Retinoic acid signaling cascade in differentiating murine epidermal keratinocytes: Alterations in papilloma- and carcinoma-derived cell lines

Molecular Carcinogenesis

Volumn 20, Issue 1, 1997, Pages 58-67

  Vettermann, Oliver ^a   Siegenthaler, Georges ^b   Winter, Hermelita ^a   Schweizer, Jürgen ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Epidermal cells; Gene expression; Transformation

Indexed keywords

CALCIUM ION; CELL NUCLEUS RECEPTOR; CELLULAR RETINOL BINDING PROTEIN; CHLORAMPHENICOL ACETYLTRANSFERASE; CITRAL; DIMETHYLBENZ[A]ANTHRACENE; DIPEPTIDYL CARBOXYPEPTIDASE; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; RETINOIC ACID; RETINOIC ACID BINDING PROTEIN; RETINOL;

ANIMAL CELL; ANIMAL TISSUE; CELL DIFFERENTIATION; CONFERENCE PAPER; CONTROLLED STUDY; EPIDERMIS CELL; GENETIC TRANSFECTION; KERATINOCYTE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; SIGNAL TRANSDUCTION; SKIN CARCINOMA; SKIN PAPILLOMA; TRANSACTIVATION;

ANIMALS; CALCIUM; CARCINOMA; CELL DIFFERENTIATION; CHLORAMPHENICOL O-ACETYLTRANSFERASE; GENES, REPORTER; KERATINOCYTES; MICE; MICE, INBRED STRAINS; PAPILLOMA; RECEPTORS, RETINOIC ACID; SIGNAL TRANSDUCTION; SKIN; SKIN NEOPLASMS; SKIN PHYSIOLOGY; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TRETINOIN; VITAMIN A;

ANIMALIA; FELIS CATUS; MURINAE;

EID: 0030730358     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199709)20:1<58::AID-MC7>3.0.CO;2-E     Document Type: Conference Paper

References (64)

1. Wolbach SB, Howe PR. Tissue changes following deprivation of fat soluble vitamin A. J Exp Med 62:753-777, 1925.
2. Beckingham-Smith K. Early effects of vitamin A on protein synthesis in the epidermis of embryonic chick skin cultured in serum containing medium. Dev Biol 30:241-248, 1973.
3. Fell HB, Mellanby E. Metaplasia produced in chick ectoderm by high vitamin A. J Physiol 119:470-488, 1953.
4. Peck GI, Olsen TG, Butkus D. Treatment of basal cell carcinomas with 13-cis-retinoic acid. Proceedings of the American Association for Cancer Research 20:56, 1979.
5. Ehrmann CW, Voorhees JJ. International study of the efficacy of etritinate in the treatment of psoriasis. J Am Acad Dermatol 6:692-696, 1982.
6. Kraemer KH, Digiovanna JJ, Marshall AN, Tarone RE, Peck GL. Prevention of skin cancer in xeroderma pigmentosum with the use of oral isotretinoin. N Engl J Med 318:1633-1637, 1988.
7. Hong WK, Lippmann SM, Itri LM. Prevention of second primary tumors with isoretinoin in squamous-cell carcinoma of the head and neck. N Engl J Med 328:795-801, 1990.
8. Rafal ES, Griffths CEM, Ditre CM, Finkel LJ, et al. Topical tretinoin (retinoic acid) treatment for liver spots associated with photodamage. N Engl J Med 326:368-374, 1992.
9. Fuchs E, Green H. Regulation of terminal differentiation of cultured human keratinocytes by vitamin A. Cell 25:617-625, 1981.
10. Kopan R, Fuchs E. The use of retinoic acid to probe the relation between hyperproliferation-associated keratins and cell proliferation in normal and malignant epidermal cells. J Cell Biol 109:295-307, 1989.
11. Asselineau D, Dale BA, Bernard BA. Filaggrin production by cultured human epidermal keratinocytes and its regulation by retinoic acid. Differentiation 45:221-229, 1990.
12. Hohl D, Lichti U, Breitkreuz D, Steinert PM, Roop DR. Transcription of the human loricrin gene in vitro is induced by calcium and cell density and suppressed by retinoic acid. J Invest Dermatol 96:414-418, 1991.
13. Yuspa SH, Harris CC. Altered differentiation of mouse epidermal cells treated with retinyl acetate in vitro. Exp Cell Res 86:95-105, 1974.
14. Green H, Watt F. Regulation by vitamin A of envelope crosslinking in cultured keratinocytes derived from different human epithelia. Mol Cell Biol 2:1115-1117, 1982.
15. Blomhoff R, Green MH, Berg T, Norum KR. Transport on storage of vitamin A. Science 250:399-404, 1990.
16. Napoli JL, Boerman HEM, Chan X, Zhai Y, Fiorella PD. Enzymes and binding proteins affecting retinoic acid concentrations. J Steroid Biochem Mol Biol 53:497-502, 1995.
17. Donovan M, Olofsson B, Gustafson AI, Denker L, Eriksson U. The cellular retinoic acid binding proteins. J Steroid Biochem Mol Biol 53:459-465, 1995.
18. Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J 10:940-954, 1996.
19. Fisher GJ, Voorhees JJ. Molecular mechanisms of retinoid actions in skin. FASEB J 10:1002-1013, 1996.
20. Siegenthaler G, Tomatis I, Chatellard-Gruez D, Jaconi S, Eriksson U, Saurat JH. Expression of CRABP-I and CRABP-II in human epidermal cells. Alteration of relative protein amounts is linked to the state of differentiation. Biochem J 287:383-389, 1992.
21. Siegenthaler G. Extra- and intracellular transport of retinoids: A reappraisal. Horm Res 45:122-127, 1996.
22. Glass GK, Direnzo J, Kurokawa R, Han Z. Regulation of gene expression by retinoic acid receptors. DNA Cell Biol 10:623-638, 1991.
23. Xiao JH, Durand B, Chambon P, Voorhees JJ. Endogenous retinoic acid receptors (RAR)-retinoid X receptor (RXR) heterodimers are the major functional forms regulating retinoid responsive elements in adult human keratinocytes. J Biol Chem 1995:3001-3011, 1995.
24. Schweizer J, Kinjo M, Fürstenberger G, Winter H. Sequential expression of mRNA encoded keratin sets in neonatal mouse epidermis. Basal cells with properties of terminally differentiating cells. Cell 37:159-170, 1994.
25. Strickland JE, Greenhalgh DA, Koceva-Chyla A, et al. Development of murine epidermal cell lines which contain an activated Ha ras oncogene and form papillomas in skin grafts on athymic nude mouse hosts. Cancer Res 48:165-169, 1988.
26. Fürstenberger G, Gross M, Schweizer J, Vogt I, Marks F. Isolation, characterization and in vitro cultivation of subfractions of neonatal mouse keratinocytes: Effects of phorbol esters. Carcinogenesis 7:1745-1753, 1986.
27. Sucor HM, Murakami KK, Evans RM. Characterization of an autoregulated response element in the mouse retinoic acid receptor type β gene. Proc Natl Acad Sci USA 87:5392-5396, 1990.
28. Luckow B, Schütz G. CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res 15:5490, 1987.
29. Winter H, Fink P, Schweizer J. Retinoic acid induced normal and tumor associated aberrant expression of the murine keratin K13 gene does not involve a promoter sequence with striking homology to a natural retinoic acid responsive element. Carcinogenesis 15:2653-2656, 1994.
30. Jiang CK, Connoly DM, Blumenberg M. Comparison of methods for transfection of human epidermal keratinocytes. J Invest Dermatol 97:969-973, 1991.
31. Huff CA, Yuspa SH, Rosenthal D. Identification of control elements 3′ to the human keratin 1 gene that regulates cell type and differentiation specific expression. J Biol Chem 268:377-384, 1993.
32. 2+ inducible epidermal specific regulatory element in the 3′-flanking region of the human keratin 1. J Invest Dermatol 101:506-513, 1993.
33. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254, 1976.
34. Lowry OH, Rosebrough MJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275, 1951.
35. Siegenthaler G. Gel electrophoresis of cellular retinoic acid-binding protein, cellular retinol-binding protein, and serum retinol binding protein. Methods enzymol 189:299-307, 1990.
36. Siegenthaler G, Saurat J-H. A slab gel electrophoresis technique for measurement plasma retinol-binding protein, cellular retinol, and retinoic acid-binding proteins in human skin. Eur J Biochem 166:209-214, 1967.
37. Siegenthaler G, Gurnowski-Sunek D, Saurat J-H. Metabolism of natural retinoids in psoriatic epidermis. J Invest Dermatol 95:47S-48S, 1990.
38. Siegenthaler G, Saurat J-H, Ponec M. Retinol and retinal metabolism: Relationship to the state of differentiation of cultured human keratinocytes. Biochem J 268:371-378, 1990.
39. Schweizer J, Goerttler K. Synthesis in vitro of keratin polypeptides directed by mRNA isolated from newborn and adult mouse epidermis. Eur J Biochem 112:243-249, 1980.
40. Fregien N, Dolecki GJ, Mandel M, Humphreys L, Ward DC. Molecular cloning of five individual stage- and tissue-specific in RNA sequences from sea urchin pluteus embryos MoI Cell Biol 3:1021-1031, 1988.
41. Hennings H, Michael D, Cheng CK, Steinert PM, Holbrook KA, Yuspa SH. Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19:245-254, 1980.
42. 2+ and vitamin A acid in mouse epidermal cell lines. Exp Cell Res 195:183-193, 1991.
43. Giguère V, Lyn S, Yip P, Sin CH, Amin S Molecular cloning of cDNA encoding a second cellular retinoic acid binding protein. Proc Natl Acad Sci USA 87:6233-6237, 1990.
44. Busch C, Siegenthaler G, Vahlquist A, et al. Expression of cellular retinoid-binding proteins during normal and abnormal epidermal differentiation. J Invest Dermatol 99:795-802, 1992.
45. Ong DE, Newcomer ME, Chytil F. Cellular retinoid-binding proteins. In: Sporn MB, Roberts AB, Goodman DS (eds) The Retinoids. Biology, Chemistry, and Medicine. 2nd ed., Raven Press, New York, 1994, pp. 283-318.
46. Siegenthaler G, Saurat J-H. Natural retinoids: Metabolism and transport in human epidermal cells. In: Saurat J-H (ed) Retinoids 10 Years On. pp. 56-68. Karger, Basel, 1991.
47. Connor J, Smit MH. Terminal-group oxidation of retinol by mouse epidermis. Biochem J 244:489-492, 1987.
48. Vollberg TM, Nervi C, George MD, Fujimoto W, Krust A, Jetten AM. Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation. Mol Endocrinol 6:667-676, 1992.
49. Barua AB. Analysis of water-soluble compounds: Glucuronides. Methods Enzymol 189:136-145, 1990.
50. Kurlansky SB, Duell EA, Kang S, Voorhees JJ, Fisher GJ. Auto regulation of retinoic acid biosynthesis through regulation of retinol esterification in human keratinocytes. J Biol Chem 271:15346-15352, 1996.
51. Kurlansky SB, Xiao JH, Duell EA, Voorhees JJ, Fischer GJ. Biological activity of all trans retinol regions metabolic conversion to all trans retinoic acid and is mediated through activities of nuclear retinoid receptors in human keratinocytes. J Biol Chem 269:32821-32827, 1994.
52. Smith WC, Nakshatri H, Leroy P, Rees J, Chambon P. A retinoic acid response element is present in the mouse cellular retinol binding protein I (CRBPI) promoter. EMBO J 10:2223-2230, 1991.
53. Durand B, Saunders M, Leroy P, Leid M, Chambon P. All trans and 9-cis retinoic acid induction of CRABPII transcription is mediated through RAR:RXR heterodimers bound to DR1 and DR2 repeated motifs. Cell 71:73-85, 1996.
54. Astroem A, Petterson U, Chambon P, Voorhees JJ. Retinoic acid induction of human cellular retinoic acid binding protein II gene transcription is mediated by retinoic acid receptor-retinoid X receptor heterodimers bound to one far upstream retinoic acid responsive element with 5-base pair spacing. J Biol Chem 269:22334-22339, 1994.
55. Siegenthaler G, Tomatis I, Didierjean L, Jaconi S, Saurat J-H. Over-expression of cellular retinoic acid-binding protein type II (CRABP-II) and down-regulation of CRABP-I in psoriatic skin. Dermatology 185:251-256, 1992.
56. Winter H, Schweizer J, Goerttler K. Keratins as markers of malignancy in mouse epidermal tumors. Carcinogenesis 1:391-398, 1980.
57. Roop DR, Krieg TM, Mehrel T, Cheng CK, Yuspa SH. Transcriptional control of molecular weight keratin gene expression in multistage mouse skin carcinogenesis. Cancer Res 48:3245-3252, 1988.
58. Roop DR, Huitfeld H, Kilkenny A, Yuspa SH. Regulated expression of differentiation associated keratins in cultured epidermal cells detected by monospecific antibodies to unique peptides of mouse epidermal keratins. Differentiation 35:143-150, 1987.
59. Cheng CK, Kilkenny AE, Roop DR, Yuspa SH. The v-ras oncogene inhibits the expression of differentiation markers and facilitates expression of cytokeratins 8 and 18 in mouse keratinocytes. Mol Carcinog 3:363-373, 1990.
60. Caulin C, Bauluz C, Gandarillas A, Cano A, Quintanilla M. Changes in keratin expression during malignant progression of transformed mouse epidermal keratinocytes. Exp Cell Res 204:11-21, 1993.
61. Agarwal C, Rorke EA, Boyce M, et al. Retinoid-dependent transcriptional suppression of cytokeratin gene expression in human epidermal squamous cell carcinoma cells. Differentiation 52:185-191, 1993.
62. Aneskievich BJ, Fuchs E. Terminal differentiation in keratinocytes involves positive as well as negative regulation by retinoic acid receptors and retinoid X receptors at retinoid response elements. Mol Cell Biol 12:4862-4871, 1992.
63. Buchmann A, Ruggeri B, Klein-Szanto AJP, Balmain A. Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7. Cancer Res 51:4097-4101, 1991.
64. Stoler AB, Stenbach F, Balmain A. The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event. J Cell Biol 122:1103-1117, 1993.