Local drug delivery and tissue engineering regulate vascular injury

Current Pharmaceutical Design

Volumn 3, Issue 6, 1997, Pages 529-544

  Nugent, Helen M ^a   Edelman, Elazer R ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPEPTIN; ANTICOAGULANT AGENT; ANTISENSE OLIGONUCLEOTIDE; BASIC FIBROBLAST GROWTH FACTOR; CALCIUM CHANNEL BLOCKING AGENT; COLCHICINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HEPARIN; HIRUDIN; LOW MOLECULAR WEIGHT HEPARIN; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEINASE INHIBITOR; STEROID;

ANGINA PECTORIS; ANIMAL MODEL; ARTERIOSCLEROSIS; ARTERY INJURY; BALLOON DILATATION; BLEEDING; BLOOD VESSEL INJURY; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CELL TRANSPLANTATION; CONTROLLED STUDY; CYTOCHEMISTRY; DRUG DELIVERY SYSTEM; ENDOTHELIUM CELL; HEART INFARCTION; HUMAN; IMPLANT; INTRAVENOUS CATHETER; INTRAVENOUS DRUG ADMINISTRATION; IONTOPHORESIS; METAL IMPLANTATION; NONHUMAN; PATIENT COMPLIANCE; PRIORITY JOURNAL; RAT; RESTENOSIS; REVIEW; SMOOTH MUSCLE FIBER; STENT; SUBCUTANEOUS DRUG ADMINISTRATION; SUSTAINED DRUG RELEASE; VASCULAR DISEASE; VASCULAR ENDOTHELIUM;

EID: 0030728310     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (148)

1. Ip JH, Fuster V, Badimon L, Badimon J, Taubman MB, and Chesebro, J.H. (1990) Syndromes of accelerated atherosclerosis: Role of vascular injury and smooth muscle proliferation. JACC 15, 1667-1687.
2. McBride, W., Lange, R.A., and Hillis, L.D. (1988) Restenosis after successful coronary angioplasty: Pathophysiology and prevention. New. Engl J. Med. 318, 1734-1738.
3. Liu, M.W , Roubin, G.S., and Spencer, B.K (1989) Restenosis after coronary angioplasty. Potential biologic determinants and role of intimal hyperplasia. Circulation 79, 1374-1387.
4. Fanelli, C.R., and Aronoff, R. (1990) Restenosis following coronary angioplasty. Am. Heart J. 119, 357-366.
5. O'Keefe, J. H., and Hartzler, G.O. (1989) Restenosis after coronary angioplasty. I. Inv. Car. 1, 109-122.
6. Davies, M.G., and Hagen, P.O. (1993) Vascular endothelium: A new horizon. Annals Surgery 218, 593-609.
7. Rubanyi, G.M. (1993) The role of endothelium in cardiovascular homeostasis and diseases. J Cardiovascular Pharmacology 22, S1-514.
8. Furchgott, R.F., and Zawadzki, J.V. (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetycholine. Nature 288, 373-376.
9. Busse, R.G., Trogisch, G , and Bassenge, E (1985) The role of the endothelium in the control of vessel tone. Basic Res. Cardiol. 80, 475-490.
10. Autio, I., Maol, R.U., Kallioniemi, O.P. and Nikkari, T. (1989) Cultured bovine aortic endothelial cells secrete factor(s) chemotactic for aortic smooth muscle cells. Artery 16,72.
11. Sheppard, B.L., and French, J.E. (1971) Platelet adhesion m the rabbit abdominal aorta following the removal of the endothelium: A scanning and transmission electron microscopical study Proc. R. Soc. Lond. (Biol) 176, 427.
12. Doherty, D.E., Haslett, C., Tonnesen, M.G., and Henson, P.M. (1987) Human monocyte adherence: a primary effect of chemotactic factors on the monocyte to stimulate adherence to human endothelium. J. Immunol 138, 1762-1771.
13. Cybulsky, M I., and Gimbrone, M. A. (1991) Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 251, 788-791.
14. Casscells, W. (1992) Migration of smooth muscle and endothelial cells: critical events in restenosis Circulation 86, 723-729.
15. Gee, A.P., and Minta, J.O. (1984) Migration of porcine endothelial and smooth muscle cells in response to platelet associated factors. Am. J. Hematol. 17, 29-38.
16. Castellot, J.J., Addonizio, M.L., Rosenberg, R.D., and Karnovsky, M.J. (1981) Cultured endothelial cells produce a heparin-hke inhibition of smooth muscle growth. J. Cell. Biol 90, 372-379.
17. Clowes, A.W., Reidy, M A., and Clowes, M. M. (1983) Kinetics of cellular proliferation after arterial injury I: Smooth muscle growth in the absence of endothelium. Lab. Invest. 49, 327-333.
18. Nugent, M.A., Karnovsky, M.J., and Edelman, E.R. (1993) Vascular heparan sulfate inhibits bFGF binding and smooth muscle cell mitogenesis in a coupled fashion. Circ. Res. 73, 1051-1060
19. Ross, R. (1986) The pathogenesis of atherosclerosis-an update. N. Eng. J. Med. 314, 488-500.
20. Edelman, E.R., Nugent, M.A., Smith, L T., and Karnovsky, M.J (1992) Basic fibroblast growth factor enhances the coupling of intimai hyperplasia and proliferation of vasa vasorum in injured rat arteries. J. Clin. Invest. 89, 465-473.
21. Clowes, A.W. and Karnovsky, M J. (1977) Suppression by heparin of smooth muscle cell proliferation in injured arteries. Nature 265, 625-6.
22. Clowes, A.W. and Karnovsky, M J. (1977) Failure of certain antiplatelet drugs to affect myointimal thickening following arterial endothelial injury in the rat. Lab. Invest. 36, 452-64.
23. Bjornsson, T.D., Dryjski, M., Tluczek, J. et al. (1991) Acidic fibroblast growth factor promotes vascular repair. Proc. Natl. Acad. Sci. USA 88, 8651-5.
24. Epstein, S.E., Siegall, C.B., Biro, S. et al. (1991) Cytotoxic effects of a recombinant chimeric toxin on rapidly proliferating vascular smooth muscle cells. Circulation 84, 778-87.
25. Ferns, G, Reidy, M. and Ross, R (1990) Vascular effects of cyclosporine A in vivo and in vitro. Am. J. Pathol. 137, 403-13
26. Hoberg, E., Schwartz, F., Schomig, A. et al. (1990) Prevention of restenosis by verapamil. The verapamil angioplasty study (VAS). Circulation 82, III-428.
27. Liu, M.W., Roubin, G.S., Robinson, K.A. et al (1990) Trapadil in preventing restenosis after balloon angioplasty in the atherosclerotic rabbit. Circulation 81, 1089-93.
28. Okamoto, S., Inden, M., Setuda, M. et al. (1990) Trapadil (triazolopyrimidine), a platelet derived growth factor (PDGF) antagonist in preventing restenosis after percutaneous coronary angioplasty Circulation 82, III-428.
29. Ellis, S.G., Roubin, G.S., Wilentz, J. et al. (1987) Results of a randomized trial of heparin and aspirin versus aspirin alone for prevention of abrupt closure and restenosis after angioplasty. (Abstract) Circulation 76, 213.
30. Hettleman, B.D., Aplin, R.L., Sullivan, P.R. et al. (1990) Three days of heparin pretreatment reduces major complications of coronary angioplasty in patients with unstable angina. J. Am. Coll. Cardiol. 15, 154A.
31. Pepin, C J., Hirshfeld, J.W., MacDonald, R.G. et al (1990) A controlled trial of corticosteroids to prevent restenosis after coronary angioplasty. Circulation 81, 1753-61.
32. Ellis, S.G., Roubin, G S., Wilentz, J. et al. (1989) Effect of 18- to 24-hour heparin administration for prevention of restenosis after uncomplicated coronary angioplasty. Am Heart J. 117, 777-82.
33. Lehmann, K.G., Doria, R.J., Feuer, J.M , et al. (1991) Paradoxical increase in restenosis rate with chronic heparin use: final results of a randomized trial. J. Am. Coll. Cardiol. 17, 181A (Abstract).
34. Leung, W-H , Kaplan, A.V , Grant, G W. et al. (1990) Local delivery of antithrombin agent reduces platelet deposition at the site of balloon angioplasty. Circulation 82, III-428 (Abstract).
35. Muller, D.W.M., Topol, E.J., Abrams, G et al. (1990) Intramural methotrexate therapy for the prevention of intimai proliferation following porcine carotid balloon angioplasty. Circulation 82, III-429 (Abstract).
36. Whitworth, H.B., Roubin, G.S., Hollman, J. et al. (1986) Effect of nifedipine in recurrent stenosis after percutaneous coronary angioplasty. J. Am Coll. Cardiol. 8, 1271-6.
37. Laskey, M.A , Deutsch, E., Hirshfeld, J.W. et al. (1990) Influence of heparin therapy on percutaneous transluminal coronary angioplasty outcomes in patients with coronary arterial thrombus. Am. J. Cardiol. 65, 179-82
38. Powell, J.S., Clozel, J-P., Muller, R.K.M. et al. (1989) Inhibitions of angiotensin- converting enzyme prevent myointimal proliferation after vascular injury. Science 245, 187-9.
39. Gimple, L.W., Owen, R.W., Lodge, V.P. et al. (1992) Reduction in angioplasty restenosis in rabbits by chronic subcutaneous heparin with or without intramural heparin delivery. Circulation 82, III-338 (Abstract).
40. Handley, D.A., van Valen, R.G., Melden, M.K. and Saunders, R N. (1986) Suppression of rat carotid lesion development by the calcium channel blocker PN-200-110. Am. J Pathol. 124, 88-93.
41. Jackson, C.L., Bush, R.C. and Bowyer, D.E. (1988) Inhibitory effect of calcium antagonists on balloon catheter-induced arterial smooth muscle cell proliferation and lesion size. Atherosclerosis 69, 115-22.
42. Lundergan, C.F , Foegh, M.L. and Ramwell, P.W. (1991) Peptide inhibition of myointimal proliferation by angiopeptin, a somatosatin analogue. J. Am. Coll. Cardiol. 17, 132B-136B.
43. Faxon, D., Spiro, T., Monor, S. et al. (1992) Enoxaprin, a low molecular weight heparin, in the prevention of restenosis after angioplasty: the results of a double blind randomized trial. J. Am Coll. Cardiol. 19, 258A (Abstract).
44. MERCATOR (1992) Does the new angiotensin convening enzyme inhibitor cilazapril prevent restenosis after percutaneous transluminal coronary angioplasty? Circulation 86, 100-10.
45. Henry, P.D. and Bentley, K.I. (1981) Suppression of atherogenesis in cholesterol-fed rabbits treated with nifedipine. J. Clin. Invest. 68, 1366-9.
46. El-Sanadiki, M.N., Cross, S.S., Murray, J.J et al. (1990) Reduction of intimal hyperplasia and enhanced reactivity of experimental vein bypass grafts with verapamil treatment. Ann. Surg. 212, 87-96.
47. Castelott, J.J., Cochran, D.L. and Karnovsky, M.J. (1985) Effect of heparin on vascular smooth muscle cells. I. Cell Metabolism J. Cell Physiol. 124, 21-8.
48. Clowes, A.W. and Clowes, M M. (1986) Kinetics of cellular proliferation after arterial injury. IV. Heparin inhibits rat smooth muscle mitogenesis and migration. Circ. Res, 58, 839-45. .
49. Clowes, A.W., Clowes, M.M., and Reidy, M.A. (1986) Kinetics of cellular proliferation after arterial injury. III. Endothelial and smooth muscle growth in chronically denuded vessels Lab. Invest. 54, 295-303. .
50. Clowes, A.W., Clowes, M.M., Fingerle, J. and Reidy, M.A. (1989) Kinetics of cellular proliferation after arterial injury. V Role of acute distension in the induction of smooth muscle proliferation. Lab Invest. 60, 360-4. .
51. Clowes, A.W. and Clowes, M.M. (1985) Kinetics of cellular proliferation after arterial injury. II. Inhibition of smooth muscle growth by heparin. Lab Invest. 52, 611-16.
52. Castellot, J.J., Wright, T.C. and Karnovsky, M.J. (1987) Regulation of vascular smooth muscle cell growth by heparin and heparan sulfate. Semin. Thromb. Hemost. 13, 489-503.
53. Pukac, L A., Hirsch, G.M., Lormeau, J-C. et al. (1991) Antiproliferative effects of novel nonanticoagulant heparin derivatives on vascular smooth muscle cells in vitro and in vivo. Am. J. Pathol. 139, 11501-9 .
54. Hirsch, G. and Karnovsky, M. (1991) Heparin inhibits neointimal proliferation in rat arterio-venous interposition grafts. Am. J. Pathol. 139, 581-7.
55. Edelman, E.R., Pukac, L. and Karnovsky, M.J. (1993) Protamine and protamine insulins exacerbate vascular injury. J. Clin. Invest. 91, 2308-13.
56. Edelman, E.R., Adams, D.A. and Karnovsky, M.J. (1990) Effect of controlled adventitial heparin delivery on smooth muscle cell proliferation following endothelial injury. Proc Natl. Acad. Sci. USA 87, 3773-7.
57. Rogers, C., Karnovsky, M.J. and Edelman, E.R. (1993) Inhibition of experimental neointimal hyperplasia and thrombosis depends on the type of vascular injury and the site of drug administration. Circulation 88, 1215-21.
58. Wolinsky, H. and Thung, S N. (1990) Use of a perforated balloon catheter to deliver concentrated heparin into the wall of the normal canine artery. J. Am. Coll. Cardiol. 15, 475-81.
59. Fram, D.B., Aretz, T., Azrin, M.A. et al. (1994) Localized intramural drug delivery during balloon angioplasty using hydrogel-coated balloons and pressure-augmented diffusion. J. Am. Coll. Cardiol. 23, 1570-7.
60. Riessen, R., Rahimizadeh, H , Blessing, E. et al. (1993) Arterial gene transfer using pure DNA applied directly to a hydrogel coated angioplasty balloon. Hum. Gene Ther. 4, 749-58.
61. Fernandez-Oritz, A., Meyer, B.J., Mailhac, A. et al. (1994) A new approach for local intravascular drug delivery. Circulation 89, 1518-22.
62. Hong, M.K., Bhatti, T., Matthews, B.J. et al. (1993) The effect of porous infusion balloon delivered angiopeptin on myointimal hyperplasia after balloon injury in the rabbit. Circulation 88, 638-48.
63. Franklin, S.M., Kalan, J M., Currier, J.W. et al. (1992) Effects of local delivery of doxorubicin or saline on restenosis following angioplasty in atherosclerotic rabbits Circulation 86, I-52.
64. Wilensky, R.L., Gradus-Pizlo, I , March, K.L. et al. (1992) Efficacy of local intramural injection of colchicine in reducing restenosis following angioplasty in the atherosclerotic rabbit model. Circulation 86, I-52.
65. Nunes, G L , King, S.B., Hanson, S.R et al. (1992) Hydrogel-coated PTCA balloon catheter delivery of an antithrombin inhibits platelet dependent thrombosis. Circulation 86, I-360.
66. Levine, M.J. Leonard, B.M., Burke, J.A. et al (1990) Clinical and angiographic results of balloon-expandable intracoronary stents in right coronary arteries. J. Am. Coll. Cardiol. 16, 332-9.
67. Schatz, R.A., Palmaz, J.C., Tio, F.O. et al. (1987) Balloon-expandable intracoronary stents in the adult dog. Circulation 76, 450-7.
68. Schatz, R.A., Baim, D.S., Leon, M. et al. (1991) Clinical experience with the Palmaz- Schatz coronary stent: initial results of a multicenter study. Circulation 83, 148-61.
69. Sigwart, U., Puel, J., Mirkovitch, V. et al. (1987) Intravascular stents to prevent occlusion and restenosis after transluminal angioplasty. N Engl J. Med. 316, 701-6.
70. Serruys, P.W., Strauss, B.H., Beatt, K.J et al. (1991) Angiographic follow-up of a self- expanding coronary-artery stent. N. Engl. J. Med. 324, 13-17.
71. Sigwart, U., Urban, P., Golf, S. et al. (1988) Emergency stenting for acute occlusion after coronary balloon angioplasty. Circulation 78, 1121-7.
72. Urban, P., Sigwart, U., Golf, S. et al. (1989) Intravascular stenting for stenosis of aortocoronary venous bypass grafts. J Am. Coll Cardiol. 13, 1085-91.
73. Sheth, S., Park, K.D., Dev, V. et al. (1994) Prevention of stent subacute thrombosis by segmented polyurethaneurea-polyethylene oxide-heparin coating in the rabbit carotid. J. Am. Coll. Cardiol. 23, 187A.
74. Cox, D A, Anderson, P.G., Roubin, G S. et al. (1991) Local delivery of heparin and methotrexate fails to inhibit in vivo smooth muscle proliferation. Circulation 84, II-71 (Abstract).
75. Cox, D.A., Anderson, P.G., Roubin, G S. et al (1992) Effect of local delivery of heparin and methotrexate on neointimal proliferation in stented porcine coronary arteries. Cor. Art. Dis. 3, 237-48.
76. Langer, R , Brown, L , Leong, K. et al. (1985) Controlled release and magnetically modulated systems for macromolecular drugs. Ann. NY Acad Sci. 446, 1-13.
77. Langer, R., Brown, L. and Edelman, E R. (1985) Controlled release and magnetically modulated release systems for macromolecules. Methods Enzymol. 112, 399-422.
78. Langer, R. (1990) New methods of drug delivery. Science 249, 1527-33.
79. Brown, L., Munoz, C., Seimer, L. et al. (1986) Controlled release of insulin from polymer matrices: control of diabetes in rats. Diabetes 35, 692-7.
80. Murray, J., Brown, L., Klagsbrun, M. and Langer, R. (1983) A micro sustained release system for epidermal growth factor. In Vitro 19, 743-8.
81. Edelman, E.R., Mathiowitz, E., Langer, R. and Klagsbrun, M. (1991) Controlled and modulated release of basic fibroblast growth factor. Biomaterials 12, 619-26.
82. Langer, R., Brem, H., Falterman, K. et al. (1976) Isolation of a cartilage factor that inhibits tumor neovascularization. Science 192, 70-2.
83. Langer, R. and Murray, J.B. (1983) Angiogenesis inhibitors and their delivery systems. Appl. Biochem. Biotech. 8, 9-24.
84. Levy, R.J., Wolfrum, J., Schoen, F.J. et al. (1985) Inhibition of calcification of bioprosthetic heart valves by local controlled-release diphosphonate. Science 228, 190-2.
85. Preis, I. and Langer, R. (1979) A single step immunization by sustained antigen release J. Immunol. Meth. 28, 193-7.
86. Edelman, E.R., Adams, D.A. and Karnovsky, M.J. (1990) Effect of controlled adventitial heparin delivery on smooth muscle cell proliferation following endothelial injury. Proc. Natl. Acad. Sci. USA 87, 3773-7.
87. Edelman, E.R and Karnovsky, M.J. (1994) Contrasting effects of the intermittent and continuous administration of heparin in experimental restenosis. Circulation 89, 770-6.
88. Edelman, E.R , Nugent, M.A. and Karnovsky, M.J. (1993) Perivascular and intravenous administration of basic fibroblast growth factor: vascular and solid organ deposition. Proc. Natl. Acad. Sci. USA 90, 1513-7.
89. Rogers, C., Karnovsky, M.J. and Edelman, E.R. (1993) Inhibition of experimental neointimal hyperplasia and thrombosis depends on the type of vascular injury and the site of drug administration. Circulation 88, 1215-21.
90. Rogers, C. and Edelman, E.R. (1995) Endovascular stent design dictates experimental restenosis and thrombosis. Circulation 91, 2995-3001. .
91. Nathan, A., Katada, M. and Edelman, E.R. (1994) Perivascular heparin delivery using biodegradable polymers Polym. Mater. Sci. Eng 70, 320-1.
92. Simons, M. and Rosenberg, R.D. (1992) Antisense nonmuscle myosin heavy chain and c-myb oligonucleotides suppress smooth muscle cell proliferation in vitro. Circ. Res. 70, 835-43.
93. Edelman, E.R., Simons, M., Sirois, M.G., Rosenberg, R.D. (1995) c-myc in vasculoproliferative disease. Circ. Res. 76, 176-82.
94. Shi, Y., Fard., A., Galeo, A. et al. (1994) Transcatheter delivery of c-myc antisense oligomers reduces neointimal formation in a porcine model of coronary artery balloon injury. Circulation 90, 944-51.
95. Abe, J-i., Zhou, W., Taguchi, J-i. et al. (1994) Suppression of neointimal smooth muscle cell accumulation in vivo by antisense cdc2 and cdk2 oligonucleotides in rat carotid artery. Biochem. Biophy Res Comm 198, 16-24.
96. Morishita, R., Gibbons, G.H., EllIison, K.E. et al (1993) Single intramural delivery of antisense cdc2 kinase and proliferaring-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc. Natl. Acad Sci. USA 90, 8474-8478.
97. Koo, E.W.Y. and Edelman, E.R. (1996) Cellular effects of antisense c-myc oligonucleotides are delivery dependent. Drug Delivery 3, 149-1154
98. Baird, A. and Ling, N. (1987) Fibroblast growth factors are present in the extracellular matrix produced by endothelial cells in vitro: implications for a role of heparinase-like enzymes in the neovascular response Biochem. Biophys. Res. Commun. 142, 428-35.
99. Vlodavsky, I., Folkman, J., Sullivan, R. et al (1987) Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into the subendothelial extracellular matrix. Proc. Natl. Acad. Sci. USA 84, 2292-6.
100. Folkman, J., Klagsbrun, M., Sasse, J. et al. (1988) A heparin-binding angiogenic protein- basic fibroblast growth factor - is stored within basement membrane. Am. J. Pathol. 130, 393-400.
101. Bashkin, P., Doctrow, S., Klagsbrun, M. et al. (1989) Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules. Biochemistry 28, 17337-43.
102. Nugent, M.A. and Edelman, E.R. (1992) Kinetics of basic fibroblast growth factor binding to its receptor and heparan sulfate proteoglycan: a mechanism for cooperativity. Biochemistry 31, 8876-83.
103. Garasic, J., Rogers, C. and Edelman, E.R. (1997) Stent design and the biologic response, in Frontiers in Interventional Cardiology, Beyer, Keren, Serruys and Leon, Editors. Martin Dunitz, Ltd.:London.
104. Bolling, S.F., Lin, H., Annesley, T.M. et al. (1991) Local cyclosporin immunotherapy of heart transplants in rats enhances survival. J. Heart Lung Transplant. 10, 577-83.
105. Villa, A.E., Guzman, L.A., Chen, W. et al. (1994) Local delivery of dexamethasone for prevention of neointimal proliferation in a rat model of balloon angioplasty. J Clin. Invest. 93, 1243-9.
106. Muller, D.W , Golomb, G., Gordon, D. et al. (1992) Local adventitial hirulog delivery for the prevention of stent thrombosis and neointimal thickening Circulation 86, 1-381 (Abstract).
107. Nabel, E.G, Plautz, G., Boyce, F. M. et al. (1989) Recombinant gene expression in vivo within endothelial cells of the arterial wall. Science 244, 1342-1344.
108. Messina, L.M., Podrazik, R.M., Whitehill, T.A. et al. (1992) Adhesion and incorporation of lacZ-transduced endothelial cells into the intact capillary wall in the rat. Proc. Natl. Acad. Sci. USA 89, 12018-12022.
109. Conte, M.S, Birinyi, L , Miyata, T. et al. (1994) Efficient repopulation of denuded rabbit arteries with autologous genetically modified endothelial cells. Circulation 23, 2161-69.
110. Wilson, J.W., Birinyi, L.K., Salomon, R.N. et al. (1989) Implantation of vascular grafts lined with genetically modified endothelial cells. Science 244, 1344-1346.
111. Zwiebel, J.A., Freeman, S.M., Kantoff, P.W. et al. (1989) High-level recombinant gene expression in rabbit endothelial cells transduced by retroviral vectors. Science 243, 220-2
112. Dichek, D.A., Neville, R.F., Zwiebel, J.A. et al. (1989) Seeding of intravascular stents with genetically engineered endothelial cells. Circulation 80, 1347-1353.
113. Herring, M , Gardner, A., Glover, J. (1978) A single staged technique for seeding vascular grafts with autologous endothelium. Surg. 84, 498-504.
114. van Wachem, P.B., Beugeling, T., Feijen, J. et al. (1985) Interaction of cultured human endothelial cells with polymeric surfaces of different wettabilities. Biomaterials 6, 403-408.
115. van Wachem, P.B., Hogt, A H., Beugeling, T et al (1987) Adhesion of cultured human endothelial cells onto methacrylate polymers with varying surface wettability and charge Biomaterials 8, 323-328.
116. McAuslan, B.R. and Johnson, G. (1987) Cell responses to biomaterials I: Adhesion and growth of vascular endothelial cells on poly(hydroxyethyl methacrylate) following surface modification by hydrolytic etching. J. Biomed. Mat Res. 21, 921-935.
117. Absolom, D.R., Hawthorn, L.A. and Chang, G. (1988) Endothelialization of polymer surfaces. J. Biomed. Mat. Res 22, 271-285.
118. McAuslan, B.R., Johnson, G., Hannan, G.N. et al. (1988) Cell responses to biomateriats II: Endothelial cell adhesion and growth on perfluorosulfonic acid. J. Biomed. Mat. Res. 22, 963-976.
119. Steele, H.G., Johnson, G., Norris, W.D. et al. (1991) Adhesion and growth of cultured human endothelial cells on perfluorosulphonate: role of vitronectin and fibronectin in cell attachment. Biomaterials 12, 531-539.
120. Wigod, M.D. and Klitzman, B. (1993) Quantification of in vitro endothelial cell adhesion to vascular graft material. J. Biomed. Mat. Res. 27, 1057-1062.
121. Brunstedt, M.R., Ziats, N.P., Rose-Caprara, V. et al. (1993) Attachment and proliferation of bovine aortic endothelial cells onto additive modified poly(ether urethane ureas). J Biomed. Mat Res. 27, 483-492.
122. Zhang, J.C., Wojta, J. and Binder, B.R. (1995) Growth and fibrinolytic parameters of human umbilical vein endothelial cells seeded onto cardiovascular grafts. J. Thor. Card. Surg. 109, 1059-1065. .
123. Storck, J., Razek, H. and Zimmerman, E.R. (1996) Effect of polyvinyl chloride plastic on the growth and physiology of human umbilical vein endothelial ceils. Biomaterials 17, 1791-1794.
124. Bouaziz, A. Richert, A. and Caprani, A. (1997) Vascular endothelial cell response to different electrically charged poly(vinylidene fluoride) supports under static and oscillating low conditions. Biomaterials 18, 107-112.
125. Cenni, E., Granchi, D., Ciapetti, G. et al (1997) Expression of adhesion molecules on endothelial cells after contact with knitted Dacron. Biomaterials 18, 489-494.
126. Cenni, E., Granchi, D., Ciapetti, G. et al (1997) Cytokine production and adhesive protein expression by endothelial cells after contact with polyethylene terephthalate. Biomaterials 17, 2071-2076.
127. Yeager, A. and Callow, A.D. (1988) New graft materials and current approaches to an acceptable small diameter vascular graft. Trans. Am. Soc Artif Inter. Organs 34, 88-94
128. Massia, S.P. and Hubbell, J.A. (1991) Human endothelial cell interactions with surface- coupled adhesion peptides on a nonadhesive glass substrate and two polymeric biomaterials. J. Biomed. Mat. Res. 25, 223-242
129. Cheresh, D.A. (1987) Human endothelial cells synthesize and express Arg-Gly-Asp directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. Proc. Natl. Acad. Sci. USA 84, 6471-6475.
130. Dejana, E., Languino, L.R., Colella, S. et al (1988) The localization of platelet gbIIb-IIIa- related protein in endothelial cell adhesion structures. Blood 71, 566-572
131. Charo, I F., Bekeart, L.S. and Philips, D.R (1987) Platelet glycoprotein IIb-IIIa-like proteins mediate endothelial cell attachment to adhesive proteins and the extracellular matrix. J. Biol Chem. 262, 9935-9938. .
132. Lin, H-B , Sun, W., Mosher, D.F. et al (1994) Synthesis, surface and cell-adhesion properties of polyurethanes containing covalently grafted RGD-peptides. J. Biomed Met. Res. 28, 329-342.
133. Massia, S.P. and Hubbell, J.A. (1990) Covalently attached GRGD on polymer surfaces promotes biospecific adhesion of mammalian cells. Ann. N.Y. Acad. Sci. 589, 261-270.
134. Holland, J., Hersh, L , Bryhan, M. et al. (1996) Culture of human vascular endothelial cells on an RGD-containing synthetic peptide attached to a starch-coated polystyrene surface: comparison with fibronectin-coated tissue culture grade polystyrene. Biomaterials 17, 2147-2156.
135. Hubbell, J.A., Massia, S.P., Desai, N P et al. (1991) Endothelial cell-selective materials for tissue engineering in the vascular graft via a new receptor. Biotech. 9, 568-572.
136. Massia, S.P. and Hubbell, J.A. (1992) Vascular endothelial cell adhesion and spreading promoted by the peptide REDV of the HICS region of plasma fibronectin is mediated by integrin alpha 4 beta 1 J. Biol. Chem. 267, 14019-26.
137. Humphries, M.J., Akiyama, S.K., Komoriya, A. et al. (1986) Identification of an alternately spliced site in human plasma fibronectin that mediates cell type specific adhesion. J Cell Biol 103, 2637-2647.
138. Shayani, V., Newman, K.D. and Dichek, D.A. (1994) Optimization of recombinant t-PA secretion from seeded vascular grafts. J. Surg. Res. 57, 495-504.
139. Flugelman, M.Y., Virmani, R , Leon, M.B. et al (1992) Genetically engineered endothelial cells remain adherent and viable after stent deployment and exposure to flow in vitro. Cir. Res. 70, 348-354.
140. Nathan, A., Nugent, M.A. and Edelman, E.R. (1995) Tissue engineered perivascular endothelial cell implants regulate vascular injury. Proc. Natl. Acad. Sci. USA 92, 8130-8134.
141. Oberhoff, M , Herdeg, C., Shamet, K. et al. (1993) Delivery of low molecular weight heparin via porous balloon catheter for the prevention of smooth muscle cell proliferation Circulation I-661 (Abstract).
142. Wilensky, R.L., March, K.L. and Hathaway, D.R. (1991) Restenosis in an atherosclerotic rabbit model is reduced by a thiol protease inhibitor. J. Am. Coll. Cardiol. 17, 268A.
143. Gradus-Pizlo, I, Wilensky, R.L., March, K.L. et al. (1993) Local delivery of biodegradable microparticles containing colchicine or colchicine analog does not block restenosis in atherosclerotic rabbit femoral arteries. Circulation 88, 1-372.
144. Soria, I., Hassinger, N.L., Owen, W.G. and Chesebro, J.H (1993) Local delivery of hirudin into rabbit carotid arteries with an iontophoretic balloon catheter. Circulation 88, I-660
145. Avitall, B., Hare, J. and Zander, G. (1992) Iontophoretic transmyocardial drug delivery. A novel approach to antiarrhythmic drug delivery. Circulation 85, 1582-93. .
146. Singh, J. and Roberts, M.S. (1989) Transdermal delivery of drugs by iontophoresis. Drug Des. Deliv. 4, 1-12.
147. Dinbergs, I.D., Brown, L. and Edelman, E.R. (1996) Cellular response to transforming growth factor-β1 and basic fibroblast growth factor depends on release kinetics and extracellular matrix interactions. J. Biol. Chem. 271, 29822-29.
148. Nathan, A and Edelman, E.R. (1995) Local interventions for vasculoproliferative diseases in Molecular Interventions and Local Drug Delivery, Edelman, Editor. W.B. Saunders Company Ltd.: London.