The role of adrenal hormones in the activation of tryptophan 2,3- dioxygenase by nicotinic acid in rat liver

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 19, Issue 7, 1997, Pages 465-470

  Sainio, Eeva Liisa ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b National Consumer Administration   (Finland)

Author keywords

Minipumps; Nicotinic acid; Reconstitution; Supplementation; Tryptophan; Tryptophan 2,3 dioxygenase

Indexed keywords

ADRENALIN; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CORTICOSTERONE; NICOTINIC ACID; PHENOXYBENZAMINE; PROPRANOLOL; SODIUM CHLORIDE; TRYPTOPHAN 2,3 DIOXYGENASE;

ADRENALECTOMY; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HORMONE ACTION; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER METABOLISM; MALE; NONHUMAN; RAT; TRYPTOPHAN METABOLISM;

ADRENALECTOMY; ANIMALS; CORTICOSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EPINEPHRINE; INFUSION PUMPS, IMPLANTABLE; LIVER; NIACIN; RATS; TRYPTOPHAN; TRYPTOPHAN OXYGENASE;

EID: 0030733131     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Sainio, E.-L., Sainio. P. Comparison of effects of nicotinic acid or tryptophan on tryptophan 2,3-dioxygenase in acute and chronic studies. Toxicol Appl Pharmacol 1990, 102: 251-8.
2. Knox, W.E., Mehler, A.H. The conversion of tryptophan to kynurenine in liver I. J Biol Chem 1950, 187: 419-30.
3. Badawy, A.A.-B. The functions and regulation of tryptophan pyrrolase. Life Sci 1977, 21: 755-67.
4. Feigelson, P., Greengard, O.J. A microsomal iron-porphyrin peroxidase in the rat. J Biol Chem 1961, 236: 153-7.
5. Knox, W.E., Auerbach. V.H. The hormonal control of tryptophan peroxidase in the rat. J Biol Chem 1955, 214: 307-13.
6. 2+-heme. Prostaglandins Med 1980, 5: 357-64.
7. Salter, M., Pogson, C.J. The role of tryptophan 2,3-dioxygenase in the hormonal control of tryptophan metabolism in isolated rat liver cells. Biochem J 1985, 229: 499-504.
8. Stowell, L., Morland, J. Ethanol-induced increase in liver tryptophan oxygenase activity in the starved rat: Evidence against tryptophan mediation. Biochem Pharmacol 1984, 33: 2397-405.
9. Badawy, A. A.-B., Morgan, C.J., Davis, N.R. Effects of the haem 5-aminolaevulinate on tryptophan metabolism and disposition in the rat. Biochem J 1987, 248: 293-5.
10. Young, S.N., Teff, K.L. Tryptophan availability, 5-HT synthesis and 5-HT function. Prog Neuropsychopharmacol Biol Psychiatry 1989, 13: 373-9.