Analysis of the effects of candesartan in the mesenteric vascular bed of the cat

Hypertension

Volumn 30, Issue 5, 1997, Pages 1260-1266

  Champion, Hunter C ^a   Kadowitz, Philip J ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiotensin peptides; Angiotensin receptor subtypes; Vasoconstriction

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; 1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLCHOLINE; ADENOSINE; ADENOSINE TRIPHOSPHATE DERIVATIVE; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANGIOTENSIN II [3-8]; ANGIOTENSIN III; ANGIOTENSIN RECEPTOR; BRADYKININ; CANDESARTAN; ENDOTHELIN 1; MECLOFENAMATE SODIUM; NEUROPEPTIDE Y; NORADRENALIN; RECEPTOR SUBTYPE; VASOPRESSIN;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; CAT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MESENTERY BLOOD FLOW; NONHUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL; VASOCONSTRICTION;

EID: 0030713094     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.30.5.1260     Document Type: Article

References (31)

1. Regoli D, Park WK, Rioux ND. Pharmacology of angiotensin. Pharmacol Rev. 1974;26:69-123.
2. Peach MJ. Renin-angiotensin system: biochemistry and mechanisms of action. Physiol Rev. 1977;57:313-370.
3. Timmermans PBMWM, Wong PC, Chiu AT, Herblin WF, Benfield P, Carini DJ, Lee RJ, Wexler RR, Saye JM, Smith RD. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev. 1993;45:205-251.
4. Cheng DY, DeWitt BJ, Dent EL, Nossaman BD, Kadowitz PJ. Analysis of responses to angiotensin IV in the pulmonary vascular bed of the cat. Eur J Pharmacol. 1994;261:223-227.
5. Garrison EA, Santiago JA, Kadowitz PJ. Analysis of responses to angiotensin peptides in the hindquarters vascular bed of the cat. Am J Physiol. 1995;268:H2425-H2428.
6. Garrison EA, Kadowitz PJ. Analysis of responses to angiotensin I-(3-10) in the hindlimb vascular bed of the cat. Am J Physiol. 1996;270:H1172-H1177.
7. Champion HC, Garrison EA, Estrada LS, Potter JM, Kadowitz PJ. Analysis of responses to angiotensin I and angiotensin I-(3-10) in the mesenteric vascular bed of the cat. Eur J Pharmacol. 1996;309:251-259.
8. 2 subtype. J Med Chem. 1991;34:3248-3260.
9. Chiu AT, Herblin WF, McCall DE, Ardecky RJ, Carini DJ, Duncia JV, Pease LJ, Wong PC, Wexler RR, Johnson AL, Timmermans PBMWM. Identification of angiotensin II receptor subtypes. Biochem Biophys Res Commun. 1989;165:196-203.
10. Charm RSL, Lotti VJ. Two distinct angiotensin II receptor binding sites in rat adrenal revealed by new selective nonpeptide ligands. Mol Pharmacol. 1990;37:347-351.
11. Bauer PH, Chiu AT, Garrison JC. DuP 753 can antagonize the effects of angiotensin II in rat liver. Mol Pharmacol. 1991;39:579-585.
12. de Gasparo M, Whitebread S, Mele M, Motani AS, Whitcombe PJ, Ramjoue H, Kamber B. Biochemical characterization of two angiotensin II receptor subtypes in the rat. J Cardiovasc Pharmacol. 1990;16:S31-S35.
13. Dudley DT, Panek RL, Major TC, Lu GH, Burns RF, Klinkefus BA, Hodges JC, Weishaar RE. Subclasses of angiotensin II binding sites and their functional significance. Mol Pharmacol. 1990;38:370-377.
14. Sechi LA, Grady EF, Griffin CA, Kalikyak JE, Schambelan M. Distribution of angiotensin II receptor subtypes in rat and human kidney. Am J Physiol. 1992;262:F236-F240.
15. Scheuer DA, Perrone MH. Angiotensin type 1 receptors mediate depressor phase of biphasic pressure response to angiotensin. Am J Physiol. 1993;264:R917-R923.
16. Bottari SP, de Gasparo M, Stackelings UM, Levens NR. Angiotensin II receptor subtypes: characterization, signaling mechanisms, and possible physiological implications. Front Neuroendocrinol. 1993;14:123-171.
17. Wong PC, Hart SD, Zaspel AM, Chiu AT, Ardecky RJ, Smith RD, Timmermans PBMWM. Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2). J Pharmacol Exp Ther. 1990;255:584-592.
18. Williams GH. Converting enzyme inhibitors in the treatment of hypertension. N Engl J Med. 1988;319:1517-1525.
19. Osei S, Minkes RK, Bellan JA, Kadowitz PJ. Effects of DuP 753 and EXP3471 on responses to angiotensin II in the hindquarters vascular bed of the cat. J Pharmacol Exp Ther. 1993;264:1104-1109.
20. Noda M, Shibouta Y, Inada Y, Ojima M, Wada T, Sanada T, Kubo J, Kohara Y, Naka T, Nishikawa K. Inhibition of rabbit aortic angiotensin II (AII) receptor by CV-11974, a new nonpeptide AII antagonist. Biochem Pharmacol. 1993;46:311-318.
21. Shibouta Y, Inada Y, Ojima M, Wada T, Noda M, Sanada T, Kubo K, Kohara Y, Naka T, Nishikawa K. Pharmacological profile of a highly potent and long-lasting angiotensin II receptor antagonist, 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole- 7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonyloxy)-ethyl-1-ethoxy-1-[[2′-(1H- tetrazol-5-yl)biphenyl-4-yl]rnethyl]-1H-benzimidazole-8-carhoxylate (TCV-116). J Pharmacol Exp Ther. 1993;266:114-120.
22. Wada T, Inada Y, Sanada T, Ojima M, Shibouta Y, Noda M, Nishikawa K. Effect of an angiotensin II receptor antagonist, CV-11974, and its prodrug, TCV-116, on production of aldosterone. Eur J Pharmacol. 1994;253:27-34.
23. 1 receptor antagonist CV-11974 in conscious renal hypertensive rats. Hypertension. 1995;26:989-997.
24. Snedecor GW, Cochran WG. Statistical Methods. Ames, Iowa: Iowa State University Press; 1967.
25. Swanson GN, Hanesworth JM, Sardinia MF, Coleman JKM, Wright JW, Hall KL, Miller-Wing AV, Stobb JW, Cook VI, Harding EC, Harding JW. Discovery of a distinct binding site for angiotensin II(3-8), a putative angiotensin IV receptor. Regul Pept. 1992;40:409-419.
26. Kono T, Ikeda F, Taniguchi A, Imura H, Osekio F, Yoshioka M, Khosla MC. Responses of patients with Bartter's syndrome to angiotensin II and angiotensin II-(3-8) hexapeptide. Acta Endocrinol. 1985;109:240-253.
27. Gardiner SM, Kemp PA, March JE, Bennett T. Regional haemodynamic effects of angiotensin II(3-8) in conscious rats. Br J Pharmacol. 1993;110:159-162.
28. Nickerson M. Receptor occupancy and tissue responses. Nature. 1956;178:697-698.
29. Stephenson RP. A modification of receptor theory. Br J Pharmacol. 1956;11:379-393.
30. Kwok YC, Moore GJ. Photoaffinity labeling of the rat isolated portal vein: determination of affinity constants and 'spare' receptors for angiotensins II and III. J Pharmacol Exp Ther. 1984;231:137-140.
31. Kwok YG, Moore GJ. Comparison of angiotensin receptors in isolated smooth muscle tissues by photoaffinity labelling. Eur J Pharmacol. 1985;115:53-58.