Determination of 5-hydroxy-l-[β-11C]tryptophan and its in vivo- formed radiolabeled metabolites in brain tissue using high performance liquid chromatography: A study supporting radiotracer kinetics obtained with positron emission tomography

Nuclear Medicine and Biology

Volumn 24, Issue 8, 1997, Pages 733-738

  Lindner, Karl Johan ^a,b,c   Hartvig, Per ^a,b,c   Bjurling, Peter ^a   Fasth, Karl Johan ^a   Westerberg, Göran ^a   Långström, Bengt ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

5 Hydroxy L 11C tryptophan; Brain; HPLC; PET; Serotonin synthesis

Indexed keywords

5 HYDROXYTRYPTOPHAN; 5 HYDROXYTRYPTOPHAN C 11; CARBON 11; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; BRAIN TISSUE; DECARBOXYLATION; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT;

5-HYDROXYTRYPTOPHAN; ANIMALS; BRAIN; CARBON RADIOISOTOPES; CARBOXYLIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROXYINDOLEACETIC ACID; MALE; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0030723195     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(97)00114-5     Document Type: Article

References (20)

1. 11C]5-hydroxytryptophan in major depression: A positron emission tomography study on patients and healthy volunteers. Acta Psychiatr. Scand. 83, 449-455.
2. 11C]L-DOPA in healthy volunteers and patients with unipolar major depression. Depression 1, 71-81.
3. 11C-labeled L-tryptophan and 5-hydroxy-L-tryptophan using a multi-enzymatic reaction route. J. Chem. Soc. Perkin. Trans. 1, 1331-1334.
4. Consolazione A. and Cuello A. C. (1982) CNS serotonin pathways. In: Biology of Serotomergic Transmission (Edited by Osborne N. N.), pp. 29-61. John Wiley and Sons, Chichester, UK.
5. Endo Y. (1985) Evidence that the accumulation of 5-hydroxytryptamine in the liver but not in the brain may cause the hypoglycemia induced by 5-hydroxytryptophan. Br. J. Pharmacol. 85, 591-598.
6. Eriksson B., Lilja A., Ahlström H., Bjurling P., Bergström M., Lindner K.-J., Långström B. and Öberg K. (1994) Positron-emission tomography as a radiological technique in neuroendocrine gastrointestinal tumors. Ann. N. Y. Acad. Sci. 733, 446-452.
7. Eriksson B.-M. and Persson B.-A. (1988) Determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in plasma by direct injection in coupled-column liquid chromatography with electrochemical detection. J. Chromatogr. 459, 351-360.
8. Gessa G. L. and Tagliamonte A. (1974) Possible role of free serum tryptophan in the control of brain tryptophan level and serotonin synthesis. Adv. Biochem. Psychopharmacol. 11, 119-131.
9. Gordon J. L. and Olverman H. J. (1978) 5-Hydroxytryptamine and dopamine transport by rat and human blood platelets. Br. J. Pharmacol. 62, 219-226.
10. 11C]DOPA in humans studied by positron emission tomography. J. Neural Transm. 86, 25-41.
11. 11C-labeled L-tryptophan and 5-hydroxy-L-tryptophan in the Rhesus monkey: A study using positron emission tomography. J Neural Transm. 88, 1-10.
12. Itskovitz H. D., Werber J. L., Sheridan A. M., Brewer T. F. and Stier C. H. Jr. (1988) 5-Hydroxytryptophan and carbidopa in spontaneously hypertensive rats. J. Hypertens. 7, 311-315.
13. 11C]DOPA and its metabolites for the validation of positron emission tomography-studies. J. Pharm. Biomed. Anal. 13, 361-367.
14. Melamed E., Hefti F. and Wurtman R. (1980) L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan decarboxylase activities in rat striatum: Effect of selective destruction of dopaminergic or serotonergic input. J. Neurochem. 34, 1753-1756.
15. Neff N. H., Tozer T. N. and Brodie B. B. (1967) Application of steady-state kinetics to studies of the transfer of 5-hydroxyindoleacetic acid from brain to plasma. J. Pharmacol. Exp. Ther. 158, 214-218.
16. Rahman M. K., Nagatsu T. and Kato T. (1981) Aromatic L-amino acid decarboxylase activity in central and peripheral tissues and serum of rats with L-DOPA and L-5-hydroxytryptophan as substrates. Biochem. Pharmacol. 30, 645-649.
17. 11C]5-hydroxytryptophan in human brain studied by positron emission tomography. Psychiatry Res. [Neuroimaging] 45, 215-225.
18. Sims K. L., Davis G. A. and Bloom F. E. (1973) Activities of 3,4-dihydroxy-L-phenylalanine and 5-hydroxy-L-tryptophan decarboxylase in rat brain: Assay characteristics and distribution. J. Neurochem. 20, 449-464.
19. 11C)-L-3,4-dihydroxy-phenylalanine (DOPA) in the primate by positron emission tomography. Acta Neurol. Scand. 85, 166-173.
20. van Wijk M., Sebens J. B. and Korf J. (1979) Probenecid induced increase of 5-hydroxytryptamine synthesis in rat brain, as measured by formation of 5-hydroxytryptophan. Psychopharmacology 60, 229-235.