NO38 expression and nucleolar counts are correlated with cellular DNA content but not with proliferation parameters in colorectal carcinomas

Journal of Clinical Pathology - Molecular Pathology

Volumn 50, Issue 4, 1997, Pages 201-208

  De Angelis, Paula M ^a,b   Stokke, Trond ^a   Clausen, Ole Petter F ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Cellular DNA content; Colorectal tumours; DNA index; Ki67 labelling index; NO38 expression; Nucleolar counts; S phase fraction

Indexed keywords

BIOTIN; DNA; FLUORESCEIN ISOTHIOCYANATE; KI 67 ANTIGEN; STREPTAVIDIN;

APOPTOSIS; ARTICLE; CELL CYCLE S PHASE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DIAGNOSIS; DNA CONTENT; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; LABELING INDEX; PLOIDY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0030720999     PISSN: 13668714     EISSN: None     Source Type: Journal    
DOI: 10.1136/mp.50.4.201     Document Type: Article

References (34)

1. Spector DL, Ochs RL, Busch H. Silver staining, immunofluorescence, and immunoelectron microscope localization of nucleolar phosphoproteins B23 and C23 Chromosoma 1984;90:139-48.
2. Goessens G. Nucleolar structure. Int Rev Cytol 1984;87:107-58.
3. Jordan EG. Interpreting nucleolar structure: where are the transcribing genes? J Cell Sci 1991;98:437-42.
4. Dumbar TS, Gentry GA, Olson MOJ. Interaction of nucleolar phosphoprotein B23 with nucleic acids. Biochemistry 1989;28:9495-501.
5. Feuerstein N, Mond JJ, Kinchington PR, Hickey K, Lindsberg M-LK, Hay I, et al. Evidence for DNA binding activity of numatrin (B23), a cell cycle-regulated nuclear matrix protein. Biochem Biophys 1990;1087:127-36.
6. Valdez BC, Perlaky I., Henning D, Saijo Y, Chan P-K, Busch H. Identification of the nuclear and nucleolar localization signals of the protein p120. Interaction with translocation protein B23. J Biol Chem 1994;249:23776-83.
7. Beckmann R, Buchner K, Jungblut PR. Eckerskorn C, Weise C, Hilbert R, et al. Nuclear substrates of protein kinase C. Eur J Biochem 1992;210:45-51.
8. Feuerstein N. Phosphorylation of numatrin and other nuclear proteins by cdc2 containing CTD kinase cdc2 p58. J Biol Chem 1991;266:16200-6.
9. Pfaff M, Anderer FA. Casein kinase II accumulation in the nucleolus and its role in nucleolar phosphorylation. Biochem Biophys Acta 1988;969:100-9.
10. Feuerstein N, Mond JJ. "Numatrin", a nuclear matrix protein associated with induction of proliferation in B lymphocytes. J Biol Chem 1987;262:11 389-97.
11. Patterson SD, Grossman JS, D'Andrea P, Latter GI. Reduced numatrin/B23/ nucleophosmin labelling in apoptotic Jurkat T-lymphoblasts. J Biol Chem 1995;270:429-36.
12. Lischwe MA, Smetana K, Olson MO, Busch H. Proteins C23 and B23 are the major nucleolar silver staining proteins. Life Sci 1979;25:701-8.
13. Buys CHCM, Osinga J. Selective staining of the same set of nucleolar phosphoproteins by silver and Giemsa. A combined biochemical and cytochemical study on staining of NORs. Chromosoma 1984;89:387-96.
14. Miller DA, Breg WR, Warburton D, Dev VG, Miller OJ, Regulation of rRNA gene expression in a human familial 14p+ marker chromosome. Hum Genet 1978;43:289-97.
15. Bauer KD, Bagwell CB, Giaretti W, Melamed M, Zarbo RJ, Witzig TE, et al. Consensus review of the clinical utility of DNA flow cytometry in colorectal cancer. Cytometry 1993;14:486-91.
16. Edmin A, Stenling R, Roos G. Prognostic value of DNA content in colorectal carcinoma. A flow cytometric study with some methodologic aspects. Cancer 1987;60:1282-7.
17. Bauer KD, Lincoln ST, Vera-Roman JM, Wallemark CB, Chmiel JS, Madurski ML, et al. Prognostic implications of proliferative activity and DNA aneuploidy in colonic adenocarcinomas. Lab Invest 1987;57:329-35.
18. Gerdes J, Schwab U, Lemke H, Stein H. Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 1993;31:13-20.
19. Cattoretti G, Becker MH, Key CJ, Duchrow M, Schluter C, Galle J, et al. Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 1992;168:357-63.
20. Dukes CK. The classification of cancer of the rectum. J Pathol Bacteriol 1932;35:323-32.
21. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1070;227:680-5.
22. De Angelis P, Stokke T, Smedshammer L, Lothe RA, Meling GI, Rofstad M, et al. p53 expression is associated with a high degree of tumour DNA aneuploidy and incidence of p53 gene mutation, and is localized to the ancuploid component in colorectal carcinomas. Int J Oncol 1093;3:305-12.
23. Lømo J, Smeland EB, Krajewski S, Reed JC, Blomhoff HK. Expression of the Bcl-2 homologue Mcl-1 correlates with survival of peripheral blood B lymphocytes. Cancer Res 1996;56:40-3.
24. Vindelov LL, Christensen IJ, Nissen NI. A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cytometry 1983;3:323-7.
25. Shankey TV, Rabinovitch PS, Bagwell B, Bauer KD, Duque RE, Hedley DW, et al. Guidelines for implementation of clinical DNA cytometry. International Society for Analytical Cytology, Cytometry 1993;14:472-7.
26. MacCarty WC, Haumeder E. Has the cancer cell any differential characteristics? Am J Cancer 1934;20:403-7.
27. Caspersson T.O. In: Cell growth and cell function. A cytochemical study. New York: Norton, 1950.
28. Derenzini M, Betts CM, Ceccarelli C, Eusebi V. Ultrastructural organization of nucleoli in benign naevi and malignant melanomas. Virchows Arch B Cell Pathol 1986;5:- 343-52.
29. Crocker J, Egan MJ. Correlation between NOR sizes and numbers in non-Hodgkin's lymphomas. J Pathol 1988;156:233-9.
30. Yang P, Huang OS, Zhu XS. Role of nucleolar organiser regions in differentiating malignant from benign tumours of the colon. J Clin Pathol 1990;43:235-8.
31. Kram N, Nessim S, Geller SA. A study of colonic adenocarcinoma, with comparison of histopathology, DNA flow cytometric data, and number of nucleolar organizer regions. Med Pathol 1989;2:468-72.
32. Rosa J, Mehta A, Filipe MI. Nueleolar organizer regions, proliferative activity, and DNA index in gastric carcinoma. Hsitopathology 1990;16:614-6.
33. Giri DD, Nottingham JF, Lawry J, Dundas SAC, Underwood JCE. Silver-binding nucleolar organizer regions (AgNORs) in benign and malignant breast lesions: correlations with ploidy and growth phase by DNA flow cytometry. J Pahtol 1989;157:307-13.
34. Hasegawa S, Okamura K, Shimoji T, Miyake K, Yamakawa Y, Sakamoto H. Evaluation of testicular germ cell tumour proliferation using DNA flow cytometry and nucleolar organizer silver staining. Cytometry 1994;15:59-63.