Differential in vivo and in vitro bronchorelaxant activities of CP-80,633, a selective phosphodiesterase 4 inhibitor

Canadian Journal of Physiology and Pharmacology

Volumn 75, Issue 8, 1997, Pages 1001-1008

  Wright, Kathryn F ^a   Turner, Claudia R ^a   Jayasinghe Beck, Ruani ^a   Cohan, Victoria L ^a   Cheng, John B ^a   Watson, John W ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Airway smooth muscle; Bronchodilation; cAMP; CP 80,633; Phosphodiesterase 4

Indexed keywords

ATIZORAM; HISTAMINE; IMAZODAN; MILRINONE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; PROPRANOLOL; SALBUTAMOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHODILATATION; CATECHOLAMINE BLOOD LEVEL; CONTROLLED STUDY; EPITHELIUM; GUINEA PIG; IN VITRO STUDY; INTRAARTERIAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE RELAXATION; TRACHEA;

EID: 0030723865     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y97-123     Document Type: Article

References (3)

1. Bulbring, E., and Tomita, T. 1987. Catecholamine action on smooth muscle. Pharmacol. Rev. 39: 49-96.
2. Cohan, V.L., Showell, H.J., Fisher, D.A., Pazoles, C.J., Watson, J.W., Turner, C.R., and Cheng, J.B. 1996. In vitro pharmacology of the novel phosphodiesterase 4 inhibitor, CP-80,633. J. Pharmacol. Exp.Ther. 278: 1356-1361.
3. Cortijo, J., Bou, J., Beleta, J., Cardelus, I., Llenas, J., Morcillo, E., and Gristwood, R.W. 1993. Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus. Br. J. Pharmacol. 108: 562-568.