Quantitative assessment of myelin basic protein-reactive T cell entry to the central nervous system by using oligonucleotide probes complementary to VDJ junctional sequences of rat TCR β-chain

Journal of Immunological Methods

Volumn 207, Issue 2, 1997, Pages 125-134

  Sun, Deming ^a   Coleclough, Christopher ^b   Cao, Ligong ^a   Sun, Sheher ^a   Whitaker, John N ^a  

^a The University of Alabama at Birmingham   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Clonal T cell marker; Experimental autoimmune encephalomyelitis; MBP reactive T cell; T cell receptor

Indexed keywords

MYELIN BASIC PROTEIN; OLIGONUCLEOTIDE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BETA CHAIN; CELL CLONE; DNA PROBE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RAT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE RECEPTOR GENE;

ANIMALIA;

EID: 0030721546     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(97)00111-7     Document Type: Article

References (39)

1. Barbarese, E., Soares, H., Yang, S., Clark, R.B., 1992. Comparison of CNS homing pattern among murine TH cell lines responsive to myelin basic protein. J. Neuroimmunol. 39, 151.
2. Baron, J.L., Madri, J.A., Ruddle, N.H., Hashim, G., Janeway, C.A. Jr., 1993. Surface expression of α4 integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med. 177, 57.
3. Barten, D.M., Clark, R.B., Ruddle, N.H., 1995. Presence of T cells with activated and memory phenotypes in inflammatory spinal cord lesions. J. Immunol. 155, 5409.
4. Bell, R.B., Lindsey, J.W., Sobel, R.A., Hodgkinson, S., Steinman, L., 1993. Diverse T cell receptor Vβ gene usage in the central nervous system in experimental allergic encephalomyelitis. J. Immunol. 150, 4085.
5. Ben-Nun, A., Wekerle, H., Cohen, I.R., 1981. The rapid isolation of clonable, antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur. J. Immunol. 11, 195.
6. Caspi, R.R., Roberge, F.G., 1989. Glial cells as suppressor cells: Characterization of the inhibitory function. J. Autoimmun. 2, 709.
7. 14C-labeled cells during acute, chronic and relapsing experimental allergic encephalomyelitis. Lab. Invest. 63, 162.
8. Davis, M.M., Bjorkman, P.J., 1988. T-cell antigen receptor genes and T-cell recognition. Nature 334, 395.
9. Engel, I., Hedrick, S.M., 1988. Site-directed mutations in the VDJ junctional region of a T cell receptor beta chain cause changes in the antigenic peptide recognition. Cell 54, 437.
10. Engelhardt, B., Conley, F.K., Kilshaw, P.J., Butch, E.C., 1995. Lymphocytes infiltrating the CNS during inflammation display a distinct phenotype and bind to VCAM-1 but not to MAd-CAM-1. Int. Immunol. 7, 481.
11. Fontana, A., Fierz, W., Wekerle, H., 1984. Astrocytes present myelin basic protein to encephalitogenic T-cell lines. Nature 307, 273.
12. Gold, D.P., Offner, H., Sun, D., Wiley, S., Vandenbark, A.A., Wilson, D.B., 1991. Analysis of T cell receptor β chains in Lewis rats with experimental allergic encephalomyelitis: Conserved complementarity determining region 3. J. Exp. Med. 174, 1467.
13. Hedrick, S.M., Cohen, D.I., Nielson, E.A., Davis, M.M., 1984. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature 308, 149.
14. Hickey, W.F., 1991. Migration of hematogenous cells through the blood-brain barrier and the initiation of CNS inflammation. Brain Pathol. 1, 97.
15. Huang, K., Geoffroy, J.S., Singer, M.S., Rosen, S.D., 1991. A lymphocyte homing receptor (L-selectin) mediates the in vitro attachment of lymphocytes to myelinated tracts of the central nervous system. J. Clin. Invest. 88, 1778.
16. Janzer, R.C., Raff, M.C., 1987. Astrocytes induce blood-brain barrier properties in endothelial cells. Nature 325, 253.
17. Jones, R.E., Bourdette, D., Offner, H., Vandenbark, A.A., 1992. The synthetic 87-99 peptide of myelin basic protein is encephalitogenic in Buffalo rats. J. Neuroimmunol. 37, 203.
18. Karlsson, L., Surh, C.D., Sprent, J., Peterson, P.A., 1992. An unusual class II molecule. Immunol. Today 13, 469.
19. Körner, H., Goodsall, A.L., Lemckert, F.A., Scallon, B.J., Ghrayeb, J., Ford, A.L., Sedgwick, J.D., 1995. Unimpaired autoreactive T-cell traffic within the central nervous system during tumor necrosis factor receptor-mediated inhibition of experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 92, 11066.
20. Kronenberg, M., Goverman, J., Haars, R., Malissen, M., Kraig, E., Phillips, L., Delovitch, T., Suciu-Foca, N., Hood, L., 1985. Rearrangement and transcription of the beta-chain genes of the T-cell antigen receptor in different types of murine lymphocytes. Nature 313, 647.
21. Lannes Vieira, J., Gehrmann, J., Kreutzberg, G.W., Wekerle, H., 1994. The inflammatory lesion of T cell line transferred experimental autoimmune encephalomyelitis of the Lewis rat: Distinct nature of parenchymal and perivascular infiltrates. Acta Neuropathol. Berl. 87, 435.
22. Offner, H., Hashim, G.A., Celnik, B., Galang, A., Li, X., Burns, F.R., Shen, N., Heber-Katz, E., Vandenbark, A.A., 1989. T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats. J. Exp. Med. 170, 355.
23. Oldstone, M.B.A., Southern, P.J., 1993. Trafficking of activated cytotoxic T lymphocytes into the central nervous system: Use of a transgenic model. J. Neuroimmunol. 46, 25.
24. Skundric, D.S., Kim, C., Tse, H.Y., Raine, C.S., 1993. Homing of T cells to the central nervous system throughout the course of relapsing experimental autoimmune encephalomyelitis in Thy-1 congenic mice. J. Neuroimmunol. 46, 113.
25. β repertoire in rats and implications for endogenous superantigens. Eur. J. Immunol. 22, 641.
26. Stepaniak, J.A., Gould, K.E., Sun, D., Swanborg, R.H., 1995. A comparative study of experimental autoimmune encephalomyelitis in Lewis and DA rats. J. Immunol. 155, 2762.
27. Sun, D., Myermann, R., Wekerle, H., 1988a. Up- and down-regulatory activities of astrocyte clones. Ann. N.Y. Acad. Sci. 430, 463.
28. Sun, D., Qin, Y., Chluba, J., Epplen, J.T., Wekerle, H., 1988b. Suppression of experimentally induced autoimmune encephalomyelitis by cytolytic T-T cell interactions. Nature 332, 843.
29. β 8 T cell receptors. Eur. J. Immunol. 22, 591.
30. Sun, D., Le, J., Coleclough, C., 1993a. Diverse T cell receptor β chain usage by rat encephalitogenic T cells reactive to residues 68-88 of myelin basic protein. Eur. J. Immunol. 23, 494.
31. Sun, D., Le, J., Yang, S., Malotkey, M., Coleclough, C., 1993b. Major role of antigen-presenting cells in the response of rat encephalitogenic T cells to myelin basic proteins. J. Immunol. 151, 111.
32. Sun, D., Hu, X., Le, J., Swanborg, R.H., 1994a. Characterization of brain-isolated rat encephalitogenic T cell lines. Eur. J. Immunol. 24, 1359.
33. Sun, D., Shah, R., Coleclough, C., 1994b. Repertoire of rat MBP-reactive T cells: DNA sequencing analysis further demonstrates the clonal heterogeneity of rat T cells reactive against encephalitogenic epitopes. Cell. Immunol. 156, 389.
34. Sun, D., Coleclough, C., Hu, X., 1995a. Heterogeneity of rat encephalitogenic T cells elicited by variants of the MBP(68-88) peptide. Eur. J. Immunol. 25, 1687.
35. Sun, D., Hu, X., Coleclough, C., 1995b. The clonal composition of myelin basic protein-reactive encephalitogenic T cell populations is influenced both by the structure of relevant antigens and the nature of antigen-presenting cells. Eur. J. Immunol. 25, 69.
36. Sun, D., Wekerle, H., 1986. Ia-restricted encephalitogenic T lymphocytes mediating EAE lyse autoantigen-presenting astrocytes. Nature 320, 70.
37. Toyonaga, B., Yanagi, Y., Suciu-Foca, N., Minden, M., Mak, T.W., 1984. Rearrangements of T-cell receptor gene YT35 in human DNA from thymic leukemia T-cell lines and functional T-cell clones. Nature 311, 385.
38. Wekerle, H., Linington, C., Lassmann, H., Meyermann, R., 1986. Cellular immune reactivity within the CNS. Trends Neurosci. 9, 271.
39. Wekerle, H., Sun, D., 1987. Immune reactivity in the nervous system: Modulation of T lymphocyte activation by glial cells. J. Exp. Biol. 132, 43.