Chronic administration of the selective dopamine uptake inhibitor GBR 12909, but not cocaine, produces marked decreases in dopamine transporter density

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 356, Issue 5, 1997, Pages 562-569

  Kunko, Paul M ^a   Loeloff, Richard J ^a   Izenwasser, Sari ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Caudate putamen; Cocaine; Continuous infusions; Dopamine transporters; Dopamine uptake; GBR 12909; Nucleus accumbens; Uptake inhibitors

Indexed keywords

COCAINE; DOPAMINE TRANSPORTER; DOPAMINE UPTAKE INHIBITOR; VANOXERINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG BINDING; DRUG TOLERANCE; MALE; NONHUMAN; OSMOTIC MINIPUMP; RAT;

ANIMALS; BRAIN; COCAINE; DOPAMINE; DOPAMINE UPTAKE INHIBITORS; MALE; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030725932     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005091     Document Type: Article

References (49)

1. 3H]GBR-12935 binding after chronic treatment with dopamine active drugs. Psychopharmacology 102:291-294
2. Andersen PH (1989) The dopamine uptake inhibitor GBR 12909: selectivity and molecular mechanism of action. Eur J Pharmacol 166:493-504
3. Baumann MH, Char GU, Costa BRD, Rice KC, Rothman RB (1994) GBR 12909 attenuates cocaine-induced activation of mesolimbic dopamine neurons in the rat. J Pharmacol Exp Ther 271:1216-1222
4. Berger P, Elsworth JD, Arroyo J, Roth RH (1990) Interaction of [3H]GBR 12935 and GBR 12909 with the dopamine uptake complex in nucleus accumbens. Eur J Pharmacol 177:91-94
5. 3H]dopamine uptake is similar in both the rat striatum and nucleus accumbens. Eur J Pharmacol 173:215-217
6. Boja JW, Rahman MA, Philip A, Lewin AH, Carroll FI, Kuhar MJ (1991) Isothiocyanate derivatives of cocaine: Irreversible inhibition of ligand binding at the dopamine transporter. Mol Pharmacol 39:339-345
7. Boja JW, Markham L, Patel A, Uhl G, Kuhar MJ (1992) Expression of a single dopamine transporter cDNA can conter two cocaine binding sites. Mol Neurosci 3:247-248
8. 3H]GBR 12783 binding to a specific site associated with the neuronal dopamine uptake complex in the central nervous system. Eur J Pharmacol 126:211-222
9. Borowsky B, Hoffman BJ (1995) Neurotransmitter transporters: molecular biology, function, and regulation. Int Rev Neurobiol 38:139-199
10. Boulay D, Leroux-Nicollet I, Duterte-Boucher D, Naudon L, and Coslentin J (1994) Invariance of the density of dopamine uptake sites and dopamine metabolism in the rat brain after a chronic treatment with the dopamine uptake inhibitor GBR 12783. J Neural Transm 98:209-215
11. Cass WA, Gerhardt GA, Mayfield RD, Curella P, and Zahniser NR (1992) Differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration. J Neurochem 59:259-266
12. Cerruti C, Pilotte NS, Uhl G, Kuhar MJ (1994) Reduction in dopamine transporter mRNA after cessation ot repeated cocaine administration. Mol Brain Res 22:132-138
13. French D, Izenwasser S (1996) Tolerance and sensitization to cocaine are mediated via independent mechanisms. Soc Neurosci Abstr 22:921
14. Graybiel AM, Moratalla R (1989) Dopamine uptake sites in the striatum arc distributed differentially in striosome and matrix compartments. Proc Natl Acad Sci USA 86:9020-9024
15. Heikkila RE, Manzino L (1984) Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: specific inhibitors of dopamine uptake. Eur J Pharmacol 103:241-248
16. Heron C, Costentin J, Bonnet J-J (1994) Evidence that pure uptake inhibitors including cocaine interact slowly with the dopamine neuronal carrier. Eur J Pharmacol 264:391-398
17. Ikegami H, Prasad C (1990) Neuropeptide-dopamine interactions. V. cyclo(his-pro) regulation of striatal dopamine transporter complex. Peptides 11:145-148
18. Izenwasser S (1994) Increased mu-opioid efficacy for inhibition of adenylyl cyclase induced by chronic treatment with naltrexone or cocaine. Regul Pept 54: S119-120
19. Izenwasser S (1995) Interactions between chronic cocaine and morphine on locomotor activity and dopamine receptor function. Soc Neurosci Abstr 21:717
20. Izenwasser S, Cox BM (1992) Inhibition of dopamine uptake by cocaine and nicotine: tolerance to chronic treatments. Brain Res 573:119-125
21. Izenwasser S, Werling LL, Cox BM (1990a) Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex. Brain Res 520:303-309
22. 3H]GBR 12935 (1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-piperazine) to membranes and to solubilized membrane extracts from terminal field regions of mesolimbic, mesocortical and nigrostriatal dopamine pathways. Neuropharmacology 29:1017-1024
23. Izenwasser S, Rosenberger JG, Cox BM (1993) The cocaine analog WIN 35,428 binds to two sites in fresh rat caudate-putamen: significance of assay procedures. Life Sci /Pharmacol Lett 52:PL 141-145
24. Izenwasser S, Terry P, Heller B, Witkin JM, Katz JL (1994) Differential relationships among dopamine transporter affinities and stimulant potencies of various uptake inhibitors. Eur J Pharmacol 263:277-283
25. Kilty JE, Lorang D, Amara SG (1991) Cloning and expression of a cocaine-sensitive rat dopamine transporter. Science 254:578-579
26. King GR, Joyner C, Lee T, Kuhn C, Ellinwood Jr. EH (1992) Intermittent and continuous cocaine administration: Residual behavioral states during withdrawal. Pharmacol Biochem Behav 43:243-248
27. KuIa NS, Baldessarini RJ (1991) Lack of increase in dopamine transporter binding or function in rat brain tissue after treatment with blockers of neuronal uptake of dopamine. Neuropharmacology 30:89-92
28. Kunko PM, Carroll FI, Izenwasser S (1996) Chronic continuous administration of monoamine uptake inhibitors produces behavioral tolerance but not a cocaine-like activity pattern. Soc Neurosci Abstr 22:920
29. Lew R, Grigoriadis D, Wilson A, Boja JW, Simantov R, Kuhar MJ (1991a) Dopamine transporter: deglycosylation with exo- and endodycosidases. Brain Res 539:239-246
30. Lew R, Vaughn R, Simantov R, Wilson A, Kuhar MJ (1991b) Dopamine transporters in the nucleus accumbens and the striatum have different apparent molecular weights. Synapse 8:152-153
31. Little KY, Kirkman JA, Carroll FI, Clark TB, Duncan GE (1993) Cocaine use increases [3H]WIN 35428 binding sites in human striatum. Brain Res 628:17-25
32. 3H]2β-carbomethoxy-3β-(4-fluorophenyl)tropane. Mol Pharmacol 36:518-524
33. Munson PJ, Rodbard D (1980) Ligand: a versatile approach for characterization of ligand-binding systems. Anal Biochem 107:220-239
34. 3H]-WIN 35,428 binding to dopamine uptake sites in vivo more rapidly than mazindol or GBR 12909. Eur J Pharmacol 198:203-205
35. Reith MEA, Benuck M, Lajtha A (1987) Cocaine disposition in the brain after continuous or intermittent treatment and locomotor stimulation in mice. J Pharmacol Exp Ther 243:281-287
36. Reith MEA, de Costa B, Rice KC, Jacobson AE (1992) Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and dopamine to the dopamine transporter. Eur J Pharmacol 227:417-425
37. Reith MEA, Coffey LL, Xu C, Chen N-H (1994) GBR 12909 and 12935 block uptake into brain synaptic vesicles as well as nerve endings. Eur J Pharmacol 253:175-178
38. Ritz MC, Cone EJ, Kuhar MJ (1990) Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: a structure activity relationship. Life Sci 46:635-645
39. Rothman RB, Glowa JR (1995) A review of the effects of dopaminergic agents on humans, animals, and drug-seeking behavior, and its implications for medication development. Mol Neurobiol 11:1-19
40. Rothman RB, Mele A, Reid AA, Akunne HC, Greig N, Thurkauf A, Costa BRd, Rice KC, Pert A (1991) GBR 12909 antagonizes the ability of cocaine to elevate extracellular levels of dopamine. Pharmacol Biochem Behav 40:387-397
41. Rothman RB, Greig N, Kim A, Costa BRD, Rice KC, Carroll FI, Pert A (1992) Cocaine and GBR12909 produce equivalent motoric responses at different occupancy of the dopamine transporter. Pharmacol Biochem Behav 43:1135-1142
42. Saadouni S, Refahi-Lyamani F, Costentin J, Bonnet J-J (1994) Cocaine and GBR 12783 recognize nonidentical, overlapping binding domains on the dopamine neuronal carrier. Eur J Pharmacol 268:187-197
43. Sharkey J, Glen KA, Wolfe S, Kuhar MJ (1988) Cocaine binding at sigma receptors. Eur J Pharmacol 149:171-174
44. 3H]mazindol-labeling of dopamine transporter in rat nucleus accumbens. Eur J Pharmacol 203:141-144
45. Shimada S, Kitayama S, Lin C-L, Patel A, Nanthakumar E, Gregor P, Kuhar M, Uhl G (1991) Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA. Science 254:576-580
46. Sivam SP (1995) Dopaminergic modulation of serotonin metabolism in rat striatum: A study with dopamine uptake inhibitor GBR-12909. Life Sci 56:PL 467-472
47. Tella SR, Ladenheim B, Andrews AM, Goldberg SR, Cadet JL (1996) Differential reinforcing effects of cocaine and GBR-12909: Biochemical evidence for divergent neuroadaptive changes in the mesolimbic dopaminergic system. J Neurosci 16:7416-7427
48. van der Zee P, Koger HS, Gootjes J, Hespe W (1980) Aryl 1,4-dialk(en)ylpiperazines as selective and very potent inhibitors of dopamine uptake. Eur J Med Chem 15:363-370
49. Xia Y, Goebel DJ, Kapatos G, Bannon MJ (1992) Quantitation of rat dopamine transporter mRNA: Effects of cocaine treatment and withdrawal. J Neurochem 59:1179-1182