Synthesis and biological activity of new bradykinin pseudopeptide B1 receptor agonists containing alkylic spacers

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 20, 1997, Pages 2661-2664

  Tancredi, Mariella ^a   Galoppini, Claudia ^a   Meini, Stefania ^b   Quartara, Laura ^b   Maggi, Carlo A ^b   Rovero, Paolo ^a  

^a CNR   (Italy)

^b Menarini Ricerche SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BRADYKININ B1 RECEPTOR; BRADYKININ B1 RECEPTOR AGONIST; BRADYKININ DERIVATIVE; TETRAPEPTIDE;

ANIMAL TISSUE; ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; ILEUM CONTRACTION; MUSCLE CONTRACTILITY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 0030725856     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10042-7     Document Type: Article

References (9)

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8. Peptides were synthesized as previously described in Rovero, P.; Viganò, S.; Pegoraro, S.; Quartara, L. Lett. Pept. Sci., 1995, 2, 319. Briefly, syntheses were performed on a Milligen 9050 automatic synthesizer, using standard Fmoc chemistry on PEG-PS resin and continuous-flow strategy. Crude products were purified to homogeneity by preparative RP-HPLC and characterized by mass spectrometry.
9. 1 agonists in the rat ileum were performed at 5 h from set-up.