Effect of Panpal pretreatment and antidotal treatment (HI-6 plus benactyzine) on respiratory and circulatory function in soman-poisoned rats

Human and Experimental Toxicology

Volumn 16, Issue 10, 1997, Pages 563-569

  Kassa, J ^a   Fusek, J ^a  

^a DEPARTMENT OF TOXICOLOGY   (Czech Republic)

Author keywords

Benactyzine; Circulation; HI 6; Panpal; Rat; Respiration; Soman

Indexed keywords

ACETYLCHOLINESTERASE; BENACTYZINE; PYRIDOSTIGMINE; SOMAN; TRIHEXYPHENIDYL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREATHING RATE; CARDIOVASCULAR FUNCTION; DIAPHRAGM; INTOXICATION; LUNG MINUTE VOLUME; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY FUNCTION;

EID: 0030727344     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/096032719701601003     Document Type: Article

References (28)

1. Maynard RL, Beswick W. Organophosphorus compounds as chemical warfare agents. In Ballantyne B, Marrs TC (eds.) Clinical and Experimental Toxicology of Organophosphates and Carbamates. Butterworth - Heinemann, Oxford, England, 1992.
2. Dawson RM. Review of oximes available for the treatment of nerve agent poisoning. Journal of Applied Toxicology 1994; 14: 317-331.
3. Kassa J. Comparison of efficacy of two oximes (HI-6 and obidoxime) in soman poisoning in rats. Toxicology 1995; 101: 167-174.
4. Koplovitz I. Stewart JR. A comparison of the efficacy of HI-6 and 2-PAM against soman, tabun, sarin and VX in the rabbit. Toxicology Letters 1994; 70: 269-279.
5. Shih T-M, Whalley ChE, Valdes JJ. A comparison of cholinergic effects of HI-6 and pralidoxime-2-chloride (2-PAM) in soman poisoning. Toxicology Letters 1991; 55: 131-147.
6. Shih T-M. Comparison of several oximes on reactivation of soman-induced blood, brain and tissue cholinesterase activity in rats. Archives of Toxicology 1993; 67: 637-646.
7. Marrs TC. Organophosphate poisoning. Pharmacology and Therapy 1993; 58: 51-66.
8. Chang EC et al. Neurophysiological concomitants of soman-induced respiratory depression in awake, behaving guinea pigs. Toxicology and Applied Pharmacology 1990; 102: 233-250.
9. Rickett DL, Glenn JF, Beers ET. Central respiratory effects versus neuromuscular actions of nerve agents. Neurotoxicology 1986; 7: 225-236.
10. Maksimovic M, Bregovec J, Deljac V, Binenfeld Z. Reactivation of organophosphate-inhibited cholinesterase by 4-cycloalkylcarbonyl-substituted bispyridinium monoximes. Archives of Toxicology 1984; 55: 199-205.
11. Wolthuis O, Berends F, Meeter E. Problems in the therapy of soman poisoning. Fundamental and Applied Toxicology 1981; 1: 183-189.
12. Rousseaux CG, Dua AK. Pharmacology of HI-6, an H series oxime. Canadian Journal of Physiology and Pharmacology 1989; 67: 1183-1189.
13. Kloog Y, Sokolovsky M. Bisquaternary pyridinium oximes as allosteric inhibitors of rat brain and muscarinic receptors. Molecular Pharmacology 1985; 27: 418-428.
14. Bajgar J, Fusek J, Vachek J. Theoretical approaches and practical possibilities of medical prophylaxis against nerve agent poisoning. GATE 95, May 2-6, 1995, Brno, Czech Republic.
15. Brodbeck U, Gentinetta R. Inhibition of blood acetylcholinesterase after single and repeated doses of pyridostigmine. CBW Medical Treatment Symposium, December 5-8, 1994, Spiez, Switzerland.
16. Worek F, Szinicz L. Cardiorespiratory function in nerve agent poisoned and oxime+atropine treated guinea pigs: effect of pyridostigmine pretreatment. Archives of Toxicology 1995; 69: 322-329.
17. Worek F, Kleine A, Szinicz L. Effect of pyridostigmine pretreatment on Cardiorespiratory function in tabun poisoning. Human & Experimental Toxicology 1995; 14: 634-642.
18. Bajgar J, Fusek J, Vachek J. Treatment and prophylaxis against nerve agent poisoning. ASA Newsletter 1994; 94-4: 10-11.
19. Ellman GL, Courtney DK, Andres JrV, Featherstone FM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemistry and Pharmacology 1961; 7: 88-95.
20. Sachs L. (1992). Angewandte Statistik, Berlin: Springer, 1992.
21. Kok A. REM sleep pathways and anticholinesterase intoxication: a mechanism for nerve agent-induced central respiratory failure. Medical Hypotheses 1993; 41: 141-149.
22. Brezenoff HE, McGee J, Knight V. The hypertensive response to soman and its relation to brain AChE inhibition. Acta Pharmacologica and Toxicologica 1984; 55: 270-277.
23. McCain WC, Wilcke J, Lee JC, Ehrich M. Effect of cyclic phenyl saligenin phosphate and paraoxon treatment on vascular response to adrenergic and cholinergic agents in hens. Journal of Toxicology and Environmental Health 1995; 44: 167-187.
24. van Helden HPM, de Jonge J, Busker RW, Melchers BP. Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivation. Archives of Toxicology 1991; 65: 586-593.
25. Klimmek R, Eyer P. Pharmacokinetics and pharmacodynamics of the oxime HI6 in dogs. Archives of Toxicology 1986; 59: 272-278.
26. Worek F, Szinicz L. Investigation of acute cardiovascular and respiratory toxicity of HLö7 dimethansulfonate and HI6 dichloride in anaesthetized guinea pigs. Pharmacology and Toxicology 1993; 73: 91-95.
27. Anderson DR, Harris LW, Woodard CL, Lennox WJ. The effect of pyridostigmine pretreatment on oxime efficacy against intoxication by soman or VX in rats. Drug and Chemical Toxicology 1992; 15: 285-294.
28. Kassa J, Bajgar J. The influence of pharmacological pretreatment on efficacy of HI-6 oxime in combination with benactyzine in soman poisoning in rats. Human & Experimental Toxicology 1996; 15: 383-388.