Megakaryocyte growth and development factor: A review of early clinical studies

Oncologist

Volumn 2, Issue 5, 1997, Pages 311-318

  Abraham, Rick ^a   Basser, Russell L ^a,b  

^a Centre for Development of Cancer Therapeutics   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Aggregation; c mp; Chemotherapy; Clinical; Human; Megakaryocyte growth and development factor; Mpl ligand; Phase 1; Platelet function; Platelets; Progenitor cell mobilization; Safety; Thrombopoietin; Toxicity Thrombocytopenia

Indexed keywords

CARBOPLATIN; CYCLOPHOSPHAMIDE; MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ADULT; AGED; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG EFFECT; DRUG POTENTIATION; DRUG SAFETY; FEMALE; GASTROINTESTINAL TOXICITY; GROWTH REGULATION; HEMATOPOIETIC STEM CELL; HOT FLUSH; HUMAN; HYPOKALEMIA; KIDNEY CARCINOMA; LUNG CARCINOMA; MALE; MEGAKARYOCYTE; NEUROTOXICITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; STOMACH CARCINOMA; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS; THROMBOEMBOLISM;

EID: 0030709471     PISSN: 10837159     EISSN: None     Source Type: Journal    
DOI: 10.1634/theoncologist.2-5-311     Document Type: Review

References (16)

1. Kelemen E, Csehati I, Tanos B. Demonstration and some properties of human thrombopoietin in thrombocythemic sera. Acta Haematol 1958;20:350-355.
2. McDonald TP. Thrombopoietin: its biology, purification, and characterization. Exp Hematol 1988;16:201-205.
3. Hill RJ, Leven RM, Levin FC et al. The effect of partially purified thrombopoietin on guinea pig megakaryocyte ploidy in vitro. Exp Hematol 1989;17:903-907.
4. Vannucchi AM, Grossi A, Rafanelli D et al. Partial purification and biochemical characterization of human plasma thrombopoietin. Leukemia 1988;2:236-240.
5. Miyake T, Kawakita M, Enomoto K et al. Partial purification and biological properties of thrombopoietin extracted from the urine of aplastic anemia patients. STEM CELLS 1982;2:129-144.
6. McDonald TP, Cottrell M, Clift R et al. Studies on the purification of thrombopoietin from kidney cell culture medium. J Lab Clin Med 1985;106:162-174.
7. Wendung F, Varlet P, Charon M et al. MPLV: a retrovirus complex inducing an acute myeloproliferative leukemia disorder in adult mice. Virology 1986;149:242-246.
8. Souyri M, Vigon I, Penciolelli JF et al. A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 1990;63:1137-1147.
9. Methia N, Louache F, Vainchenker W et al. Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 1993;82:1395-1401.
10. Bartley TD, Bogenberger J, Hunt P et al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor mpl. Cell 1994;77:1117-1124.
11. de Sauvage FJ, Hass PE, Spencer SD et al. Stimulation of megakaryopoiesis and thrombopoiesis by the c-mpl ligand. Nature 1994;369:533-538.
12. Lok S, Kaushansky K, Holly RD et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 1994;369:565-568.
13. Kato T, Ogami K, Shimada Y et al. Purification and characterization of thrombopoietin. J Biochem (Tokyo) 1995;118:229-236.
14. Kuter DJ, Beeler DL, Rosenberg RD. The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci USA 1994;91:11104-11108.
15. Wendling F, Maraskovsky E, Debili N et al. c-mpl ligand is a humoral regulator of megakaryopoiesis. Nature 1994;369:571-574.
16. Kaushansky K. Thrombopoietin: the primary regulator of platelet production. Blood 1995;86:419-431.