Effects of a high n-3 fatty acid diet on membrane lipid composition of heart and skeletal muscle in normal swine and in swine with the genetic mutation for malignant hyperthermia

Journal of Lipid Research

Volumn 38, Issue 10, 1997, Pages 2023-2034

  Otten, W ^a   Iaizzo, P A ^b   Eichinger, H M ^c  

^a LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^b UNIVERSITY OF MINNESOTA   (United States)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Diet supplementation; Docosahexaenoic acid; Eicosapentaenoic acid; Fish oil; Phospholipids

Indexed keywords

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; LINOLEIC ACID; MEDIUM CHAIN FATTY ACID; OMEGA 3 FATTY ACID; PHOSPHOLIPID; SATURATED FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FAT INTAKE; GENE MUTATION; HEART MUSCLE; LIPID COMPOSITION; MALE; MALIGNANT HYPERTHERMIA; NONHUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE; SWINE;

ANIMALS; CARDIOLIPINS; FATTY ACIDS; FATTY ACIDS, OMEGA-3; FISH OILS; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; MALE; MALIGNANT HYPERTHERMIA; MEMBRANE LIPIDS; MUSCLE, SKELETAL; MUTATION; MYOCARDIUM; PHOSPHATIDIC ACIDS; PHOSPHOLIPIDS; SPHINGOMYELINS; SWINE;

EID: 0030724051     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Deufel, T., A. Golla, D. Iles, A. Meindl, T. Meitinger, D. Schindelhauer, A. DeVries, D. Pongratz, D. H. MacLennan, K. J. Johnson, and F. Lehmann-Horn. 1992. Evidence for genetic heterogeneity of malignant hyperthermia susceptibility. Am. J. Hum. Genet. 50: 1151-1161.
2. Gillard, E. F., K. Otsu, J. Fujii, C. Duff, S. De Leon, V. K. Khanna, B. A. Britt, R. G. Worton, and D. H. MacLennan 1991. A substitution of cysteine for arginine 614 in the ryanodine receptor is potentially causative of human malignant hyperthermia. Genomics 11: 751-755.
3. 2/d-subunits of the L-type voltage-dependent calcium channel to chromosome 7q and analysis of the segregation of flanking markers in malignant hyperthermia susceptible families. Hum. Mol. Genet. 3: 969-975.
4. MacLennan, D. H., C. Duff, F. Zorzato, J. Fujii, M. Phillips, R. G. Korneluk, W. Frodis, B. A. Britt, and R. G. Worton, 1990. Ryanodine receptor gene is a candidate for predisposition to malignant hyperthennia. Nature. 343: 559-561.
5. McCarthy, T. V., J. M. S. Healy, J. J. A. Heffron, M. Lehane, T. Deufel, F. Lehmann-Horn, M. Farall, and K. Johnson. 1990. Localization of the malignant hyperthermia susceptibility locus to human chromosome 19q112-13.2. Nature. 343: 562-564.
6. Quane, K. A., K. E. Keating, B. M. Manning, J. M. S. Healing, K. Monsieurs, J. J. A. Heffron, M. Lehane, L. Heytens, R. Krivosic-Horber, P. Adnet, F. R. Effis, N. Monnier, J. Lunardi, and T. V. McCarthy 1994. Detection of a novel common mutation in the ryanodine receptor gene in malignant hyperthermia: implications for diagnosis and heterogeneity studies. Hum. Mol. Genet. 3: 471-476.
7. Sudbrak, R., V. Procaccio, M. Klausnitzer, J. L. Curran, K. Monsieurs, C. Van Broeckhover, R. Ellis, L. Heytens, E. J. Hartung, G. Kozak-Ribbins, D. Heilinger, J. Weissenback, F. Lehmann-Horn, C. R. Müller, T. Deufel, A. D. Stewart, and J. Lunardi. 1995. Mapping of a further malignant hyperthermia susceptibility locus to chromosome 3q13.1. Am. J. Hum. Genet. 56: 684-691.
8. MacLennan, D. H., and M. S. Phillips. 1992. Malignant hyperthermia. Science. 256: 789-794.
9. Otsu, K., V. K. Khanna, A. L. Archibald, and D. H. MacLennan. 1991. Co-segregation of porcine malignant hyperthermia and a probable causal mutation in the skeletal muscle ryanodine receptor gene in backcross families. Genomics. 11: 744-750.
10. Fujii, J., K. Otsu, F. Zorzato, S. DeLeon, V. K. Khanna, J. E. Weiler, P. J. O'Brien, and D. H. MacLennan. 1991. Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia. Science. 253: 448-451.
11. Gronert, G. A. 1994. Malignant hyperthermia. In Myology. A. G. Engel and C. Franzini-Armstrong, editors. McGraw-Hill, New York. 1661-1678.
12. Iaizzo, P. A., W. Klein, and F. Lehmann-Horn. 1988. Fura-2 detected myoplasmic calcium and its correlation with contracture force in skeletal muscle from normal and malignant hyperthermia susceptible pigs. Pflüg. Arch. 411: 648-653.
13. 2+] in human skeletal muscle. Cell Calcium. 10: 151-158.
14. Hall, G. M., J. R. Bendall, J. N. Lucke, and D. Lister. 1976. Porcine malignant hyperthermia. II: heat production. Br. J. Anaesth. 48: 305-308.
15. Iaizzo, P. A., G. H. Kehler, R. S. Zink, K. G. Belani, and D. I. Sessler 1996. Thermal response in acute porcine malignant hyperthermia. Anesth. Analg. 82: 782-789.
16. Lucke, J. N., G. M. Hall, and D. Lister. 1976. Porcine malignant hyperthermia. I: metabolic and physiological changes. Br. J. Anesth. 48: 297-304.
17. Clark, M. G., C. H. Williams, W. F. Pfeifer, D. P. Bloxham, P. C. Holland, C. A. Taylor, and H. H. Lardy. 1973. Accelerated substrate cycling of fructose-6-phosphate in muscle of malignant hyperthermic pigs. Nature. 245: 99-101.
18. Ervasti, J. M., M. T. Classens, J. R. Mickelson, and C. F. Louis. 1989. Altered transverse tubule dihydropyridine receptor binding in malignant hyperthermia. J. Biol. Chem. 264: 2711-2717.
19. Iaizzo, P. A., F. Lehmann-Horn, S. R. Taylor, and E. M. Gallant. 1989. Malignant hyperthermia: effects of halothane on the surface membrane. Muscle Nerve. 12:173-179.
20. Mickelson, J. R., H. S. Thatte, T. M. Beaudry, E. M. Gallant, and C. F. Louis. 1987. Increased skeletal muscle acetylcliolinesterase activity in porcine malignant hyperthermia. Muscle Nerve. 10: 723-727.
21. Mickelson, J. R., J. A. Ross, R. J. Hyslop, E. M. Gallant, and C. F. Louis. 1987. Skeletal muscle sarcolemma in malignant hyperthermia: evidence for a defect in calcium regulation. Biochim. Biophys. Acta. 897: 364-376.
22. Mickelson, J. R., E. M. Gallant, L. A. Litterer, K. M. Johnson, and C. F. Louis. 1988. Abnormal sarcoplasmic reticulum ryanodine receptor in malignant hyperthermia. J. Biol. Chem. 263: 9310-9315.
23. 2+ in the ryanodine receptor of human malignant hyperthermia. Am. J. Physiol. 30: C237-C245.
24. Otten, W., A. Berrer, T. Bergerhoff, M. Goldberg, and H. M. Eichinger. 1995. Effects of a dietary magnesium fumarate supplementation on blood metabolites and meat quality in swine. Magnesium-Bulletin. 17: 91-95.
25. Simpson, S. P., and A. J. Webb. 1989. Growth and carcass performance of British Landrace pigs heterozygous at the halothane locus. Anim. Prod. 49: 503-509.
26. Webb, A. J., and S. P. Simpson. 1986. Performance of British Landrace pigs selected for high and low incidence of halothane sensitivity. 2. Growth and carcass traits. Anim. Prod. 43: 493-503.
27. Otten, W., and H. M. Eichinger. 1996. Carbohydrate and lipid metabolism at rest and under physical and metabolic load in normal swine and those with the genetic mutation for malignant hyperthermia. Anim. Sci. 62: 581-590.
28. Seewald, M. J., H. M. Eichinger, and P. A. Iaizzo. 1991. Malignant hyperthermia: an altered phospholipid and fatty acid composition in muscle membranes. Acta Anaesthesiol. Scand. 35: 380-386.
29. Bayorh, M. A., L. McGee, and G. Feuerstein. 1989. Acute and chronic effects of eicosapentaenoic acid (EPA) on the cardiovascular system. Res. Commun. Chem. Pathol. Pharmacol. 66: 355-374.
30. Hwang, D. 1992. Dietary fatty acids and eicosanoids. In Fatty Acids in Foods and Their Health Implications. C. K. Chow, editor. Marcel Dekker, New York. 531-544.
31. Siess, W., P. Roth, B. Scherer, I. Kurzmann, B. Böhlig, and P. C. Weber. 1980. Platelet-membrane fatty acids, platelet aggregation and thromboxane formation during a mackerel diet. Lancet. 1: 441-444.
32. Simopoulos, A. P. 1991. Omega-3 fatty acids in health and disease and in growth and development. Am. J. Clin. Nutr. 54: 438-463.
33. Singer, P., M. Wirth, S. Voigt, E. Richter-Heinrich, W. Goedicke, I. Berger, E. Naumann, J. Listing, W. Hartrodt, and C. Taube. 1985. Blood pressure-and lipid-lowering effect of mackerel and herring diet in patients with mild essential hypertension. Atherosclerosis. 56: 223-235.
34. Weber, P. C., and A. Leaf. 1991. Cardiovascular effects of omega-3 fatty acids. World Rev. Nutr. Diet. 66: 218-232.
35. Wolfram, G. 1990. N-3 fatty acids - health aspects. In Marine Foods. J.C. Somogyi and D. Hötzel, editors. Bibl. Nutr. Dieta 46, Karger, Basel. 110-119.
36. Berdanier, C. D. 1992. Fatty acids and membrane function. In Fatty Acids in Foods and Their Health Implications. C. K. Chow, editor. Marcel Dekker, New York. 531-544.
37. Bruckner, G. 1992. Biological effects of polyunsaturated fatty acids. In Fatty Acids in Foods and Their Health Implications. C. K. Chow, editor. Marcel Dekker, New York. 631-646.
38. Murphy, M. G. 1990. Dietary fatty acids and membrane protein function. J. Nutr. Biochem. 1: 68-79.
39. Sellmayer, A., H. Obermeier, C. Weber, and P. C. Weber. 1993. Modulation of cell activation by omega-3 fatty acids. In N-3 Fatty Acids and Vascular Disease. R. DeCaterina, S. Endres, S. D. Kristensen and E. B. Schmidt, editors. Springer-Verlag, Bi & Gi Publishers, Verona. 21-30.
40. Weber, P. C., and A. Sellmayer. 1990. Modification of the eicosanoid system and cell signaling by precursor fatty acids. Adv. Prostaglandin, Thromboxane Leukotriene Res. 21: 217-224.
41. Otten, W., C. Wirth, P. A. Iaizzo, and H. M. Eichinger. 1993. A high omega-3 fatty acid diet alters fatty acid composition of heart, liver, kidney, adipose tissue and skeletal muscle in swine. Ann. Nutr. Metab. 37: 134-141.
42. Bligh, E. G., and W. J. Dyer. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. 37: 911-917.
43. Seewald, M., and H. M. Eichinger. 1989. Separation of major phospholipid classes by high-performance liquid chromatography and subsequent analysis of phospholipid-bound fatty acids using gas-chromalography. J. Chromatogr. 469: 271-280.
44. Shehata, A. Y., J. M. De Man, and J. C. Alexander. 1979. A simple and rapid method for the preparation of methyl esters of fats in milligram amounts for gas chromatography. Can. Inst. Food. Technol. J. 3: 85-89.
45. Statistical Analysis Systems Institute. 1989. SAS/STAT User's Guide. Version 6. 4th edition. Volume 2. SAS Institute, Inc., Cary, NC.
46. Jensen, P., and P. A. Barton-Gade. 1985. Performance and carcass characteristics of pigs with known genotypes for halothane susceptibility. In Stress Susceptibility and Meat Quality in Pigs. EAAP Pub. 33: 80-87.
47. Barcelli, U. O., D. C. Beach, and V. E. Pollak. 1988. The influence of n-6 and n-3 fatty acids on kidney phospholipid composition and on eisosanoid production in aging rats. Lipids. 23: 309-312.
48. Cherian, G., and J. S. Sim. 1995. Dietary alpha-linolenic acid alters the fatty acid composition of lipid classes in swine tissues. J. Agr. Food Chem. 43: 2911-2916.
49. Fragikos, B., A. C. Chan, and P. C. Choy. 1986. Competition of n-3 and n-6 polyunsaturated fatty acids in the isolated perfused rat heart. Ann. Nutr. Metab. 30: 331-334.
50. Galloway, J. H., I. J. Cartwright, B. E. Woodcock, M. Greaves, R. G. G. Russel, and E. Preston. 1985. Effects of dietary fish oil supplementation on the fatty acid composition of the human platelet membrane: demonstration of selectivity in the incorporation of eicosapentaenoic acid into membrane phospholipid pools. Clin. Sci. 68: 449-454.
51. Hartog, J. M., J. M. J. Lamers, A. Montfoort, A. E. Becker, M. Klompe, H. Morse, F. J. Ten Cate, L. Van der Werf, W. C. Hülsmann, P. G. Hugenholz, and P. D. Verdouw. 1987. Comparison of mackerel oil and lard fat-enriched diets on plasma lipids, cardiac membrane phospholipids, cardiovascular performance, and morphology in young pigs. Am. J. Clin. Nutr. 46: 258-266.
52. Ruiter, A., A. W. Jongbloed, C. M. Van Gent, L. H. J. C. Danse, and S. H. M. Metz. 1978. The influence of dietary mackerel oil on the condition of organs and on blood lipid composition in the young growing pig. Am. J. Clin. Nutr. 31: 2159-2166.
53. Fill, M., R. Coronado, J. R. Mickelson, J. Vilven, J. Ma, B. A. Jacobsen, and C. F. Louis. 1990. Abnormal ryanodine receptor channels in malignant hyperthermia. Biophys. J. 50: 471-476.
54. Iaizzo, P. A., and D. J. Wedel. 1994. Response to succinylcholine in porcine malignant hyperthermia. Anesth. Analg. 79: 143-151.
55. Scholz, J., N. Roewer, U. Rum, W. Schmitz, H. Scholz, and J. Schulte am Esch. 1991. Effects of caffeine, halothane, succinylcholine, phenylephrine and isoproterenol on myocardial force of contraction of malignant hyperthermia susceptible swine. Acta Anaesthesiol. Scand. 35: 320-325.
56. Wahle, K. W. J., P. C. Morrice, J. R. Arthur, and G. G. Duthie. 1995. Decreased phospholipid polyunsaturated fatty acid content and superoxide dismutase activity in cardiac muscle of malignant hyperthermia-susceptible swine. Comp. Biochem. Phys. B. 112: 283-286.
57. Foster, P. S., E. Gesini, C. Claudianos, K. C. Hopkinson, and M. A. Denborough. 1989. Inositol 1,4,5-trisphosphate phosphatase deficiency and malignant hyperpyrexia in swine. Lancet. 2: 124-126.
58. 2-adrenoceptors in skeletal and cardiac muscle. Acta Anaesthesiol. Scand. 37: 575-583.
59. Scholz, J., N. Roewer, U. Rum, W. Schmitz, H. Scholz, and J. Schulte am Esch. 1991. Possible involvement of inositol-lipid metabolism in malignant hyperthermia. Br. J. Anaesth. 66: 692-696.
60. 2+ release channel of skeletal muscle sarcoplasmic reticulum by palmitoyl carnitine. Biophys. J. 65: 779-789.