Diagnosis of a case of acute chloroquine poisoning using 1H NMR spectroscopy: Characterisation of drug metabolites in urine

NMR in Biomedicine

Volumn 10, Issue 6, 1997, Pages 277-284

  Maschke, Susanna ^a   Azaroual, Nathalie ^b   Wieruszeski, Jean Michel ^c   Lippens, Guy ^c   Imbenotte, Michel ^a   Mathieu, Daniel ^a   Vermeersch, Gaston ^b   Lhermitte, Michel ^a  

^a UNIV LILLE   (France)

^b CNRS   (France)

^c INSTITUT PASTEUR DE LILLE   (France)

Author keywords

1H NMR; Chloraquine; Poisoning; Urine

Indexed keywords

ALCOHOL; CHLOROQUINE; DRUG METABOLITE;

ADULT; ARTICLE; CASE REPORT; DRUG INTOXICATION; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SUICIDE ATTEMPT; URINALYSIS;

EID: 0030732213     PISSN: 09523480     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1492(199709)10:6<277::AID-NBM479>3.0.CO;2-M     Document Type: Article

References (26)

1. White, N. J., Miller, K. D., Churchill, F. C., Berry, C., Brown, J., Williams, S. B. and Greenwood, B. M. Chloroquine treatment of severe malaria in children. Pharmacokinetics, toxicity and new dosage recommendations. N. Engl. J. Med. 319, 1493-1500 (1988).
2. Fackenzie, A. H. and Scharbel, A. L. Chloroquine and HO-chloroquine in rheumatical therapy. In Huskinson Antirheumatic drugs, pp. 623-645. Praeger Publ, New York (1983).
3. Kelly, J. C., Wassermann, G. S., Bernard, W. D., Schultz, C. and Knapp, J. Chloroquine poisoning in a child. Ann. Emerg. Med. 19, 47-50 (1990).
4. Kintz, P., Ritter-Lohaner, S., Lamant, J. M., Tracqui, A., Mangin, P., Lugnier, A. A. and Chaumont, A. J. Fatal chloroquine selfpoisoing. Hum. Toxicol. 7, 541-543 (1988).
5. Lelijveld, J. and Kortmann, H. The eosin colour test of Dill and Glazko: a simple field test to detect chloroquine in urine. Bull. WHO 42, 477-479 (1970).
6. Haskins, W. T. A simple qualitative test for chloroquine in urine. Am. J. Trop. Med. Hyg. 7, 199-200 (1958).
7. Tapanes, R. D., Ramos, F. and Perez Avila, J. Contribution to the determination of chloroquine in biological fluids. J. Chromatogr. 493, 196-210 (1989).
8. Mount, D. L., Patchen, L. C., Williams, S. B. and Churchill, F. C. Colorimetric and thin-layer chromatographic methods for field assay of chloroquine and its metabolites in urine. Bull. WHO 65, 615-623 (1987).
9. Patchen, L. C., Mount, D. L., Schwartz, I. K. and Churchill, F. C. Analysis of filter-paper-absorbed, finger stick blood samples for chloroquine and its major metabolite using high-performance liquid chromatography with fluorescence detection. J. Chromatogr. 278, 81-89 (1983).
10. Escande, C., Chevalier, P., Verdier, F. and Bourdon, R. Sensitive radioimmunoassay and enzyme-linked immunosorbent assay for the simultaneous determination of chloroquine and its metabolites in biological fluids. J. Pharm. Sci. 79, 23-27 (1990).
11. 13C NMR spectroscopy of human blood plasma. Anal. Chem. 67, 793-811 (1995).
12. Foxall, P. J. D., Parkinson, J. A., Sadler, I. H., Lindon, J. C. and Nicholson, J. K. Analysis of biological fluids using 600 MHz proton NMR spectroscopy: application of homonuclear two-dimensional J-resolved spectroscopy to urine and plasma for spectral simplification and assignment. J. Pharm. Biomed. Anal. 11, 21-31 (1993).
13. 1H NMR spectroscopy for assignment of endogenous metabolite resonances in biofluids. J. Pharm. Biomed. Anal. 12, 613-618 (1994).
14. Holmes, E., Foxall, P. J. D. and Nicholson, J. K. Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and the recovery from nephrotoxic lesions in the rat induced by mercury(II)chloride and 2-bromoethanamine. Mol. Pharmacol. 42, 922-933 (1992).
15. Anthony, M. L., Sweatman, B. C., Beddell, C. R., Lindon, J. C. and Nicholson, J. K. Pattern recognition classification of the site of nephrotoxicity based on metabolic data derived from proton nuclear magnetic resonance spectra of urine. Mol. Pharmacol. 46, 199-211 (1994).
16. 1H NMR spectroscopy of biofluids and the investigation of xenobiotic-induced changes in liver biochemistry. J. Pharm. Biomed. Anal. 8, 945-949 (1990).
17. 1H NMR spectroscopy: a new method for studying penicillin metabolism. J. Chem. Soc. 9, 894-895 (1984).
18. Maschke, S., Azaroual, N., Imbenotte, M., Vermeersch, G., Leclerc, F. and Lhermitte, M. Salicylate poisoning: two-dimensional J-resolved NMR urinalysis. NMR Biomed. 8, 19-24 (1995).
19. Bales, J. R., Bell, J. D., Nicholson, J. K., Sadler, P. J., Timbrell, J. A., Hughes, R. D., Bennett, P. N. and Williams, R. Metabolic profiling of body fluids by proton NMR spectroscopy: self-poisoning episodes with paracetamol (acetaminophen). Magn. Reson. Med. 6, 301-309 (1988).
20. Bales, J. R., Higham, D. P., Howe, I., Nicholson, J. K. and Sadler, P. J. Use of high-resolution proton nuclear magnetic resonance spectroscopy for rapid multi-component analysts of urine. Clin. Chem. 30, 426-432 (1984).
21. Iles, R. A., Hind, A. J. and Chalmers, R. A. Use of proton nuclear magnetic resonance spectroscopy in detection and study of organic acidurias. Clin. Chem. 31, 1795-1801 (1985).
22. Le Moyec, L., Pruna, A., Eugene, M., Bedrossian, J., Idatte, J. M., Huneau, J. F. and Tom, D. Proton nuclear magnetic resonance spectroscopy of urine and plasma in renal transplantation followup. Nephron 65, 433-439 (1993).
23. Bell, J. D., Brown, J. and Sadler, P. J. One and two-dimensional proton NMR spectroscopy studies of body fluids: practical methods for water suppression. Biochem. Soc. Trans. 14, 1263-4 (1986).
24. Koppel, C., Tenczer, J. and Ibe, K. Urinary metabolism of chloroquine. Drug Res. 37, 208-211 (1987).
25. Titus, E. O. Recent developments in the understanding of the pharmacokinetics and mechanism of action of chloroquine. Ther. Drug Monit. 11, 369-379 (1989).
26. Houzé, P. and Reinies, A. Simultaneous determination of chloroquine and its three metabolites in human plasma, whole blood and urine by ion-pair high-performance liquid chromatography. J. Chromatogr. 574, 305-312 (1992).