Region-specific and agent-specific dilation of intracerebral microvessels by volatile anesthetics in rat brain slices

Anesthesiology

Volumn 87, Issue 5, 1997, Pages 1191-1198

  Farber, Neil E ^b   Harkin, Christopher P ^c   Niedfeldt, Jennifer ^c   Hudetz, Antal G ^c   Kampine, John P ^c   Schmeling, William T ^a  

^a CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c NONE

Author keywords

Anesthetics, volatile: halothane; isoflurane; Brain: brain slices; hippocampus; neocortex; Cerebral arterioles: vasodilation; microvessel

Indexed keywords

HALOTHANE; INHALATION ANESTHETIC AGENT; ISOFLURANE; PROSTAGLANDIN F2 ALPHA;

ANIMAL TISSUE; ARTERIOLE; ARTICLE; BLOOD VESSEL DIAMETER; BRAIN BLOOD FLOW; BRAIN MICROCIRCULATION; BRAIN SLICE; BRAIN VASCULAR RESISTANCE; CONTROLLED STUDY; HIPPOCAMPUS; INHALATION ANESTHESIA; INHALATIONAL DRUG ADMINISTRATION; MALE; MICROSCOPY; MINIMUM LUNG ALVEOLUS CONCENTRATION; NEOCORTEX; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION; VIDEORECORDING;

ANESTHETICS, INHALATION; ANIMALS; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; HALOTHANE; HIPPOCAMPUS; ISOFLURANE; MALE; MICROCIRCULATION; RATS; RATS, SPRAGUE-DAWLEY; VASODILATION;

EID: 0030731982     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199711000-00024     Document Type: Article

References (39)

1. 133Xenon for measurement of regional cerebral blood flow (rCBF) during halothane, enflurane, and isoflurane anesthesia in humans. ANESTHESIOLOGY 1985; 63:391-4
2. Drummond JC, Todd MM, Scheller MS, Shapiro HM: A comparison of the direct cerebral vasodilating potencies of halothane and isoflurane in the New Zealand white rabbit. ANESTHESIOLOGY 1986; 65:462-7
3. Todd MM, Drummond JC: A comparison of the cerebrovascular and metabolic effects of halothane and isoflurane in the cat. ANESTHESIOLOGY 1984; 60:276-82
4. Flynn NM, Buljubasic N, Bosnjak ZJ, Kampine JP: Isoflurane produces endothelium-independent relaxation in canine middle cerebral arteries. ANESTHESIOLOGY 1992; 76:461-7
5. Jensen NF, Todd MM, Kramer DJ, Leonard PA, Warner DS: A comparison of the vasodilating effects of halothane and isoflurane on the isolated rabbit basilar artery with and without intact endothelium. ANESTHESIOLOGY 1992; 76:624-34
6. Eskinder H, Hillard CJ, Flynn N, Bosnjak ZJ, Kampine JP: Role of guanylate cyclase-cGMP systems in halothane-induced vasodilation in canine cerebral arteries. ANESTHESIOLOGY 1992; 77:482-7
7. Hansen TD, Warner DS, Todd MM, Vust LJ, Trawick DC: Distribution of cerebral blood flow during halothane versus isoflurane anesthesia in rats. ANESTHESIOLOGY 1988; 69:332-7
8. Hansen TD, Warner DS, Todd MM, Vust LJ, Trawick DC: The role of cerebral metabolism in determining the local cerebral blood flow effects on volatile anesthetics: Evidence for persistent flow-metabolism coupling. J Cereb Flow Metab 1989; 9:323-8
9. Matta BF, Mayberg TS, Lam AM: Direct cerebrovasodilatory effects of halothane, isoflurane, and desflurane during propofol-induced isoelectric electroencephalogram in humans. ANESTHESIOLOGY 1995; 83:980-5
10. Lee JG, Hudetz AG, Smith JJ, Hillard CJ, Bosnjak ZJ, Kampine JP: The effects of halothane and isoflurane on cerebrocortical microcirculation and autoregulation as assessed by laser-Dopper flowmetry. Anesth Analg 1994; 79:58-65
11. Gelman S, Fowler KC, Smith LR: Regional blood flow during isoflurane and halothane anesthesia. Anesth Analg 1984; 63:557-65
12. Reinstrup P, Ryding E, Algotsson L, Messeter K, Asgeirsson B, Uski T: Distribution of cerebral blood flow during anesthesia with isoflurane or halothane in humans. ANESTHESIOLOGY 1995; 82:359-66
13. Faraci FM, Heistad DD, Mayhan WG: Role of large arteries in regulation of blood flow to brain stem in cats. J Physiol 1987; 387:115-23
14. Baumbach GL, Heistad DD: Effects of sympathetic stimulation and changes in arterial pressure on segmental resistance of cerebral vessels in rabbits and cats. Circ Res 1983; 52:527-33
15. Smith JJ, Hudetz AG, Bosnjak ZJ, Kampine JP: The role of nitric oxide in cerebrocortical laser Doppler flow response to halothane in the rat. J Neurosurg Anesth 1995; 7:187-95
16. Sagher O, Zhang X-Q, Szeto W, Thai QA, Jin Y, Kassell NF, Lee KS: Live computerized videomicroscopy of cerebral microvessels in brain slices. J Cereb Blood Flow Metab 1993; 13:676-82
17. Jin Y, Sagher O, Thai QA, Kassell NF, Lee KS: The effects of papaverine on phorbol dibutyrate-induced vasoconstriction in brain slice microvessels. J Neurosurg 1994; 81:575-8
18. Fergus A, Jin Y, Thai Q-A, Kassell NF, Lee KS: Vasodilatory actions of calcitonin gene-related peptide and nitric oxide in parenchymal microvessels of the rat hippocampus. Brain Research 1995; 694:78-84
19. Harkin CP, Hudetz AG, Schmeling WT, Kampine JP, Farber NE: Halothane-induced dilatation of intraparenchymal arterioles in rat brain slices: A comparison to sodium nitroprusside. ANESTHESIOLOGY 1997; 86:885-94
20. Pellegrino LJ, Cushman AJ: A Stereotaxic Atlas of the Rat Brain. New York, Meridith Publishing Co, 1967, pp 42-53
21. Halsey MJ: Potency and properties of inhalational anaesthetics, General Anaesthesia, Part 1. Edited by Nunn JF, Utting JE, Brown BR Jr. London, Butterworths, 1989, pp 7-18
22. Farber NE, Hudetz AG, Schmeling WT, Kampine JP: Direct measurement of cerebral microvessel responsiveness in brain slices. ANESTHESIOLOGY 1995; 83(3):A711
23. + channels in dog cerebral arterial muscle cells. ANESTHESIOLOGY 1995; 82:479-90
24. Dacey RG, Duling BR: A study of rat intracerebral arterioles: methods, morphology and reactivity. Am J Physiol 1982; 243:H598-H606
25. Dacey RG, Bassett JE: Cholinergic vasodilation of intracerebral arterioles in rats. Am J Physiol 1987; 253:H1253-60
26. Harkin CP, Schwabe D, Kampine JP, Schmeling WT, Farber NE: The effects of hyper- and hypocarbia on intraparenchymal arterioles in rat brain slices. NeuroReport 1997; 8:1-5
27. Kuschinsky W: Coupling of blood flow and metabolism in the brain, The Regulation of Cerebral Blood Flow, Edited by Phillis JW. Boca Raton, FL, CRC Press, 1993.
28. Nakai M, ladecola C, Ruggiero DA, Tucker LW, Reis DJ: Electrical stimulation of cerebellar fastigial nucleus increases cerebral cortical blood flow without change in local metabolism: Evidence for an intrinsic system in brain for primary vasodilation. Brain Res 1983; 260:35-49
29. Perouansky M, Baranov D, Salman M, Yaari Y: Effects of halothane on glutamate receptor-mediated excitatory postsynaptic currents. A patch-clamp study in adult mouse hippocampal slices. ANESTHESIOLOGY 1995; 83:109-19
30. Spencer GE, Syed NI, Lukowiak K, Winlow W: Halothane affects both inhibitory and excitatory synaptic transmission at a single identified molluscan synapse, in vivo and in vitro. Brain Res 1996; 714:38-48
31. Mody I, Tanelian DL, Maclver MB: Halothane enhances tonic neuronal inhibition by elevating intracellular calcium. Brain Res 1991; 538:319-23
32. Ludvig N, Mishra PK, Yan Q, Lasley SM, Burger RL, Jobe PC: The paradoxical effect of NMDA receptor stimulation on electrical activity of the sensorimotor cortex in freely behaving rats: Analysis by combined EEG-intracerebral microdialysis. Synapse 1992; 12:87-98
33. Franks NP, Lieb WR: Molecular and cellular mechanisms of general anaesthesia. Nature 1994; 367:607-14
34. Salord F, Keita H, Lacharny J-B, Henzel D, Desmonts J-M, Mantz J: Halothane and isoflurane differentially affect the regulation of dopamine and gamma-aminobutyric acid release mediated by presynaptic acetylcholine receptors in the rat striatum. ANESTHESIOLOGY 1997; 86:632-41
35. Farber NE, Schmidt JE, Kampine JP, Schmeling WT: Halothane modulates thermosensitive hypothalamic neurons in rat brain slices. ANESTHESIOLOGY 1995; 83:1241-53
36. Schmidt JE, Farber NE, Schmeling WT: Halothane and isoflurane differentially effect firing rates of locus coeruleus neurons in rat brain slices. ANESTHESIOLOGY 1996; 85:A689
37. Koenig HM, Pelligrino DA, Albrecht RF: Halothane vasodilation and nitric oxide in rat pial vessels. J Neurosurg Anesth 1993; 5:264-71
38. Koenig HM, Pelligrino DA, Wang Q, Albrecht RF: Role of nitric oxide and endothelium in rat pial vessel dilation response to isoflurane. Anesth Analg 1994; 79:886-91
39. Moore LE, Kirsch JR, Helfaer MA, Tobin JR, McPherson RW, Traystman RJ: Nitric oxide and prostanoids contribute to isoflurane-induced cerebral hyperemia in pigs. ANESTHESIOLOGY 1994; 80:1328-37