Chronic ethanol exposure alters leukocyte subsets in repopulating spleens, but does not alter negative selection in thymuses of sublethally irradiated mice

Alcoholism: Clinical and Experimental Research

Volumn 21, Issue 8, 1997, Pages 1520-1529

  Livant, Emily J ^a   Welles, Elizabeth G ^a   Ewald, Sandra J ^a  

^a AUBURN UNIVERSITY   (United States)

Author keywords

Ethanol; Flow Cytometry; Negative Selection; Spleen; Thymus

Indexed keywords

ALCOHOL; T LYMPHOCYTE RECEPTOR;

ALCOHOL BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GAMMA IRRADIATION; LEUKOCYTE; LONG TERM EXPOSURE; MOUSE; NONHUMAN; PRENATAL DEVELOPMENT; PRENATAL EXPOSURE; PRIORITY JOURNAL; SPLEEN; T LYMPHOCYTE; THYMUS;

EID: 0030725426     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1997.tb04484.x     Document Type: Article

References (46)

1. Robey E: Selective events in T cell development. Annu Rev Immunol 12:675-705, 1994
2. + thymocytes undergoing thymic selection: Requirement of calcineurin activation for thymic positive selection but not negative selection. J Exp Med 181:927-941, 1995
3. ras distinguishes positive and negative selection in thymocytes. EMBO J 14:276-285, 1995
4. Alberola-Ila J, Hogquist KA, Swan KA, Bevan MJ, Perlmutter M: Positive and negative selection invoke distinct signaling pathways. J Exp Med 184:9-18, 1996
5. Ewald SJ, Walden SM: Flow cytometric and histological analysis of mouse thymus in fetal alcohol syndrome. J Leukoc Biol 44:434-440, 1988
6. Ewald SJ: T lymphocyte populations in fetal alcohol syndrome. Alcohol Clin Exp Res 13:485-489, 1989
7. Shao H, Zhou J, Ewald SJ: Regulation of signal transduction and DNA fragmentation in thymocytes by ethanol. Cell Immunol 164:11-19, 1995
8. Gao E-K, Lo D, Cheney R, Kanagawa O, Sprent J: Abnormal differentiation of thymocytes in mice treated with cyclosporin A. Nature 336:176-179, 1988
9. Jenkins MK, Schwartz RH, Pardoll DM: Effects of cyclosporine A on T cell development and clonal deletion. Science 241:1655-1658, 1988
10. Lobach DF, Haynes BF: Ontogeny of the human thymus during fetal development. J Clin Immunol 7:81-97, 1987
11. Penit C, Vasseur F: Cell proliferation and differentiation in the fetal and early postnatal mouse thymus. J Immunol 142:3369-3377, 1989
12. Signorelli K, Benoist C, Mathis D: Why is clonal deletion of neonatal thymocytes defective? Eur J Immunol 22:2487, 1992
13. Finkel TH, Kappler JW, Marrack PC: Immature thymocytes are protected from deletion early in ontogeny. Proc Natl Acad Sci USA 89:3372, 1992
14. Vilaro S, Vinas O, Remesar X, Herrera E: Effects of chronic ethanol consumption on lactational performance in rat: Mammary gland and milk composition and pup growth and metabolism. Pharmacol Biochem Behav 27:333-339, 1987
15. Barron S, Kelly SJ, Riley EP: Neonatal alcohol exposure alters suckling behavior in neonatal rat pups. Pharmacol Biochem Behav 39:423-427, 1990
16. Abel EL: Fetal Alcohol Syndrome and Fetal Alcohol Effects. New York, Plenum Press, 1984
17. Zajac CS, Abel EL: Animal models of prenatal alcohol exposure. Int J Epidemiol 21(Suppl. 1):S24-S32, 1992
18. Gottesfeld Z, LeGrue SJ: Lactational alcohol exposure elicits long-term immune deficits and increased noradrenergic synaptic transmission in lymphoid organs. Life Sci 47:457-465, 1990
19. Tomooka S, Matsuzaki G, Kishihara K, Tanaka K, Yoshikai Y, Taniguchi K, Himeno K, Nomoto K: Sequential appearance of thymocyte subpopulations and T cell antigen receptor gene messages in the mouse thymus after sublethal irradiation. J Immunol 139:3986-3990, 1987
20. Zuniga-Pflucker JC, Kruisbeek AM: Intrathymic radioresistant stem cells follow an IL-2/IL-2R pathway during thymic repopulation after sublethal irradiation. J Immunol 144:3736-3740, 1990
21. Bill J, Kanagawa O, Woodland DL, Palmer E: The MHC molecule I-E is necessary but not sufficient for the clonal deletion of Vβ11-bearing T cells. J Exp Med 169:1405-1419, 1989
22. Duke RC, Cohen JJ: Quantitation of apoptotic cell index and cell viability using fluorescent dyes, in Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W (eds): Current Protocols in Immunology. John Wiley and Sons, Inc., 1994, pp 3.17.2-3.17.4
23. Takada A, Takada Y, Huang CC, Ambrus JL: Biphasic pattern of thymus regeneration after whole-body irradiation. J Exp Med 129:445-456, 1969
24. Penit C, Ezine S: Cell proliferation and thymocyte subset reconstitution in sublethally irradiated mice: Compared kinetics of endogenous and intrathymically transferred progenitors. Immunology 86:5547-5551, 1989
25. Kadish JL, Basch RS: Thymic regeneration after lethal irradiation: Evidence for an intra-thymic radioresistant T cell precursor. J Immunol 114:452-458, 1975
26. Scollay R, Smith J, Stauffer V: Dynamics of early T cells: Prothymocyte migration and proliferation in the adult mouse thymus. Immunol Rev 91:129-157, 1986
27. Ikuta K, Uchida N, Friedman J, Weissman IL: Lymphocyte development from stem cells. Annu Rev Immunol 10:759-83, 1992
28. Kappler JW, Roehm N, Marrack P: T cell tolerance by clonal elimination in the thymus. Cell 49:273-280, 1987
29. Kappler JW, Wade T, White J, Kushnir E, Blackman M, Bill J, Roehm N, Marack P: A T cell receptor Vβ segment that imparts reactivity to a class II major histocompatibility complex product. Cell 49:263-271, 1987
30. Bray LA, Shao H, Ewald SJ: Effect of ethanol on development of fetal mouse thymocytes in organ culture. Cell Immunol 151:12-23, 1993
31. Johnson S, Knight R, Manner DJ, Steele RW: Immune deficiency in fetal alcohol syndrome. Pediatr Res 15:908-911, 1981
32. Ewald SJ, Shao H: Ethanol increases apoptotic cell death of thymocytes in vitro. Alcohol Clin Exp Res 17:359-365, 1993
33. Wolcott RM, Jennings SR, Chervenak R: In utero exposure to ethanol affects postnatal development of T- and B-lymphocytes, but not natural killer cells. Alcohol Clin Exp Res 19:170-176, 1995
34. Giberson PK, Blakley BR: Effect of postnatal ethanol exposure on expression of differentiation antigens of murine splenic lymphocytes. Alcohol Clin Exp Res 18:21-28, 1994
35. Saad AJ, Jerrells TR: Flow cytometric and immunohistochemical evaluation of ethanol-induced changes in splenic and thymic lymphoid cell populations. Alcohol Clin Exp Res 15:796-803, 1991
36. Meadows GG, Wallendal M, Atsushi K, Wunderlich J, Singer DS: Ethanol induces marked changes in lymphocyte populations and natural killer cell activity in mice. Alcohol Clin Exp Res 16:474-479, 1992
37. Lindenbaum J: Hematologic complications of alcohol abuse. Semin Liver Dis 7:169-181, 1987
38. Ballard HS: Hematological complications of alcoholism. Alcohol Clin Exp Res 13:706-720, 1989
39. Marietta CA, Jerrells TR, Meagher RC, Karanian JW, Weight FF, Eckardt MJ: Effects of long-term ethanol inhalation on the immune and hematopoietic systems of the rat. Alcohol Clin Exp Res 12:211-214, 1988
40. Lindenbaum J, Hargrove RL: Thrombocytopenia in alcoholics. Ann Intern Med 68:526-532, 1968
41. Liu YK: Leukopenia in alcoholics. Am J Med 54:605-610, 1973
42. Liu YK: Effects of alcohol on granulocytes and lymphocytes. Semin Hematol 17:130-136, 1980
43. + peripheral blood T lymphocytes contain lymphokine-activated killer cell precursors. Eur J Immunol 19:1037-1044, 1989
44. + cytotoxic T cell activation and memory in virus infection. J Immunol 149:1326-1333, 1992
45. Cook RT, Garvey MJ, Booth BM, Goeken JA, Stewart B, Noel M: Activated CD-8 cells and HLA DR expression in alcoholics without overt liver disease. J Clin Immunol 11:246-253, 1991
46. Cook RT, Waldschmidt TJ, Ballas ZK, Cook BL, Booth BM, Stewart BC, Garvey MJ: Fine T-cell subsets in alcoholics as determined by the expression of L-selectin, leukocyte common antigen, and β-integrin. Alcohol Clin Exp Res 18:71-80, 1994