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Volumn 86, Issue 423, 1997, Pages 88-91

Hypothalamic targets for growth hormone secretagogues

Author keywords

Adrenocorticotrophin; GH secretagogue receptor; Growth hormone secretagogue; Growth hormone releasing hormone; Growth hormone releasing peptide 6; Transgenic rats

Indexed keywords

CORTICOTROPIN; GROWTH HORMONE DERIVATIVE; GROWTH HORMONE RECEPTOR; GROWTH HORMONE RELEASING FACTOR; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; UNCLASSIFIED DRUG;

EID: 0030726944     PISSN: 08035326     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (7)

References (41)
  • 1
    • 0018899801 scopus 로고
    • Structure-activity relationships of a synthetic pentapeptide that specifically releases GH in vitro
    • Bowers C, Momany F, Chang D, Hong A, Chang K. Structure-activity relationships of a synthetic pentapeptide that specifically releases GH in vitro Endocrinology 1980; 106:663-7
    • (1980) Endocrinology , vol.106 , pp. 663-667
    • Bowers, C.1    Momany, F.2    Chang, D.3    Hong, A.4    Chang, K.5
  • 2
    • 0021322884 scopus 로고
    • On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone
    • Bowers CY, Momany F, Reynolds GA, Hong A. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 1984;114:1537-45
    • (1984) Endocrinology , vol.114 , pp. 1537-1545
    • Bowers, C.Y.1    Momany, F.2    Reynolds, G.A.3    Hong, A.4
  • 3
    • 0025267776 scopus 로고
    • Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone
    • Bowers CY, Reynolds GA, Durham D, Barrera CM, Pezzoli SS, Thorner MO. Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone. J Clin Endocrinol Metab 1990;70:975-82
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 975-982
    • Bowers, C.Y.1    Reynolds, G.A.2    Durham, D.3    Barrera, C.M.4    Pezzoli, S.S.5    Thorner, M.O.6
  • 4
    • 0027419864 scopus 로고
    • Massive growth hormone (GH) discharge in obese subjects after the combined administration of GH-releasing hormone and GHRP-6: Evidence for a marked somatotroph secretory capability in obesity
    • Cordido F, Penalva A, Dieguez C, Casanueva FF. Massive growth hormone (GH) discharge in obese subjects after the combined administration of GH-releasing hormone and GHRP-6: evidence for a marked somatotroph secretory capability in obesity. J Clin Endocrinol Metab 1993;76:819-23
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 819-823
    • Cordido, F.1    Penalva, A.2    Dieguez, C.3    Casanueva, F.F.4
  • 6
    • 0026647332 scopus 로고
    • Oral administration of growth hormone (GH)-releasing peptide stimulates GH secretion in normal men
    • Hartman ML, Farello G, Pezzoli SS, Thorner MO. Oral administration of growth hormone (GH)-releasing peptide stimulates GH secretion in normal men. J Clin Endocrinol Metab 1992;74:1378-84
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 1378-1384
    • Hartman, M.L.1    Farello, G.2    Pezzoli, S.S.3    Thorner, M.O.4
  • 10
    • 10144227766 scopus 로고    scopus 로고
    • Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men
    • Copinschi G, Van Onderbergen A, L'Hermite-Baleriaux M, Mendel CM, Caufriez A, Leproult R, et al. Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men. J Clin Endocrinol Metab 1996;81:2776-82
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 2776-2782
    • Copinschi, G.1    Van Onderbergen, A.2    L'Hermite-Baleriaux, M.3    Mendel, C.M.4    Caufriez, A.5    Leproult, R.6
  • 11
    • 0026016294 scopus 로고
    • 2 stimulate growth hormone release through distinct receptor sites
    • 2 stimulate growth hormone release through distinct receptor sites. J Endocrinol 1991;129:11-19
    • (1991) J Endocrinol , vol.129 , pp. 11-19
    • Blake, A.D.1    Smith, R.G.2
  • 13
    • 0028968462 scopus 로고
    • Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection; evidence that GHRP-6 main action is exerted at the hypothalamic level
    • Popovic V, Damjanovic S, Micic D, Djurovic M, Dieguez C, Casanueva FF. Blocked growth hormone-releasing peptide (GHRP-6)-induced GH secretion and absence of the synergic action of GHRP-6 plus GH-releasing hormone in patients with hypothalamopituitary disconnection; evidence that GHRP-6 main action is exerted at the hypothalamic level. J Clin Endocrinol Metab 1995;80:942-7
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 942-947
    • Popovic, V.1    Damjanovic, S.2    Micic, D.3    Djurovic, M.4    Dieguez, C.5    Casanueva, F.F.6
  • 14
    • 0022466170 scopus 로고
    • Receptor associated resistance to growth hormone-releasing hormone in dwarf 'little' mice
    • Jansson JO, Downs TR, Beamer WG, Frohman LA. Receptor associated resistance to growth hormone-releasing hormone in dwarf 'little' mice. Science 1986;232:511-13
    • (1986) Science , vol.232 , pp. 511-513
    • Jansson, J.O.1    Downs, T.R.2    Beamer, W.G.3    Frohman, L.A.4
  • 15
    • 0024453883 scopus 로고
    • The effects of a growth hormone-releasing peptide and growth hormone-releasing factor in conscious and anaesthetized rats
    • Clark RG, Carlsson LMS, Trojnar J, Robinson ICAF. The effects of a growth hormone-releasing peptide and growth hormone-releasing factor in conscious and anaesthetized rats. J Neuroendocrinol 1989;1:249-55
    • (1989) J Neuroendocrinol , vol.1 , pp. 249-255
    • Clark, R.G.1    Carlsson, L.M.S.2    Trojnar, J.3    Robinson, I.C.A.F.4
  • 17
    • 0027414444 scopus 로고
    • Systemic administration of growth hormone-releasing peptide activates hypothalamic arcuate neurons
    • Dickson SL, Leng G, Robinson ICAF. Systemic administration of growth hormone-releasing peptide activates hypothalamic arcuate neurons. Neuroscience 1993;53:303-6
    • (1993) Neuroscience , vol.53 , pp. 303-306
    • Dickson, S.L.1    Leng, G.2    Robinson, I.C.A.F.3
  • 18
    • 0028983836 scopus 로고
    • Central actions of peptide and non-peptide growth hormone secretagogues in the rat
    • Dickson SL, Leng G, Dyball RE, Smith RG. Central actions of peptide and non-peptide growth hormone secretagogues in the rat. Neuroendocrinology 1995;61:36-43
    • (1995) Neuroendocrinology , vol.61 , pp. 36-43
    • Dickson, S.L.1    Leng, G.2    Dyball, R.E.3    Smith, R.G.4
  • 19
    • 0028929627 scopus 로고
    • Central effects of growth hormone-releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin action
    • Fairhall KM, Mynett A, Robinson ICAF. Central effects of growth hormone-releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin action. J Endocrinol 1995;144:555-60
    • (1995) J Endocrinol , vol.144 , pp. 555-560
    • Fairhall, K.M.1    Mynett, A.2    Robinson, I.C.A.F.3
  • 20
    • 0028026646 scopus 로고
    • Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep
    • Guillame V, Magnan E, Cataldi M, Dutour A, Sauze N, Renard M, et al. Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep. Endocrinology 1994;135:1073-6
    • (1994) Endocrinology , vol.135 , pp. 1073-1076
    • Guillame, V.1    Magnan, E.2    Cataldi, M.3    Dutour, A.4    Sauze, N.5    Renard, M.6
  • 21
    • 0029074029 scopus 로고
    • Consistent GH responses to repeated injection of GH-releasing hexapeptide (GHRP-6) and the non-peptide GH secretaeogue, L-692,585
    • Fairhall KM, Mynett A, Smith RG, Robinson ICAF. Consistent GH responses to repeated injection of GH-releasing hexapeptide (GHRP-6) and the non-peptide GH secretaeogue, L-692,585. J Endocrinol 1995;145:417-26
    • (1995) J Endocrinol , vol.145 , pp. 417-426
    • Fairhall, K.M.1    Mynett, A.2    Smith, R.G.3    Robinson, I.C.A.F.4
  • 22
    • 0029948675 scopus 로고    scopus 로고
    • The effect of repeated administration of hexarelin, a growth hormone releasing peptide, and growth hormone releasing hormone on growth hormone responsivity
    • Massoud AF, Hindmarsh PC, Matthews DR, Brook CG. The effect of repeated administration of hexarelin, a growth hormone releasing peptide, and growth hormone releasing hormone on growth hormone responsivity. Clin Endocrinol 1996;44:555-62
    • (1996) Clin Endocrinol , vol.44 , pp. 555-562
    • Massoud, A.F.1    Hindmarsh, P.C.2    Matthews, D.R.3    Brook, C.G.4
  • 23
    • 0027278470 scopus 로고
    • Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus
    • Huhn WC, Hartman ML, Pezzoli SS, Thorner MO. Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus. J Clin Endocrinol Metab 1993;76:1202-8
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 1202-1208
    • Huhn, W.C.1    Hartman, M.L.2    Pezzoli, S.S.3    Thorner, M.O.4
  • 24
    • 0025740899 scopus 로고
    • Growth hormone (GH) secretion during continuous infusion of GH-releasing peptide: Partial response attenuation
    • DeBell WK, Pezzoli SS, Thorner MO. Growth hormone (GH) secretion during continuous infusion of GH-releasing peptide: partial response attenuation. J Clin Endocrinol Metab 1991; 72:1312-16
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 1312-1316
    • DeBell, W.K.1    Pezzoli, S.S.2    Thorner, M.O.3
  • 25
    • 0031049262 scopus 로고    scopus 로고
    • Repeat administration of the GH secretagogue MK-0677 increases and maintains elevated IGF-1 levels in beagles
    • Hickey GJ, Jacks TM, Schleim K-D, Frazier E, Chen HY, Krupa D, et al. Repeat administration of the GH secretagogue MK-0677 increases and maintains elevated IGF-1 levels in beagles. J Endocrinol 1997;152:183-92
    • (1997) J Endocrinol , vol.152 , pp. 183-192
    • Hickey, G.J.1    Jacks, T.M.2    Schleim, K.-D.3    Frazier, E.4    Chen, H.Y.5    Krupa, D.6
  • 26
    • 0026443528 scopus 로고
    • Effects of coadministered growth hormone (GH)-releasing hormone and GH-releasing hexapeptide on maladaptive aspects of obesity in Zucker rats
    • Bercu BB, Yang SW, Masuda R, Hu CS, Walker RF. Effects of coadministered growth hormone (GH)-releasing hormone and GH-releasing hexapeptide on maladaptive aspects of obesity in Zucker rats. Endocrinology 1992;131:2800-4
    • (1992) Endocrinology , vol.131 , pp. 2800-2804
    • Bercu, B.B.1    Yang, S.W.2    Masuda, R.3    Hu, C.S.4    Walker, R.F.5
  • 27
    • 0026045803 scopus 로고
    • Robust growth hormone (GH) secretion in aged female rats co-administered GH-releasing hexapeptide (GHRP-6) and GH-releasing hormone (GHRH)
    • Walker RF, Yang SW, Bercu BB. Robust growth hormone (GH) secretion in aged female rats co-administered GH-releasing hexapeptide (GHRP-6) and GH-releasing hormone (GHRH). Life Sci 1991;49:1499-504
    • (1991) Life Sci , vol.49 , pp. 1499-1504
    • Walker, R.F.1    Yang, S.W.2    Bercu, B.B.3
  • 28
    • 0029783602 scopus 로고    scopus 로고
    • Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons
    • Flavell DM, Wells T, Wells SE, Carmignac DF, Thomas GB, Robinson ICAF. Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons. EMBO J 1996; 15:3871-9
    • (1996) EMBO J , vol.15 , pp. 3871-3879
    • Flavell, D.M.1    Wells, T.2    Wells, S.E.3    Carmignac, D.F.4    Thomas, G.B.5    Robinson, I.C.A.F.6
  • 30
    • 0027944106 scopus 로고
    • Effects of acute and repeated intravenous administration of L-692,585, a novel peptidyl growth hormone secretagogue, on plasma growth hormone, IGF-1, ACTH, Cortisol, prolactin, insulin, and thyroxine levels in beagles
    • Jacks T, Hickey G, Judith F, Taylor J, Chen H, Krupa D, et al. Effects of acute and repeated intravenous administration of L-692,585, a novel peptidyl growth hormone secretagogue, on plasma growth hormone, IGF-1, ACTH, Cortisol, prolactin, insulin, and thyroxine levels in beagles. J Endocrinol 1994;143:399-406
    • (1994) J Endocrinol , vol.143 , pp. 399-406
    • Jacks, T.1    Hickey, G.2    Judith, F.3    Taylor, J.4    Chen, H.5    Krupa, D.6
  • 32
    • 0029061494 scopus 로고
    • Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man
    • Frieboes RM, Murck H, Maier P, Schier T, Holsboer F, Steiger A. Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man. Neuroendocrinology 1995;61:584-9
    • (1995) Neuroendocrinology , vol.61 , pp. 584-589
    • Frieboes, R.M.1    Murck, H.2    Maier, P.3    Schier, T.4    Holsboer, F.5    Steiger, A.6
  • 33
    • 0030028289 scopus 로고    scopus 로고
    • Hexarelin, a synthetic growth hormone releasing peptide, stimulates prolactin secretion in acroinegalic but not in hyperprolactinaemic patients
    • Ciccarelli E, Grottoli S, Razzore P, Gianotti L, Arvat E, Deghenghi R, et al. Hexarelin, a synthetic growth hormone releasing peptide, stimulates prolactin secretion in acroinegalic but not in hyperprolactinaemic patients. Clin Endocrinol 1996;44:67-71
    • (1996) Clin Endocrinol , vol.44 , pp. 67-71
    • Ciccarelli, E.1    Grottoli, S.2    Razzore, P.3    Gianotti, L.4    Arvat, E.5    Deghenghi, R.6
  • 34
    • 0029886860 scopus 로고    scopus 로고
    • Hypothalamic control of growth hormone (GH) secretion in type I diabetic men: Effect of the combined administration of GH-releasing hormone and hexarelin, a novel GHRP-6 analog
    • Giustina A, Desenzani P, Perini P, Deghenghi R, Bugari G, Wehrenberg WB, et al. Hypothalamic control of growth hormone (GH) secretion in type I diabetic men: effect of the combined administration of GH-releasing hormone and hexarelin, a novel GHRP-6 analog. Endocr Res 1996; 22:159-74
    • (1996) Endocr Res , vol.22 , pp. 159-174
    • Giustina, A.1    Desenzani, P.2    Perini, P.3    Deghenghi, R.4    Bugari, G.5    Wehrenberg, W.B.6
  • 36
    • 0030909925 scopus 로고    scopus 로고
    • Activation of the hypothalamo-pituitary-adrenal axis by the growth-hormone (GH) secretagogue, GH-releasing peptide-6, in rats
    • Thomas GB, Fairhall KM, Robinson ICAF. Activation of the hypothalamo-pituitary-adrenal axis by the growth-hormone (GH) secretagogue, GH-releasing peptide-6, in rats. Endocrinology 1997;138:1585-91
    • (1997) Endocrinology , vol.138 , pp. 1585-1591
    • Thomas, G.B.1    Fairhall, K.M.2    Robinson, I.C.A.F.3
  • 37
    • 9044228028 scopus 로고    scopus 로고
    • Mediation by the central nervous system is critical to the in vivo activity of the GH secretagogue L-692,585
    • Hickey GJ, Drisko J, Faidley T, Chang C, Anderson LL, Nicolich S, et al. Mediation by the central nervous system is critical to the in vivo activity of the GH secretagogue L-692,585. J Endocrinol 1996;148:371-80
    • (1996) J Endocrinol , vol.148 , pp. 371-380
    • Hickey, G.J.1    Drisko, J.2    Faidley, T.3    Chang, C.4    Anderson, L.L.5    Nicolich, S.6
  • 40
    • 0024396484 scopus 로고
    • Binding of a growth hormone releasing hexapeptide to specific hypothalamic and pituitary binding sites
    • Codd EE, Shu AYL, Walker RF. Binding of a growth hormone releasing hexapeptide to specific hypothalamic and pituitary binding sites. Neuropharmacology 1989;28:1139-44
    • (1989) Neuropharmacology , vol.28 , pp. 1139-1144
    • Codd, E.E.1    Shu, A.Y.L.2    Walker, R.F.3
  • 41
    • 0031057817 scopus 로고    scopus 로고
    • Induction of c-fos messenger ribonucleic acid in neuropeptide Y and growth hormone (GH)-releasing factor neurons in the rat arcuate nucleus following systemic injection of the GH secretagogue, GH-releasing peptide-6
    • Dickson SL, Luckman SM. Induction of c-fos messenger ribonucleic acid in neuropeptide Y and growth hormone (GH)-releasing factor neurons in the rat arcuate nucleus following systemic injection of the GH secretagogue, GH-releasing peptide-6. Endocrinology 1997;138:771-7
    • (1997) Endocrinology , vol.138 , pp. 771-777
    • Dickson, S.L.1    Luckman, S.M.2


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