(R,S)-α-methyl-4-carboxyphenylglycine (MCPG) fails to block long-term potentiation under urethane anaesthesia in vivo

Neuropharmacology

Volumn 36, Issue 10, 1997, Pages 1339-1354

  Martin, S J ^a   Morris, R G M ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Depotentiation; Hippocampus; Long term potentiation (LTP); MCPG; Metabotropic glutamate receptors

Indexed keywords

ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; URETHAN;

ANIMAL EXPERIMENT; ARTICLE; DENTATE GYRUS; GRANULE CELL; LONG TERM POTENTIATION; MALE; MEMORY; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALYSIS OF VARIANCE; ANESTHESIA; ANESTHETICS, INTRAVENOUS; ANIMALS; BENZOATES; BODY TEMPERATURE; BRAIN; CYCLOLEUCINE; DRUG SYNERGISM; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; HIPPOCAMPUS; MALE; NEUROPROTECTIVE AGENTS; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; TETANUS; TIME FACTORS; URETHANE;

EID: 0030732020     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(97)00129-9     Document Type: Article

References (53)

1. Arai A., Kessler M., Xiao P., Ambros-Ingerson J., Rogers G. and Lynch G. 1990b A centrally active drug that modulates AMPA receptor gated currents. Brain Research 638: 343-346.
2. Barrionuevo G., Schottler F. and Lynch G. (1980) The effects of repetitive low frequency stimulation on control and "potentiated" synaptic responses in the hippocampus. Life Sciences 27: 2385-2391.
3. Bashir Z. I., Bortolotto Z. A., Davies C. H., Berretta N., Irving A. J., Seal A. J., Henley J. M., Jane D. E., Watkins J. C. and Collingridge G. L. (1993) The synaptic activation of glutamate metabotropic receptors is necessary for the induction of LTP in the hippocampus. Nature 363: 347-350.
4. Bashir Z. I. and Collingridge G. L. (1994) An investigation of depotentiation of long-term potentiation in the CA1 region of the hippocampus. Experimental Brain Research 100: 437-443.
5. Behnisch T. and Reymann K. G. (1993) Co-activation of metabotropic glutamate and N-methyl-D-aspartate receptors is involved in mechanisms of long-term potentiation maintenance in rat hippocampal CA1 neurons. Neuroscience Letters 192: 185-188.
6. Bliss T. V. P. and Collingridge G. L. (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361: 31-39.
7. Bliss T. V. P. and Lømo T. (1973) Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetised rabbit following stimulation of the perforant path. Journal of Physiology (London) 232: 331-356.
8. Bordi F. and Ugolini A. (1995) Antagonists of the metabotropic glutamate receptor do not prevent induction of long-term potentiation in the dentate gyrus of rats. European Journal of Pharmacology 273: 291-294.
9. Bortolotto Z. A., Bashir Z. I., Davies C. H. and Collingridge G. L. (1994) A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation. Nature 368: 740-743.
10. Bortolotto Z. A., Bashir Z. I., Davies C. H., Taira T., Kaila K. and Collingridge G. L. (1995) Studies on the role of metabotropic glutamate receptors in long-term potentiation: some methodological considerations. Journal of Neuroscience Methods 59: 19-24.
11. Bortolotto Z. A. and Collingridge G. L. (1993) Characterisation of LTP induced by the activation of glutamate metabotropic receptors in area CA1 of the hippocampus. Neuropharmacology 32: 1-9.
12. Bortolotto Z. A. and Collingridge G. L. (1995) On the mechanism of long-term potentiation induced by (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) in rat hippocampal slices. Neuropharmacology 34: 1003-1004.
13. Brabet I., Mary S., Bockaert J. and Pin J. -P. (1995) Phenylglycine derivatives discriminate between mGluR1-and mGluR5-mediated responses. Neuropharmacology 34: 895-903.
14. Brown R. E., Rabe H. and Reymann K. G. (1994) (R,S)-α-Methyl-4-carboxyphenylglycine (MCPG) does not block theta-burst induced long-term potentiation in area CA1 of rat hippocampal slices. Neuroscience Letters 170: 17-21.
15. Chinestra P., Aniksztejn L., Diabira D. and Ben-Ari Y. (1993) (R,S)-α-Methyl-4-carboxyphenylglycine neither prevents induction of LTP nor antagonizes metabotropic glutamate receptors in CA1 hippocampus. Journal of Neurophysiology 70: 2684-2689.
16. Collingridge G. L., Kehl S. J. and McLennan H. (1983) Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. Journal of Physiology (London) 334: 36-46.
17. Davies C. H., Clarke V. R., Jane D. E. and Collingridge G. L. (1995) Pharmacology of postsynaptic metabotropic glutamate receptors in rat hippocampal CA1 pyramidal neurones. British Journal of Pharmacology 116: 1859-1869.
18. Davis S. and Laroche S. (1996) Activation of metabotropic glutamate receptors induce differential effects on synaptic transmission in the dentate gyrus and CA1 of the hippocampus in the anaesthetized rat. Neuropharmacology 35: 337-346.
19. Desai M. A. and Conn P. J. (1991) Excitatory effects of ACPD receptor activation in the hippocampus are mediated by direct effects on pyramidal cells and blockade of synaptic inhibition. Journal of Neurophysiology 66: 40-52.
20. Errington M. L., Bliss T. V. P., Morris R. J., Laroche S. and Davis S. (1997) Long-term potentiation in awake mutant mice. Nature 387: 666-667.
21. Errington M. L., Bliss T. V. P., Richter-Levin G., Yenk K., Doyère V. and Laroche S. (1995) Stimulation at 1-5 Hz does not produce long-term depression or depotentiation in the hippocampus of the adult rat in vivo. Journal of Neurophysiology 74: 1793-1799.
22. Errington M. L., Lynch M. A. and Bliss T. V. P. (1987) Long-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by D-APV. Neuroscience 20: 279-284.
23. Evans R. H. and Smith D. A. S. (1982) Effect of urethane on synaptic and amino acid-induced excitation in isolated spinal cord preparations. Neuropharmacology 21: 857-860.
24. Fotuhi M., Standaert D. G., Testa C. M., Penney J. B. and Young A. B. (1994) Differential expression of metabotropic glutamate receptors in the hippocampus and entorhinal cortex of the rat. Molecular Brain Research 21: 283-292.
25. Fujii S., Saito K., Miyakawa H., Ito K. and Kato K. (1991) Reversal of long-term potentiation (depotentiation) induced by tetanus stimulation of the input to CA1 neurons of guinea pig hippocampal slices. Brain Research 555: 112-122.
26. Harris E. W., Ganong A. H. and Cotman C. W. (1984) Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors. Brain Research 323: 132-137.
27. Hayashi Y., Sekiyama N., Nakanishi S., Jane D. E., Sunter D. C., Birse E. F., Udvarhelyi P. M. and Watkins J. C. (1994) Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. Journal of Neuroscience 14: 3370-3377.
28. Kauer J. A., Malenka R. C. and Nicoll R. A. (1988) NMDA application potentiates synaptic transmission in the hippocampus. Neuron 1: 911-917.
29. Keele N. B., Arvanov V., Holmes K. and Shinnck-Gallagher P. (1995) Agonist action of (R,S)-α-methyl-4-carboxyphenylglycine (MCPG) in the amygdala. Neuroreport 6: 1058-1062.
30. Kemp M., Roberts P., Pook P., Jane D., Jones P., Sunter D., Udvarhelyi P. and Watkins J. (1994) Antagonism of presynaptically mediated depressant responses and cyclic AMP-coupled metabotropic glutamate receptors. European Journal of Pharmacology - Molecular Pharmacology Section 266: 187-192.
31. Larson J., Xiao P. and Lynch G. (1993) Reversal of LTP by theta frequency stimulation. Brain Research 600: 97-102.
32. Littman L. and Robinson M. B. (1994) The effects of L-glutamate and trans-(±)-1-amino-1,3-cyclopentanedicarboxylate on phosphoinositide hydrolysis can be pharmacologically differentiated. Journal of Neurochemistry 63: 1291-1302.
33. Manahan-Vaughan D. and Reymann K. G. (1995) 1S,3R-ACPD dose-dependently induces a slow-onset potentiation in the dentate gyrus in vivo. European Journal of Pharmacology 294: 497-503.
34. Manzoni O. J., Weisskopf M. G. and Nicoll R. A. (1994) MCPG antagonizes metabotropic glutamate receptors but not long-term potentiation in the hippocampus. European Journal of Neuroscience 6: 1050-1054.
35. McGuinness N., Anwyl R. and Rowan M. (1991) Trans-ACPD enhances long-term potentiation in the hippocampus. European Journal of Pharmacology 197: 231-232.
36. Morris R. G. M., Anderson E., Lynch G. S. and Baudry M. (1986) Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319: 774-776.
37. Morris R. G. M., Davis S. and Butcher S. P. (1990) Hippocampal synaptic plasticity and NMDA receptors: a role in information storage?. Philosophical Transactions of the Royal Society London B329: 187-204.
38. Nakanishi S. (1992) Molecular diversity of glutamate receptors and implications for brain function. Science 258: 597-603.
39. Nosten-Bertrand M., Errington M. L., Murphy K. P. S. J., Tokugawa Y., Barboni E., Kozlova E., Michalovich D., Morris R. G. M., Silver J., Stewart C. A., Bliss T. V. P. and Morris R. J. (1996) Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1. Nature 379: 826-829.
40. O'Dell T. and Kandel E. (1994) Low-frequency stimulation erases LTP through an NMDA receptor-mediated activation of protein phosphatases. Learning and Memory 1: 129-139.
41. Otani S. and Ben-Ari Y. (1991) Metabotropic receptor-mediated long-term potentiation in rat hippocampal slices. European Journal of Pharmacology 205: 325-326.
42. Pin J. -P. and Duvoisin R. (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacology 43: 1-26.
43. Richter-Levin G., Errington M. L., Maegawa H. and Bliss T. V. P. (1994) Activation of metabotropic glutamate receptors is necessary for long-term potentiation in the dentate gyrus and for spatial learning. Neuropharmacology 33: 853-857.
44. Riedel G., Casabona G. and Reymann K. G. (1995) Inhibition of long-term potentiation in the dentate gyrus of freely-moving rats by the metabotropic glutamate receptor antagonist MCPG. Journal of Neuroscience 15: 87-98.
45. Riedel G., Seidenbecher T. and Reymann K. G. (1994) LTP in hippocampal CA1 of urethane-narcotized rats requires stronger tetanization parameters. Physiology and Behavior 55: 1141-1146.
46. Riedel G., Wetzel W. and Reymann K. G. (1996) Comparing the role of metabotropic glutamate receptors in learning and memory. Progress in Neuro-psychopharmacology and Biological Psychiatry 20: 761-789.
47. Selig D. K., Lee H. -K., Bear M. F. and Malenka R. C. (1995) Reexamination of the effects of MCPG on hippocampal LTP, LTD, and depotentiation. Journal of Neurophysiology 74: 1075-1082.
48. Shirasaka Y. and Wasterlain C. G. (1995) The effect of urethane on evoked potentials in dentate gyrus. European Journal of Pharmacology 282: 11-17.
49. Stäubli U. and Chun D. (1996) Factors regulating the reversibility of long-term potentiation. Journal of Neuroscience 16: 853-860.
50. Stäubli U. and Lynch G. (1990) Stable depression of potentiated synaptic responses in the hippocampus with 1-5 Hz stimulation. Brain Research 513: 113-118.
51. Thomas M. J. and O'Dell T. J. (1995) The molecular switch hypothesis fails to explain the inconsistent effects of the metabotropic glutamate-receptor antagonist MCPG on long-term potentiation. Brain Research 695: 45-52.
52. Wang Y., Rowan M. J. and Anwyl R. (1995) (R,S)-α-Methyl-4-carboxyphenylglycine inhibits long-term potentiation only following the application of low frequency stimulation in the rat dentate gyrus in vitro. Neuroscience Letters 197: 207-210.
53. Watkins J. C. and Collingridge G. L. (1994) Phenylglycine derivatives as antagonists of metabotropic glutamate receptors. Trends in Pharmacology 15: 333-342.