Intraclonal molecular heterogeneity suggests a hierarchy of pathogenetic events in Burkitt's lymphoma

Annals of Oncology

Volumn 8, Issue 10, 1997, Pages 987-994

  Gutierrez M I ^a   Bhatia, K ^a   Cherney, B ^b   Capello, D ^c   Gaidano, G ^c   Magrath, I ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

bcl 6; c myc; EBV; p53; Pathogenesis

Indexed keywords

MYC PROTEIN; ONCOPROTEIN; PROTEIN BCL 6; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; B CELL LYMPHOMA; BURKITT LYMPHOMA; CHROMOSOME ABERRATION; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; EPSTEIN BARR VIRUS; GENE MUTATION; HUMAN; HUMAN CELL; KARYOTYPING; ONCOGENE C MYC; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; VIRUS GENE;

ADULT; BURKITT LYMPHOMA; CHILD, PRESCHOOL; CLONE CELLS; DISEASE PROGRESSION; DNA-BINDING PROTEINS; GENES, MYC; GENES, P53; GENETIC HETEROGENEITY; HERPESVIRUS 4, HUMAN; HUMANS; LYMPHOMA, AIDS-RELATED; MALE; POINT MUTATION; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-6; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0030713009     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008265304712     Document Type: Article

References (23)

1. Magrath IT. Small noncleaved cell lymphomas (Burkitt's and Burkitt-like lymphomas). In Magrath IT (ed): The Non-Hodgkin's Lymphomas, 2nd edition. London: Arnold 1997.
2. Berger R, Bernheim A. Cytogenetics of Burkitt's lymphoma-leukemia: A review. IARC Sci Publ 1985; 60: 65-80.
3. Bhatia K, Gutierrez MI, Magrath IT. Burkitt's lymphoma cells frequently carry monoallelic DJ rearrangements. Curr Topics Microbiol Immunol 1993; 182: 319-24.
4. Magrath IT and Bhatia K. Pathogenesis of small noncleaved cell lymphomas (Burkitt's lymphoma). In Magrath IT (ed): The Non-Hodgkin's Lymphomas, 2nd edition. London: Arnold 1997.
5. Adams JM, Harris AW, Pinkert CA et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 1985; 318: 533-8.
6. Sidman CL, Shaffer DJ, Jacobsen K et al. Cell populations during tumorigenesis in Eu-myc transgenic mice. Leukemia 1993; 7: 887-95.
7. Bhatia K, Huppi K, Spangler G et al. Point mutations in the c-myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytoma. Nature Genet 1993; 5: 56-61.
8. Gu W, Bhatia K, Magrath IT et al. Binding and suppression of the c-myc transcriptional activation domain by p107. Science 1994; 264: 251-60.
9. Migliazza A, Martinotti S, Chen W et al. Frequent somatic hypermutation of the 5′ noncoding region of the bcl-6 gene in B-cell lymphoma. Proc Natl Acad Sci USA 1995; 92: 12520-4.
10. Gaidano G, Carbone A, Pastore C et al. Frequent mutation of the 5′ noncoding region of the bcl-6 gene in acquired immunodeficiency syndrome-related non-Hodgkin's lymphomas. Blood 1997; 89: 3755-62.
11. Bhatia K, Gutierrez MI, Huppi K. et al. The pattern of p53 mutations in Burkitt's lymphoma differs from that of solid tumors. Cancer Res 1992; 52: 4273-6.
12. Gutierrez MI, Bhatia K, Diez B et al. Prognostic significance of p53 mutations in small non-cleaved cell lymphomas. Int J Oncol 1994; 4: 567-71.
13. Fan S, el-Deiry WS, Bae I et al. p53 mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. Cancer Res 1994; 54: 5824-30.
14. Cherney B, Bhatia K, Sgadari C et al. Role of the p53 tumor suppressor gene in the tumorigenicity of Burkitt's lymphoma cells. Cancer Res 1997; 57: 2508-15.
15. Magrath IT, Jain V, Bhatia K. Epstein-Barr virus and Burkitt's lymphoma. Semin Cancer Biol 1992; 3: 285-95.
16. Neri A, Barriga F, Inghirami G et al. Epstein-Barr virus infection precedes clonal expansion in Burkitt's and acquired immunodeficiency syndrome-associated lymphoma. Blood 1991; 77: 1092-5.
17. Shiramizu B, Barriga F, Neequaye J et al. Patterns of chromosomal breakpoint locations in Burkitt's lymphoma: Relevance to geography and EBV association. Blood 1991; 77: 1516-26.
18. Shibata D, Weiss LM, Nathwani BN et al. Epstein-Barr virus in benign lymph node biopsies from individuals infected with the human immunodeficiency virus is associated with concurrent or subsequent development of non-Hodgkin's lymphoma. Blood 1991; 77: 1527-33.
19. Land H, Parada LF, Weinberg RA. Cellular oncogenes and multi-step carcinogenesis. Science 1983; 222: 771-8.
20. Lo Coco F, Gaidano G, Louie CD et al. p53 mutations are associated with histologic transformation in follicular lymphomas. Blood 1993; 82: 2289-95.
21. Zelenetz AD, Chen TT, Levy R. Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection. J Exp Med 1992; 176: 1137-48.
22. Height SE, Swansbury GJ, Matutes E et al. Analysis of clonal rearrangements of the Ig heavy chain locus in acute leukemia. Blood 1996; 87: 5242-50.
23. Roncella S, Di Celle PF, Cutrona G et al. Cytogenetic rearrangements of c-myc oncogene occurs prior to infection with Epstein-Barr virus in the monoclonal malignant B cells from an AIDS patient. Leuk Lymph 1993; 9: 157-64.