Phenytoin-induced depletion of folate in rats originates in liver and involves a mechanism that does not discriminate folate form

Journal of Nutrition

Volumn 127, Issue 11, 1997, Pages 2231-2238

  Carl, G Franklin ^b   Hudson, Farlyn Z ^a   McGuire Jr , Byron S ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Folate; Liver; Phenytoin; Rats

Indexed keywords

FOLIC ACID; GLUTAMIC ACID DERIVATIVE; METHYLENETETRAHYDROFOLIC ACID; PHENYTOIN; PTERIDINE DERIVATIVE;

ANIMAL TISSUE; ANTICONVULSANT THERAPY; ARTICLE; BILE; BRAIN; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; INTESTINE MUCOSA; LIVER; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; TISSUE LEVEL;

EID: 0030729022     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/127.11.2231     Document Type: Article

References (25)

1. Billings, R. E. (1984) Decreased hepatic 5, 10-methylenetetrahydrofolate reductase activity in mice after chronic phenytoin treatment. Molec. Pharmacol. 25: 459-466.
2. Carl, G. F. & Smith, D. B. (1983) The effect of chronic phenytoin treatment on tissue folate concentrations and on the activities of the methyl synthetic enzymes in the rat. J. Nutr. 113: 2368-2374.
3. Carl, G. F., Hudson, F. Z. & McGuire, B. S. (1995) Rat liver subcellular folate distribution shows association of formyltetrahydropteroylpentaglutamates with mitochondria and methyltetrahydropteroylhexaglutamates with cytoplasm. J. Nutr. 125: 2096-2103.
4. Carl, G. F. & Smith, M. L. (1995) Simultaneous measurement of one-carbon and polyglutamate derivatives of folic acid in rat liver using enzymatic interconversions of folates followed by ternary complex formation with thymidylate synthetase and 5-fluorodeoxyuridylic acid: Standardization of the method. J. Nutr. 125: 1245-1257.
5. Carl, G. F., Smith, M. L., Furman, G. M., Eto, I., Schatz, R. A. & Krumdieck, C. L. (1991) Phenytoin treatment and folate supplementation affect folate concentrations and methylation. J. Nutr. 121: 1214-1221.
6. Cassady, I. A., Budge, M. M., Healy, M. J. & Nixon, P. F. (1980) An inverse relationship of rat liver folate polyglutamate chain length to nutritional folate sufficiency. Biochim. Biophys. Acta 633: 258-268.
7. Chanarin, I. (1979) Effects of anticonvulsant drugs. In: Folic Acid in Neurology, Psychiatry, and Internal Medicine, (Botez, M. I. & Reynolds, E. H., eds.), pp. 75-80. Raven Press, New York, NY.
8. Cichowicz, D. J. & Shane, B. (1987) Mammalian folylpolygammaglutamate synthetase. 2. Substrate specificity and kinetic properties. Biochemistry 26: 513-521.
9. Cook, R. J. & Blair, J. A. (1979) The distribution and chemical nature of radioactive folates in rat liver cells and rat liver mitochondria. Biochem. J. 178: 651-659.
10. Critchfield, J. W., Carl, G. F. & Keen, C. L. (1993) Anticonvulsant-induced changes in tissue manganese, zinc, copper, and iron concentrations in Wistar rats. Metabolism 42: 907-910.
11. Daniel, W. W. (1987) Biostatistics: A Foundation for Analysis in the Health Sciences, 4th ed., pp. 273-366. John Wiley and Sons, New York, NY.
12. Duncan, H. M. & Mackler, B. (1966) Electron transport systems of yeast. III. Preparation and properties of cytochrome oxidase. J. Biol. Chem. 241: 1694-1697.
13. Hoffbrand, A. V. & Necheles, T. F. (1968) Mechanism of folate deficiency in patients receiving phenytoin. Lancet 2: 528-530.
14. Hoppner, K. & Lampi, B. (1989) The effect of phenytoin on folate bioavailability evaluated by rat liver bioassay. Nutr. Rpts. Int. 40: 663-672.
15. Johnson, M. K. & Whittaker, V. P. (1963) Lactate dehydrogenase as a cytoplasmic marker in brain. J. Biochem. 88: 404-409.
16. Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951) Protein measurement with Folin phenol reagent. J. Biol. Chem. 193: 265-275.
17. Pisciotta, A. V. (1982) Phenytoin: Hematological toxicity. In: Antiepileptic Drugs, (Woodbury, D. M., Penry, J. K. & Pippenger, C. E., eds.), 2nd Ed., pp. 257-268. Raven Press, New York, NY.
18. Richardson, R. E., Healy, M. J. & Nixon, P. F. (1979) Folates of rat tissue: Bioassay of tissue folylpolyglutamates and a relationship of liver folylpolyglutamates to nutritional folate deficiency. Biochim. Biophys. Acta 585: 128-133.
19. Rosenberg, I. H., Selhub, J. & Dhar, G. J. (1979) Absorption and malabsorption of folates. In: Folic Acid in Neurology, Psychiatry, and Intenal Medicine, (Botez, M. I. & Reynolds, E. H., eds.), pp. 95-111. Raven Press, New York, NY.
20. Schirch, V. & Strong, W. B. (1989) Interactions of folylpolyglutamates with enzymes in one-carbon metabolism. Arch. Biochem. Biophys. 269: 371-380.
21. Schron, C. M. (1991) pH Modulation of the kinetics of rabbit jejunal, brush-border folate transport. J. Membrane Biol. 120: 192-200.
22. Smith, D. B. & Carl, G. F. (1981) Anticonvulsant-folate interactions. In: Advances in Epileptology: Xllth Epilepsy International Symposium, (Dam, M., Gram, L. & Penry, J. K., eds.), pp. 671-678. Raven Press, New York, NY.
23. Smith, D. B. & Obbens, E.A.M.T. (1979) Antifolate-antiepileptic relationships. In: Folic Acid in Neurology, Psychiatry, and Internal Medicine, (Botez, M. I. & Reynolds, E. H., eds.), pp. 267-283, Raven Press, New York, NY.
24. Varela-Moreiras, G. & Selhub, J. (1992) Long-term folate deficiency alters folate content and distribution differentially in rat tissues. J. Nutr. 122: 986-991.
25. Ward, G. J. & Nixon, P. F. (1990) Modulation of pteroylpolyglutamate concentration and length in response to altered folate nutrition in a comprehensive range of rat tissues. J. Nutr. 120: 476-484.