Comparative mutagenic and genotoxic effects of three propionic acid derivatives ibuprofen, ketoprofen and naproxen

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 393, Issue 1-2, 1997, Pages 123-131

  Philipose, B ^a   Singh, R ^a   Khan, K A ^b   Giri, A K ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Genotoxicity; Ibuprofen; Ketoprofen; Mouse; Mutagenicity; Naproxen; Salmonella

Indexed keywords

IBUPROFEN; KETOPROFEN; NAPROXEN; PROPIONIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; GENOTOXICITY; MALE; MOUSE; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SISTER CHROMATID EXCHANGE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BONE MARROW CELLS; IBUPROFEN; KETOPROFEN; MALE; MICE; MICROSOMES, LIVER; MUTAGENICITY TESTS; MUTAGENS; NAPROXEN; RATS; SALMONELLA TYPHIMURIUM; SISTER CHROMATID EXCHANGE;

ANIMALIA; SALMONELLA;

EID: 0030724973     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(97)00095-8     Document Type: Article

References (35)

1. Martindale, The Extra Pharmacopoeia, The Universally acclaimed Source of Drug Information, The Pharmaceutical Press, 1993, London, pp. 17-25.
2. R.J. Flower, S. Moncada, J.R. Vane, Analgesic-antipyretic and anti-inflammatory agents; drugs employed in the treatment of gout, in: A.G. Gilman, L.S. Goodman, T.W. Rall, F. Murad (Eds.), The Pharmacological Basis of Therapeutics, Macmillan, New York, 1985, pp. 700-702.
3. A. Woltex, Drug Facts and Comparisons, Kluwer, St. Louis, MO, 1995, pp. 1272-1277.
4. Suraez S.M., Cohen P.R., DeLeo V.A. Bullous photosensitivity to naproxen 'Pseudoporphyria'. Arthritis Rheum. 33:1990;903-908.
5. Stempel D.A., Miller J.J. Lymphopenia and hepatic toxicity with ibuprofen. J. Pediatr. 90:1977;657-658.
6. Lussier A., Arsenault A., Varady J. Gastrointestinal microbleeding after aspirin and naproxen. Clin. Pharmacol. Ther. 23:1978;402-407.
7. Cioli V., Putzolu S., Rossi V., Scorza B.P., Corradino C. The role of direct tissue contact in the production of gastrointestinal ulcers by anti-inflammatory drugs in rats. Toxicol. Appl. Pharmacol. 50:1979;283-289.
8. Samuelson C.O. Jr., Williams H.J. Ibuprofen associated asceptic meningitis in systemic lupus erythematosus. West. J. Med. 131:1979;57-59.
9. Bernstein R.F. Ibuprofen related meningitis in mixed connective tissue disease. Ann. Intern. Med. 92:1980;206-207.
10. Gavrisiuk V.K., Diachenko A.P., Krasnoshup N.A., Yachnik A.I., Draga N.P. Vasoconstrictive effect of ibuprofen in the treatment of patients with pulmonary hypertension. Med. Profess. 1:1989;62-64.
11. Halpern S.M., Fitzpatrick R., Volans G.N. Ibuprofen toxicity - a review of adverse reactions and over dose. Adverse drug reaction. Toxicol. Rev. 12:1993;107-128.
12. Bender W.L., Whelton A., Beschorner W.E., Darwish M.O., Craggs M.H., Solez K. Interstitial nephritis, proteinuria and renal failure caused by nonsteroidal anti-inflammatory drugs. Immunologic characterization of the inflammatory infiltrate. Am. J. Med. 76:1984;1006-1012.
13. Hein T., Bosse G.M., Tsai Yi.Yi. Ibuprofen overdose complicated by renal failure, adult respiratory distress syndrome and metabolic acidosis. J. Toxicol. Clin. Toxicol. 32:1994;315-320.
14. Valsecchi R., Falgheri G., Cainelli T. Contact dermatitis from ketprofen. Contact Dermatitis. 9:1983;163-164.
15. Satterwhite J.H., Boudinot F.D. Pharmacokinetics of ketoprofen in rats; effect of age and dose. Biopharm. Drug Dispos. 13:1992;197-212.
16. Fredell E.W., Strand L.J. Naproxen overdose. J. Am. Med. Assoc. 238:1977;938.
17. Caruana R.J., Semble E.L. Renal papillary necrosis due to naproxen. J. Rheumatol. 11:1984;90-91.
18. Kulling P.E.J., Beckman E.A., Skagius A.S.M. Renal impairment after acute diclofenac, naproxen and sulindac over doses. J. Toxicol. Clin. Toxicol. 33:1995;173-177.
19. Oldham J.W., Preston R.F., Paulson J.D. Mutagenicity testing of selected analgesics in Ames Salmonella strains. J. Appl. Toxicol. 6:1986;237-243.
20. Kadotani S., Arisawa M., Maruyama H.B. Mutagenicity examination of several non-steroidal anti-inflammatory drugs in bacterial systems. Mutation Res. 138:1984;133-136.
21. Giri A.K. Genetic toxicology of paracetamol and aspirin - a review. Mutation Res. 296:1993;199-210.
22. Giri A.K. Genetic toxicology of vinyl chloride - a review. Mutation Res. 339:1995;1-14.
23. Giri A.K., Messerly E.A., Sinsheimer J.E. Sister chromatid exchange and chromosome aberrations for four aliphatic epoxides in mice. Mutation Res. 224:1989;253-261.
24. Giri A.K., Messerly E.A., Chakraborty P.K., Hooberman B.H., Sinsheimer J.E. DNA strand breaks in liver for four aliphatic epoxides in mice. Mutation Res. 242:1990;187-194.
25. Giri A.K., Sai Sivam S., Khan K.A. Sister chromatid exchange and chromosome aberrations induced by paracetamol in vivo in bone marrow cells of mice. Mutation Res. 278:1992;253-257.
26. A.K. Giri, N. Adhikari, K.A. Khan, Comparative genotoxicity of six salicylic acid derivatives in bone marrow cells of mice, Mutation Res. 370 (1996) 1-9.
27. Garner R.C., Miller E.C., Miller J.A. Liver microsomal metabolism of aflatoxin B1 to a reactive derivative toxic to Salmonella typhimurium TA1530. Cancer Res. 32:1972;2066-2085.
28. Maron D.M., Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutation Res. 113:1983;173-215.
29. Adams S.S., Bough R.G., Cliffe E.E., Lessel B., Mills R.F.N. Absorption distribution and toxicity of ibuprofen. Toxicol. Appl. Pharmacol. 15:1969;310-330.
30. McFee A.F., Lowe K., San Sebastian J.R. Improved sister chromatid differentiation using paraffin coated bromodeoxyuridine tablets in mice. Mutation Res. 119:1983;83-88.
31. Tice R.R., Ivett J.L., McFee A.F. The effect of agent treatment time on the induction of sister chromatid exchange in mouse bone marrow cells in vivo. Mutation Res. 182:1987;15-29.
32. Preston R.J., Dean B.J., Galloway S., Holden H., McFee A.F., Shelby M. Mammalian in vivo cytogenetic assays. Analysis of chromosome aberrations in bone marrow cells. Mutation Res. 198:1987;157-165.
33. World Health Organization, Environmental Health Criteria 51, Guide to Short-Term Test for Detecting Mutagenic and Carcinogenic Chemicals, WHO, Geneva, 1985, pp. 100-110.
34. Dunnett C.W. A multiple comparison procedure for comparing several treatments with a control. Am. J. Stat. Assoc. 50:1955;1096-1121.
35. Margolin B.H., Resnick M.A., Rimpo J.Y., Archer P., Galloway S.M., Bloom A.D., Zeiger E. Statistical analysis for in vitro cytogenetic assays using Chinese Hamster overy cells. Environ. Mutagen. 8:1986;183-204.