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Volumn 8, Issue 6, 1997, Pages 757-762

Innovative approaches to novel antibacterial drug discovery

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT;

EID: 0030723134     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0958-1669(97)80131-0     Document Type: Article
Times cited : (39)

References (57)
  • 1
    • 0029796373 scopus 로고    scopus 로고
    • New directions in antibacterial research
    • of outstanding interest. The authors provide a thorough and broad overview of the current state of research in antibacterial disease. New work is placed within the context of the past several decades of the field.
    • Chu DTW, Plattner JJ, Katz L. New directions in antibacterial research. of outstanding interest J Med Chem. 39:1996;3853-3874 The authors provide a thorough and broad overview of the current state of research in antibacterial disease. New work is placed within the context of the past several decades of the field.
    • (1996) J Med Chem , vol.39 , pp. 3853-3874
    • Chu, D.T.W.1    Plattner, J.J.2    Katz, L.3
  • 2
    • 0029802138 scopus 로고    scopus 로고
    • Antimicrobial-drug resistance
    • Gold HS, Moellering RC. Antimicrobial-drug resistance. N Engl J Med. 335:1996;1445-1453.
    • (1996) N Engl J Med , vol.335 , pp. 1445-1453
    • Gold, H.S.1    Moellering, R.C.2
  • 4
    • 0030841073 scopus 로고    scopus 로고
    • Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility
    • of outstanding interest. This is the first report of an S. aureus methicillin resistant strain isolated from a patient that did not respond to vancomycin treatment. This strain had reduced susceptibility to the glycopeptide and the mechanism of resistance is different than that of enterococci.
    • Hiramatsu K, Hanaki H, Ino T, Yabuta K, Oguri T, Tenover FC. Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility. of outstanding interest J Antimicrob Chem. 40:1997;135-136 This is the first report of an S. aureus methicillin resistant strain isolated from a patient that did not respond to vancomycin treatment. This strain had reduced susceptibility to the glycopeptide and the mechanism of resistance is different than that of enterococci.
    • (1997) J Antimicrob Chem , vol.40 , pp. 135-136
    • Hiramatsu, K.1    Hanaki, H.2    Ino, T.3    Yabuta, K.4    Oguri, T.5    Tenover, F.C.6
  • 5
    • 0031029660 scopus 로고    scopus 로고
    • Antibiotic resistance in Streptococcus pneumoniae
    • Tomasz A. Antibiotic resistance in Streptococcus pneumoniae. Clin Infect Dis. 24:1997;S85-S88.
    • (1997) Clin Infect Dis , vol.24
    • Tomasz, A.1
  • 6
    • 0029155375 scopus 로고
    • Identification of multiple clones of extended-spectrum cephalosporin-resistant Streptococcus pneumoniae isolates in the United States
    • McDougal LK, Rasheed JK, Biddle JW, Tenover FC. Identification of multiple clones of extended-spectrum cephalosporin-resistant Streptococcus pneumoniae isolates in the United States. Antimicrob Agents Chemother. 39:1995;2282-2288.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 2282-2288
    • McDougal, L.K.1    Rasheed, J.K.2    Biddle, J.W.3    Tenover, F.C.4
  • 7
    • 0000842940 scopus 로고    scopus 로고
    • What is a pathogen?
    • Falkow S. What is a pathogen? ASM News. 63:1997;359-365.
    • (1997) ASM News , vol.63 , pp. 359-365
    • Falkow, S.1
  • 8
    • 0007796627 scopus 로고
    • The effects of changing social organization on the infectious diseases of man
    • Boyden S.V. Toronto: University of Toronto Press
    • Fenner F. The effects of changing social organization on the infectious diseases of man. Boyden SV. The Impact of Civilisation on the Biology of Man. 1970;3-73 University of Toronto Press, Toronto.
    • (1970) The Impact of Civilisation on the Biology of Man , pp. 3-73
    • Fenner, F.1
  • 9
    • 0001770208 scopus 로고
    • Management of opportunistic infections associated with HIV infection
    • G.L. Mandell, J.E. Bennett, Dolin R. New York: Churchill Livingstone
    • Masur H. Management of opportunistic infections associated with HIV infection. Mandell GL, Bennett JE, Dolin R. Principles and Practice of Infectious Diseases. 1995;1280-1294 Churchill Livingstone, New York.
    • (1995) Principles and Practice of Infectious Diseases , pp. 1280-1294
    • Masur, H.1
  • 10
    • 0030603841 scopus 로고    scopus 로고
    • Changing the natural history of HIV disease
    • Feinberg MB. Changing the natural history of HIV disease. Lancet. 348:1996;239-246.
    • (1996) Lancet , vol.348 , pp. 239-246
    • Feinberg, M.B.1
  • 11
    • 0030757024 scopus 로고    scopus 로고
    • Chronic infections and coronary heart disease: Is there a link?
    • of special interest. A discussion of the current evidence for the link between cronary diseases and infections by C. pneumoniae and H. pylori.
    • Danesh J, Collins R, Peto R. Chronic infections and coronary heart disease: is there a link? of special interest Lancet. 350:1997;430-436 A discussion of the current evidence for the link between cronary diseases and infections by C. pneumoniae and H. pylori.
    • (1997) Lancet , vol.350 , pp. 430-436
    • Danesh, J.1    Collins, R.2    Peto, R.3
  • 12
    • 0027070575 scopus 로고
    • Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer: A randomized, controlled study
    • Graham DY, Lew GM, Klein PD, Evans DG, Evans DJ. Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer: a randomized, controlled study. Ann Intern Med. 116:1992;705-708.
    • (1992) Ann Intern Med , vol.116 , pp. 705-708
    • Graham, D.Y.1    Lew, G.M.2    Klein, P.D.3    Evans, D.G.4    Evans, D.J.5
  • 13
    • 0030845069 scopus 로고    scopus 로고
    • Randomised trial of roxithromycin in non-Q-wave coronary syndromes: ROXIS pilot study
    • of outstanding interest. This paper shows that coronary heart diseases associated to C. pneumoniae exposure can be treated with a macrolide antibiotic in a controlled trial and reduce mortality. The clinical trial results suggest that some cronary diseases can be treated with antibiotics.
    • Gurfinkel E, Bozovich G, Daroca A, Beck E, Mautner B. Randomised trial of roxithromycin in non-Q-wave coronary syndromes: ROXIS pilot study. of outstanding interest Lancet. 350:1997;404-407 This paper shows that coronary heart diseases associated to C. pneumoniae exposure can be treated with a macrolide antibiotic in a controlled trial and reduce mortality. The clinical trial results suggest that some cronary diseases can be treated with antibiotics.
    • (1997) Lancet , vol.350 , pp. 404-407
    • Gurfinkel, E.1    Bozovich, G.2    Daroca, A.3    Beck, E.4    Mautner, B.5
  • 15
    • 0028243847 scopus 로고
    • Applications of combinatorial technologies to drug discovery. Part 1. Background and combinatorial peptide libraries
    • Gallop MA, Barrett RW, Dower WJ, Fodor SPA, Gordon EM. Applications of combinatorial technologies to drug discovery. Part 1. Background and combinatorial peptide libraries. J Med Chem. 37:1994;1233-1251.
    • (1994) J Med Chem , vol.37 , pp. 1233-1251
    • Gallop, M.A.1    Barrett, R.W.2    Dower, W.J.3    Fodor, S.P.A.4    Gordon, E.M.5
  • 16
    • 0028318863 scopus 로고
    • Applications of combinatorial technologies to drug discovery. Part 2. Combinatorial organic synthesis. Library screening strategies and future directions
    • Gordon EM, Barrett RW, Dower WJ, Fodor SPA, Gallop MA. Applications of combinatorial technologies to drug discovery. Part 2. Combinatorial organic synthesis. Library screening strategies and future directions. J Med Chem. 37:1994;1385-1401.
    • (1994) J Med Chem , vol.37 , pp. 1385-1401
    • Gordon, E.M.1    Barrett, R.W.2    Dower, W.J.3    Fodor, S.P.A.4    Gallop, M.A.5
  • 17
    • 0000074870 scopus 로고    scopus 로고
    • Strategy and tactics in combinatorial organic synthesis. Applications to drug discovery
    • of outstanding interest. Actual accounts of the preparation of small molecule combinatorial libraries for drug discovery applications.
    • Gordon EM, Gallop MA, Patel DV. Strategy and tactics in combinatorial organic synthesis. Applications to drug discovery. of outstanding interest Accounts Chem Res. 29:1996;144-154 Actual accounts of the preparation of small molecule combinatorial libraries for drug discovery applications.
    • (1996) Accounts Chem Res , vol.29 , pp. 144-154
    • Gordon, E.M.1    Gallop, M.A.2    Patel, D.V.3
  • 18
    • 0000122370 scopus 로고    scopus 로고
    • Applications of small molecule combinatorial chemistry to drug discovery
    • Gordon EM. Applications of small molecule combinatorial chemistry to drug discovery. Drug Discov Today. 1:1996;134-144.
    • (1996) Drug Discov Today , vol.1 , pp. 134-144
    • Gordon, E.M.1
  • 19
    • 2842561522 scopus 로고    scopus 로고
    • Design synthesis and evaluation of small-molecule libraries
    • of outstanding interest. This short review describes a significant body of seminal work from one of the leading research groups in the field.
    • Ellman JA. Design synthesis and evaluation of small-molecule libraries. of outstanding interest Accounts Chem Res. 29:1996;132-143 This short review describes a significant body of seminal work from one of the leading research groups in the field.
    • (1996) Accounts Chem Res , vol.29 , pp. 132-143
    • Ellman, J.A.1
  • 20
    • 0029795596 scopus 로고    scopus 로고
    • Recent advances in the generation of small molecule combinatorial libraries: Encoded split synthesis and solid-phase synthetic methodology
    • Baldwin JJ, Henderson I. Recent advances in the generation of small molecule combinatorial libraries: encoded split synthesis and solid-phase synthetic methodology. Med Res Rev. 16:1996;391-405.
    • (1996) Med Res Rev , vol.16 , pp. 391-405
    • Baldwin, J.J.1    Henderson, I.2
  • 21
    • 0029042575 scopus 로고
    • Combinatorial organic synthesis of highly functionalized pyrrolidines: Identification of a potent angiotensin converting enzyme inhibitor from a mercaptoacyl proline library
    • Murphy MM, Schullek JR, Gordon EM, Gallop MA. Combinatorial organic synthesis of highly functionalized pyrrolidines: identification of a potent angiotensin converting enzyme inhibitor from a mercaptoacyl proline library. J Am Chem Soc. 117:1995;7029-7030.
    • (1995) J Am Chem Soc , vol.117 , pp. 7029-7030
    • Murphy, M.M.1    Schullek, J.R.2    Gordon, E.M.3    Gallop, M.A.4
  • 22
    • 0030064961 scopus 로고
    • Solid-supported combinatorial synthesis of structurally diverse β-lactams
    • of outstanding interest. An early example of solid phase combinatorial organic synthesis of small molecules. The monocyclic β-lactam products are of clear relevance to infectious disease medicinal chemistry. Extension of this type of approach could lead to monobactam libraries.
    • Ruhland B, Bandari A, Gordon EM, Gallop MA. Solid-supported combinatorial synthesis of structurally diverse β-lactams. of outstanding interest J Am Chem Soc. 118:1995;253-254 An early example of solid phase combinatorial organic synthesis of small molecules. The monocyclic β-lactam products are of clear relevance to infectious disease medicinal chemistry. Extension of this type of approach could lead to monobactam libraries.
    • (1995) J Am Chem Soc , vol.118 , pp. 253-254
    • Ruhland, B.1    Bandari, A.2    Gordon, E.M.3    Gallop, M.A.4
  • 23
    • 85030304393 scopus 로고    scopus 로고
    • MAGPIE on World Wide Web URL: of outstanding interest
    • MAGPIE on World Wide Web URL: http://www.mcs.anl.gov/home/gaasterl/genomes.html of outstanding interest.
  • 24
    • 85030302945 scopus 로고    scopus 로고
    • This World Wide Web site has updated information on microbial and eukaryotic genome projects. It provides useful links to other sites for individual genomes and status of projects.
    • This World Wide Web site has updated information on microbial and eukaryotic genome projects. It provides useful links to other sites for individual genomes and status of projects.
  • 26
    • 0029805706 scopus 로고    scopus 로고
    • The new genomics: Global views of biology
    • of special interest. This paper includes a thorough discussion on the application of genomics to drug discovery that can be applied to all therapeutic areas. The impact of genomic information on understanding gene expression and protein levels is also discussed.
    • Lander ES. The new genomics: global views of biology. of special interest Science. 274:1996;536-539 This paper includes a thorough discussion on the application of genomics to drug discovery that can be applied to all therapeutic areas. The impact of genomic information on understanding gene expression and protein levels is also discussed.
    • (1996) Science , vol.274 , pp. 536-539
    • Lander, E.S.1
  • 27
    • 85084247357 scopus 로고    scopus 로고
    • High-throughput screening for drug discovery
    • of outstanding interest. The field of screening is presently quite dynamic as researchers seek to identify novel methodologies which exploit and integrate with the methods of combinatorial chemistry. This is a very good overview of the current state of thinking in the screening field.
    • Broach JR, Thorner J. High-throughput screening for drug discovery. of outstanding interest Nature. 384S:1996;14-16 The field of screening is presently quite dynamic as researchers seek to identify novel methodologies which exploit and integrate with the methods of combinatorial chemistry. This is a very good overview of the current state of thinking in the screening field.
    • (1996) Nature , vol.384 , pp. 14-16
    • Broach, J.R.1    Thorner, J.2
  • 28
    • 0000887796 scopus 로고    scopus 로고
    • A dual culture assay for the detection of antimicrobial activity
    • of special interest. A one-pot growth assay for unrelated microorganisms was developed for screening large combinatorial libraries, the paper shows that it is possible to develop novel screening strategies which complement the formats of combinatorial library synthesis.
    • Oldenburg KR, Vo KT, Ruhland B, Schatz PJ, Yuan Z. A dual culture assay for the detection of antimicrobial activity. of special interest J Biomol Screen. 1:1996;123-130 A one-pot growth assay for unrelated microorganisms was developed for screening large combinatorial libraries, the paper shows that it is possible to develop novel screening strategies which complement the formats of combinatorial library synthesis.
    • (1996) J Biomol Screen , vol.1 , pp. 123-130
    • Oldenburg, K.R.1    Vo, K.T.2    Ruhland, B.3    Schatz, P.J.4    Yuan, Z.5
  • 30
    • 0024040909 scopus 로고
    • Penicillin-binding proteins of Gram-negative bacteria
    • Spratt BG, Cromie KD. Penicillin-binding proteins of Gram-negative bacteria. Rev Infect Dis. 10:1988;699-711.
    • (1988) Rev Infect Dis , vol.10 , pp. 699-711
    • Spratt, B.G.1    Cromie, K.D.2
  • 31
    • 0028963048 scopus 로고
    • Erythromycin inhibits the assembly of the large ribosomal subunit in growing Escherichia coli cells
    • Chittum HS, Champney WS. Erythromycin inhibits the assembly of the large ribosomal subunit in growing Escherichia coli cells. Curr Microbiol. 30:1995;273-279.
    • (1995) Curr Microbiol , vol.30 , pp. 273-279
    • Chittum, H.S.1    Champney, W.S.2
  • 32
    • 0029991408 scopus 로고    scopus 로고
    • 50S Ribosomal subunit synthesis and translation are equivalent targets for erythromycin inhibition in Staphylococcus aureus
    • Champney WS, Burdine R. 50S Ribosomal subunit synthesis and translation are equivalent targets for erythromycin inhibition in Staphylococcus aureus. Antimicrob Agents Chemother. 40:1996;1301-1303.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 1301-1303
    • Champney, W.S.1    Burdine, R.2
  • 33
    • 0029157585 scopus 로고
    • Macrolide antibiotics inhibit 50S ribosomal subunit assembly in Bacillus subtilis and Staphylococcus aureus
    • Champney WS, Burdine R. Macrolide antibiotics inhibit 50S ribosomal subunit assembly in Bacillus subtilis and Staphylococcus aureus. Antimicrob Agents Chemother. 39:1995;2141-2144.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 2141-2144
    • Champney, W.S.1    Burdine, R.2
  • 34
    • 0029825658 scopus 로고    scopus 로고
    • Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic
    • of outstanding interest. The RNA - paromycin structure was solved using NMR. This paper describes the interaction between the 30S ribosomal A-site and the aminoglycoside using NMR. This site can be used for the rational drug design of novel antibiotics.
    • Fourmy D, Recht MI, Blanchard SC, Puglisi JD. Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic. of outstanding interest Science. 274:1996;1367-1371 The RNA - paromycin structure was solved using NMR. This paper describes the interaction between the 30S ribosomal A-site and the aminoglycoside using NMR. This site can be used for the rational drug design of novel antibiotics.
    • (1996) Science , vol.274 , pp. 1367-1371
    • Fourmy, D.1    Recht, M.I.2    Blanchard, S.C.3    Puglisi, J.D.4
  • 35
    • 0027313566 scopus 로고
    • Surface action of gentamicin on Pseudomonas aeruginosa
    • Kadurugamuwa JL, Clarke AJ, Beveridge TJ. Surface action of gentamicin on Pseudomonas aeruginosa. J Bacteriol. 175:1993;5798-5805.
    • (1993) J Bacteriol , vol.175 , pp. 5798-5805
    • Kadurugamuwa, J.L.1    Clarke, A.J.2    Beveridge, T.J.3
  • 36
    • 0029911379 scopus 로고    scopus 로고
    • Contribution of mutations in gyrA and parC genes to fluoroquinolone resistance of Streptococcus pneumoniae obtained in vivo and in vitro
    • Tankovic J, Perichon B, Duval J, Courvalin P. Contribution of mutations in gyrA and parC genes to fluoroquinolone resistance of Streptococcus pneumoniae obtained in vivo and in vitro. Antimicrob Agents Chemother. 40:1996;2505-2510.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 2505-2510
    • Tankovic, J.1    Perichon, B.2    Duval, J.3    Courvalin, P.4
  • 37
    • 0027939140 scopus 로고
    • Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition
    • Hoshino K, Kitamura A, Morrissey I, Sato K, Kato J, Ikeda H. Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition. Antimicrob Agents Chemother. 38:1994;2623-2627.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 2623-2627
    • Hoshino, K.1    Kitamura, A.2    Morrissey, I.3    Sato, K.4    Kato, J.5    Ikeda, H.6
  • 38
    • 0030964241 scopus 로고    scopus 로고
    • Exploitation of mammalian host cell functions by bacterial pathogens
    • of special interest. The interaction between bacteria and host cells is reviewed. The significance of signal transduction pathways, cytoskeletal rearrangements, and vacuolar trafficking are examined.
    • Finlay BB, Cossart P. Exploitation of mammalian host cell functions by bacterial pathogens. of special interest Science. 276:1997;719-725 The interaction between bacteria and host cells is reviewed. The significance of signal transduction pathways, cytoskeletal rearrangements, and vacuolar trafficking are examined.
    • (1997) Science , vol.276 , pp. 719-725
    • Finlay, B.B.1    Cossart, P.2
  • 39
    • 0030790687 scopus 로고    scopus 로고
    • Common themes is microbial pathogenicity revisited
    • of special interest. This is an excellent review on genetic strategies used by bacteria to cause infections. Productin of toxins, adherence and invasion of host cells, mechanisms of survival of intracellular pathogens are examined.
    • Finlay BB, Falkow S. Common themes is microbial pathogenicity revisited. of special interest Microbiol Mol Biol Rev. 61:1997;136-169 This is an excellent review on genetic strategies used by bacteria to cause infections. Productin of toxins, adherence and invasion of host cells, mechanisms of survival of intracellular pathogens are examined.
    • (1997) Microbiol Mol Biol Rev , vol.61 , pp. 136-169
    • Finlay, B.B.1    Falkow, S.2
  • 40
    • 0028883838 scopus 로고
    • Antibiotics that resist resistance
    • Service RF. Antibiotics that resist resistance. Science. 270:1995;724-727.
    • (1995) Science , vol.270 , pp. 724-727
    • Service, R.F.1
  • 41
    • 0030606233 scopus 로고    scopus 로고
    • Pathogenicity islands: Bacterial evolution in quantum leaps
    • Groisman EA, Ochman H. Pathogenicity islands: bacterial evolution in quantum leaps. Cell. 87:1996;791-794.
    • (1996) Cell , vol.87 , pp. 791-794
    • Groisman, E.A.1    Ochman, H.2
  • 42
    • 0030953242 scopus 로고    scopus 로고
    • Microbial pathogenesis: Genomics and beyond
    • Strauss EJ, Falkow S. Microbial pathogenesis: genomics and beyond. Science. 276:1997;707-712.
    • (1997) Science , vol.276 , pp. 707-712
    • Strauss, E.J.1    Falkow, S.2
  • 44
    • 0029117137 scopus 로고
    • Simultaneous identification of bacterial virulence genes by negative selection
    • Hensel M, Shea JE, Gleeson C, Jones MD, Dalton E, Holden DW. Simultaneous identification of bacterial virulence genes by negative selection. Science. 269:1995;400-403.
    • (1995) Science , vol.269 , pp. 400-403
    • Hensel, M.1    Shea, J.E.2    Gleeson, C.3    Jones, M.D.4    Dalton, E.5    Holden, D.W.6
  • 45
    • 0027497926 scopus 로고
    • Selection of bacterial virulence genes that are specifically induced in host tissues
    • Mahan MJ, Slauch JM, Mekalanos JJ. Selection of bacterial virulence genes that are specifically induced in host tissues. Science. 259:1993;686-688.
    • (1993) Science , vol.259 , pp. 686-688
    • Mahan, M.J.1    Slauch, J.M.2    Mekalanos, J.J.3
  • 46
    • 0027261491 scopus 로고
    • Excursions in drug discovery
    • Patchett AA. Excursions in drug discovery. J Med Chem. 36:1993;2051-2058.
    • (1993) J Med Chem , vol.36 , pp. 2051-2058
    • Patchett, A.A.1
  • 47
    • 0025997018 scopus 로고
    • Medicinal chemistry in the golden age of biology: Lessons from steroid and peptide research
    • Int Ed
    • Hirschmann R. Medicinal chemistry in the golden age of biology: lessons from steroid and peptide research. Int Ed Angew Chem. 30:1991;1278-1301.
    • (1991) Angew Chem , vol.30 , pp. 1278-1301
    • Hirschmann, R.1
  • 49
    • 0031020216 scopus 로고    scopus 로고
    • D-Alanine:D-alanine ligase: Phosphonate and phosphinate intermediates with wild type and the Y216F mutant
    • Fan C, Park IS, Walsh CT, Knox JR. D-Alanine:D-alanine ligase: phosphonate and phosphinate intermediates with wild type and the Y216F mutant. Biochem. 36:1997;2531-2538.
    • (1997) Biochem , vol.36 , pp. 2531-2538
    • Fan, C.1    Park, I.S.2    Walsh, C.T.3    Knox, J.R.4
  • 50
  • 51
    • 0027521101 scopus 로고
    • Treatment strategies for Helicobacter pylori infections
    • Marshall BJ. Treatment strategies for Helicobacter pylori infections. Gastroenterol Clin North Am. 22:1993;183-198.
    • (1993) Gastroenterol Clin North Am , vol.22 , pp. 183-198
    • Marshall, B.J.1
  • 52
    • 0008028384 scopus 로고
    • Antibiotic transport in mycobacteria
    • Georgopapapdakou N. New York: Marcel Dekker
    • Trias J. Antibiotic transport in mycobacteria. Georgopapapdakou N. Drug Transport in Antimicrobial and Anticancer Chemotherapy. 1995;269-288 Marcel Dekker, New York.
    • (1995) Drug Transport in Antimicrobial and Anticancer Chemotherapy , pp. 269-288
    • Trias, J.1
  • 53
    • 0025852336 scopus 로고
    • Mycobacterium avium complex infection in the acquired immunodeficiency syndrome
    • Horsburg JR. Mycobacterium avium complex infection in the acquired immunodeficiency syndrome. N Engl J Med. 324:1991;1332-1338.
    • (1991) N Engl J Med , vol.324 , pp. 1332-1338
    • Horsburg, J.R.1
  • 54
    • 9344235425 scopus 로고    scopus 로고
    • A randomized trial of clarithromycin as prophylaxis against disseminated Mycobacterium avium complex infection in patients with advanced acquired immunodeficiency syndrome
    • Pierce M, Crampon S, Henry D, Heifets L, LaMarca A, Montecalvo M, Wormser GP, Jablonowski H, Jemsek J, Cynamon M, et al. A randomized trial of clarithromycin as prophylaxis against disseminated Mycobacterium avium complex infection in patients with advanced acquired immunodeficiency syndrome. N Engl J Med. 335:1996;384-391.
    • (1996) N Engl J Med , vol.335 , pp. 384-391
    • Pierce, M.1    Crampon, S.2    Henry, D.3    Heifets, L.4    Lamarca, A.5    Montecalvo, M.6    Wormser, G.P.7    Jablonowski, H.8    Jemsek, J.9    Cynamon, M.10
  • 56
    • 0343158284 scopus 로고    scopus 로고
    • How genes will revolutionise health care
    • Fodor S. How genes will revolutionise health care. Curr Opin Biotechnol. 1997.
    • (1997) Curr Opin Biotechnol
    • Fodor, S.1
  • 57
    • 0029941855 scopus 로고    scopus 로고
    • Resolution of refractory AIDS-related mucosal candidiasis after initiation of didanosine plus saquinovir
    • of special interest. This is one of the first published accounts of changes in AIDS opportunistic infections after treatment with HIV protease inhibitor, and shows that the incidence of AIDS-associated infections can follow the success of HIV therapy in AIDs patients.
    • Zingman BS. Resolution of refractory AIDS-related mucosal candidiasis after initiation of didanosine plus saquinovir. of special interest N Engl J Med. 334:1996;1674-1675 This is one of the first published accounts of changes in AIDS opportunistic infections after treatment with HIV protease inhibitor, and shows that the incidence of AIDS-associated infections can follow the success of HIV therapy in AIDs patients.
    • (1996) N Engl J Med , vol.334 , pp. 1674-1675
    • Zingman, B.S.1


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