Successful lowering of epididymal carnitine by administration of pivalate to rats

International Journal of Andrology

Volumn 20, Issue 3, 1997, Pages 180-188

  Cooper, T G ^a   Wang, X S ^a,c   Yeung, C H ^a   Lewin, L M ^b  

^a INST OF REPRO MED OF THE UNIV   (Germany)

^b TEL AVIV UNIVERSITY   (Israel)

^c BQingdao University   (China)

Author keywords

Carnitine; CASA; Epididymis; Fertility; Pivalate; Sperm motility

Indexed keywords

CARNITINE; PIVALIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; BODY WEIGHT; CONTROLLED STUDY; DRUG TRANSPORT; EPIDIDYMIS; MALE; MALE FERTILITY; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; RAT; SPERMATOZOON MOTILITY; TISSUE LEVEL;

EID: 0030729240     PISSN: 01056263     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2605.1997.00059.x     Document Type: Article

References (25)

1. Binchi, P. B. & Davis, A. T. (1991) Sodium pivalate treatment reduces tissue carnitines and enhances ketosis in rats. Journal of Nutrition, 121, 2029-2036.
2. Brooks, D. E. (1979a) Influence ot androgens on the weights of the male accessory reproductive organs and on the activities of mitochondria] enzymes in the epididymis ot the rat. Journal of Endocrinology, 82, 293-303.
3. Brooks, D. E. (1979b) Biochemical environment of maturing spermatozoa. In: The Spermatozoon (ed. D. W. Fawcett & J. M. Bedford), pp. 23-34. Urban & Schwarzenberg, Baltimore.
4. Brooks, D. E. & McIntosh, J. E. A. (1975) Turnover of carnitine by rat tissues. Biochemical Journal, 148, 439-445.
5. 3H)carnitine by the rat epididymis. Biochemical Biophysical Research Communications, 52, 1354-1360.
6. Brooks, D. E., Hamilton, D. W. & Mallek, A. H. (1974) Carnitine and glycerylphosphorylcholine in the reproductive tract of the rat. Journal of Reproduction and Fertility, 36, 141-146.
7. Cejka, J. & Kithier, K. (1992) Serum carnitine quantification. Clinical Chemistry, 38, 304-305.
8. Cooper, T. G. (1986) The Epididymis, Sperm Maturation and Fertilisation. Springer Verlag, Berlin.
9. Cooper, T. G. (1992) The epididymis as a site of contraceptive attack. In: Spermatogenesis, Fertilization, Contraception, Molecular, Cellular and Endocrine Events in Male Reproduction, 4 (ed. U. Habenicht & E. Nieschlag), pp. 419-460. Springer Verlag, Berlin.
10. Cooper, T. G., Gudermann, T. W. & Yeung, C.-H. (1986) Characteristics of the transport of carnitine into the cauda epididymidis of the rat as ascertained by luminal perfusion in vitro. International Journal of Andrology, 9, 348-358.
11. Diep, Q. N., Bohmer, T. & Schjerven, L. (1992) Reduced carnitine and ketogenesis in the pivampicillin treated rat. Biochemical Pharmacology, 44, 1226-1228.
12. Diep, Q. N., Bohmer, T. & Skrede, S. (1995) Formation of pivaloylcarnitine in heart and brown adipose tissue in the rat. Biochemica et Biophysica Acta, 1243, 65-70.
13. Hinton, B. T. & Hernandez, H. (1985) Selective luminal absorption of L-carnitine from the proximal regions of the rat epididymis. Possible relationship to development of sperm motility. Journal of Andrology, 6, 300-305.
14. Hinton, B. T., Snoswell, A. M. & Setchell, B. P. (1979) The concentration of carnitine in the luminal fluid of the testis and epididymis of the rat and some other mammals. Journal of Reproduction and Fertility, 56, 105-111.
15. Hinton, B. T., Brooks, D. E., Dott, H. M. & Setchell, B. P. (1981) Effects of carnitine and some related compounds on the motility of rat spermatozoa from the caput epididymidis. Journal of Reproduction and Fertility, 61, 59-64.
16. Jeulin, C. & Lewin, L. M. (1996) Role of free L-carnitine and acetyl-L-carnitine in post-gonadal maturation of mammalian spermatozoa. Human Reproduction Update, 2, 87-102.
17. Jeyendran, R. S., van der Ven, H. H., Rosecrans, R., Perez-Pelaez, M., Al-Hasani, S. & Zaneveld, L. J. D. (1989) Chemical constituents of human seminal plasma: relationship to fertility. Andrologia, 21, 423-428.
18. Lane, R. D., Federman, D., Flora, J. L. & Beck, B. L. (1986) Computer-assisted determination of protein concentrations from dye-binding and bicinchoninic acid protein assays performed in microtiter plates. Journal of Immunological Methods, 92, 261-270.
19. Oberländer, G., Yeung, C. H. & Cooper, T. G. (1994) Induction of reversible infertility in male rats by oral ornidazole and its effects on sperm motility and epididymal secretions. Journal of Reproduction and Fertility, 100, 551-559.
20. Setchell, B. P., Hinton, B. T. (1981) The effects on the spermatozoa of changes in the composition of luminal fluid as it passes along the epididymis. In: Epididymis and Fertility: Biology & Pathology, Progress in Reproductive Biology, Vol. 8 (ed. C. Bollack & A. Clavert), pp. 58-66. Karger, Basel.
21. Turner, T., Plesums, J. L. & Cabot, C. L. (1979) Luminal fluid proteins of the male rat reproductive tract. Biology of Reproduction, 21, 883-890.
22. Yeung, C. H., Cooper, T. G. (1994) Study of the role of epididymal α-glucosidase in the fertility of male rats by administration ot the enzyme inhibitor castanospermine. Journal of Reproduction and Fertility, 102, 401-410.
23. Yeung, C. H., Cooper, T. G. & Waites, G. M. H. (1980) Carnitine transport into the perfused epididymis ot the rat: regional differences, stereospecificity, stimulation by choline and effects of other luminal compounds. Biology of Reproduction, 23, 294-304.
24. Yeung, C. H., Oberländer, G. & Cooper, T. G. (1992) Characterization of the motility of rat spermatozoa by computer-aided objective measurement. Journal of Reproduction and Fertility, 96, 427-441.
25. Yeung, C. H., Oberländer, G. & Cooper, T. G. (1995) Effects of the male antifertility agent ornidazole on sperm function in vitro and in the female genital tract. Journal of Reproduction and Fertility, 103, 257-264.