Managing vaginal trichomoniasis resistant to high-dose metronidazole therapy

International Journal of STD and AIDS

Volumn 8, Issue 12, 1997, Pages 780-784

  Lewis, D A ^a,c   Habgood, L ^b   White, R ^a   Barker, K F ^a   Murphy, S M ^a  

^a CENTRAL MIDDLESEX HOSPITAL   (United Kingdom)

^b ST MARY S HOSPITAL   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Metronidazole resistance; Trichomoniasis

Indexed keywords

CLOTRIMAZOLE; METRONIDAZOLE; NONOXINOL 9; TINIDAZOLE;

ADULT; ARTICLE; CASE REPORT; DISEASE TRANSMISSION; HUMAN; INTRAVAGINAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SEXUAL INTERCOURSE; TRICHOMONAS VAGINALIS; TRICHOMONIASIS; VAGINA DISCHARGE; VAGINA PESSARY; VAGINITIS;

ADULT; ANIMALS; ANTITRICHOMONAL AGENTS; DRUG RESISTANCE; FEMALE; FOLLOW-UP STUDIES; HUMANS; METRONIDAZOLE; MIDDLE AGED; NONOXYNOL; TINIDAZOLE; TRICHOMONAS VAGINALIS; TRICHOMONAS VAGINITIS;

EID: 0030733268     PISSN: 09564624     EISSN: None     Source Type: Journal    
DOI: 10.1258/0956462971919110     Document Type: Article

References (29)

1. Donne A. Animacules observes dans les matières purulentes et le produit des secretions des organes génitaux de l'homme et de la femme. C R Acad Sci (Paris) 1836;3:385-6
2. Hesseltine HC, Wolters SL, Campbell A. Experimental human vaginal trichomoniasis. J Infect Dis 1942;71:127-30
3. Cosar C, Julou, L. Activite de l'9 hydroxy-2-ethyl-1-methyl-2-nitro-5-imidazole (8823 R.P.) vis-à-vis des infections expérimentales àTrichomonas vaginalis. Ann Inst Pasteur 1959;96:238-41
4. Durel P, Roiron V, Siboulet A, Borel LJ. Systemic treatment of human trichomoniasis with a derivative of nitro-imidazole 8823 R.P. Br J Vener Dis 1960;36:21-6
5. Robinson SC. Trichomonal vaginitis resistant to metronidazole. Can Med Assoc J 1962;86:665
6. Waitkins SA, Thomas DJ. Isolation of Trichomonas vaginalis resistant to metronidazole. Lancet 1981;ii:590
7. Hamed KA, Studemeister MD. Successful response of metronidazole resistant trichomonal vaginitis to tinidazole. Sex Transm Dis 1992;19:339-40
8. Meingassner JG, Thurner J. Strain of Trichomonas vaginalis resistant to metronidazole and other 5-nitroimidazoles. Antimicrob Agents Chemother 1979;15:254-7
9. Heyworth R, Simpson D, McNeillage GJC, Robertson DHH, Young H. Isolation of T. vaginalis resistant to metronidazole. Lancet 1980;ii:476-8
10. Robertson DHH, Heyworth R, Harrison C, Lumsden WHR. Treatment failure in Trichomonas vaginalis infections in females. 1. Concentrations of metronidazole in plasma and vaginal content during normal and high dosage. J Antimicrob Chemother 1988;21:373-8
11. Ralph ED, Clarke DA. Inactivation of metronidazole by anaerobic and aerobic bacteria. Antimicrob Agents Chemother 1978;14:377-83
12. Sprott MS, Kearns AM, Pattman RS. Trichomonal vaginitis refractory to treatment: case report. Genitourin Med 1988;64: 369-72
13. Willmott F, Say J, Downey D, Hookham A. Zinc and recalcitrant trichomoniasis. Lancet 1983;i:1053
14. Kreiger JN, Rein MF. Zinc sensitivity of Trichomonas vaginalis: in vitro studies and clinical implications. J infect Dis 1982;146:341-5
15. Ahmed-Jushuf IH, Murray AE, McKeown J. Managing trichomonal vaginitis refractory to conventional treatment with metronidazole. Genitourin Med 1988;64:25-9
16. Lossick JG, Muller M, Gorrell TE. In vitro drug susceptibility and doses of metronidazole required for cure in cases of refractory vaginal trichomoniasis. J Infect Dis 1986;153: 948-55
17. Kulda J, Tachezy J, Cerkasovova A, Cerkasov J. Trichomonas vaginalis: anaerobic resistance to metronidazole induced in vitro. International Symposium on Trichomonads and Trichomoniasis, Prague, 1985, p. 100
18. Kulda J, Kabickova H, Tachezy J, Cerkasovova A, Cerkasov J. Metronidazole resistant trichomonads: mechanisms of in vitro developed anaerobic resistance. In: Lloyd D, Coombs GH, Paget T, eds. Biochemistry and Molecular Biology of Anaerobic Protozoa. Chur: Harwood Academic Publishers, 1989:137-60
19. Quon DVK, D'Oliveira CE, Johnson PJ. Reduced transcription of the ferredoxin gene in metronidazole-resistant Trichomonas vaginalis. Proc Natl Acad Sci USA 1992;89: 4402-6
20. Schnell JD. The incidence of vaginal Candida and trichomonas infections and treatment of trichomonas vaginitis with clotrimazole. Postgrad Med J 1974;50:S79
21. Livengood III CH, Lossick JG. Resolution of resistant vaginal trichomoniasis associated with the use of intra-vaginal nonoxynol-9. Obstet Gynecol 1991;78:954-6
22. Nyirjesy P, Weitz MV, Gelone SP, et al. Paromomycin for nitroimidazole-resistant trichomoniasis. Lancet 1995;346: 1110
23. Martindale. The Extra Pharmacopoeia (25th edn). London: The Pharmaceutical Press, 1967:573
24. Watson PG, Pattman RS. Arsenical pessaries in the successful elimination of metronidazole-resistant T. vaginalis. Int J STD AIDS 1996;7:296-7
25. Forgan R. History of the treatment of trichomoniasis. Br J Vener Dis 1972;48:522-5
26. Bowen DAL, Lewis TLT, Edwards WR. Acute arsenical poisoning due to acetarsol suppositories. BMJ 1961;i:1282
27. Seligman SA. Trichomonal vaginitis refractory to conventional treatment. Genitourin Med 1989;65:200-1
28. Pattman RS, Sprott MS, Kearns AM. Trichomonal vaginitis refractory to conventional treatment. Genitourin Med 1989;65:349
29. Alderete JF. Does lactobacillus vaccine for trichomoniasis, Solco Trichovac, induce antibody reactive with Trichomonas vaginalis. Genitourin Med 1988;64:118-23