Biological and mechanistic activities of phenazine antibiotics produced by culture LL-141352

Journal of Antibiotics

Volumn 50, Issue 9, 1997, Pages 785-787

  Singh, Maya P ^a   Menendez, Ana T ^a,b   Petersen, Peter J ^a   Ding, Wei Dong ^a   Maiese, William M ^a   Greenstein, Michael ^a  

^a PFIZER INC   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CHLORAMPHENICOL; CIPROFLOXACIN; LL 141352; PHENAZINE DERIVATIVE; POLYMYXIN B; RIFAMPICIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC BIOSYNTHESIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; ESCHERICHIA COLI; HUMAN; HUMAN CELL; LD 50; MACROMOLECULE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030730621     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.50.785     Document Type: Article

References (12)

1. GREENSTEIN, M.; M. J. WILDEY & W. M. MAIESE: The biochemical induction assay and its application in the detection of the calicheamicins. In Enediyne Antibiotics as Antitumor Agents. Ed., D. B. BORDERS & T. W. DOYLE, pp. 17-27, Marcel Dekker Inc, NY, 1993
2. BERNAN, V. & D. A. MONTENEGRO: Personal communication
3. IMAMURA, N.; M. NISHIJIMA, T. TAKADERA, K. ADACHI, M. SAKAI & H. SANO: New anticancer antibiotic pelagiomicin, produced by a new marine bacterium Pelagiobacter variabilis. J. Antibiotics 50: 8-12, 1997
4. 2, a novel antibiotic produced by S. viridodiastaticus subsp. "litoralis" LL-31F508. Antimicrob. Agents Chemother. 38: 1808-1812, 1994
5. TAKAHASHI, K.; I. TAKAHASHI, M. MORIMOTO & F. TOMITA: DC-86-M, a novel antitumor antibiotic II. Structure determination and biological activities. J. Antibiotics 39: 624-628, 1986
6. SHOJI, J.; R. SAKAZAKI, H. NAKAI, Y. TERUI, T. HATTORI, O. SHIRATORI, E. KONDO & T. KONISHI: Isolation of a new phenazine antibiotic, DOB-41, from Pseudomonas species. J. Antibiotics 41: 589-594, 1988
7. NAKAIKE, S.; T. YAMAGISHI, K. NANAUMI, S. OTOMO & S. TSUKAGOSHI: Cell-killing activity and kinetic analysis of a novel antitumor compound NC-190, a benzo[a]phenazine derivative. Jpn. J. Cancer Res. 83: 402-409, 1992
8. TARUI, M.; M. DOI, T. ISHIDA, M. INOUE, S. NAKAIKE & K. KITAMURA: DNA-binding characterization of a novel anti-tumor benzo[a]phenazine derivative NC-182: spectroscopic and viscometric studies. Biochem. J. 304: 271-279, 1994
9. PRATESI, G.; M. TORTERETO, C. CORTI, R. GIARDINI & F. ZUNINO: Successful local regional therapy with topotecan of intraperitoneally growing human ovarian carcinoma xenografts. British J. Cancer 71: 525-528, 1995
10. ALVAREZ, M.; K. PAULL, A. MONKS, C. HOSE, J. S. LEE, J. WEINSTEIN, M. GREVER, S. BATES & T. FOJO: Generation of a resistance profile by quantitation of mdr-1/p-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen. J. Clin. Invest. 95: 2205-2214, 1995
11. CHIN, K. V. & B. LIU: Regulation of the multidrug resistance (MDR1) gene expression. In Vivo 8: 835-841, 1994
12. ZHANG, X. P.; M. K. RITKE, J. C. YALOWICH, M. L. SLOVAK, J. P. HO, K. I. COLLINS, T. ANNABLE, R. J. ARCECI, P. E. DURR & L. M. GREENBERGER: P-glycoprotein mediated profound resistance to bisantrene. Oncology Research 6: 291-301, 1994