A new method for evaluation of motor deficits in 3-acetylpyridine- treated rats

Journal of Neuroscience Methods

Volumn 77, Issue 1, 1997, Pages 25-29

  Watanabe, Yumi ^a   Kinoshita, Kiyoshi ^a   Koguchi, Atushi ^a   Yamamura, Michio ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

3 acetylpyridine; Ataxia; Maximal height of vertical jump; Neurological deficits

Indexed keywords

3 ACETYLPYRIDINE; NICOTINAMIDE;

ANIMAL EXPERIMENT; ARTICLE; ATAXIA; CONTROLLED STUDY; ELECTRIC SHOCK; INTRAPERITONEAL DRUG ADMINISTRATION; JUMPING; MALE; MOTOR DYSFUNCTION; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RAT;

ANIMALS; ATAXIA; BODY WEIGHT; EVALUATION STUDIES; GAIT; MALE; MOTOR ACTIVITY; NERVOUS SYSTEM; PYRIDINES; RATS; RATS, WISTAR;

EID: 0030722992     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0270(97)00104-0     Document Type: Article

References (7)

1. Denk H., Haider M., Kovac W., Studynka G. Behavioural changes and neuropathological feature in rats intoxicated with 3-acetylpyridine. Acta Neuropathologica. 10:1968;34-44.
2. Desclin J.C., Escubi J. Effects of 3-acetylpyridine on the central nervous system of the rat, as demonstrated by silver methods. Brain Res. 77:1974;349-364.
3. Desclin J.C. Histological evidence supporting the inferior olive as the major source of cerebellar climbing fibers in the rat. Brain Res. 77:1974;365-384.
4. Gibson G.E., Blass J.P. Oxidative metabolism and acetylcholine synthesis during acetylpyridine treatment. Neurochem Res. 10(4):1985;453-467.
5. Kinoshita K., Fujitsuka T., Yamamura M., Matsuoka Y. Effects of TA-0910, a novel orally active thyrotropin-releasing hormone analog, on the gait of ataxic animals. Eur J Pharmacol. 274:1995;65-72.
6. Kurahashi K., Kannari K., Kimura K., Matsunaga M., Takebe K. Histydyl-proline diketopiperazine (HPD), a metabolite of thyrotropin-releasing hormone (TRH), improves the ataxic gait in 3-acetylpyridine (3-AP) treated rats. Brain Nerve. 38(9):1986;893-898.
7. Llinas R., Walton K., Hillman D.E. Inferior olive: Its role in motor learning. Science. 190:1975;1230-1231.