Organization of opioid receptors in human brain and drug interactions studied by PET and SPECT imaging: Implications for treatment strategies for opiate addiction

Seminars in the Neurosciences

Volumn 9, Issue 3-4, 1997, Pages 131-139

  Melichar, Jan K ^a,b   Malizia, Andrea L ^a,b   Nutt, David J ^a  

^a SCHOOL OF MEDICAL SCIENCES   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Addiction; Opioid receptors; PET; Radionuclide imaging; SPECT

Indexed keywords

BRAIN RECEPTOR; CARFENTANIL; DIPRENORPHINE; OPIATE; OPIATE RECEPTOR; RADIOLIGAND;

BINDING KINETICS; BRAIN; DRUG RECEPTOR BINDING; HUMAN; OPIATE ADDICTION; POSITRON EMISSION TOMOGRAPHY; RECEPTOR BINDING; REVIEW; SCINTISCANNING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

EID: 0030720302     PISSN: 10445765     EISSN: None     Source Type: Journal    
DOI: 10.1006/smns.1997.0113     Document Type: Article

References (56)

1. 1. Matthes, H., Maldonado, R., Simonin, F., et al. (1996) Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature 383, 819-823.
2. 2. Meunier, J. C., Mollereau, C., Toll, L., et al. (1995) Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor [see comments]. Nature 377, 532-535.
3. 3. Mollereau, C., Simons, M. J., Soularue, P., et al. (1996) Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene. Proc. Natl. Acad. Sci. USA 93, 8666-8670.
4. 4. Mollereau, C., Parmentier, M., Mailleux, P., et al. (1994) ORL1, a novel member of the opioid receptor family: Cloning, functional expression and localization. FEBS Lett. 341, 33-38.
5. 5. Bailey, D., Zito, F., Gilard, M., et al. (1994) Performance comparison of a state-of-the-art neuro-SPET scanner and a dedicated neuro-PET scanner. Eur. J. Nucl. Med. 21, 381-387.
6. 6. Pike, V. W. (1993) Positron-emitting radioligands for studies in vivo - Probes for human psychopharmacology. J. Psychopharmacol. 7, 139-158.
7. 7. Cunningham, V. J., Lammertsma, A. A. (1994) Radioligand studies in brain: Kinetic analysis of PET data. Med. Chem. Res. 5, 79-96.
8. 8. Mintun, M. A., Raichle, M. E., Kilbourn, M. R. et al. (1984) A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann. Neurol. 15, 217-227.
9. 11C]flumazenil and a single experiment protocol. J. Cereb. Blood Flow Metab. 15, 284-300.
10. 10. Frey, K. A., Holthoff, V. A., Koeppe, R. A., et al. (1991) Parametric in vivo imaging of benzodiazepine receptor distribution in human brain. Ann. Neurol. 30, 663-672.
11. 11. Gunn, R. N., Lammertsma, A. A., Hume, S. P., et al. (1997) Parametric imaging of ligand-receptor binding in PET using a simplified reference region model. NeuroImage, in press.
12. 12. Cunningham, V. J., and Jones, T. (1993) Spectral analysis of dynamic PET studies. J. Cereb. Blood Flow Metab. 13, 15-23.
13. 13. Lassen, N. A. (1992) Neuroreceptor quantitation in vivo by the steady state principle using constant infusion or bolus injection of radioactive tracers. J. Cereb. Blood Flow Metab. 12, 709-716.
14. 14. Frost, J. J., Wagner, H. N., Jr., Dannals, R. F., et al. (1985) Imaging opiate receptors in the human brain by positron tomography. J. Comput. Assist. Tomogr. 9, 231-236.
15. 15. Sadzot, B., and Frost, J. J. (1990) Pain and opiate receptors: Considerations for the design of positron emission tomography studies. Anesth. Prog. 37, 113-120.
16. 16. Richards, M. L., and Sadee, W. (1985) In vivo opiate receptor binding of oripavines to mu, delta and kappa sites in rat brain as determined by an ex vivo labeling method. Eur. J. Pharmacol. 114, 343-353.
17. 17. Jones, A. K., Luthra, S. K., Maziere, B., et al. (1988) Regional cerebral opioid receptor studies with [11C]diprenorphine in normal volunteers. J. Neurosci. Methods 23, 121-129.
18. 18. Jones, A. K., Luthra, S. K., Pike, V. W., et al. (1985) New labeled ligand for in-vivo studies of opioid physiology. Lancet 665-666.
19. 11C)pethidine in the brain of the rhesus monkey studied with positron emission tomography. Pharmacol. Toxicol 66, 37-40.
20. 11C-labeled opiates in the brain of rhesus monkeys. J. Pharmacol. Exp. Ther. 230, 250-255.
21. 18F-Cyclofoxy PET imaging in man. J. Nucl. Med. 29, 796.
22. 18F]cyclofoxy. Epilepsy Res. 13, 129-139.
23. 11C-methyl)naltrindole and PET. J. Nucl. Med. 34, 103P.
24. 11C-methyl) naltrindole in human brain with PET. J. Nucl. Med. 35, 67P.
25. 25. Madar, I., Lesser, R. P., Krauss, G., et al. (1994) Alterations in delta opioid receptors in temporal lobe epilepsy demonstrated by PET: Comparison with mu opioid receptors and metabolic activity. J. Nuc. Med. 35, 31P.
26. 26. Kinter, C. M., and Lever, J. R. (1995) Synthesis of radioiodinated naltrindole analogues: Ligands for studies of delta opioid receptors. Nucl. Med. Biol. 22, 599-606.
27. 27. Lever, J. R., Kinter, C. M., Stathis, M., et al. (1994) Radioiodinated 7′-iodonaltrindole: A ligand for in vitro and in vivo studies of cerebral delta opioid receptors. J. Nucl. Med. 35, 245P-246P.
28. 11C]methyl]buprenorphine in baboon brain. Nucl. Med. Biol. 23, 325-331.
29. 18F]fluoropropyl)-N-nordiprenorphine - synthesis, anatomical distribution in mice and rats, and tomographic studies in a baboon. Int. J. Rad. Appl. Instrum. B 17, 217-227.
30. 30. Lever, J. R., Scheffel, U., Stathis, M., et al. (1994) Evaluation of radioiodinated C6-O-and N-iodoallyl analogues of diprenorphine as ligands for cerebral opioid receptors. J. Nucl. Med. 35, 128P.
31. 11C]diprenorphine and positron emission tomography. Epilepsy Res. 19, 71-77.
32. 32. Bartenstein, P. A., Duncan, J. S., Prevett, M. C., et al. (1993) Investigation of the opioid system in absence seizures with positron emission tomography. J. Neurol. Neurosurg. Psychiatry 56, 1295-1302.
33. 33. Mayberg, H. S., Sadzot, B., Meltzer, C. C., et al. (1991) Quantification of mu and non-mu opiate receptors in temporal lobe epilepsy using positron emission tomography. Ann. Neurol. 30, 3-11.
34. 34. Jones, A. K., Cunningham, V. J., Ha-Kawa, S., et al. (1994) Changes in central opioid receptor binding in relation to inflammation and pain in patients with rheumatoid arthritis. Br. J. Rheumatol. 33, 909-916.
35. 35. Jones, A. K., Qi, L. Y., Fujirawa, T., et al. (1991) In vivo distribution of opioid receptors in man in relation to the cortical projections of the medial and lateral pain systems measured with positron emission tomography. Neurosci. Lett. 126, 25-28.
36. 36. van Heerden, B., Price, J. C., Jeffrey, P., et al. (1992) The effects of nitrous oxide on the endogenous opiate system, measured with PET and C-11 Carfentanil. J. Nucl. Med. 33, 883-884.
37. 37. Zubieta, J., Gorelick, D., Stauffer, R., et al. (1996) Increased mu opioid receptor binding detected by PET in cocaine-dependent men is associated with cocaine craving. Nature Med. 2, 1225-1229.
38. 11C]carfentanil binding to opiate receptors in humans by positron emission tomography. J. Cereb. Blood Flow Metab. 10, 484-492.
39. 39. Pilapil, C., Welner, S., Magnan, J., et al. (1987) Autoradiographic distribution of multiple classes of opioid receptor binding sites in human forebrain. Brain Res. Bull. 19, 611-615.
40. 40. Cross, A. J., Hille, C., and Slater, P. (1987) Subtraction autoradiography of opiate receptor subtypes in human brain. Brain Res. 418, 343-348.
41. 41. Maurer, R., Cortes, R., Probst, A., et al. (1983) Multiple opiate receptor in human brain: an autoradiographic investigation. Life Sci. 33(Suppl 1).
42. 11C]diprenorphine cerebral kinetics in man acquired by PET using presaturation, pulse-chase and traceronly protocols. J. Neurosci. Methods 51, 123-134.
43. 11C]diprenorphine and positron emission tomography. J. Cereb. Blood Flow Metab. 11, 204-219. [published erratum appears in J. Cereb. Blood Flow Metab., 1992, Sep;12(5):885]
44. 44. Walter, K., Price, J., van Heerden, B., et al. (1993) Ethanol increases mu-opioid receptor binding in man measured by C-11 Carfentanil and PET. J. Nuclear Med. 34.
45. 45. Frost, J. J., Mayberg, H. S., Fisher, R. S., et al. (1988) Mu-opiate receptors measured by positron emission tomography are increased in temporal lobe epilepsy. Ann. Neurol. 23, 231-237.
46. 18F]cyclofoxy and positron emission tomography. J. Cereb. Blood Flow Metab. 13, 24-42.
47. 47. Jones, A. K., Friston, K. J., Qi, L. Y., et al. (1991) Sites of action of morphine in the brain. Lancet 338, 825. [letter].
48. 48. Berman, J. (1995) Imaging pain in humans. British J. Anaesthesia 75, 209-215.
49. 11C]diprenorphine PET study. Brain 118, 951-958.
50. 50. Bice, A. N., Wagner, H. N., Jr., Frost, J. J., et al. (1986) Simplified detection system for neuroreceptor studies in the human brain. J. Nucl. Med. 27, 184-191.
51. 11C]carfentanil in vivo binding to opiate receptors in man using a dual detector system. Eur. J. Pharmacol. 257, 195-197.
52. 52. Malizia, A., Forse, G., Haida, A., et al. (1995) A new human (psycho)pharmacology tool: The multiple organs coincidences counter (MOCC). J. Psychopharmacol. 9, 294-306.
53. 53. Malizia, A., Gunn, R. N., Wilson, S. J., et al. (1996) Benzodiazepine site pharmacokinetic/pharmacodynamic quantification in man: Direct measurement of drug occupancy and effects on the human brain in vivo. Neuropharmacology 35, 1483-1491.
54. 54. Strain, E. C., Preston, K. L., Liebson, I. A., et al. (1992) Acute effects of buprenorphine, hydromorphone and naloxone in methadone-maintained volunteers. J. Pharmacol. Exp. Ther. 261, 985-993.
55. 55. Zacny, J., Lichtor, J., Zaragoza, J., et al. (1992) Subjective and behavioural responses to intravenous fentanyl in healthy volunteers. Psychopharmacology 107, 319-326.
56. 56. Farde, L., Wiesel, F. A., Halldin, C., et al. (1988) Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs. Arch. Gen. Psychiatry 45, 71-76.