Expression of CD44 standard and isoforms in human breast cancer xenografts and shedding of soluble forms into serum of nude mice

Anticancer Research

Volumn 17, Issue 5 A, 1997, Pages 3633-3645

  Fichtner, I ^a   Dehmel, A ^a   Naundorf, H ^a   Finke, L H ^b  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b MERCK KGAA   (Germany)

Author keywords

Breast cancer; CD44 isoforms; Metastasis; Nude mice; Xenograft

Indexed keywords

HERMES ANTIGEN; HORMONE RECEPTOR; MEMBRANE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CARCINOMA; FEMALE; GROWTH RATE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SERUM; TUMOR VOLUME; TUMOR XENOGRAFT;

ALTERNATIVE SPLICING; ANIMALS; ANTIGENS, CD44; BREAST NEOPLASMS; CELL DIVISION; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOLOGIC TECHNIQUES; MICE; MICE, NUDE; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; PROGNOSIS; RNA, MESSENGER; RNA, NEOPLASM; SOLUBILITY; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0030728784     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Günthert U: CD44 a multitude of isoforms with diverse functions. CTMI 184: 47-63, 1993.
2. Ruiz P, Schwarzler C, Gunthert U: CD44 isoforms during differentiation and development. Bioessays 17: 17-24, 1993.
3. Gunthert U, Stauder R, Mayer B, Terpe HJ, Finke L, Friedrichs K: Are CD44 variant isoforms involved in human tumour progression. Cancer Surv 24: 9-42, 1995.
4. Zoller M: CD44: physiological expression of distinct isoforms as evidence for organspecific metastasis formation. J Mol Med 73: 425-438, 1995.
5. Sleeman J, Moll J, Sherman L, Dall P, Pals ST, Ponta H, Herrlich P: The role of CD44 splice variants in human metastastic cancer. Ciba Found Symp 189: 142-151, 1995.
6. Dammrich J, Vollmers HP, Heider KH, Muller-Hermelin HK: Importance of different CD44v6 expression in human gastric intestinal and diffuse type cancers for metastatic lymphogenic spreading. J Mol Med 73: 395-401, 1995.
7. Rodriguez C, Monges G, Rouanet P, Dutrillaux B, Lefrancois D, Theillet C: CD44 expression patterns in breast and colon tumors: a PCR-based study of splice variants. Int J Cancer 64: 347-354, 1995.
8. Herrlich P, Pals S, Ponta H: CD44 in colon cancer. Eur J Cancer 31A: 1110-1112, 1995.
9. Wielenga VJ, Heider KH, Offerhaus GJA, Adolf GR, van den Berg FM, Ponta H, Herrlich P, Pals ST: Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression. Cancer Res 53: 4754-4756, 1943.
10. Heider KH, Dammrich J, Skroch-Angel P, Muller-Hermelink HK, Vollmers HP, Herrlich P, Ponta H: Differential expression of CD44 splice variants in intestinal- and diffuse-type human gastric carcinomas and normal gastric mucosa. Cancer Res 53: 4197-4203, 1993.
11. Mulder JWR, Wielenga VJM, Polak MM, van den Berg FM, Adolf GR, Herrlich P, Pals ST, Offerhaus GJA: Expression of mutant p53 and CD44 variant proteins in colorectal tumorigenesis. Gut 36: 76-80, 1995.
12. Finke LH, Terpe HJ, Zorb C, Haensch W, Schlag PM: Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins. Lancet 345: 583, 1995.
13. Friedrichs K, Franke F, Lisboa BW, Kugler G, Gille I, Terpe HJ, Holzel F, Maass H, Gunthert U: CD44 isoforms correlate with cellular differentiation but not with prognosis in human breast cancer. Cancer Res 55: 5424-5433, 1995.
14. Kaufmann M, Heider KH, Sinn HP, von Minckwitz G, Ponta H, Herrlich P: CD44 variant exon epitopes in primary breast cancer and length of survival. Lancet 345: 615-619, 1995.
15. Iida N, Bourguignon LYW: New CD44 splice variants associated with human breast cancers. J Cell Physiol 162: 127-133, 1995.
16. Guo YJ, Liu G, Wang X, Jin D, Wu M, Ma J, Sy MS: Potential use of soluble CD44 in serum as indicator of tumor burden and metastasis in patients with gastric or colon cancer. Cancer Res 54: 422-426, 1994.
17. Stauder R, Eisterer W, Thaler J, Gunthert U: CD44 variant isoforms in non-Hodgkin's lymphoma: A new independent prognostic factor. Blood 85: 2885-2899, 1995.
18. Naundorf H, Fichtner I, Elbe B, Saul GJ, Haensch W, Zschiesche W, Reineke S: Establishment and characteristics of two new human mammary carcinoma lines in nude mice with special reference to the estradiol receptor status and the importance of stroma for in vivo and in vitro growth. Breast Cancer Res Treat 32: 187-196, 1994.
19. 18a Naundorf H, Fichtner I, Saul GJ, Haensch W, Buttner B: Establishment and characteristics of two new human mammary carcinoma lines serially transplantable in nude mice. J Cancer Res Clin Oncol 119: 652-656, 1993.
20. Terpe HJ, Stark H, Prehm P, Gunthert U: CD44 variant isoforms are preferentially expressed in basal epithelia of non-malignant human fetal and adult tissues. Histochemistry 101: 79-89, 1994.
21. Fox BS, Gatter KC, Jackson DG, Screaton GR, Bell MV, Bell JI, Harris AL, Simmons D, Fawcett J: CD44 and cancer screening. Lancet 342: 548-549, 1993.
22. Woodman A, Sugiyama M, Yoshida K, Sugino T, Gorham H, Bolodeoku J, Goodison S, Matsumura Y, Tarin D: Disorganized CD44 gene transcription and translation in colon, breast and bladder cancer: Clinical implications. Proc. Am Assoc Cancer Res 37: 87, 1996.
23. Watson PH, Snell LS: CD44 expression and estrogen receptor status in breast cancer. Proc Am Assoc Cancer Res 35: 83, 1994.
24. Fu X, Le P, Hoffman RM: A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer. Anticancer Res 13: 901-904, 1993.
25. Sliutz G, Tempter C, Winkler S, Kohlberger P, Reinthaller A, Kainz C: Immunohistochemical and sereological evaluation of CD44 splice variants in human ovarian cancer. Br J Cancer 72: 1494-1497, 1995.
26. Price JA, Polyzos A, Zhang RD, Daniels LM: Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice. Cancer Res 50: 171-172, 1990.
27. Yoshida K, Bolodeoku J, Sugino T, Goodison S, Matsumura Y, Warren BF, Toge T, Tahara E, Tarin D: Abnormal retention of intron 9 in CD44 gene transcripts in human gastrointestinal tumors. Cancer Res 55: 4273-4277, 1995.
28. Kerbel RS, Kobayashi H, Graham CH: Intrinsic or acquired drug resistance and metastasis: Are they linked phenotypes? J Cell Biochem 56: 37-47, 1994.
29. Sinn HP, Heider KH, Skroch-Angel P, Minckwitz Gv, Kaufmann M, Herrlich P, Ponta H: Human mammary carcinomas express homologues of rat metastasis-associated variants of CD44. Breast Cancer Res Treatm 36: 307-313, 1995.
30. Stickeler E, Runnebaum IB, Mobus VJ, Kreienberg R: Expression of CD44 variant isoforms v5, v6 and v7 in 43 human ovarian cancer cell lines. Proc Am Assoc Cancer Res 37: 63, 1996.
31. Hong RL, Lee WJ, Shun CT, Chu JS, Chen YC: Expression of CD44 and its clinical implication in diffuse-type and intestinal-type gastric adenocarcinomas. Oncology 52: 334-339, 1995.
32. Ichikawa W: Positive relationship between expression of CD44 and hepatic metastases in colorectal cancer. Pathobiology 62: 172-179, 1994.
33. Jackson PA, Green MA, Pouli A, Hubbard R, Marks CG, Cook MG: Relation between stage, grade, proliferation and expression of p53 and CD44 in adenomas and carcinomas of the colorectum. J Clin Pathol 48: 1098-1101, 1995.
34. Miiwa T, Watanabe A, Yamada Y, Shino Y, Yamada T, Yamashita J, Matsuda M, Nakano H: Progression in gastric carcinoma relative to the ratio of CD44 epithelial variant transkript to CD44 hematopoietic variant transkript. Cancer 77: 25-29, 1996.
35. Suh SI, Back WK, Püark JW, Bae OS, Suh MH, Choe BK: Identification of CD44 splice variant in Korean colorectal cancers and cell lines. J Jorean Med Sci 10: 169-175, 1995.
36. Tanabe KK, Ellis LM, Saya H: Expression of CD44R1 adhesion molecule in colon carcinomas and metastases. Lancet 341: 725-726, 1993.
37. Kim H, Yang XL, Rosada C, Hamilton SR, August JT: CD44 expression in colorectal adenomas is an early event occuring prior to K-ras and p53 gene mutation. Arch Biochem Biophys 310: 504-507, 1994.
38. Mayer B, Jauch KW, Gunthert U, Figdor CG, Schildberg FW, Funke I, Johnson J: Denovo expression of CD44 and survival in gastric cancer. Lancet 342: 1019-1022, 1993.
39. Gansauge F, Gansauge S, Zobywalski A, Scharnweber C, Link KH, Nussler AK, Beger HG: Differential expression of CD44 splice variants in human pancreatic adenocarcinoma and in normal pancreas. Cancer Res 55: 5499-5503, 1995.
40. Rall CJN, Rustgi AK: CD44 isoform expression in primary and metastatic pancreatic adenocarcinoma. Cancer Res 55: 1831-1835, 1995.
41. Kainz C, Kohlberger P, Tempfer C, Sliutz G, Gitsch G, Reinthaller A, Breitenecker G: Prognostic value of CD44 splice variants in human stage III cervical cancer. Eur J Cancer 31A: 1706-1709, 1995.
42. Matsumura Y, Sugiyama M, Matsumura S, Hayle AJ, Robinson P, Smith JC, Tarin D: Unusual retention of introns in CD44 gene transcripts in bladder cancer provides new diagnostic and clinical oncological opportunities. J Pathol 11: 177-120, 1995.
43. Kan M, Aki M, Akiyama K, Naruo S, Kanayama H, Kagawa S: High-level expression of the CD44 variant sharing exon v10 in renal cancer. Jpn J Cancer Res 86: 847-853, 1995.
44. Terpe HJ, Storkel S, Zimmer U, Anquez V, Fischer C, Pantel K, Gunthert U: Expression of CD44 isoforms in renal cell tumors: positive correlation to tumor progression. Am J Pathol 148: 453-463, 1996.
45. Kuppner MC, van Meir E, Gauthier T, Hamou MF, de Tribolet N: Differential expression of the CD44 molecule in human brain tumours. Int J Cancer 50: 572-577, 1992.
46. Resnick NM, Resnick DK, Welch WC, Cooper DL: Regulation of CD44 gene expression in tumors of the central nervous system. Proc Am Assoc Cancer Res 37: 80, 1996.
47. Li H, Hamou MF, de Tribolet N, Jaufeerally R, Hofmann M, Diserens AC, van Meir EG: Variant CD44 adhesion molelcules are expressed in human brain metastases but not in glioblastomas. Cancer Res 53: 5345-5349, 1993.
48. Combaret V, Lasset C, Frappaz D, Bouvier R, Thiesse P, Rebillard AC, Philip T, Favrot MC: Evaluation of CD44 prognostic value in neuroblastoma: comparison with the other prognostic factors. Eur J Cancer 31: 545-549, 1995.
49. Combaret V, Gross N, Lasset C, Frappaz D, Peruisseau G, Philip T, Beck D, Favrot MC: Clinical relevance of CD44 cell-surface expression and N-myc gene amplification in a multicentric analysis of 121 pediatric neuroblastomas. J Clin Oncol 14: 25-34, 1996.
50. Korabiowska M, Brinck U, Honig J, Mora O, Bartkowski S, Schauer A: CD44: a marker of metastases of head and neck melanomas. In Vivo 9: 253-256, 1995.
51. Joensuu H, Ristamaki R, Klemi PJ, Jalkanen S: Lymphocyte homing receptor (CD44) expression is associated with poor prognosis in gastrointestinal lymphoma. Br J Cancer 68: 428-432, 1993.
52. Koopman G, Heider KH, Horst E, Adolf GR, van den Berg F, Ponta H, Herrlich P, Pals ST: Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis - associated variant of CD44. J Exp Med 177: 897-904, 1993.