Thrombin has a bimodal effect on glioma cell growth

British Journal of Cancer

Volumn 76, Issue 12, 1997, Pages 1592-1595

  Schafberg, H ^a   Nowak, G ^a   Kaufmann, R ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

C6 cell; Proliferation; Thrombin; Thrombin receptor; TRAP 6

Indexed keywords

ANTIMITOTIC AGENT; THROMBIN; THROMBIN RECEPTOR; THROMBIN RECEPTOR ACTIVATING PEPTIDE;

ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; GLIOMA; GLIOMA CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030724757     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.602     Document Type: Article

References (21)

1. 2+ mobilization in rat C6 glioma cells. J Neurosci 14: 5858-5864
2. Bar-Shavit R, Mudd M, Wilner G, Mann K and Fenton JW II (1983) Monocyte chemotaxis: stimulation by specific exosite region in thrombin. Science 220: 728-731
3. Berndt M and Philipps D (1981) Platelet membrane proteins: composition and receptor function. In: Platelets in Biology and Pathology, Gordon J (ed), pp. 43-47. Elsevier/North Holland Biomedical Press: Amsterdam.
4. Carney DH, Scott DL, Gordon EA and Labelle EF (1985) Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide in turnover and initiation of cell proliferation. Cell 42: 479-488.
5. Chen LB and Buchanan JM (1975) Mitogenic activity of blood components. I. Thrombin and prothrombin. Proc Natl Acad Sci USA 72: 131-135
6. 2+], oscillations in single rat glioma cells induced by thrombin through activation of cell surface receptors. Neuro Report 6: 1249-1252
7. Glenn K, Carney D, Fenton JW II and Cunningham D (1980) Thrombin active-site regions required for fibroblast receptor binding and initiation of cell division. J Biol Chem 255: 6609-6616
8. Herbert JM, Dupuy E, Laplace MC, Zini JM, Bar Shavit R and Tobelem G (1994) Thrombin induces endothelial cell growth via both a proteolytic and a non-proteolytic pathway. Biochem J 303: 227-231
9. Hollenberg MD (1996) Protease-mediated signalling: new paradigms for cell regulation and drug development. Trends Pharmacol Sci 17: 3-6
10. Kaufmann R, Lindschau C, Höer A, Henklein P, Adomeit A, Haller H, Oberdisse E and Nowak G (1996) Signaling effects of α-thrombin and SFLLRN in rat glioma C6 cells. J Neurosci Res 46: 641-651
11. Nanevicz T, Ishii, M, Wang L, Chen M, Chen J, Turck CW, Cohen FE and Coughlin SR (1995) Mechanism of thrombin receptor agonist specificity. Chimeric receptors and complementary mutations identify an agonist recognition site. J Biol Chem 270: 21619-21625
12. Nierodzik ML, Kajumo LR and Karpatkin S (1992) Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo. Cancer Res 52: 3267-3272
13. Plantier JL, Berthier R, Rival Y, Schweitzer A and Rabiet MJ (1994) Evidence for a selective inhibitory effect of thrombin on megakaryocyte progenitor growth mediated by the thrombin receptor. Br J Haematol 87: 755-762
14. Rydel TJ, Ravichandran KG, Tulinsky A, Bode W, Huber R, Roitch C and Fenton II JW (1990) The structure of a complex of recombinant hirudin and human α-thrombin. Science 249: 277-280
15. Strawn LM, Mann E, Elliger SS, Chu LM, Germain LL, Niederfellner G, Ullrich A and Shawver LK (1994) Inhibition of glioma cell growth by a truncated platelet-derived growth factor-β receptor. J Biol Chem 269: 21215-21222
16. Takano S, Gately S, Engelhard H, Tsanaclis AMC and Brem S (1994) Suramin inhibits glioma cell proliferation in vivo and in the brain. J Neuro-Oncol 21: 189-201
17. Tas PW and Koschel K (1990) Thrombin reverts the beta-adrenergic agonist induced morphological response in rat glioma C6 cells. Exp Cell Res 189: 22-27
18. Turner JS, Redpath GT, Humphries JE, Gonias SL and Vandenberg SR (1994) Plasmin modulates the thrombin-evoked calcium response in C6 glioma cells. Biochem J 297: 175-179
19. Vu T-KH, Hung DT, Wheaton VI and Coughlin SR (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolylic mechanism of receptor activation. Cell 6: 1057-1068
20. Wojtukiewicz MZ, Tang DG, Ben-Josef E, Nenaud C, Walz DA and Honn KV (1995) Solid tumor cells express functional "tethered ligand" thrombin receptor. Cancer Res 55: 698-704
21. Zacharski LR (1987) Small cell carcinoma of the lung: interaction with the blood coagulation mechanism and treatment with anticoagulants. Onkologie 10: 264-270