Calphostin C synergistically induces apoptosis with VP-16 in lymphoma cells which express abundant phosphorylated Bcl-2 protein

Cellular and Molecular Life Sciences

Volumn 53, Issue 9, 1997, Pages 737-743

  Murata, M ^a   Nagai, M ^a   Fujita, M ^a   Ohmori, M ^a   Takahara, J ^a  

^a KAGAWA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Bcl 2; Follicular lymphoma; Phosphorylation; Protein kinase C

Indexed keywords

CALPHOSTIN C; DNA FRAGMENT; ETOPOSIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN BCL 2; PROTEIN KINASE C;

APOPTOSIS; ARTICLE; CHROMOSOME TRANSLOCATION 14; CONTROLLED STUDY; DEPHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LYMPHOMA CELL; PROTEIN PHOSPHORYLATION;

APOPTOSIS; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 18; DNA FRAGMENTATION; DRUG SYNERGISM; ETOPOSIDE; HUMANS; LYMPHOMA; NAPHTHALENES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; TETRADECANOYLPHORBOL ACETATE; TRANSLOCATION, GENETIC; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0030714175     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000180050093     Document Type: Article

References (35)

1. Rowley J. D. (1982) Identification of the constant chromosome regions involved in human hematologic malignant disease. Science 216: 749-751
2. Yunis J. J., Frizzera G., Oken M. M., McKenna J., Theologides A. and Arnesen M. (1987) Multiple recurrent genomic defects in follicular lymphoma. A possible model for cancer. New Engl. J. Med. 316: 79-84
3. Tsujimoto Y., Gorham J., Cossman J., Jaffe E. and Croce C. M. (1985) The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 229: 1390-1393
4. Bakhshi A., Jensen J. P., Goldman P., Wright J. J., McBride O. W. Epstein A. L. et al. (1985) Cloning the chromosomal breakpoint of t(14;18) human lymphomas: Clustering around JH on chromosome 14 and near a transcription unit on chromosome 18. Cell 41: 889-906
5. Cleary M. L., Smith S. D. and Sklar J. (1986) Cloning and structural analysis of cDNAs for bcl-2 and a hybrid Bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 47: 19-28
6. Graninger W. B., Seto M., Boutain B., Goldman P. and Korsmeyer S. J. (1987) Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells. J. Clin. Invest. 80: 1512-1515
7. Korsmeyer S. J. (1992) Bcl-2 initiates a new category of oncogenes: Regulators of cell death. Blood 80: 879-886
8. Kaufmann S. H. (1989) Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: A cautionary note. Cancer Res. 49: 5870-5878
9. Nicoletti I., Migliorati G., Pagliacci M. C., Grignani F. and Riccardi C. (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Meth. 139: 271-279
10. Sellins K. S. and Cohen J. J. (1987) Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes. J. Immunol. 139: 3199-3206
11. Murata M., Kubota Y., Tanaka T., Iida-Tanaka K., Takahara J. and Irino S. (1994) Effect of ubenimex on the proliferation and differentiation of U937 human histiocytic lymphoma cells. Leukemia 8: 2188-2193
12. Kobayashi E., Nakano H., Morimoto M. and Tamaoki T. (1989) Calphostin C (UCN-1028C), a novel microbial compound and highly potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun. 159: 548-553
13. Collins R. J., Harmon B. V., Souvlis T., Pope J. H. and Kerr J. F. (1991) Effects of cycloheximide on B-chronic lymphocytic leukaemic and normal lymphocytes in vitro: induction of apoptosis. Br. J. Cancer 64: 518-552
14. Baxter G. D. and Lavin M. F. (1992) Specific protein dephosphorylation in apoptosis induced by ionizing radiation and heat shock in human lymphoid tumour lines. J. Immunol. 148: 1949-1954
15. Alnemri E. S., Robertson N. M., Fernandes T. F., Croce C. M. and Litwack G. (1992) Overexpressed full-length human Bcl2 extends the survival of baculovirus-infected Sf9 insect cells. Proc. Natl Acad. Sci. USA 89: 7295-7299
16. May W. S., Tyler P. G., Ito T., Armstrong D. K., Qatsha K. A. and Davidson N. E. (1994) Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of Bcl-2 alpha in association with suppression of apoptosis. J. Biol. Chem. 269: 26865-26870
17. Guan R. J., Moss S. F., Arber N., Krajewski S., Reed J. C. and Holt P. R. (1996) 30 KDa phosphorylated form of Bcl-2 protein in human colon. Oncogene 12: 2605-2609
18. Liu L. F. (1989) DNA topoisomerase poisons as antitumour drugs. Ann. Rev. Biochem. 58: 351-375
19. Negri C., Bernardi R., Braghetti A., Ricotti G. C. and Scovassi A. I. (1993) The effect of the chemotherapeutic drug VP-16 on poly(ADP-ribosylation) in apoptotic HeLa cells. Carcinogenesis 14: 2559-2564
20. Seimiya H., Mashima T., Toho M. and Tsuruo T. (1997) c-Jun NH2-terminal kinase-mediated activation of interleukin-1β converting enzyme CED-3-like protease during anticancer drug-induced apoptosis. J. Biol. Chem. 272: 4631-4636
21. Hashimoto H., Chatterjee S. and Berger N. A. (1995) Inhibition of etoposide (VP-16)-induced DNA recombination and mutant frequency by Bcl-2 protein overexpression. Cancer Res. 55: 4029-4035
22. Nishizuka Y. (1988) The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature (Lond.) 334: 661-665
23. Negrini M., Silini E., Kozak C., Tsujimoto Y. and Croce C. M. (1987) Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma. Cell 49: 455-463
24. Lotem J., Cragoe E. J. Jr. and Sachs L. (1991) Rescue from programmed cell death in leukemic and normal myeloid cells. Blood 78: 953-960
25. Forbes I. J., Zalewski P. D., Giannakis C. and Cowled P. A. (1992) Induction of apoptosis in chronic lymphocytic leukemia cells and its prevention by phorbol ester. Exp. Cell Res. 198: 367-372
26. Tarduchy G. R. and Rivas A. L. (1989) Phorbol esters inhibit apoptosis in IL-2-dependent T lymphocytes. Biochem. Biophys. Res. Commun. 164: 1069-1075
27. 2+ requirements and sensitivity to cyclosporin A. J. Immunol. 142: 4085-4092
28. Cotter T. G., Lennon S. V., Glynn J. M. and Green D. R. (1992) Micro-filament-disrupting agents prevent the formation of apoptotic bodies in tumour cells undergoing apoptosis. Cancer Res. 52: 997-1005
29. Boe R., Gjertsen B. T., Vintermyr O. K., Hounge G., Lanotte M. and Doskeland S. O. (1991) The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp. Cell Res. 195: 237-246
30. Kiguchi K., Giometti C., Chubb C. H., Fujiki H. and Huberman E. (1992) Differentiation induction in human breast tumour cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A. Biochem. Biophys. Res. Commun. 189: 1261-1267
31. Haldar S., Jena N. and Croce C. M. (1995) Inactivation of Bcl-2 by phosphorylation. Proc. Natl Acad. Sci. USA 92: 4507-4511
32. 2+-sensitive phospholipid-dependent protein kinase activity in phorbol diester-treated 3T3 cells. Biochem. Biophys. Res. Commun. 120: 1053-1059
33. Oltvai Z. N., Milliman C. L. and Korsmeyer S. J. (1993) Bcl-2 hetero-dimerizes in vivo with a conserved homolog. Bax, that accelerates programmed cell death. Cell 74: 609-619
34. Boise L. H., Gonzalez-Garcia M., Postema C. E., Ding L., Lindsten T., Turka L.A. et al. (1993) Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74: 597-608
35. Takayama S., Sato T., Krajewski S., Kochel K., Irie S., Millan J. A. et al. (1995) Cloning and functional analysis of BAG-1: A novel Bcl-2 binding protein with anti-cell death activity. Cell 80: 279-284