In vivo overexpression of c-erbB-2 oncoprotein in xenografts of mice implanted with human colon cancer lines

Anticancer Research

Volumn 17, Issue 5 A, 1997, Pages 3463-3468

  Yang, Jia Lin ^a,b   Hanley, Janelle R ^a   Yu, Yan ^a   Berney, Christophe R ^a   Russell, Pamela J ^a   Crowe, Philip J ^a  

^a PRINCE OF WALES HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

C erbB 2; Colon cancer cell line; Immunohistochemistry; Xenograft

Indexed keywords

ONCOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CECUM CANCER; COLON CANCER; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; LUNG METASTASIS; LYMPH NODE METASTASIS; MALE; MOUSE; NONHUMAN; ONCOGENE C ERB; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR XENOGRAFT;

ANIMALS; COLONIC NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER NEOPLASMS; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MICE; MICE, NUDE; NEOPLASM METASTASIS; RECEPTOR, ERBB-2; TUMOR CELLS, CULTURED;

EID: 0030731511     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal tumour development. N Engl J Med 319: 525-532, 1988.
2. Marshall CJ: Tumour suppressor genes. Cell 64: 313-26, 1991.
3. Yang J-L, Russell PJ, Crowe PJ, et al: Higher expression of oncoprotein c-myc, c-neu, PCNA and p53 in metastasising colorectal cancer (CRC) than in non-metastasising CRC. Ann Surg Onco 3: 574-579, 1996.
4. Yang J-L, Russell PJ, Crowe PJ, et al: Overexpression of c-erbB-2 mRNA and/or c-neu oncoprotein is a predictor for metastases from colorectal cancer. Anticancer Res 17: 1023-1026, 1997.
5. Kapitanovic S, Spaventi R, Poljak L, et al: High c-erbB-2 protein level in colorectal adenocarcinomas correlates with clinical parameters. Cancer Detect Prevent 18: 97-101, 1994.
6. Omori K: DNA content and c-erbB-2 oncoprotein expression in hepatic metastases, from colorectal carcinoma-in relation to clinicopathologic findings and prognosis. Japanese J Surgery 92: 1469-1479, 1991.
7. Coussens L, Yang-Feng TL, Liao YC, et al: Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal localisation with neu oncogene. Science 230: 1132-1139, 1985.
8. Fukushige S, Matsubara K, Yoshida M, et al: Localisation of a novel v-erbB-related gene, cerbB-2 on human chromosome-17 and its amplification in a gastric cell line. Mol Cell Biol 6: 955-958, 1986.
9. Schlechter AL, Stern DF, Vaidyanarhan L, et al: The neu oncogene: an erbB-related gene encoding a 185,000-MW tumour antigen. Nature 312: 513-516, 1984.
10. Slamon DJ, Clark GM, Wong SG, et al: Human breast cancer: correlation of relapse and survival with amplification of Her-2/neu oncogene. Science 235: 177-182, 1987.
11. Slamon DJ, Godolphin W, Jones LA, et al: Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244: 707-712, 1989.
12. Yokota J, Yamamoto T, Miyajima N, et al: Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification ofthe v-erbA homologue. Oncogene 2: 283-287, 1988.
13. Zhau HE, Pisters LL, Hall MC, et al: Bio-markers associated with prostate cancer progression. J Cellular Biochem (Suppl) 19: 208-216, 1994.
14. Yu D and Hung MC: Expression of activated ras neu oncogene is sufficient to induce experimental metastasis in 3T3 cells. Oncogene 6: 1991-1996, 1991.
15. Brattain MG, Fine WD, Khaled FM, et al: Heterogeneity of malignant cells from a human colonie carcinoma. Cancer Res 41: 1751-1756, 1981.
16. Kyriazis AP, Dipersio L, Michael GJ. et al: Growth patterns and behavior of human tumors growing in athymic mice. Cancer Res 38: 3186-3190, 1978.
17. Morikawa KM, Walker SM, Nakajima M, et al: Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice. Cancer Res 48: 6863-6871, 1988.
18. Whitehead RH, Macrae FA, St. John DJB, et al: A colon cancer cell line (LIM1215) derived from a patient with inherited nonpolyposis colorectal cancer. JNCI 74: 759-762, 1985.
19. Yang J-L, Crowe PJ, Russell PJ, et al: DNA flow-cytometric analysis in colorectal cancer: a comparison of metastasising and non-metastasising tumours. J Gastroenterol Hepatol 11: 319-324, 1996.
20. Giavazzi R, Campbell DE, Jessup JM, et al. Metastatic behavior of tumor cells isolated from primary and metastatic human colorectal carcinomas implanted into different sites in nude mice. Cancer Res 46: 1928-1933, 1986.
21. Guy CT, Webster MA, Schaller M, et al: Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci USA: 89: 10578-1082, 1992.
22. Baselga J, Tripathy D, Mendelsohn J, et al: Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neuoverexpressing metastatic breast cancer. J Clin Oncol 14: 737-744, 1996.
23. Borg A, Tandon AK, Sigurdsson H, et al: Her-2/neu amplification predicts poor survival in node-positive breast cancer. Cancer Res 50: 4332-4337, 1990.
24. Berchuck A, Kamel A, Whittaker R, et al: Overexpression of HER-2 neu is associated with poor survival in advanced epithelial ovarian cancer. Cancer Res 50: 4087-4091, 1940.
25. Kern JA, Schwartz DA, Nordherg JE, et al: p185neu expression in human lung adenocarcinomas predicts shortened survival., Cancer Res 50: 5184-5187, 1990.
26. Kameda T, Yasui W, Yoshida K, et al: Expression of ERBB2 in human gastric carcinomas: relationship between pl 85erbB2 expression and the gene amplification. Cancer Res 50: 8002-8009, 1990.
27. Weidner U, Peter S, Strohmeyer T, et al: Inverse relationship of epidermal growth factor receptor and HER-2/neu gene expression in human renal cell carcinoma. Cancer Res 50: 4504-4509, 1990.
28. Tsioulias GJ, Muto T, Morioka Y, et al: erbB-2 gene expression in colorectal cancer. Japan J Exp Med 60: 343-349, 1990.
29. Lazaris AC, Theodoropoulos GE, Anastassopoulos P, et al: Prognostic significance of p53 and c-erbB-2 immunohistochemical evaluation in colorectal adenocarcinoma. Histol Histopathol 10: 661-668, 1995.
30. Qian X, Decker SJ and Greene MI: p185c-neu and epidermal growth factor receptor associate into a structure composed of activated kinases. Proc Natl Acad Sci USA 89: 1330-1334, 1992.
31. Gum R, Wang S-W, Lengyel E, et al: Up-regulation of urokinase-type plasminogen activator expression by the HER2/neu proto-oncogene. Anticancer Res 15: 1167-1172, 1995.
32. Verde P, Boast S, Franze A, et al: An upstream enhancer and a negative element in the S' flanking region of the human urokinase plasminogen activator gene. Nucleic Acids Res 16: 10699-10715, 1988.
33. Trggvason K, Hoyhtya M and Salo T: Proteolytic degradation of extracellular matrix in tumour invasion. Biochim Biophys Acta 907: 191-217, 1987.
34. Hudziak RM, Lewis GD, Shalahy MR, et al: Amplified expression of the HER2/ErhB2 oncogene induces resistance to tumour necrosis factor-alpha in NIH3T3 cells. Proc Natl Acad Sci USA 85: 5102-5106, 1988.