Prospective study of bone loss in pre- and post-menopausal women on L- thyroxine therapy for non-toxic goitre

Clinical Endocrinology

Volumn 47, Issue 5, 1997, Pages 529-535

  De Rosa, Giovina ^a,b   Testa, Americo ^a   Giacomini, Denise ^a   Carrozza, Cinzia ^a   Astazi, Pietro ^a   Caradonna, Paolo ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b NONE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CREATININE; HYDROXYPROLINE; LEVOTHYROXINE; LIOTHYRONINE; OSTEOCALCIN; THYROTROPIN; THYROXINE;

ADULT; ARTICLE; BONE ATROPHY; BONE DENSITY; BONE MINERAL; BONE TURNOVER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; GOITER; HUMAN; LONGITUDINAL STUDY; LUMBAR SPINE; MAJOR CLINICAL STUDY; OSTEOLYSIS; POSTMENOPAUSE; PREMENOPAUSE; PRIORITY JOURNAL; THYROID HORMONE BLOOD LEVEL;

EID: 0030722289     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1997.3221125.x     Document Type: Article

References (25)

1. Allain, T.J. & McGregor, A.M. (1993) Thyroid hormones and bone. Journal of Endocrinology, 139, 9-18.
2. Coindre, J.M., David, J.P., Riviere, L., Goussot, J.-F., Roger, P., de Mascarel, A. & Meunier, P.J. (1986) Bone loss in hypothyroidism with hormone replacement: a histomorphometric study. Archives of Internal Medicine, 146, 48-53.
3. De Rosa, G., Testa, A., Maussier, M.L., Calla', C., Astazi, P. & Albanese, C.V. (1995) A slightly suppressive dose of 1-thyroxine does not affect bone turnover and bone mineral density in pre- and postmenopausal women with nontoxic goitre. Hormone and Metabolic Research, 27, 503-507.
4. De Rosa, G., Testa, A., Giacomini, D., Carrozza, C., Maussier, M.L., Valenza, V. & D'Errico, F.L. (1996) Comparison between TRH-stimulated TSH and basal TSH measurement by a commercial immunoradiometric assay in the management of thyroid disease. Quarterly Journal of Nuclear Medicine, 40, 182-187.
5. Diamond, T., Nery, L. & Hales, I. (1991) A therapeutic dilemma: suppressive dose of thyroxine significantly reduces bone mineral measurements in both premenopausal and postmenopausal women with thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism, 72, 1184-1188.
6. Egsmose, C., Hegedüs, L., Lund, B. & Mølholm Hansen, J.E. (1992) Bone minerals and levothyroxine. Lancet, 340, 436.
7. Franklyn, J.A., Betteridge, J., Daykin, J., Holder, R., Oates, G.D., Parle, J.V., Lilley, J., Heath, D.A. & Sheppard, M.C. (1992) Long-term thyroxine treatment and bone mineral density. Lancet, 340, 9-13.
8. Frevert, E.U., Biester, A., Müller, M.J., Schmidt-Gayk, H., von zur Mühlen, A. & Brabant, G. (1994) Markers of bone metabolism during short-term administration of thyroxine in healthy volunteers. European Journal of Endocrinology, 131, 145-149.
9. Krølner, B., Vesterdal Jørgensen, J. & Pors Nielsen, S. (1983) Spinal bone mineral content in myxoedema and thyrotoxicosis. Effects of thyroid hormone(s) and antithyroid treatment. Clinical Endocrinology, 18, 439-446.
10. Kung, A.W.C. & Pun, K.K. (1991) Bone mineral density in premenopausal women receiving long-term physiological doses of levothyroxine. Journal of American Medical Association, 265, 2688-2691.
11. Marcocci, C., Golia, F., Bruno-Bossio, G., Vignali, E. & Pinchera, A. (1994) Carefully monitored levothyroxine suppressive therapy is not associated with bone loss in premenopausal women. Journal of Clinical Endocrinology and Metabolism, 78, 818-823.
12. Mosekilde, L., Eriksen, E.F. & Charles, P. (1990) Effects of thyroid hormones on bone and mineral metabolism. Endocrinology and Metabolism Clinics of North America, 19, 35-63.
13. Ongphiphadhanakul, B., Alex, S., Braverman, L.E. & Baran, D.T. (1992) Excessive L-thyroxine therapy decreases femoral bone mineral densities in the rat: effect of hypogonadism and calcitonin. Journal of Bone and Mineral Research, 7, 1227-1231.
14. Paul, T.L., Kerrigan, J., Kelly, A.M. Braverman, L.E. & Baran, D.T. (1988) Long-term L-thyroxine therapy is associated with decreased hip bone density in premenopausal women. Journal of American Medical Association, 259, 3137-3141.
15. Pioli, G., Pedrazzoni, M., Palummeri, E., Sianes. M., Del Frate, R., Vescovi, P.P., Prisco, M., Ulietti, V., Costi, D. & Passeri, M. (1992) Longitudinal study of bone loss after thyroidectomy and suppressive thyroxine therapy in premenopausal women. Acta Endocrinologica, 126, 238-242.
16. Ribot, C., Tremollieres, F., Pouilles, J.M. & Louvet, J.P. (1990) Bone mineral density and thyroid hormone therapy. Clinical Endocrinology, 33, 143-153.
17. Ross, D.S. (1991) Monitoring L-thyroxine therapy: lessons from the effects of L-thyroxine on bone density. American Journal of Medicine, 91, 1-4.
18. Ross, D.S., Neer, R.M., Ridgway, E.C. & Daniels, G.H. (1987) Subclinical hyperthyroidism and reduced bone density as a possible result of prolonged suppression of the pituitary-thyroid axis with L-thyroxine. American Journal of Medicine, 82, 1167-1170.
19. Ross, D.S., Ardisson, L.J., Nussbaum, S.R. & Meskell, M.J. (1990) Serum osteocalcin in patients taking L-thyroxine who have subclinical hyperthyroidism. Journal of Clinical Endocrinology and Metabolism, 72, 507-509.
20. Schneider, P., Berger, P., Kruse, K. & Börner, W. (1991) Effects of calcitonin deficiency on bone density and bone turnover in totally thyroidectomized patients. Journal of Endocrinology Investigation, 14, 935-942.
21. Solomon, B.L. Wartofsky, L. & Burman, K.D. (1993) Prevalence of fractures in postmenopausal women with thyroid disease. Thyroid, 3, 17-23.
22. Stall, G.M., Harris, S., Sokol, L.J. & Daswon-Hughes, B. (1990) Accelerated bone loss in hypothyroid patients overtreated with L-thyroxine. Annals of Internal Medicine, 113, 265-269.
23. Stepan, J.J. & Limanova, Z. (1992) Biochemical assessment of bone loss in patients on long-term thyroid hormone therapy. Bone and Mineral, 17, 377-388.
24. Taelman, P., Kaufman, J.M., Janssens, X., Vandecauter, H. & Vermeulen, A. (1990) Reduced forearm bone mineral content and biochemical evidence of increased bone turnover in women with euthyroid goitre treated with thyroid hormone. Clinical Endocrinology, 33, 107-117.
25. Testa, A., Giacomini, D., Carrozza, C., Liberale, I., Valenza, V. & De Rosa, G. (1995) Body mass index has an effect on bone mineral density in pre- and postmenopausal women, whereas physical activity has not. European Journal of Internal Medicine, 6, 117-120.