Optimization of chiral resolution using packed columns with carbon dioxide-based mobile phases

Chirality

Volumn 9, Issue 7, 1997, Pages 672-677

  Lynam, Kenneth G ^a   Blackwell, John A ^a  

^a DUPONT COMPANY   (United States)

Author keywords

Chiral SFC; Efficiency; Methanol modified CO2; Packed column SFC; Retention; Selectivity; SFC; SubFC

Indexed keywords

CARBON DIOXIDE; METHANOL;

ARTICLE; CHIRAL CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRESSURE; PRIORITY JOURNAL; STEREOCHEMISTRY; STEREOSPECIFICITY; TEMPERATURE;

EID: 0030710443     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1997)9:7<672::AID-CHIR6>3.0.CO;2-9     Document Type: Article

References (20)

1. Peterson, P., Markides, K.E. Chiral separations performed by supercritical fluid chromatography. J. Chromatogr. 666:381-394, 1994.
2. Schleimer, M., Schurig, V. Enantiomer separation by capillary supercritical fluid chromatography. In: Analysis With Supercritical Fluids: Extraction and Chromatography. Wenclawiak, B., ed. New York: Springer-Verlag, 1992:135-150.
3. Terfloth, G.J., Pirkle, W.H., Lynam, K.G., Nicolas, E.C. Broadly applicable polysiloxane-based chiral stationary phase for high performance liquid chromatography and supercritical fluid chromatography. J. Chromatogr. 705:185-194, 1995.
4. Stringham, R.W., Lynam, K.G., Grasso, C.C. Application of subcritical fluid chromatography to rapid chiral method development. Anal. Chem. 66:1949-1954, 1994.
5. Blum, A.M., Lynam, K.G., Nicolas, E.C. Use of a new Pirkle-type chiral stationary phase in analytical and preparative subcritical fluid chromatography of pharmaceutical compounds. Chirality 6:302-313, 1994.
6. Whatley, J. Enantiomeric separations by packed column supercritical fluid chromatography. J. Chromatogr. 697:251-255, 1995.
7. Gasparrini, F., Misiti, D., Villani, C. Direct resolution of racemic compounds on chiral microbore columns by sub-and supercritical fluid chromatography. J. High Resolut. Chrom. 13:182-184, 1990.
8. Williams, K.L., Sander, L.C., Wise, S.A. Use of a naphthylethylcarbamoylated-β-cyclodextrin chiral stationary phase for the separation of drug enantiomers and related compounds by sub-and supercritical fluid chromatography. Chirality 8:325-331, 1996.
9. Reid, R.C., Prausnitz, J.M., Poling, B.E. The Properties of Gases and Liquids. New York: McGraw Hill, 4th ed., 1987:241-380.
10. Parcher, J.F., Strubinger, J.R. High pressure adsorption of carbon dioxide on supercritical fluid chromatography adsorbents. J. Chromatogr. 479:251-259, 1989.
11. Strubinger, J.R., Parcher, J.F. Surface excess (Gibbs) adsorption isotherms of supercritical carbon dioxide on octadecyl-bonded silica stationary phases. Anal. Chem. 61:951-955, 1989.
12. Strubinger, J.R., Parcher, J.F. High pressure phase distribution isotherms for supercritical fluid chromatographic systems. 1. Pure carbon dioxide. Anal. Chem. 63:98-103, 1991.
13. Strubinger, J.R., Parcher, J.F. High pressure phase distribution isotherms for supercritical fluid chromatographic systems. 2. Binary isotherms of carbon dioxide and methanol. Anal. Chem. 63:104-108, 1991.
14. Cheuh, P.L., Prausnitz, J.M. Vapor-liquid equilibria at high pressures: Calculation of critical temperatures, volumes and pressures of non-polar mixtures. AlChE J. 13:1107-1113, 1967.
15. 2-based mixed mobile phases: A review. J. Microcol. Sep. 4:91-122, 1992.
16. Leyendecker, D., Leyendecker, D., Schmitz, F.P., Klesper, E. Comparison of eluents in supercritical fluid chromatography. J. Liq. Chromatogr. 10:1917-1947, 1987.
17. Kelley, F.D., Chimowitz, E.H. Near-critical phenomena and resolution in supercritical fluid chromatography. AlChE J. 36:1163-1175, 1990.
18. Afrane, G., Chimowitz, E.H. A molecular thermodynamic model for adsorption equilibrium from supercritical fluids. J. Super. Fluids 6:143-154, 1993.
19. Afrane, G., Chimowitz, E.H. Adsorption in near-critical binary solvent mixtures: Thermodynamic analysis and data. Fluid Phase Equil. 111: 213-238, 1995.
20. Stringham, R.W., Blackwell, J.A. "Entropically driven" chiral separations in supercritical fluid chromatography. Confirmation of isoelution temperature and reversal of elution order. Anal. Chem. 68:2179-2185, 1996.