Adriamycin depresses in vivo and in vitro phosphatidylethanolamine N-methylation in rat heart sarcolemma

Molecular and Cellular Biochemistry

Volumn 176, Issue 1-2, 1997, Pages 235-240

  Iliskovic, Natasha ^a   Panagia, Vincenzo ^a   Slezák, Ján ^b   Kumar, Dinender ^a   Li, Timao ^a   Singal, Pawan K ^a,c  

^a UNIVERSITY OF MANITOBA   (Canada)

^b INSTITUTE OF CHEMISTRY   (Slovakia)

^c ST BONIFACE GENERAL HOSPITAL   (Canada)

Author keywords

Adriamycin cardiomyopathy; Congestive heart failure; S adenosyl L methionine

Indexed keywords

DOXORUBICIN; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE; S ADENOSYLMETHIONINE;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCITES; CALCIUM TRANSPORT; CARDIOTOXICITY; CELL DAMAGE; CELL VACUOLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DYSPNEA; ENZYME ACTIVE SITE; ENZYME INHIBITION; HEART LEFT VENTRICLE CONTRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE INJURY; INTRAPERITONEAL DRUG ADMINISTRATION; ISOTOPE LABELING; MALE; MORTALITY; NONHUMAN; OXIDATIVE STRESS; PHOSPHOLIPID METHYLATION; RAT; SYSTOLIC BLOOD PRESSURE;

ANALYSIS OF VARIANCE; ANIMALS; ANTINEOPLASTIC AGENTS; CARDIOMYOPATHIES; DOXORUBICIN; HEMODYNAMIC PROCESSES; MALE; METHYLATION; MYOCARDIUM; PHOSPHATIDYLETHANOLAMINES; RATS; RATS, SPRAGUE-DAWLEY; SARCOLEMMA; STROKE VOLUME;

ANIMALIA;

EID: 0030727454     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006805229758     Document Type: Article

References (35)

1. Lefrak EA, Pitha J, Rosenheim S, Gottleib JA: A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer 32: 302-314, 1973
2. Steinhertz LJ, Steinhertz PG, Tan CTC, Heller G, Murphy L: Cardiac toxicity 4-20 years after completing anthracycline therapy. JAMA 266: 1672-1677, 1991
3. Siveski-Iliskovic N, Kaul N, Singal PK: Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats. Circulation 89: 2829-2835, 1994
4. Siveski-Iliskovic N, Hill M, Chow D, Singal PK: Probucol protects against adriamcyin cardiomyopathy without interfering with its anti-tumor properties. Circulation 91: 10-15, 1995
5. Buja LM, Ferrans VJ, Mayer RJ, Roberts WC, Hendersson ES: Cardiac ultrastructural changes induced by daunorubicin therapy. Cancer 32: 771-778, 1973
6. Arena E, Biondo R, D'Alessandro N, Dusonchet L, Gebbia N, Gerbasi F: DNA, RNA and protein synthesis in heart, liver and brain of mice treated with daunorubicin or adriamcyin. Int Res Commun Systemic Medical Sciences 2: 1053-1061, 1974
7. Bristow MR, Sageman WS, Scott RH, Billingham ME, Bowden RE, Kernoff RS, Snidow IH, Daniels JR: Acute and chronic cardiovascular effects of doxorubicin in the dog: the cardiovascular pharmacology of drug-induced histamine release. J Cardiovasc Pharmacol 2: 487-515, 1980
8. Tong J, Ganguly PK, Singal PK: Myocardial adrenergic changes to two stages of heart failure due to adriamycin treatment in rats. Am J Physiol 260: H909-H916, 1991
9. Gosalvez M, Van Rossum GDV, Balnco MF: Inhibition of sodium-potassium activated adenosine 5 -triphosphatase and ion transport by adriamycin. Cancer Res 39: 257-261, 1979
10. 2+ binding and lipid peroxidation but depresses myocardial function. Am J Physiol 250 (Heart Circ Physiol): H419-H425, 1986
11. Singal PK, Panagia V: Direct effects of adriamcyin on the rat heart sarcolemma. Res Comm Chem Pathol Pharmacol 43: 67-77, 1984
12. Singal PK, Segstro RJ, Singh RP, Kutryk MJ: Changes in lysosomal morphology and enzyme activities during the development of adriamycin-induced cardiomyopathy. Can J Cardiol 1: 139-147, 1985
13. 2+-pump in rat sarcolemma by phosphatidylethanolamine N-methylation. Biochim Biophys Acta 856: 383-387, 1986
14. Hawagachi T, Azuma J, Schaffer S: Interaction of taurine with methionine: inhibition of myocardial phospholipid methyltransferase. J Cardiovasc Pharmacol 18: 224-230, 1991
15. Limas CJ: Effect of phospholipid methylation of β-adrenergic receptors in the normal and hypertrophied rat myocardium. Circ Res 47: 536-541, 1980
16. Siveski-Iliskovic N, Thomas TP, Kaul N, Slezak J, Singal PK: Doxorubicin-induced cardiomyopathy: A model of congestive heart failure. In: M Nagano, N Takeda, NS Dhalla (eds). The Cardiomyopathic Heart. Raven Press Ltd, New York, 1994, pp 277-283
17. Singal PK, Dhillon KS, Beamish RE, Dhalla NS: Protective effect of zinc against catecholamine-induced myocardial changes - electrocardiographic and ultrastructural studies. Lab Invest 44: 426-433, 1981
18. Dhalla NS, Anand-Srivastava MB, Tuana BS, Khandelwal RL: Solubilization of a calcium dependent adenosine triphosphatase from rat heart sarcolemma. J Mol Cell Cardiol 13: 413-423, 1981
19. 2+-dependent ATPase activities in the deoxycholate-treated rat heart sarcolemma. Int J Biochem 14: 387-397, 1982
20. Wharton DC, Tzagoloff A: Cytochrome oxidase from beef heart mitochondria. Methods Enzymol 10: 245-250, 1967
21. Martin AF, Pagani ED, Solaro RJ: Thyroxine-induced re-distribution of isoenzymes of rabbit ventricular myosin. Circ Res 50: 117-124, 1982
22. Ragnotti G, Lawford GR, Campbell PN: Biosynthesis of microsomal nicotinamide-adenine dinucleotide phosphate-cytochrome c reductase by membrane-bound and free polysomes from rat liver. Biochem J 112: 139-147, 1969
23. Panagia V, Ganguly PK, Dhalla NS: Characterization of heart sarcolemmal phospholipid methylation. Biochim Biophys Acta 792: 245-253, 1984
24. Lowry OH, Rosebrough NJ, Fair AL, Randall AJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-259, 1951
25. Glazer RI, Peale AL: Measurement of S-adenosyl-L-methionine levels by SP Sephadex chromatography. Anal Biochem 91:516-520, 1978
26. Singal PK, Siveski-Iliskovic N, Li T, Seneviratne C. Cardiomyopathie due à l'adriamycine et sa prévention. L'information Cardiologique 19: 289-302, 1995
27. Singal PK, Deally CMR, Weinberg LE: Subcellular effects of adriamycin in the heart: A concise review. J Mol Cell Cardiol 19:817-828, 1987
28. Olson HM, Young DM, Prieur DJ, Le Toy AF, Reagan RL: Electrolyte and morphologic alterations of myocardium in adriamycin-treated rabbits. Am J Pathol 77:439-454, 1974
29. Hirata F, Viveros OH, Diliberto IJ Jr, Axelrod JC: Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine. Proc Natl Acad Sci USA 75: 1718-1721, 1978
30. Hirata F, Strittmatter WJ, Axelrod J: β-Adrenergic receptor agonists increase phospholipidmethylation, membrane fluidity and β-adrenergic receptor-adenylate cyclase coupling. Proc Natl Acad Sci USA 76: 368-372, 1979
31. Bhattacharya A, Vonderhaar BK: Phospholipid methylation stimulates lactogenic binding in mouse mammary gland membranes. Proc Natl Acad Sci USA 76: 4489-4492, 1979
32. Ganguly PK, Rice KM, Panagia V, Dhalla NS : Sarcolemmal phosphatidylethanolamine N methylation in diabetic cardiomyopathy. Circ Res 55:504-512, 1984
33. Prasad C, Edwards RM: Increased phospholipid methylation in the myocardium of alcoholic rats. Biochem Biophys Res Commun 111: 710-716, 1983
34. Persad S, Panagia V: Abnormal synthesis of N-methylated phospholipids during calcium paradox of the heart. J Mol Cell Cardiol 27: 5799-587, 1995
35. Kaneko M, Panagia V, Paolillo G, Majumder S, Ou C, Dhalla NS: Inhibition of cardiac phosphatidylethanolamine N-methylation by oxygen free radicals. Biochim Biophys Acta 1021: 33-38, 1990