Sequence-specific inhibition of the tumor necrosis factor-α receptor I gene by oligodeoxynucleotides containing N7 modified 2'-deoxyguanosine

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 5, 1997, Pages 447-459

  Ojwang, Joshua O ^a   Lewis, Arthur F ^a   Revankar, Ganapathi R ^a   Walker, David ^a   Akiyama, Taishin ^b   Hogan, Michael E ^b   Rando, Robert F ^a,c  

^a Antigenics Inc   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c Dept of Virology Biology   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; DEOXYGUANOSINE DERIVATIVE; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; OLIGODEOXYNUCLEOTIDE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ARTICLE; BINDING AFFINITY; BINDING SITE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DNA FLANKING REGION; DNA HYBRIDIZATION; DNA SEQUENCE; GENE REPRESSION; HUMAN; HUMAN CELL; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RECEPTOR GENE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030727071     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.447     Document Type: Article

References (5)

1. AGGARWAL, B.B., and VILCEK, J. (1992). (eds.) Tumor Necrosis Factor: Structure, Function, and Mechanism of Action. (Marcel Dekker, New York, pp. 1-624).
2. BAGLIONI, C., McCANDLESS, S., TAVERNIER, J., and FIERS, W. (1985). Binding of human tumor necrosis factor to high affinity receptors on HeLa and lymphoblastoid cells sensitive to growth. J. Biol. Chem. 260, 13395-13397.
3. BENNETT, C.F., CHIANG, M.-Y., CHAN, H., SHOEMAKER, J.E., and MIRABELLI, C.K. (1992). Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. Mol. Pharmacol. 41, 1023-1033.
4. BLACK, L.E., FARRELLY, J.G., CAVAGNARO, J.A., AHN, C.H., DEGORGE, JJ., TAYLOR, A.S., DEFELICE, A.F., and JORDAN, A. (1994). Regulatory considerations for oligonucleotide drugs: Updated recommendations for pharmacology and toxicology studies. Antisense Res. Dev. 4, 299-301.
5. WIEGMANN, K., SCHUTZE, S., KAMPEN, E., HIMMLER, A., MACHLEIDT, T., and KRONKE, M. (1992). Human 55-kDa receptor for tumor necrosis factor coupled to signal transduction cascades. J. Biol. Chem. 267, 17997-18001.