Proinflammatory cytokines, measured in a mixed population on arrival in the Emergency Department, are related to mortality and severity of disease

Journal of Internal Medicine

Volumn 242, Issue 5, 1997, Pages 361-365

  Carlstedt, F ^a   Lind, L ^a   Lindahl, B ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

APACHE II; Cytokines; Emergency department; IL 6; Mortality and TNF

Indexed keywords

CYTOKINE; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ABDOMINAL DISEASE; ACUTE DISEASE; ADULT; AGED; ANGINA PECTORIS; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; DISEASE SEVERITY; EMERGENCY WARD; FEMALE; HEART FAILURE; HEART INFARCTION; HUMAN; INFECTION; INFLAMMATION; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; STROKE;

EID: 0030730755     PISSN: 09546820     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2796.1997.00209.x     Document Type: Article

References (25)

1. Dinarello CA. Cytokines: interleukin 1 and tumor necrosis factor (cachectin). In: Gallin J, Goldstein IM, Snyderman R, eds. Inflammation: Basic Principles and Clinical Correlates. New York: Raven Press, 1988; 195-208.
2. Yamasu K, Shimanda Y, Sakaizumi M, Soma G, Mizuno D. Activation of the systemic production of tumor necrosis factor after exposure to acute stress. Eur Cytokine Netw 1992; 3: 391-8.
3. Dinarello CA, Mier JW. Lymphokines. N Engl J Med 1987; 317: 940-45.
4. Odeh M. Tumor necrosis factor-alpha as a myocardial depressant substance. Int of Cardiology 1993; 42: 231-8.
5. Nijsten MWN, De Groot ER, Ten Duis HJ, Klasen HJ, Aarden LA. Serum levels of interleukin-6 and acute phase responses. Lancet 1987; ii: 921.
6. Damas P, Ledoux D, Nys M, Vrindts Y, De Groote D, Franchimont P, Lamy M. Cytokine serum level during severe sepsis in human, IL-6 as a marker of severity. Ann Surg 1992; 4: 356-62.
7. Hoch RC, Rodriguez R, Manning T, Bishop M, Mead P, Shoemaker WC, Abraham E. Effects of accidental trauma on cytokine and endotoxin production. Crit Care Med 1993; 6: 839-45.
8. Pullicino EA, Carli F, Poole S, Rafferty B, Malik STA, Elia M. The relationship between the circulating concentrations of IL-6, TNF and the acute phase response to elective surgery and accidental injury. Lymphokine Res 1990; 2: 231-8.
9. Roumen RM, Hendriks T, van der Ven-Jongekrijg J, Nieuwenhuijzen GA, Sauerwein RW, van der Meer JW, Goris RJ. Cytokine patterns in patients after major vascular surgery, hemmorhagic shock and severe blunt trauma. Relation with subsequent adult respiratory distress syndrome and multiple organ failure. Ann Surg 1993; 218: 769-76.
10. Strieter RM, Kunkel SL, Bone RC. Role of tumor necrosis factor alpha in disease states and inflammation. Crit Care Med 1993; 10: S447-62.
11. Barriere SL, Lowry SF. An overview of mortality risk prediction in sepsis. Crit Care Med 1995; 2: 376-93.
12. Moscovitz H, Shofer F, Mignott H, Behrman A, Kilpatrick L. Plasma cytokine determinations in emergency department patients as a predictor of bacteremia and infectious disease severity. Crit Care Med 1994; 7: 1102-8.
13. Dinarello CA. Interleukin-1 in disease. Keio J Med 1994; 43: 131-6.
14. Moldawer LL. Interleukin 1 TNF-alpha and their naturally occurring antagonists in sepsis. Blood Purif 1993; 11: 128-33.
15. Wardle N. Tumor necrosis factor and its control. Clin Int Care 1991; 2: 282-7.
16. Moldawer LL. Biology of proinflammatory cytokines and their antagonists. Crit Care Med 1994; 7: S3-7.
17. Herbert JC, O'Reilly M, Bednar MM. Modifying the host response to injury. Horizons in Trauma Surg 1995; 2: 335-49.
18. Zhou D, Kusnecov AW, Shurin MR, De Paoli M, Rabin BS. Exposure to physical an psychological Stressors elevates plasma interleukin-6: relationship to the activation of hypothalamic-pituitary-adrenal axis. Endocrinology 1993; 133: 2523-30.
19. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985; 10: 818-29.
20. Dofferhoff ASM, Bom VJJ, De Vries-Hospers HG, V. Ingen J, Van der Meer J, Hazenberg BP, et al. Patterns of cytokines, plasma endotoxin, plasminogen activator inhibitor, and acute phase proteins during the treatment of severe sepsis in humans. Crit Care Med 1992; 20: 185-92.
21. Tracey KJ, Cerami A. Tumor necrosis factor: an updated review of its biology. Crit Care Med 1993; 10: S415-21.
22. Cruickshank AM, Oldroyd KG, Cobbe SM. Serum interleukin-6 in suspected myocardial infarction. Lancet 1994; 343: 974.
23. Ikeda U, Ohkawa F, Seino Y, Yamamoto K, Hidaka Y, Kashara T, et al. Serum interleukin 6 levels become elevated in acute myocardial infarction. J Mol Cell Cardiol 1992; 24: 579-84.
24. Lesser HG, Gross C, Scheibenbogen A, Heinisch A, Salm R, Lausen M, et al. Elevation of serum interleukin-6 concentration precedes acute phase response and reflects severity in acute pancreatitis. Gastroenterology 1991; 101: 782-5.
25. Broide DH, Lotz M, Cuomo AJ, Coburn DA, Federman EC, Wasserman SI. Cytokines in symptomatic asthma airways. J Allergy Clin Immunol 1992; 89: 958-67.