Parasite and mammalian GPI biosynthetic pathways can be distinguished using synthetic substrate analogues

EMBO Journal

Volumn 16, Issue 22, 1997, Pages 6667-6675

  Smith, Terry K ^a   Sharma, Deepak K ^a   Crossman, Arthur ^a   Dix, Alexander ^a   Brimacombe, John S ^a   Ferguson, Michael A J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Glycosylphosphatidylinositol; HeLa; Leishmania; Mannosyltransferase; Trypanosome

Indexed keywords

CARBOHYDRATE; CELL SURFACE PROTEIN; GLYCOPROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL;

ARTICLE; BIOSYNTHESIS; CHEMICAL STRUCTURE; HELA CELL; HUMAN; HUMAN CELL; LEISHMANIA MAJOR; LIFE CYCLE; NONHUMAN; PARASITE; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI;

EUKARYOTA; LEISHMANIA MAJOR; MAMMALIA; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMATIDAE;

EID: 0030729928     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.22.6667     Document Type: Article

References (50)

1. Bhattacharya, A., Prasad, R. and Sacks, D.L. (1992) Identification and partial characterization of a lipophosphoglycan from a pathogenic strain of Entamoeba histolytica. Mol. Biochem. Parasitol., 56, 161-168.
2. Brown, G.M., Millar, A.R., Mastenon, C., Brimacombe, J.S., Nikolaev, A.V. and Ferguson, M.A.J. (1996) Synthetic phospho-oligosaccharide fragments of lipophosphoglycan as acceptons for Leishmania major α-D-mannosylphosphate transferase. Eur. J. Biochem., 242, 410-416.
3. Buxbaum, L.A., Milne, K.G., Werbovetz, K.A. and Englund, P.T. (1996) Myristate exchange on the Trypanosoma brucei variant surface glycoprotcin Proc. Natl Acad. Sci. USA. 93, 1178-1183.
4. Cottaz, S., Brimacombe, J.S. and Ferguson, M.A.J. (1993) The synthesis of some early and related intermediates in the biosynthetic pathway of glycosyl-phosphatidylinositol membrane anchors. J. Chem. Soc. Perkin Trans., 1, 2945-2951.
5. Cross, G.A.M. (1996) Antigenic variation in trypanosomes: secrets surface slowly. Bio Essays, 18, 283-291.
6. Crossman, A., Brimacombe, J.S. and Ferguson, M.A.J. (1997) Parasite glycoconjugatex. Part 7. Synthesis of further substrate analogues of early intermediates in the biosynthetic pathway of glycosylphosphatidylinositol membrane anchors. J. Chem. Sat: Perkin Trans., 1. 2769-2774.
7. Doering, T.L., Masterson, W.J., Englund, P.T. and Hart, G.W. (1989) Biosynthesis of the glycosyl-phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein: origin of the nonacetylated glucosamine. J. Biol. Chem., 264, 11168-11173.
8. glocorrler, W.T., Ye.J., Falck, J.R. and Lehrman, M.A. (1996) Acylation of glucosaminyl phosphalidylinositol revisited. J. Biol. Chem., 271, 27031-27038.
9. Englund, P.T. (1993) The structure and biosynthesis of glycosyl phosphatidylinositol protein anchors. Ann. Rev. Biochem., 62, 121-138.
10. Ferguson, M.A.J. (1992) Chemical and enzymic analysis of glyctisylphosphatidylinositol anchors. In Hooper, N.M. and Tumer, A.J. (eds). Lipid Modifications of Proteins: A Practical Approach. IRL Press. Oxford. UK. pp. 191-230.
11. Ferguson, M.A.J., Low, M.G. and Cross, G.A.M. (1985) Glycosyl-sn-1, 2-dimyristyl phosphatidylinositol is covalently linked to Trypanosoma brucei variant surface glycoprotein. J. Biol. Chem., 260, 14547-14555.
12. Gerold, P., Diekemann-Schuppert, A. and Schwarz, R.T. (1994) Glycosylphosphatidylinositols synthesized by asexual erythrocytic stages of the malarial parasite. P.falciparum: Candidates for plasmodial glycosylphosphatidylinositol membrane anchor precursors and pathogenicily factors. J. Biol. Chem., 269, 2397-2606.
13. Gerold, P. Schofield, L., Blackman, M.J., Holder, A.A. and Schwarz, R.T. (1996) Structural analysis of the glycosyl-phosphatidylinositol membrane anchor of the merozoite surface proteins-1 and -2 of P.falciparum. Mol. Biochem. Parasitol., 75, 131-143.
14. Güther, M.L.S. and Ferguson, M.A.J. (1995) The role of inositol acylation and inositol deacylation in GPI biosynthesis in Trypanmama brucet. EMBO J., 14, 3080-3093.
15. Güther, M.L.S., Masterson, W.J. and Ferguson, M.A.J. (1994) The effects of phenylmethylsulfonyl fluoride on inositol-acylation and fatty acid remodelling in African trypanosomes. J. Biol. Chem., 269 18694-18701.
16. Güther, M.I.S., Treumann, A. and Ferguson, M.A.J. (1996) Molecular species analysis and quantification of the glycosylphosphatidylinositol intermediate glycolipid C from Trypanosoma brucei. Mol. Biochem. Parasitol., 77, 137-145.
17. Heise, N., Raper, J., Buxbaum, L.U., Peranovich, T.M. and Almeida, M. L. (1996) Identification of complete precursors for the glycosylphosphatidylinositol protein anchors of Trypanosoma cruzi. J. Biol. Chem., 271, 16877-16887.
18. Hirose, S., Ravi, I., Hazra, S.V. and Medof, M.E. (1991) Assembly and deacetylation of N-acctylglucosaminyl-plasminylinositol in normal and affected paroxysmal nocturnal hemoglobinurea cells. Proc. Natl Acad. Sci. USA. 88, 3762-3766.
19. Hirose, S., Prince, G.M., Sevlever, D., Ravi, L., Rosenberry, T.L., Ueda, E. and Medof, M.E. (1992) Characterization of putative glycoinositol phospholipid anchor precursors in mammalian cells. Localization of phosphoethanolamine. J. Biol. Chem., 267, 16968-16974.
20. Kamitani, T. Menon, A.K., Hallaq, Y., Warren, C.O. and Yeh.E.T.H. (1992) Complexity of ethanolamine phosphate addition in the biosynthesis of glycosylphosphatidylinositol anchors in mammalian cells. J. Biol. Chem., 267, 24611-24619.
21. Maslerson, W.J., Doering, T.L., Hart, G.W. and Englund, P.T. (1989) A novel pathway for glycan assembly: biosynthesis of the glycosylphosphatidylinositol anchor of the Trypanosoma brucei variant surface glycoprotein. Cell. 56, 793-800.
22. Masterson, W.J., Raper, J., Doering, T.L., Hart, G.W. and Englund, P.T. (1990) Fatty acid remodelling: a novel reaction sequence in the biosynthesis of trypanosome glycosyl phosphatidylinositol membrane anchors. Cell. 62, 73-80.
23. McConville, M. J. and Kerguson, M.A.J. (1993) The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes. Biochem J., 294, 305-324.
24. McConville, M J., Schnur, L.F., Jaffe, C. and Schneider, P. (1995) Structure of Leishmania lipophosphoglycan: inter- and intra-specific polymorphism in Old World species. Biochem. J., 310, 807-818.
25. Medof, M.E., Nagarajan, S. and Tykocinski, M.L. (1996) Cell-surface engineering with GPI-anchored proteins. FASEB J., 10, 574-586.
26. Menon, A., Schwarz., R., Mayor, S. and Cross, G.A.M. (1990) Cell-free synthesis of glycosyl-phosphatidylinositol precursors for the glycolipid membrane anchor of Trypanosoma brucei variant surface glycoproteins. Structural characterization of putative biosynthetie intermediates. J. Biol. Chem., 265, 9033-9042.
27. Milne, K.G., Ferguson, M.A.J. and Masterson, W.J. (1992) Inhibition of the GlcNAc transfease of glycosylphosphatidylinositol anchor biosynthesis in African trypanosomes. Eur. J. Biochem., 208, 309-314.
28. Milne, K.G., Field, R.A., Masterson, W.J., Cottaz, S., Brimacombe, J.S. and Ferguson, M.A.J. (1994) Partial purification and characterisation of the N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase of glycosylphoshatidylinositol anchor biosynthesis in African trypanosomes. J. Biol. Chem., 269, 16403-16408.
29. Muhney, K.P., Knez, J.J., Ravi, L., Sevlever, D., Rosenberry, T.L., Hirose, S. and Medof, M.E. (1994) Glycoinositol phospholipid anchor-defective K562 mutants with biochemical lesions distinct from those in Thy1- murine lymphoma mutants. J. Biol. Chem., 269, 6536-6542.
30. Proudfoot, L., Schneider, P., Ferguson, M.A.J. and McConville, M.J. (1995) Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major. Biochem. J., 308, 45-55.
31. Puoti, A. and Conzelmann, A. (1993) Characterization of abnormal free glycosylphosphatidylinosilols accumulating in mutant lymphoma cells of classes B. E. F and H. J. Biol. Chem., 268, 7215-7224.
32. Ralton, J.E., Milne, K.G., Güther, M.L.S., Field, R.A. and Ferguson, M.A.J. (1993) The mechanism of inhibition of glycosyl-phosphatidylinositol anchor biosynthesis in Trypanosoma brucei by mannosamine. J. Biol. Chem., 268, 24183-2418.
33. Redman, C.A., Schneider, P., Mchlert, A. and Ferguson, M.A.J. (1995) The glycoinositol-phospholipids of Phytomonas. Biochem. J., 311, 495-503.
34. Routier, F.H., da Silveira, E.X., Wait, R., Jones, C., Previato, J.O. and Mendonca-Previato, L. (1995) Chemical characterisation of glycosylinositolphospholipids of Herpetomonas samuelpessoai. Mol. Biochem. Parasitol., 69, 61-69.
35. Sharma, D.K., Smith, T.K., Crossman, A., Brimacombe, J.S. and Ferguson. M.A.J. (1997) The substrate specificity of the N-acetylglucosaminylphosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol membrane anchor biosynthesis in African trypanosomes and human cells. Biochem. J., in press.
36. Singh, B.N., Beach, D.H., Lindmak, D.G. and Costello, C.E. (1994) Idenification of the lipid moiety and further characterization of the novel lipophosphoglycan-like glycoconjugatcs of Trichomonas vaginalis and Trichomonas foetus. Arch. Biochem. Biophys., 309, 273-280.
37. Sipos, G., Puoti, A. and Conzelmann, A. (1994) Glycosylphosphatidylinositol membrane anchors in Saccharomyces cerevisiae: absence of ceramidcs from complete precursor glycolipids. EMBO J., 13, 2789-2796.
38. Smith, T.K., Cottaz, S., Brimacombe, J.S. and Ferguson.M.AJ. (1996) Substrate specificity of the dolichol phospahte mannose: glucosaminyl phosphatidylinositol α1-4 mannosyltransferase of the glycosylphosphatidylinositol biosynthetic pathway of African trypanosomes. J. Biol. Chem., 271, 6476-6482.
39. Smith, T.K., Milne.F., Sharma, D.K., Crossman, A., Brimacombe, J.S. and Ferguson, M.A.J. (1997) Early steps in glycosylphosphatidylinositol biosynthesis in Leishinania major. Biochem. J., 326, 393-400.
40. Stevens, V.L. (1993) Regulation of glycosylphosphatidylinositol biosynthesis by GTP. Stimulation of JV-acetylglucosaminephosphatidylinositol deacetylation. J. Biol. Chem., 268, 9718-9724.
41. Stevens, V.L. (1995) Biosynthesis of glycosylphosphatidylinositol membrane anchors. Biochem. J., 310, 361-370.
42. Stevens, V.L. and Zhang, H. (1994) Coenzyme A dependence of glycosylphosphalidylinositol biosynthesis in a mammalian cell-free system. J. Biol. Chem., 269, 31397-31403.
43. Takeda, J. and Kinoshita, T. (1995) GPI-anchor biosynthesis. Trends Biochem. Sci., 20, 367-371.
44. Tomavo, S., Schwarz, R.T. and Dubremetz, J.F. (1989) Evidence for glycosyl-phosphatidylinositol anchoring of Toxoplasma gondii major surface antigens. Mol. Cell. Biol., 9, 4576-4580.
45. Tomavo, S., Dubrametz, J-F. and Schwarz, R.T. (1992) Biosynthesis of glycolipid precursors for glycosylphosphatidylinositol membrane anchors in a Toxoplasma gondii cell-free system. J. Biol. Chem., 267, 21446-21458.
46. Treumann, A., Lifely, M.R., Schneider, P. and Ferguson.M.A.J. (1995) Primary structure of CD52. J. Biol. Chem., 270, 6088-6099.
47. Treumann, A., Zitzmann, N., Hülsmeier, A., Prescotl, A.R., Almond, A., Shechan, J. and Ferguson, M.A.J. (1997) Structural characterisation of two forms of procyclic acidic repetitive protein expressed by procyclic forms of Trypanosoma brurei. J. Mol. Biol., 269, 529-547.
48. Turco, S.J. and Descoteaux, A. (1992) The lipophosphoglycan of Lerishamania parasites. Annu. Rev. Microbiol., 46, 65-94.
49. Udenfriend, S. and Kokudula, K. (1995) How glycosylphosphatidylinositol anchored membrane proteins are made. Annu. Rev. Biochem., 64, 563-591.
50. Werbovetz, K.A. and Englund, P.T. (1997) Glycosyl phosphatidylinositol myristoylation in African trypanosomes. Mol. Biochem. Parasitol., 85, 1-7.