Induction of messenger RNA for the 70 kDa heat shock protein in HeLa cells and the human endocervix following exposure to semen: Implications for antisperm antibody production and susceptibility to sexually transmitted infections

Human Reproduction

Volumn 12, Issue 9, 1997, Pages 1915-1919

  Jeremias, J ^a   David, S S ^b   Toth, M ^a   Witkin, S S ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

70 kDa heat shock protein; Endocervix; HeLa cells; Human semen; Sexual intercourse

Indexed keywords

HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN A ANTIBODY; MESSENGER RNA; SPERM ANTIBODY;

ADULT; ANTIBODY PRODUCTION; ARTICLE; COCULTURE; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENE INDUCTION; HELA CELL; HUMAN; MALE; NORMAL HUMAN; SEMINAL PLASMA; SEXUALLY TRANSMITTED DISEASE; SPERM; SPERMATOZOON; UTERINE ENDOCERVIX;

EID: 0030732963     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/12.9.1915     Document Type: Article

References (17)

1. Bendich, A. Borenfreund, E. and Sternberg, S.S. (1974) Penetration of somatic mammalian cells by sperm. Science, 183, 857-859.
2. Burel, C., Mezger, V., Pinto, M. et al. (1992) Mammalian heat shock protein families. Expression and functions. Experientia, 48, 629-634.
3. Cahill, M.C., Waterman, W.R., Xie, Y. et al. (1996) Transcriptional repression of the prointerleukin Iβ gene by heat shock factor 1. J. Biol. Chem., 271, 24874-24879.
4. Hall, T.J. (1994) Role of HSP70 in cytokine production. Experientia, 50, 1048-1053.
5. Hang, H. and Fox, M.H. (1994) Low pH suppresses synthesis of heat-shock proteins and thermotolerance, Radiation Res., 140, 24-30.
6. Hurtenbach, U. and Shearer, G.M. (1982) Germ cell induced immune suppression in mice. Effect of inoculation of syngeneic spermatozoa on cell-mediated immune responses. J. Exp. Med., 155, 827-838.
7. James, K. and Hargreave, T.B. (1984) Immunosuppression by seminal plasma and its possible clinical significance. Immunol. Today 5, 357-363.
8. Kantengwa, S., Donati, Y.R.A., Clergot, M. et al. (1991) Heat shock proteins: an autoprotective mechanism for inflammatory cells? Semin. Immunol., 3, 49-56.
9. Miller, D., Brough, S. and Al-Harbi, O. (1992) Characterization and cellular distribution of human spermatozoal heat shock proteins. Hum. Reprod., 7, 637-645.
10. Richards, J.M., Bedford, J.M. and Witkin, S.S. (1984) Rectal insemination modifies immune responses in rabbits. Science, 224, 390-392.
11. Santoro, M.G. (1994) Heat shock proteins and virus replication: HSP70s as mediators of the antiviral effects of prostaglandins. Experientia, 50, 1039-1047.
12. Schmidt, J.A. and Abdulla, E. (1988) Down-regulation of IL-1β biosynthesis by inducers of the heat-shock response. J. Immunol., 141, 2027-2034.
13. Snyder, Y.M., Guthrie, L., Evans, G.F. and Zuckerman, S.H. (1992) Transcriptional inhibition of endotoxin-induced monokine synthesis following heat shock in murine peritoneal macrophages. J. Leukocyte Biol., 51, 181-187.
14. Stanley, S.K., Bressler, P.B., Poli, G. and Fauci, AS. (1990) Heat shock induction of HIV production from chronically infected promonocytic and T cell lines. J. Immunol., 145, 11260-11266.
15. Witkin, S.S. (1988a) Mechanisms of active suppression of the immune response to spermatozoa. Am. J. Reprod. Immunol. Microbiol., 17, 61-64.
16. Witkin, S.S. (1988b) Production of Interferon gamma by lymphocytes exposed to antibody-coated spermatozoa: a mechanism for sperm antibody production in females. Fertil, Steril., 50, 498-502.
17. Witkin, S.S. (1989) Failure of sperm-induced immunosuppression: Association with antisperm antibodies in women. Am. J, Obstet. Gynecol., 160, 1166-1168.