Defining extracellular integrin α-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding

Molecular Biology of the Cell

Volumn 8, Issue 12, 1997, Pages 2647-2657

  Pujades, Cristina ^a,d   Alon, Ronen ^a,b   Yauch, Robert L ^a   Masumoto, Akihide ^a   Burkly, Linda C ^c   Chen, Chun ^b   Springer, Timothy A ^a   Lobb, Roy R ^c   Hemler, Martin E ^a,e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c Bioeen Inc   (United States)

^d ECOLE NORMALE SUPÉRIEURE   (France)

^e DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL ADHESION; CELL MEMBRANE RESISTANCE; EXTRACELLULAR MATRIX; GENE LOCATION; GENE MUTATION; GENETIC ORGANIZATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; SHEAR RATE; TUMOR GROWTH;

ANIMALIA;

EID: 0030717710     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.8.12.2647     Document Type: Article

References (76)

1. Akiyama, S.K., Yamada, S.S., Chen, W.-T., and Yamada, K.M. (1989). Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization. J. Cell Biol. 109, 863-875.
2. Alon, R., Hammer, D.A., and Springer, T.A. (1995a). Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow. Nature 374, 539-542.
3. Alon, R., Kassner, P.D., Carr, M.W., Finger, E.B., Hemler, M.E., and Springer, T.A. (1995b). The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J. Cell Biol. 128, 1243-1253.
4. 2+ coordination, by genetic engineering. J. Biol. Chem. 267, 15469-15474.
5. Bajt, M.L., Goodman, T., and McGuire, S.L. (1995). β2 (CD18) mutations abolish ligand recognition by I domain integrins LFA-1 (αLβ2, CD11a/CD18) and MAC-1 (αMβ2, CD11b/CD18). J. Biol. Chem. 270, 94-98.
6. Bergelsen, J.M., St John, N., Kawaguchi, S., Pasqualini, R., Berdichevsky, F., Hemler, M.E., and Finberg, R.W. (1994). The I domain is essential for echovirus 1 interaction with VLA-2. Cell Adhes. & Commun. 2, 455-464.
7. Berlin, C., Bargatze, R.F., Campbell, J.J., von Andrian, U.H., Szabo, M.C., Hassien, S.R., Nelson, R.D., Berg, E.L., Erlandsen, S.L., and Butcher, B.C. (1995). α4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 80, 413-422.
8. Boudreau, N., Sympson, C.J., Werb, Z., and Bissell, M.J. (1995). Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 267, 891-893.
9. Brooks, P.C., Clark, R.A.F., and Cheresh, D.A. (1994). Requirement of vascular integrin αVβ3 for angiogenesis. Science 264, 569-571.
10. D'Souza, S.E., Ginsberg, M.H., Burke, T.A., Lam, S.C.-T., and Plow, E.F. (1988). Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor. Science 242, 91-93.
11. D'Souza, S.E., Ginsberg, M.H., Burke, T.A., and Plow, E.F. (1990). The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximai to the second calcium binding domain of its α subunit. J. Biol. Chem. 265, 3440-3446.
12. D'Souza, S.E., Ginsberg, M.H., Matsueda, G.R., and Plow, E.F. (1991). A discrete sequence in a platelet integrin is involved in ligand recognition. Nature 350, 66-68.
13. Damsky, C.H., and Werb, Z. (1992). Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extra-cellular information. Curr. Opin. Cell Biol. 4, 772-781.
14. Diamond, M.S., Garcia-Aguilar, J., Bickford, J.K., Corbi, A.L., and Springer, T.A. (1993). The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands. J. Cell Biol. 120, 1031-1043.
15. Elices, M.J., Osborn, L., Takada, Y., Crouse, C., Luhowskyj, S., Hemler, M.E., and Lobb, R.R. (1990). VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 60, 577-584.
16. Fässler, R., Pfaff, M., Murphy, J., Noegel, A.A., Johansson, S., Timpl, R., and Albrecht, R. (1995). Lack of β1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts. J. Cell Biol. 128, 979-988.
17. Ferreira, O.C., Jr., García-Pardo, A., and Bianco, C. (1990). Specific binding of the human monocyte cell line U937 to the alternatively spliced connecting segment (IIICS) of fibronectin. J. Exp. Med. 171, 351-356.
18. Giancotti, F.G., and Mainiero, F. (1994). Integrin-mediated adhesion and signaling in tumorigenesis. Biochim. Biophys. Acta 1198, 47-64.
19. Guan, J.-L., and Hynes, R.O. (1990). Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1. Cell 60, 53-61.
20. 2+-binding properties of the platelet glyco-protein lib ligand-interacting domain. J. Biol. Chem. 267, 1001-1007.
21. Hemler, M.E. (1990). VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu. Rev. Immunol. 8, 365-400.
22. Hemler, M.E., Huang, C., Takada, Y., Schwarz, L., Strominger, J.L., and Clabby, M.L. (1987). Characterization of the cell surface heterodimer VLA-4 and related peptides. J. Biol. Chem. 262, 11478-11485.
23. Hemler, M.E., Sánchez-Madrid, F., Flotte, T.J., Krensky, A.M., Burakoff, S.J., Bhan, A.K., Springer, T.A., and Strominger, J.L. (1984). Glycoproteins of 210,000 and 130,000 m. w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines. J. Immunol. 132, 3011-3018.
24. Hemler, M.E., and Strominger, J.L. (1982). Monoclonal antibodies reacting with immunogenic mycoplasma proteins present in human hematopoietic cell lines. J. Immunol. 129, 2734-2738.
25. Hemler, M.E., Ware, C.F., and Strominger, J.L. (1983). Characterization of a novel differentiation antigen complex recognized by a monoclonal antibody (A-1A5): unique activation-specific molecular forms on stimulated T cells. J. Immunol. 131, 334-340.
26. Hynes, R.O. (1992). Integrins: versatility, modulation and signalling in cell adhesion. Cell 69, 11-25.
27. Isenberg, W.M., McEver, R.P., Phillips, D.R., Shuman, M.A., and Bainton, D.F. (1987). The platelet fibrinogen receptor: an immuno-gold-surface replica study of agonist-induced ligand binding and receptor clustering. J. Cell Biol. 104, 1655-1663.
28. Jakubowski, A., Rosa, M.D., Bixler, S., Lobb, R., and Burkly, L.C. (1995). Vascular cell adhesion molecule (VCAM)-Ig fusion protein defines distinct affinity states of the very late antigen-4 (VLA-4) receptor. Cell Adhes. & Commun. 3, 131-142.
29. Juliano, R.L., and Haskill, S. (1993). Signal transduction from the extracellular matrix. J. Cell Biol. 120, 577-585.
30. Kamata, T., Puzon, W., and Takada, Y. (1995). Identification of putative ligand-binding sites of the integrin α4β1 (VLA-4, CD49d/CD29). Biochem. J. 305, 945-951.
31. Kamata, T., and Takada, Y. (1995). Direct binding of collagen to the I domain of integrin α2β1 (VLA-2, CD49b/CD29) in a divalent cation-independent manner. J. Biol. Chem. 269, 26006-26010.
32. Kassner, P.D., Alon, R., Springer, T.A., and Hemler, M.E. (1995). Specialized functional roles for the integrin α4 cytoplasmic domain. Mol. Biol. Cell 6, 661-674.
33. Kern, A., Briesewitz, R., Bank, I., and Marcantonio, E.E. (1994). The role of the I domain in ligand binding of the human integrin α1/β1. J. Biol. Chem. 269, 22811-22816.
34. Lee, J.-O., Rieu, P., Arnaout, M.A., and Liddington, R. (1995). Crystal structure of the A domain from the a subunit of integrin CR3 (CD11b/CD18). Cell 80, 631-638.
35. Lemke, H., Hammerling, G.J., Hohmann, C., and Rajewsky, K. (1978). Hybrid cell lines secreting monoclonal antibody specific for major histocompatibility antigens of the mouse. Nature 271, 249-251.
36. Lenter, M., Uhlig, H., Hamann, A., Jeno, P., Imhof, B., and Vestweber, D. (1993). A monoclonal antibody against an activation epitope on mouse integrin chain β1 blocks adhesion of lymphocytes to the endothelial integrin α6β1. Proc. Natl. Acad. Sci. USA 90, 9051-9055.
37. Lobb, R.R., Chi-Rosso, G., Leone, D.R., Rosa, M.D., Newman, B.M., Luhowskyj, S., Osborn, L., Schiffer, S.G., Benjamin, C.D., Dougas, I.G., Hession, C., and Chow, E.P. (1991). Expression and functional characterization of a soluble form of vascular cell adhesion molecule 1 (VCAM-1). Biochem. Biophys. Res. Commun. 178, 1498-1504.
38. Lobb, R.R., Antognetti, G., Pepinsky, R.B., Burkly, L.C., Leone, D.R., and Whitty, A. (1995). A direct binding assay for the vascular cell adhesion molecule-1 (VCAM1) interaction with alpha4 integrins. Cell Adhes. & Commun. 3, 385-397.
39. Lobb, R.R., and Hemler, M.E. (1994). The pathophysiologic role of α4 integrins in vivo. J. Clin. Invest. 94, 1722-1728.
40. Loftus, J.C., O'Toole, T.E., Plow, E.F., Glass, A., Frelinger, A.L., and Ginsberg, M.H. (1990). A β3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation. Science 249, 915-918.
41. Loftus, J.C., Smith, J.W., and Ginsberg, M.H. (1994). Integrin mediated cell adhesion: the extracellular face. J. Biol. Chem. 269, 25235-25238.
42. Mannion, B.A., Berditchevski, F., Kraeft, S.-K., Chen, L.B., and Hemler, M.E. (1996). TM4SF proteins CD81 (TAPA-1), CD82, CD63 and CD53 specifically associate with α4βl integrin. J. Immunol. 157, 2039-2047.
43. Masumoto, A., and Hemler, M.E. (1993). Mutation of putative divalent cation sites in the α4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin. J. Cell Biol. 223, 245-253.
44. Meredith, J.E., Jr., Fazeli, B., and Schwartz, M.A. (1993). The extracellular matrix as a cell survival factor. Mol. Biol. Cell 4, 953-961.
45. Michishita, M., Videm, V., and Arnaout, M.A. (1993). A novel divalent cation-binding site in the A domain of the β2 integrin CR3 (CD11b/CD18) is essential for ligand binding. Cell 72, 857-867.
46. Miyamoto, S., Akiyama, S.K., and Yamada, K.M. (1995). Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science 267, 883-885.
47. Needham, L.A., Van Dijk, S., Pigott, R., Edwards, R.M., Shephard, M., Hemingway, I., Jack, L., and Clements, J.M. (1994). Activation dependent and independent VLA-4 binding sites on vascular cell adhesion molecule-1. Cell Adhes. & Commun. 2, 87-99.
48. Osborn, L., Vassallo, C., and Benjamin, C.D. (1992). Activated endothelium binds lymphocytes through a novel binding site in the alternatively spliced domain of vascular cell adhesion molecule-1. J. Exp. Med. 176, 99-107.
49. Perelson, A.S., and DeLisi, C. (1980). Receptor clustering on a cell surface. I. Theory of receptor crosslinking by ligands bearing two chemically identical functional groups. Math. Biosci. 48, 71-110.
50. Pujades, C., Teixidó, J., Bazzoni, G., and Hemler, M.E. (1996). Integrin cysteines 278 and 717 modulate VLA-4 ligand binding and also contribute to α4/180 formation. Biochem. J. 333, 899-908.
51. Qian, F., Vaux, D.L., and Weissman, I.L. (1994). Expression of the integrin α4β1 on melanoma cells can inhibit the invasive stage of metastasis formation. Cell 77, 335-347.
52. Randi, A.M., and Hogg, N. (1994). I domain of β2 integrin lymphocyte function-associated antigen-1 contains a binding site for ligand intercellular adhesion molecule-1. J. Biol. Chem. 269, 12395-12398.
53. Rice, G.E., Munro, J.M., and Bevilacqua, M.P. (1990). Inducible cell adhesion molecule 110 (INCAM-110) is an endothelial receptor for lymphocytes: A CD11/CD18-independent adhesion mechanism. J. Exp. Med. 171, 1369-1374.
54. Rosen, G.D., Sanes, J.R., LaChance, R., Cunningham, J.M., Roman, J., and Dean, D.C. (1992). Roles for the integrin VLA-4 and its counter receptor VCAM-1 in myogenesis. Cell 69, 1107-1119.
55. Schiffer, S.G., Hemler, M.E., Lobb, R.R., Tizard, R., and Osborn, L. (1995). Molecular mapping of functional antibody binding sites of alpha 4 integrin. J. Biol. Chem. 270, 14270-14273.
56. Schlaepfer, D.D., Hanks, S.K., Hunter, T., and Vandergeer, P. (1994). Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372, 786-791.
57. Schwartz, B.R., Wayner, E.A., Carlos, T.M., Ochs, H.D., and Harlan, J.M. (1990). Identification of surface proteins mediating adherence of CD11/CD18-deficient lymphoblastoid cells to cultured human endothelium. J. Clin. Invest. 85, 2019-2022.
58. Smith, J.W., and Cheresh, D.A. (1988). The Arg-Gly-Asp binding domain of the vitronectin receptor: photoaffinity cross-linking implicates amino acid residues 61-203 of the β subunit. J. Biol. Chem. 263, 18726-18731.
59. Smith, J.W., and Cheresh, D.A. (1990). Integrin (αVβ3)-ligand inter-action: Identification of a heterodimeric RGD binding site on the vitronectin receptor. J. Biol. Chem. 265, 2168-2172.
60. Smyth, S.S., Joneckis, C.C., and Parise, L.V. (1993). Regulation of vascular integrins. Blood 81, 2827-2843.
61. Springer, T.A. (1990). Adhesion receptors of the immune system. Nature 346, 425-434.
62. Springer, T.A. (1997). Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain. Proc. Natl. Acad. Sci. USA 94, 65-72.
63. Strynadka, N.C., and James, M.N.G. (1989). Crystal structures of the helix-loop-helix calcium-binding proteins. Annu. Rev. Biochem. 58, 951-998.
64. Takada, Y., Elices, M.J., Crouse, C., and Hemler, M.E. (1989). The primary structure of the α4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function. EMBO J. 8, 1361-1368.
65. Takada, Y., Ylänne, J., Mandelman, D., Puzon, W., and Ginsberg, M.H. (1992). A point mutation of integrin β1 subunit blocks binding of α5β1 to fibronectin and invasin but not recruitment to adhesion plaques. J. Cell Biol. 119, 913-921.
66. Tuckwell, D.S., Brass, A., and Humphries, M.J. (1992). Homology modelling of integrin EF-hands: Evidence for widespread use of a conserved cation-binding site. Biochem. J. 285, 325-331.
67. Vonderheide, R.H., and Springer, T.A. (1992). Lymphocyte adhesion through Very Late Antigen 4: evidence for a novel binding site in the alternatively spliced domain of Vascular Cell Adhesion Molecule 1 and an additional α4 integrin counter-receptor on stimulated endothelium. J. Exp. Med. 175, 1433-1442.
68. Vuori, K., and Ruoslahti, E. (1994). Association of insulin receptor substrate-1 with integrins. Science 266, 1576-1578.
69. Wayner, E.A., Garcia-Pardo, A., Humphries, M.J., McDonald, J.A., and Carter, W.G. (1989). Identification and characterization of the lymphocyte adhesion receptor for an alternative cell attachment domain in plasma fibronectin. J. Cell Biol. 109, 1321-1330.
70. Weitzman, J.B., Pujades, C., and Hemler, ME. (1997). Integrin α chain cytoplasmic tails regulate "antibody-redirected" cell adhesion, independent of ligand binding. Eur. J. Immunol. 27, 78-84.
71. Wilcox, D.A., Paddock, C.M., Lyman, S., Gill, J.C., and Newman, P.J. (1995). Glanzmann Thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb - role of the GPIIb amino terminus in integrin subunit association. J. Clin. Invest. 95, 1553-1560.
72. Williams, D.A., Rios, M., Stephens, C., and Patel, V.P. (1991). Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions. Nature 352, 438-441.
73. Yang, J.T., Rayburn, H., and Hynes, R.O. (1993). Embryonic mesodermal defects in α5 integrin-deficient mice. Development 119, 1093-1105.
74. Yang, J.T., Rayburn, H., and Hynes, R.O. (1995). Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development. Development 121, 549-560.
75. Yauch, R.L., Felsenfeld, D., Kraeft, S.-K., Chen, L.B., Sheetz, M., and Hemler, M.E. (1997). Mutational evidence for control of cell adhesion through integrin recruitment, independent of ligand binding. J. Exp. Med. 186, 1347-1355.
76. Zhou, L.B., Lee, D.H.S., Plescia, J., Lau, C.Y., and Altieri, D.C. (1994). Differential ligand binding specificities of recombinant CD11b/ CD18 integrin I domain. J. Biol. Chem. 269, 17075-17079.