The rediscovery of shiga toxin and its role in human illness

Infectious Diseases in Clinical Practice

Volumn 6, Issue 8, 1997, Pages 533-536

  Keusch, Gerald T ^a,b,c  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; SHIGA TOXIN; SHIGELLA VACCINE;

BACTERIAL INFECTION; DIARRHEA; HUMAN; PATHOGENESIS; SHIGELLA DYSENTERIAE; SHORT SURVEY; TOXIN ANALYSIS;

EID: 0030722879     PISSN: 10569103     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019048-199706080-00008     Document Type: Short Survey

References (17)

1. Mata LJ, Gangarosa EJ, Caceres A, Perera DR, Mejicanos ML. Epidemic Shiga bacillus dysentery in Central America. I. Etiologic investigations in Guatemala, 1969. J Infect Dis 1969;122:170.
2. Keusch GT, Grady GF, Mata LJ, McIver JM. The pathogenesis of shigella diarrhea. 1. Enterotoxin production by Shigella dysenteriae I. J Clin Invest 1972;51:1212.
3. Keusch GT, Grady GF, Takeuchi A, Sprinz H. The pathogenesis of shigella diarrhea. 2. Enterotoxin induced acute enteritis in rabbit ileum. J Infect Dis 1972;126:92.
4. Keusch GT, Jacewicz M. Pathogenesis of shigella diarrhea. V. Relationship of shiga enterotoxin, neurotoxin, and cytotoxin. J Infect Dis 1975;131(Suppl):S33.
5. Keusch GT, Jacewicz M. Pathogenesis of shigella diarrhea. VIII. Evidence for a cell membrane toxin receptor involving β1 → linked N-acetylglucosamine. J Exp Med 1977;146:535.
6. Jacewicz M, Keusch GT. Pathogenesis of shigella diarrhea. VIII. Evidence for a translocation step in the cytotoxic action of Shiga toxin. J Infect Dis 1983;148:844.
7. Keusch GT. The pathogenesis of shigella diarrhea. 3. Effects of shigella enterotoxin in cell culture. Trans N Y Acad Sci 1973;35:51.
8. Jacewicz M, Clausen H, Nudelman E, Donohue-Rolfe A, Keusch GT. Pathogenesis of shigella diarrhea. XI. Isolation of a shigella toxin-binding glycolipid from rabbit jejunum and HeLa cells and its identification as globotriaosylceramide. J Exp Med 1986;163:1391.
9. Kandel G, Donohue-Rolfe A, Donowitz M, Keusch GT. Pathogenesis of shigella diarrhea. XVI. Selective targeting of Shiga toxin to villus cells of rabbit jejunum explains the effect of the toxin on intestinal transport. J Clin Invest 1989;84:1509.
10. Mobassaleh M, Donohue-Rolfe A, Jacewicz M, Grand RJ, Keusch GT. Pathogenesis of shigella diarrhea. XIII. Evidence for a developmentally regulated glycolipid receptor for shigella toxin involved in the fluid secretory response of rabbit small intestine. J Infect Dis 1988;157:1023.
11. Donohue-Rolfe A, Acheson DWK, Kane AV, Keusch GT. Purification of Shiga toxin and Shiga-like toxins I and II by receptor analogue affinity chromatography with immobilized P1 glycoprotein and the production of cross-reactive monoclonal antibodies. Infect Immun 1989;57: 3888.
12. Riley LW, Temis RS, Helgerson SD, et al. Hemorrhagic colitis associated with a rare Escherichia coli serotype. N Engl J Med 1983;308:681.
13. Karmali MA, Petric M, Lim C, Fleming PC, Arbus GS, Lior H. The association between idiopathic hemolytic uremic syndrome and infection by Verotoxin-producing Escherichia coli. J Infect Dis 1985;151:775.
14. Koster F, Levin J, Walker L, et al. Hemolytic-uremic syndrome after shigellosis. N Engl J Med 1978;298:927.
15. Brandt JR, Fouser LS, Watkins SL, et al. Escherichia coli O157:H7-associated hemolytic-uremic syndrome after ingestion of contaminated hamburgers. J Pediatr 1994; 125:519.
16. Acheson DWK, Jacewicz M, Kane AV, Donohue-Rolfe A, Keusch GT. One step, high yield, affinity purification of Shiga-like toxin II variants and quantitation using enzyme linked immunosorbant assays. Microbial Pathogen 1993; 14:57.
17. Frias C, Majo M, Margall N, Llobet T, Mirelis B, Prats G. Evaluation of an enzyme immunoassay for verotoxin detection in Escherichia coli. Microbiologia 1996;12: 395.