Synthesis of a key intermediate, (S)-2-[(3-hydroxypropyl)sulfinyl]-1-(o-tolyl)imidazole, for the platelet aggregation inhibitor, OPC-29030 via lipase-catalyzed enantioselective transesterification

Tetrahedron Asymmetry

Volumn 8, Issue 22, 1997, Pages 3707-3710

  Morita, Seiji ^a   Matsubara, Jun ^a   Otsubo, Kenji ^a   Kitano, Kazuyoshi ^a   Ohtani, Tadaaki ^a   Kawano, Yoshikazu ^a   Uchida, Minoru ^a  

^a OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDRO 6 [3 [1 (2 METHYLPHENYL) 2 IMIDAZOLYLSULFINYL]PROPOXY] 2(1H) QUINOLINONE; ANTITHROMBOCYTIC AGENT; IMIDAZOLE DERIVATIVE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DRUG PURIFICATION; DRUG SYNTHESIS; ENANTIOMER; ENZYME ACTIVITY; IN VITRO STUDY; PRIORITY JOURNAL; REACTION ANALYSIS;

EID: 0030732346     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(97)00536-3     Document Type: Article

References (7)

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4. Nishi, T.; Uno, T.; Shu, Y.; Tamura, K.; Okada, M. Japan Patent 1995, 7-33765 [Chem. Abstr. 1995, 122, 16064Oz].
5. Nishi, T.; Uno, T.; Shu, Y.; Tamura, K.; Okada, M. Japan Patent 1995, 7-33765 [Chem. Abstr. 1995, 122, 16064Oz].
6. Burgess, K.; Henderson, I. Tetrahedron Lett. 1989, 30, 3633.
7. Tamai, S.; Miyauchi, S.; Morizane, C.; Miyagi, K.; Shirnizu, H.; Kume, M.; Sano, S.; Shiro, M.; Nagao, Y. Chem. Lett. 1994, 2381.