Low-dose radiation sensitivity and induced radioresistance to cell killing in HT-29 cells is distinct from the 'adaptive response' and cannot be explained by a subpopulation of sensitive cells

Radiation Research

Volumn 148, Issue 5, 1997, Pages 435-442

  Wouters, Bradly G ^a,b   Skarsgard, Lloyd D ^a  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; ARTICLE; CALCULATION; CELL KILLING; CELL SUBPOPULATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RADIATION DOSE; RADIOSENSITIVITY; TUMOR CELL LINE;

ADENOCARCINOMA; CELL SURVIVAL; COLONIC NEOPLASMS; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; TUMOR CELLS, CULTURED;

EID: 0030731858     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579320     Document Type: Article

References (39)

1. B. Palcic, B. Faddegon, B. Jaggi and L. D. Skarsgard, Automated low dose assay system for survival measurements of mammalian cells in vitro. J. Tiss. Cult. Meth. 8, 103-107 (1983).
2. B. Palcic and B. Jaggi, The use of solid state sensor technology to detect and characterize live mammalian cells growing in tissure culture. Int. J. Radiat. Biol. 50, 345-352 (1986).
3. R. E. Durand, Repair during multifraction exposures: Spheroids versus monolayers. Br. J. Cancer Suppl. 6, 203-206 (1984).
4. R. E. Durand, Use of a cell sorter for assays of cell clonogenicity. Cancer Res. 46, 2775-2778 (1986).
5. L. D. Skarsgard, I. Harrison and R. E. Durand, The radiation response of asynchronous cells at low dose: Evidence of substructure. Radiat. Res. 127, 248-256 (1991).
6. L. D. Skarsgard, D. J. Wilson and R. E. Durand, Survival at low dose in asynchronous and partially synchronized Chinese hamster V79-171 cells. Radiat. Res. 133, 102-107 (1993).
7. M. W. Skwarchuk, B. G. Wouters and L. D. Skarsgard, Substructure in the radiation survival response at low dose: Asynchronous and partially synchronized V79-WNRE cells. Int. J. Radiat. Biol. 64, 601-612 (1993).
8. L. D. Skarsgard, M. W. Skwarchuk and B. G. Wouters, The survival of asynchronous V79 cells at low radiation doses: Modeling the response of mixed cell populations. Radiat. Res. 138, S72-S75 (1994).
9. L. D. Skarsgard, M. W. Skwarchuk, B. G. Wouters and R. E. Durand, Substructure in the radiation survival response at low dose in human tumor cells. Radiat. Res. 146, 388-398 (1996).
10. B. Marples and M. C. Joiner, The response of Chinese hamster V79 cells to low radiation doses: Evidence of enhanced sensitivity of the whole cell population. Radiat. Res. 133, 41-51 (1993).
11. J. Calkins, An unusual form of response in X-irradiated protozoa and a hypothesis as to its origin. Int. J. Radiat. Biol. 12, 297-301 (1967).
12. J. Calkins, M. Einspenner, D. Blöcher and W. Greer, Responses of two mammalian cell lines to low gamma-ray doses. Int. J. Radiat. Biol. 56, 869-875 (1989).
13. P. Lambin, B. Marples, B. Fertil, E. P. Malaise and M. C. Joiner, Hypersensitivity of a human tumour cell line to very low radiation doses. Int. J. Radiat. Biol. 63, 639-650 (1993).
14. P. Lambin, E. P. Malaise and M. C. Joiner, The effect of very low radiation doses on the human bladder carcinoma cell line RT112. Radiother. Oncol. 32, 63-72 (1994).
15. P. Lambin, E. P. Malaise and M. C. Joiner, Might intrinsic radioresistance of human tumour cells be induced by radiation? Int. J. Radiat. Biol. 69, 279-290 (1996).
16. B. Singh, J. E. Arrand and M. C. Joiner, Hypersensitive response of normal human lung epithelial cells at low radiation doses. Int. J. Radiat. Biol. 65, 451-464 (1994).
17. B. G. Wouters and L. D. Skarsgard, The response of a human tumor cell line to low radiation doses: Evidence of enhanced sensitivity. Radiat. Res. 138, S76-S80 (1994).
18. B. G. Wouters, A. M. Sy and L. D. Skarsgard, Low-dose hypersensitivity and increased radioresistance in a panel of human tumor cell lines with different radiosensitivity. Radiat. Res. 146, 399-413 (1996).
19. G. Olivieri, J. Bodycote and S. Wolff, Adaptive response of human lymphocytes to low concentrations of radioactive thymidine. Science 23, 594-597 (1984).
20. S. Wolff, V. Afzal, J. K. Wiencke, G. Olivieri and A. Michaeli, Human lymphocytes exposed to low doses of ionizing radiations become refractory to high doses of radiation as well as to chemical mutagens that induce double-strand breaks in DNA. Int. J. Radiat. Biol. 53, 39-47 (1988).
21. S. Wolff, Failla Memorial Lecture: Is radiation all bad? The search for adaptation. Radiat. Res. 131, 117-123 (1992).
22. J. Seong, O. S. Chang and G. E. Kim, Adaptive response to ionizing radiation induced by low doses of gamma rays in human cell lines. Int. J. Radiat. Oncol. Biol. Phys. 33, 869-874 (1995).
23. E. I. Azzam, G. P. Raaphorst and R. E. J. Mitchel, Radiation-induced adaptive response for protection against micronucleus formation and neoplastic transformation in C3H 10T1/2 mouse embryo cells. Radiat. Res. 138, S28-S31 (1994).
24. 60Co gamma rays. Radiat. Res. 124, 300-308 (1990).
25. M. C. Joiner and H. Johns, Renal damage in the mouse: The response to very small doses per fraction. Radiat. Res. 114, 385-398 (1988).
26. C. Mothersill, J. Harney, D. Cottell, K. Parsons, D. M. Murphy and C. B. Seymour, Primary explants of human uroepithelium show an unusual response to low-dose irradiation with cobalt-60 gamma rays. Radiat. Res. 142, 181-187 (1995).
27. C. S. Hamilton, J. W. Denham, M. O'Brien, P. Ostwald, T. Kron, S. Wright and W. Dorr, Underprediction of human skin erythema at low doses per fraction by the linear quadratic model. Radiother. Oncol. 40, 23-30 (1996).
28. P. Lambin, B. Fertil, E. P. Malaise and M. C. Joiner, Multiphasic survival curves for cells of human tumor cell lines: Induced repair or hypersensitive subpopulation? Radiat. Res. 138, S32-S36 (1994).
29. B. Marples, G. K. Lam, H. Zhou and K. A. Skov, The response of Chinese hamster V79-379A cells exposed to negative pi-mesons: Evidence that increased radioresistance is dependent on linear energy transfer. Radiat. Res. 138, S81-S84 (1994).
30. J. Calkins, M. Einspenner, E. Azzam, M. Kunhi, D. Sigut and M. Hannan, Observations and an interpretation of dose-response relationships for cellular transformation in terms of induced (T) repair. Int. J. Radiat. Biol. 59, 41-51 (1991).
31. H. G. Gratzner, Monoclonal antibody to 5-bromo and 5-iododeoxyuridine: A new reagent for detection of DNA replication. Science 218, 474-475 (1982).
32. W. H. Press, B. P. Flannery, S. A. Teukolsky and W. T. Vetterling, Numerical Recipes. Cambridge University Press, Cambridge, 1989.
33. E. I. Azzam, S. M. de Toledo, G. P. Raaphorst and R. E. J. Mitchel, Radiation-induced radioresistance in a normal human skin fibroblast cell line. In Low Dose Irradiation and Biological Defense Mechanisms (T. Sugahara, L. A. Sagan and T. Aoyama, Eds.), pp. 291-294. Elsevier, Amsterdam, 1992.
34. 1 phase human lymphocytes. Mutat. Res. 265, 273-281 (1992).
35. W. K. Sinclair and R. A. Morton, X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells. Radiat. Res. 29, 450-474 (1966).
36. W. K. Sinclair, Cell cycle dependence of the lethal radiation response in mammalian cells. Curr. Top. Radiat. Res. Q. 7, 264-285 (1972).
37. B. Marples and M. C. Joiner, The elimination of low-dose hypersensitivity in Chinese hamster V79-379A cells by pretreatment with X rays or hydrogen peroxide. Radiat. Res. 141, 160-169 (1995).
38. M. C. Joiner, Evidence for induced radioresistance from survival and other end points: An introduction. Radiat. Res. 138, S5-S8 (1994).
39. B. J. S. Sanderson and A. A. Morley, Exposure of human lymphocytes to ionizing radiation reduces mutagenesis by subsequent ionizing radiation. Mutat. Res. 164, 347-351 (1986).