Mapping of antigenic determinant regions of the Bor56 protein of Orientia tsutsugamushi

Infection and Immunity

Volumn 65, Issue 12, 1997, Pages 5250-5256

  Seong, Seung Yong ^a   Park, Sae Gwang ^b   Huh, Myung Suk ^b   Jang, Won Jong ^b   Kim, Hang Rae ^b   Han, Tae Hee ^c   Choi, Myung Sik ^b   Chang, Woo Hyun ^d   Kim, Ik Sang ^b  

^a Korea Institute of Science and Technology   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Sungkyunkwan University School of Medicine   (South Korea)

^d Hallym University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; EPITOPE; NEUTRALIZING ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; EPITOPE MAPPING; FEMALE; IMMUNOGENICITY; MOUSE; NONHUMAN; OPEN READING FRAME; ORIENTIA TSUTSUGAMUSHI; PRIORITY JOURNAL; SCRUB TYPHUS;

EID: 0030729698     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.12.5250-5256.1997     Document Type: Article

References (46)

1. Bell, E. J., B. L. Bennttt, and L. Whitman. 1946. Antigenic differences between strains of scrub typhus as demonstrated by cross-neutralization tests. Proc. Soc. Exp. Biol. Med. 61:134-137.
2. Bourgeois, A. L., J. G. Olson, R. C. Fang, J. Huang, C. L. Wang, L. Chow, D. Bechthold, D. T. Dennis, J. C. Coolbaugh, and E. Weiss. 1982. Humoral and cellular responses in scrub typhus patients reflecting primary infection and reinfection with Rickettsia tsutsugamushi. Am. J. Trop. Med. Hyg. 31:532-540.
3. Catanzaro, P. J., A. Shiral, L. D. Agniel, Jr., and J. V. Osterman. 1977. Host defenses in experimental scrub typhus: role of spleen and peritoneal exudate lymphocytes in cellular immunity. Infect. Immun. 18:118-123.
4. Chang, W. H. 1994. Tsutsugamushi disease in Korea. Seohung Publication, Seoul, Korea.
5. Chang, W. H., J. S. Kang, W. K. Lee, M. S. Choi, and J. H. Lee. 1990. Serological classification by monoclonal antibodies of Rickettsia tsutsugamushi isolated in Korea. J. Clin. Microbiol. 28:685-688.
6. Chou, P. Y., and G. D. Fasman. 1978. Prediction of secondary structure of proteins from their amino acid sequence. Adv. Enzymol. Related Areas Mol. Biol. 47:45-148.
7. Colma, P. M., J. N. Varghese, and W. G. Laver. 1983. Structure of the catalytic and antigenic sites in influenza virus neuraminidase. Nature 303:41-44.
8. Eisemann, C. S., and J. V. Osterman. 1981. Antigens of scrub typhus rickettsiae: separation by polyacrylamide gel electrophoresis and identification by enzyme-linked immunosorbent assay. Infect. Immun. 32:525-533.
9. Furuya, Y., Y. Yoshida, T. Katayama, S. Yamamoto, and A. Kawamura, Jr. 1993. Serotype-specific amplification of Rickettsia tsutsugamushi DNA by nested polymerase chain reaction. J. Clin. Microbiol. 31:1637-1640.
10. Hanson, B. 1985. Identification and partial characterization of Rickettsia tsutsugamushi major protein immunogens. Infect. Immun. 50:603-609.
11. Hanson, B. A. 1983. Effect of immune serum on infectivity of Rickettsia tsutsugamushi. Infect. Immun. 42:341-349.
12. Hickman, C. J., C. K. Stover, S. W. Joseph, and E. V. Oaks. 1993. Murine T-cell response to native and recombinant protein antigens of Rickettsia tsutsugamushi. Infect. Immun. 61:1674-1681.
13. Jerrells, T. R., and J. V. Osterman. 1982. Host defenses in experimental scrub typhus: delayed-type hypersensitivity responses of inbred mice. Infect. Immun. 35:117-123.
14. Jerrells, T. R., and J. V. Osterman. 1983. Development of specific and cross-reactive lymphocyte proliferative responses during chronic immunizing infections with Rickettsia tsutsugamushi. Infect. Immun. 40:147-156.
15. Jerrells, T. R., B. A. Palmer, and J. V. Osterman. 1983. Gamma-irradiated scrub typhus immunogens: development of cell-mediated immunity after vaccination of inbred mice. Infect. Immun. 39:262-269.
16. Jones, D. T., W. R. Taylor, and J. M. Thornton. 1994. A model recognition approach to the prediction of all-helical membrane protein structure and topology. Biochemistry 33:3038-3049.
17. Kim, I. S., S. Y. Seong, S. G. Woo, M. S. Choi, and W. H. Chang. 1993. High-level expression of a 56-kilodalton protein gene (bor56) of Rickettsia tsutsugamushi Boryong and its application to enzyme-linked immunosorbent assays. J. Clin. Microbiol. 31:598-605.
18. Kim, I. S., S. Y. Seong, S. G. Woo, M. S. Choi, J. S. Kang, and W. H. Chang. 1993. Rapid diagnosis of scrub typhus by a passive hemagglutination assay using recombinant 56-kilodalton polypeptides, J. Clin. Microbiol, 31:2057-2060.
19. Kodama, K., S. Kawamura, M. Yasukawa, and Y. Kobayashi. 1987. Establishment and characterization of a T-cell line specific for Rickettsia tsutsugamushi. Infect. Immun. 55:2490-2495.
20. Kyte, J., and R. F. Doolittle. 1982. A simple method for displaying the hydrophobia character of a protein. J. Mol. Biol. 157:105-132.
21. Murata, M., Y. Yoshida, M. Osono, N. Ohashi, M. Oyanagi, H. Urakami, A. Tamura, S. Nogami, H. Tanaka, and A. Kawamura, Jr. 1986. Production and characterization of monoclonal strain-specific antibodies against prototype strains of Rickettsia tsutsugamushi. Microbiol. Immunol. 30:599-610.
22. Oaks, S. C., Jr., F. M. Hetrick, and J. V. Osterman. 1980. A plaque reduction assay for studying antigenic relationships among strains of Rickettsia tsutsug- amushi. Am. J. Trop. Mod. Hyg. 29:998-1006.
23. Oaks, S. C., Jr., R. L. Ridgway, A. Shiral, and J. C. Twartz. 1983. Scrub typhus. Bull. Inst. Med. Res., vol. 21.
24. Ohashi, N., H. Nashimoto, H. Ikeda, and A. Tamura. 1990. Cloning and sequencing of the gene (tsg56) encoding a type-specific antigen from Rickettsia tsutsugamushi. Gene 91:119-122.
25. Ohashi, N., H. Nashimoto, H. Ikeda, and A. Tamura. 1992. Diversity of immunodominant 56-kDa type-specific antigen (TSA) of Rickettsia tsutsugamushi. Sequence and comparative analyses of the genes encoding TSA homologues from four antigenic variants. J. Biol. Chem. 267:12728-12735.
26. Ohashi, N., A. Tamura, M. Ohta, and K. Hayashi. 1989. Purification and partial characterization of a type-specific antigen of Rickeitsia tsutsugamushi. Infect. Immun. 57:1427-1431,
27. Ohashi, N., A. Tamura, and T. Suto. 1988. Immunoblotting analysis of anti-rickettsial antibodies produced in patients of tsutsugamushi disease. Microbiol. Immunol. 32:1085-1092.
28. Palmer, B. A., F. M. Hetrick, and T. R. Jerrells. 1984. Gamma interferon production in response to homologous and heterologous strain antigens in mice chronically infected with Rickettsia tsutsugamushi. Infect. Immun. 46: 237-244.
29. Paul, W. E. 1993. Immunogenicity and antigen structure, p. 235-282. In W. E. Paul (ed.), Fundamental immunology, 3rd ed. Raven Press, Ltd., New York, N.Y.
30. Rights, F. L., J. E. Smadel, and E. B. Jackson. 1948. Studies on scrub typhus (tsutsugamushi disease). III. Heterogeneity of strains of Rickettsia tsutsugamushi as demonstrated by cross vaccination studies. J. Exp, Med. 87:339-351.
31. Rikihisa, Y., and S. Ito. 1983. Effect of antibody on entry of Rickettsia tsutsugamushi into polymorphonuclear leukocyte cytoplasm. Infect. Immun. 39:928-938.
32. Robinson, D. M., E. Gan, T. C. Chan, and D. L. Huxsoll. 1981. Clinical and immunologic responses of silvered leaf monkeys (Presbytis cristatus) to experimental reinfection with Rickettsia tsutsugamushi. J. Infect. Dis. 143:558-561.
33. Robinson, D. M., and D. L. Huxsoll. 1975. Protection against scrub typhus infection engendered by the passive transfer of immune sera. Southeast Asian J. Trop. Med. Public Health 6:477-482.
34. Seong, S. Y., M. S. Huh, W. J. Jang, S. G. Park, J. G. Kim, S. G. Woo, M. S. Choi, I. S. Kim, and W. H. Chang. 1997. Induction of homologous immune response to Rickettsia tsutsugamushi Boryong with a partial 56-kilodalton recombinant antigen fused with the maltose-binding protein MBP-Bor56. Infect. Immun. 65:1541-1545.
35. Seong, S. Y., H. R. Kim, M. S. Huh, S. G. Park, J. S. Kang, T. H. Han, M. S. Choi, W. H. Chang, and I. S. Kim. Induction of neutralizing antibody in mice by immunization with recombinant 56-kilodalton protein of Orientia tsutsugamushi. Vaccine, in press.
36. Seong, S. Y., S. G. Park, M. S. Huh, M. S. Choi, and I. S. Kim. 1997. T-track PCR fingerprinting for the rapid detection of genetic polymorphism. FEMS Microbiol. Lett. 152:37-44.
37. Seong, S. Y., S. G. Park, H. R. Kim, T. H. Han, J. S. Kang, M. S. Choi, I. S. Kim, and W. H. Chang. 1997, Isolation of a new Orientia tsutsugamushi serotype. Microbiol. Immunol. 41:437-443.
38. Shirai, A., P. J. Catanzaro, S. M. Phillips, and J. V. Osterman. 1976. Host defenses in experimental scrub typhus: role of cellular immunity in heterologous protection. Infect. Immun. 14:39-46.
39. Stover, C. K., D. P. Marana, J. M. Carter, B. A. Roe, E. Mardis, and E. V. Oaks. 1990. The 56-kilodalton major protein antigen of Rickettsia tsutsugamushi: molecular cloning and sequence analysis of the sta56 gene and precise identification of a strain-specific epitope. Infect. Immun. 58:2076-2084.
40. Tainer, J. A., E. D. Getzoff, H. Alexander, R. A. Houghten, A. J. Olson, R. A. Lerner, and W. A. Hendrickson. 1984. The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein. Nature 312:127-154.
41. Takahashi, K., H. Urakami, and A. Tamura. 1985. Purification of cell envelopes of Rickettsia tsutsugamushi. Microbiol. Immunol. 29:475-478.
42. Tamura, A., N. Ohashi, H. Urakami, and S. Miyamura. 1995. Classification of Rickettsia tsutsugamushi in a new genus, Orientia gen. nov., as Orientia tsutsugamushi comb. nov. Int. J. Syst. Bacteriol. 45:589-591.
43. Tamura, A., N. Ohashi, H. Urakami, K. Takahashi, and M. Oyanagi. 1985. Analysis of polypeptide composition and antigenic components of Rickettsia tsutsugamushi by polyacrylamide gel electrophoresis and immunoblotting. Infect. Immun. 48:671-675.
44. Traub, R., and C. L. Wisseman, Jr. 1974. The ecology of chigger-borne rickettsiosis (scrub typhus). J. Med. Entomol. 11:237-303.
45. Van Regenmortel, M. H. 1992. Protein antigenicity. Mol. Biol. Rep. 16:133-108.
46. Westhof, E., D. Altschuh, D. Moras, A. C. Bloomer, A. Mondragon, A. Klug, and M. H. Van Regenmortel. 1984. Correlation between segmental mobility and the location of antigenic determinants in proteins. Nature 311:123-106.