1988;318:733-41.
5. De Bruin PC, Jiwa M, Oudejans JJ, Van der Valk P, Van Heerde P, Sabourin JC, et al. Presence of Epstein-Barr virus in extranodal T-cell lymphomas: differences in relation to site. Blood 1994;83:1612-18.
6. Kanavaros P, Briere J, Leses MC, Gaulard P. Epstein-Barr virus in non-Hodgkin's lymphomas of the upper respiratory tract: association with sinonasal localization and expression of NK and/or T-cell antigen by tumour cells. J Pathol 1996;178:297-302.
7. Purtilo DT, Sakamoto K, Saemundsen AK. Documentation of Epstein-Barr virus infection in immunodeficient patients with life threatening lymphoproliferative disease by clinical, virological and immunopathological studies. Cancer Res 1981;41:4226.
8. Rowe M, Lear AL, Croom-Carter D, Davies AH, Rickinson AB. Three pathways of Epstein-Barr virus gene activation from EBNA1-positive latency in B lymphocytes. J Virol 1992;66:122-31.
9. Rowe M, Rowe DT, Gregory CD, Young LS, Farrell PJ, Rupani H, et al. Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells. EMBO J 1987;6: 2743-51.
10. Deacon EM, Pallesen G, Nieboditek G, Crocker J, Brooks L, Rickinson AB, et al. Epstein-Barr virus and Hodgkin's disease: transcriptional analysis of virus latency in the malignant cells. J Exp Med 1993;177:339-49.
11. Chen C, Sadler RH, Walling DM, Su IH, Hsieh H, Raab Traub N. Epstein-Barr virus (EBV) gene expression in EBV-positive peripheral T-cell lymphomas. J Virol 1993;67: 6303-8.
12. Speck SH, Strominger JL. Transcription of Epstein-Barr virus in latently infected growth transfromed lymphocytes. Adv Virol Oncol 1989;8:133-50.
13. Gratama JW, Zutter MM, Minarovits J, Oosterveer MA, Thomas ED, Klein G, et al. Expression of Epstein-Barr virus-encoded growth-transformation-associated proteins in lymphoproliferations of bone-marrow transplant recipients. Int J Cancer 1941;47:188-92.
14. Oudejans JJ, Van den Brule AJC, Jiwa NM, de Bruin PC, Ossenkoppele GJ, van der Valk P, et al. BHRF1, the Epstein-Barr virus (EBV) homologue of the bcl-2 (proto)-oncogene, is transcribed in EBV associated B-cell lymphomas and in reactive lymphocytes. Blood 1995;86:1893-902.
15. Rea D, Delecluse HJ, Hamilton-Dutoit SJ, Marelle L, Joab I, Edelman L, et al. Epstein-Barr virus latent and replicative gene expression in post-transplant lymphoproliferative disorders and AIDS-related non-Hodgkin's lymphomas. French Study Group of Pathology for HIV-associated Tumors. Ann Oncol 1994;5(suppl 1):S113-16.
16. Rea D, Fourcade C, Leblond V, Rowe M, Joab I, Edelman L, et al. Patterns of Epstein-Barr virus latent and replicative gene expression in Epstein-Barr virus B cell lymphoproliferative disorders after organ transplantation. Transplant Proc 1994;58:317-24.
17. Oudejans JJ, Jiwa M, van den Brule AJC, Grasser FA, Horstman A, Vos W, et al. Detection of heterogeneous Epstein-Barr virus gene expression patterns within individual post-transplantation lymphoproliferative disorders. Am J Pathol 1995;147:923-33.
18. Hamilton-Dutoit SJ, Rea D, Raphael M, Sandvej K, Delecluse HJ, Gisselbrecht C, et al. Epstein-Barr virus-latent gene expression and tumor cell phenotype in acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma. Correlation of lymphoma phenotype with three distinct patterns of viral latency. Am J Pathol 1993;143: 1072-85.
19. Carbone A, Dolcetti R, Gloghini A, Maestro R, Vaccher E, di Luca D, et al. Immunophenotypic and molecular analyses of acquired immune deficiency syndrome-related and Epstein-Barr virus associated lymphomas. Hum Pathol 1996;27:133-46.
20. Pallesen G, Hamilton-Dutoit SJ, Rowe M, Lisse I, Ralfkiaer E, Sandvej K, et al. Expression of Epstein-Barr virus replicative proteins in AIDS-related non-Hodgkin's lymphoma cells. J Pathol 1991;165:289-99.
21. Alfieri C, Birkenbach M, Kieff E. Early events in Epstein-Barr virus infection of human B lymphocytes. Virology 1991;181:595-608.
22. Kerr BM, Lear AL, Rowe M. Three transcriptionally distinct forms of Epstein-Barr virus latency in somatic cell hybrids: cell phenotype dependence of promoter usage. Virology 1992;187:189-201.
23. Chetty R, Biddolph SC, Kaklamanis L, Cary N, Stewart S, Giatromanolaki A, et al. EBV latent membrane protein (LMP-1) and bcl-2 protein expression in Reed-Sternberg-like cells in post-transplant lymphoproliferative disorders. Histopathology 1996;28:257-60.
24. Chetty R, Biddolph FRCPAS, Kaklamanis L, Kremmer E, Cary N, Stewart S, et al. Immunohistochemical demonstration of Epstein-Barr virus nuclear antigens 1 and 2 in post-transplant lymphoproliferative disorders. Appl Immunohistochem 1996;4:102-5.
25. Kremmer E, Kranz BR, Hille A, Klein K, Eulitz M, Hoffmann-Fezer G, et al. Rat monoclonal antibodies differentiating between the Epstein-Barr virus nuclear antigens 2A (EBNA2A) and 2B (EBNA2B). Virology 1995; 208:336-42.
26. Jiwa NM, Kanavaros P, De Bruin PC, van der Valk P, Horstman A, Vos W, et al. Presence of Epstein-Barr virus harbouring small and intermediate-sized cells in Hodgkin's disease. Is there a relationship with Reed-Sternberg cells? J Pathol 1993;170:129-36.
27. Sample J, Young L, Martin B, Chatman T, Rickinson A, Kieff E. Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B and EBNA-3C genes. J Virol 1990; 64:4084-92.
28. Grasser FA, Murray PG, Kremmer E, Klein K, Remberger K, Feiden W, et al. Monoclonal antibodies directed against the Epstein-Barr virus-encoded nuclear antigen 1 (EBNA1): immunohistologic detection of EBNA1 in the malignant cells of Hodgkin's disease. Blood 1994;84:3792-8.
29. Jiwa NM, Oudejans JJ, Dukers DF, Vos W, Horstman A, van der Valk P, et al. Immunohistochemical demonstration of different latent membrane protein-1 epitopes of Epstein-Barr virus in lymphoproliferative diseases. J Clin Pathol 1995;48:438-42.